These results strongly suggest that P. brasiliensis survival in human
monocytes is iron dependent.

Rev Inst Med Trop Sao Paulo. 2005 Sep-Oct;47(5):263-6. Epub 2005 Nov
16. Related Articles, Links

Inhibitory effect of deferoxamine on Paracoccidioides brasiliensis
survival in human monocytes: reversal by holotransferrin not by
apotransferrin.

Dias-Melicio LA, Calvi SA, Peracoli MT, Soares AM.

Department of Microbiology and Immunology, Biosciences Institute, Sao
Paulo State University, Botucatu, SP, Brazil. acsoares@ibb.unesp.br

The mechanisms used by Paracoccidioides brasiliensis to survive into
phagocytic cells are not clear. Cellular iron metabolism is of critical
importance to the growth of several intracellular pathogens whose
capacity to multiply in mononuclear phagocytes is dependent on the
availability of intracellular iron. Thus, the objective of this paper
was to investigate the role of intracellular iron in regulating the
capacity of P. brasiliensis yeast cells to survive within human
monocytes. Treatment of monocytes with deferoxamine, an iron chelator,
suppressed the survival of yeasts in a concentration-dependent manner.
The effect of deferoxamine was reversed by iron-saturated transferrin
(holotransferrin) but not by nonsaturated transferrin (apotransferrin).
These results strongly suggest that P. brasiliensis survival in human
monocytes is iron dependent.

PMID: 16302109 [PubMed - in process]

--------------------------------------------------------------------------------

Osteomyelitis Caused by Paracoccidioides brasiliensis in a Child from
the Metropolitan Area of Rio de Janeiro
Authors: Nogueira S.A.1; Guedes A.L.2; Wanke B.3; Capella S.4;
Rodrigues K.1; Abreu T.F.2; Morais J.C.1; Lambert J.S.3

Source: Journal of Tropical Pediatrics, Volume 47, Number 5, 1 October
2001, pp. 311-315(5)

Publisher:Oxford University Press

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Abstract:

The authors describe a case of paracoccidioidomycosis in a 7-year-old
girl from the city of Rio de Janeiro who initially presented to her
physician with a lesion in her calcaneous which was misdiagnosed and
treated as bacterial osteomyelitis. Later, cutaneous manifestations,
lymph node enlargement, and hepatosplenomegaly developed and biopsy of
the skin and cervical lymph nodes showed the fungus which was also
present in the sputum. It is emphasized that Paracoccidioides
brasiliensis can be the cause of bone lesions in endemic areas of Latin
America and that response to treatment with amphotericin B is good.
Document Type: Research article

DOI: 10.1093/tropej/47.5.311

Affiliations: 1: Hospital Universitário Clementino Fraga Filho,
Serviço de Doenças Infecciosas e Parasitárias, University Federal do
Rio de Janeiro, Brazil 2: Institute Puericultura e Pediatria Matargão,
University Federal do Rio de Janeiro, Brazil 3: Institute of Human
Virology, University of Maryland, USA 4: Hospital Municipal Salgado
Filho, Brazil

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