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Re: How can one tell of too much testosterone?

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Re: How can one tell of too much testosterone?

Spread_deMocracy27 Oct 2005 23:42
Ed:  very special thank you.   All these years I have never read anything
that so clearly linked DHT to testosterone and BPH...In my own case, I asked
several specialists along the way to my PVP.  None drew the relationship
that you just did.   Your response goes in my own personal clipping file of
useful info.   Thanks much.

Curiosity question:  why are you publishing papers on this topic?  What's
your association to the field of BPH?  Good luck with the publications.

"Ed Friedman" <ed@math.uchicago.edu> wrote [SNIP]

Ed Friedman27 Oct 2005 17:18
> From time to time I check in with this newsgroup and also one of the BPH
> bloggers, (see below)..I know blogs have lots of personal opinion, but once
[quoted text clipped - 4 lines]
> I'm referring to latest posting, see "...size..." at
> http://bph-prostate-enlarged.blogspot.com/ 

Well, that web site is partly true and partly nonsense.  Basically,
estradiol will cause inappropriate cell division within the prostate, so
you want to keep that level low.  Also, DHT will prevent the normal
apoptosis that occurs for prostate cells, so you want to keep that level
very low.  Finally, testosterone is what produces the apoptotic proteins
that kills the prostate cells when they get old (or are cancerous).  So,
to eliminate BPH (and early stage prostate cancer), you want high
testosterone, very low DHT (you need a 5AR2 inhibitor to achieve this)
and low estradiol (you need arimidex to achieve this).  All of these are
only available by prescription and must be taken under a knowledgable
doctor's care.

If you want to read more about the science involved here, check out my
paper at:

http://www.tbiomed.com/content/2/1/10

My next paper should clarify this all greatly, and hopefully will be
published in that same journal before the end of this year.

Ed Friedman

Spread_deMocracy27 Oct 2005 01:54
From time to time I check in with this newsgroup and also one of the BPH
bloggers, (see below)..I know blogs have lots of personal opinion, but once
in a while my curiosity is piqued.   The new posting about hormones piques
my curiosity.  Anyone on this newsgroup able to confirm this, and if so,
provide more scientific explanations or an authoritative reference?  Thanks
in advance...
I'm referring to latest posting, see "...size..." at
http://bph-prostate-enlarged.blogspot.com/

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