And what makes YOU think that it doesn't if you don't have the
disease?  The etheno-DNA adducts don't even need copper, iron works
equally well in the lipid peroxidation reactions.  The DNA damage may
be actually useful in the brain to signal that the neurons with
screwed mitochondria overproducing ROS should be killed by apoptosis.

Taka

You are such an idiot.

Curcumin may damage DNA *if* you have Wilson's Disease.

Carcinogenesis. 2005 Jul;26(7):1307-15. Epub 2005 Mar 24.

Apoptosis and age-dependant induction of nuclear and mitochondrial
etheno-DNA adducts in Long-Evans Cinnamon (LEC) rats: enhanced DNA
damage by dietary curcumin upon copper accumulation.

Nair J, Strand S, Frank N, Knauft J, Wesch H, Galle PR, Bartsch H.
Division of Toxicology and Cancer Risk Factors, German Cancer Research
Center (DKFZ), Heidelberg, Germany.

Long-Evans Cinnamon (LEC) rats, a model for human Wilson's disease,
develop chronic hepatitis and liver tumors owing to accumulation of
copper and induced oxidative stress. Lipid peroxidation (LPO)-induced
etheno-DNA adducts in nuclear- and mitochondrial-DNA along with
apoptosis was measured in LEC rat liver. Levels of etheno-DNA adducts
(1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine) increased
with age reaching a peak at 8 and 12 weeks in nuclear and
mitochondrial DNA, respectively. This is the first demonstration that
etheno-DNA adducts are also formed in mitochondrial DNA. Apoptosis was
assessed by TUNEL+ cells in liver sections. CD95L RNA expression was
also measured by in situ hybridization in the same sections. The
highest nuclear DNA adduct levels coincided with a reduced apoptotic
rate at 8 weeks. Mitochondrial-DNA adducts peaked at 12 weeks that
coincided with the highest apoptotic rate, suggesting a link of etheno-
DNA adducts in mitochondrial DNA to apoptosis. The DNA damage in liver
was further enhanced and sustained by 0.5% curcumin in the diet.
Treatment for 2 weeks elevated etheno-DNA adducts 9- to 25-fold in
nuclear DNA and 3- to 4-fold in mitochondrial-DNA, providing a
plausible explanation as to why in our earlier study [Frank et al.
(2003) Mutat. Res., 523-524, 127-135], curcumin failed to prevent
liver tumors in LEC rats. Our results also confirm the reported in
vitro DNA damaging potential of curcumin in the presence of copper
ions by reactive oxygen species. LPO-induced adduct formation in
nuclear and mitochondrial DNA appear as early lesions in LEC rat liver
carcinogenesis and are discussed in relation to apoptotic events in
the progression of malignant disease.
PMID: 15790590