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Medical Forum / General / Vision / June 2008

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Another crazy experiment...

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Rich - 26 Jun 2008 19:07 GMT
…that’s the only kind I do  :-) …but this one is not as crazy as the
one that could have killed me, the “Optifuge” experiment (1)), but
quite unusual.

It’s the application of oxygen to the eye. I used a device called an
oxygen concentrator. By removing nitrogen from ambient air, it
delivers 90% pure oxygen, which I breathe at a rate of 5 liters per
minute through a nasal tube. (2).

So, what does this have to do with vision?  Just this: my previous
experiments have always involved myopia, but a couple of years ago I
was diagnosed with glaucoma (I didn’t know I had it), and my
ophthalmologist of course did what they all do, prescribed a
medication to lower my IOP (Intraocular Pressure), in my case, a Beta
blocker, Timolol.. Never mind that my IOP was within normal limits, he
went along with the hypothesis that glaucoma is the result of raised
IOP that damages the optic nerve.

When I asked about possible side effects, he dismissed them: “They
only occur in a small proportion of patients” (about 1 or 2 percent as
I recall). These include blurred vision, dizziness and dry eyes, as
well as more serious effects such as chest pain, fainting, and
irregular heartbeat (all these from the brochure accompanying the
medication).. Strange that they didn’t include others, such as
alopecia (hair loss)—just what I need! and impotence—Oh, great! but
then the brochure was written by the manufacturer. They didn’t include
the possibility of severe reactions like …death! (3).

Although I wasn’t bothered by the glaucoma, I also had to consider
the possibility that it could progress.

In researching the literature I kept coming across intriguing
references to the importance of oxygen to the eye. For example, how
many people are aware of the astonishing fact that the retina has “…
the highest oxygen demand of any tissue in the body.”?

Other papers dealt with the question of retinal hypoxia (def.:
deficiency in the amount of oxygen reaching body tissues) and its
possible effect on vision. For example, “…damage to the cells of the
optic nerve is now known to occur during migraine headaches, when
blood vessels constrict the flow of oxygen and other nutrients to the
cells”; “,.,neovascular glaucoma occurs in individuals in whom there
is poor blood flow to the eye. Blood supplies much of the eye with
nourishment, including oxygen, and removes waste from it”; “Decreased
blood flow to the eye causes structural changes over time that results
in increased IOP.” “Glaucoma patients have narrowed retinal blood
vessels compared to normals”.

These citations and others persuaded me that a much more convincing
case could be made that glaucoma was caused by reduced blood flow to
the eye that damaged retinal and optic nerve cells, not high
intraocular pressure.

After just a few days of breathing the 90% oxygen I noticed that
colors had become much brighter, and print appeared blacker.This
suggested that increasing the blood supply to the retina had improved
my contrast sensitivity. I later found a report on precisely this
effect. (4)

I also noticed improved visual acuity as shown on a Snellen chart, but
it is unclear whether this was due simply to the improved contrast
sensitivity or some other effect (change in the lens?,  axial
length?).

From reading hundreds of papers in the ophthalmology journals I
discovered a few that, in effect, dismiss the Glaucoma/IOP hypothesis
as nonsense. I could cite these papers, but it may be sufficient to
show the illogic of this hypothesis is by considering this: large
numbers of people with high IOP don’t have glaucoma; large numbers of
people with normal IOP have glaucoma; and of the large number of
people who lower their IOP with medication, their glaucoma continues
to progress.

Exercising, while breathing oxygen, dramatically increases the amount
of oxygen in the blood plasma, i.e., the portion of the blood outside
the red and white ells. This can be determined by testing the blood
oxygen level in the arteries and veins.

Doctors will say that you can't increase the oxygen in your blood by
breathing oxygen. But what they mean is that you can't increase the
amount of oxygen in your red blood cells, which are responsible for
transporting oxygen to the tissues. The reason the amount of oxygen in
the red cells cannot be increased is because, under most
circumstances, they are already 97 percent saturated with oxygen. So,
they say, a three percent increase will make little difference and the
red cells won't accept the extra oxygen, anyway.

      While this is true, they ignore the role of oxygen in the
plasma, the "juice" within which the red cells flow. The oxygen
content of this fluid can be dramatically increased and thus oxygen
will be "pushed" into the body's cells without the aid of the red
cells. It's called the Law of Mass Action. If you build up the
concentration of a certain component in a chemical mixture high
enough, chemical combining will take place with other elements of the
mixture that ordinarily wouldn't happen.

