Don't confuse anisometropia (ie refractive difference between the two
eyes) with monovision (correcting one eye for distance and the other
for near vision).  They are quite different animals although you can
do monovision with people with anisometropia.

So if you're referring to simply distance vision correction, contacts
are a better visual option than glasses for individuals with a
significant
anisometropia. But if you're referring to correcting your right eye for
distance (still would be the -1.00 d) and dropping the left eye
correction for NEAR (say you need a +2.00 d add- the left eye
would now be a -3.00d) the glasses could work as now you have
decreased the refractive difference. Make sense?

Basically, if you're not over the age of 40 the monovision option
likely would not
work for you.

frank

I've read that wearing contact lenses is the only option when there is
a significant disparity in uncorrected vision between the eyes (say -1D
right eye and -5D left eye).  Would it be possible to make monovision
glasses that might work without the contact lenses?