I wore monovision glasses for several years.  They didn't work well, but
they did work.  My OD was reluctant to prescribe them, but I pointed out
that I couldn't use conventional glasses or no glasses, anyway.  I wore
contacts about 14 hours a day, and pretty much 7 days a week.  The
glasses were for the little time that I wasn't wearing contacts.  I was
plano in the right eye and -10D in the left.

I don't know that I would recommend them.  Contacts are the way to go.

I've read that wearing contact lenses is the only option when there is
a significant disparity in uncorrected vision between the eyes (say -1D
right eye and -5D left eye).  Would it be possible to make monovision
glasses that might work without the contact lenses?