      Most of the oxygen in the plasma under these high-saturation
circumstances will be "wasted" in that it will not be absorbed by the
cells which expect to be "fed" oxygen by the red cells. But if only
one-tenth of one percent of the oxygen gets through, and you offer
your cells this extra oxygen every day, there will be an extensive
increase in your total tissue oxygen level.
Ophthalmologists tell their glaucoma patients that the condition can
not be reversed. What they mean, I think, is that the drugs they use
can’t do it. Apparently they are unaware that several studies show
that glaucoma CAN be reversed. Here’s one:

Bojic reports  a double-blind study where subjects who had a
glaucomatous visual field loss were exposed on a daily basis to 2.0
bars of air pressure for 90 minutes. Sixty percent of the subjects
engaged in an oxygen-breathing schedule, while the remainder breathed
only air.

The report summarizes: 1) “In the experimental group there was a
significant improvement of visual fields (p.>0.5), whereas there was
no change in the control group.” 2) “Hyperbaric oxygen did not have
any influence on intraocular pressure”. 3) “…the achieved visual field
improvements [e.g. 30% less blind spot area] remained stable for three
months…4) Our study indirectly  points to the role of a vascular
mechanism in the pathogenesis of glaucoma”. Bojic' 1993 - Bojic' L,
Racvicv G, Gošovic' S, Kovacvevic' H. The effect of hyperbaric oxygen
breathing on the visual field in glaucoma. Acta Ophth 1993; 315-319

There are hundreds of millions of people who suffer serious eye
conditions such as glaucoma, macular degeneration and diabetic
retinopathy. There is the possibility that these conditions could be
prevented, stopped, or even reversed, with oxygen therapy. It
certainly deserves to be studied much more than has been the case to
date.

--Rich
---------------------------------------------
1. www.i-see.org/optifuge.html  Other experiments involved compressing
the globe, and applying vibration to the eye, described at  http://aarcolin4.net

2. The device I used was a Respironics Millenium. Not cheap—around
$1500, but refurbished models are around $550.

  Another method is hyperbaric oxygen therapy (HBOT), which
      involves the breathing of pure oxygen while in a sealed chamber
that has been pressurized at 1.5 to 3 times normal atmospheric
pressure

3. Between 1978 and 1985 there were 450 case reports of serious
respiratory and cardiovascular events, and the FDA and the National
Registry of Drug-Induced Ocular Side Effects received reports of 32
cases of death attributed to ophthalmic Timolol

(4) “Hyperbaric oxygen treatment improves contrast sensitivity
(ability to see shades of gray) when administered to healthy
volunteers”

A useful book on the role of oxygen in human physiology is “Oxygen and
Aging” by Majid, Ali, M.D.

I should note that there are side effects to oxygen therapy for the
eyes, but unlike the drugs sold by Big Pharma, they are beneficial!
For more than 15 years I suffered from fibromyalgia in the form of
sometimes severe calf and ankle pain. After six weeks of oxygen
therapy it is almost gone!
Neil Brooks - 26 Jun 2008 21:21 GMT
Look into intravenous food-grade hydrogen peroxide.

I make no claims, and it has its own risks, but ... since you're
already playing with hyperoxygenation as a concept....
Dan Abel - 26 Jun 2008 22:24 GMT
In article
<919b4807-74e1-4187-947f-940867e9d372@h1g2000prh.googlegroups.com>,

> Look into intravenous food-grade hydrogen peroxide.
>
> I make no claims, and it has its own risks, but ... since you're
> already playing with hyperoxygenation as a concept....

I know a guy, not too well, but he was born premature, so they gave him
oxygen, so now he is blind in one eye.  Is that a good plan?

Signature

Dan Abel
Petaluma, California USA
dabel@sonic.net

Neil Brooks - 26 Jun 2008 22:31 GMT
> In article
> <919b4807-74e1-4187-947f-940867e9d...@h1g2000prh.googlegroups.com>,
[quoted text clipped - 6 lines]
> I know a guy, not too well, but he was born premature, so they gave him
> oxygen, so now he is blind in one eye.  Is that a good plan?

a) what caused his monocular blindness?  Was it the fact that he was
born premature?

b) Is what a good plan -- looking into something?  Sure.
Dan Abel - 27 Jun 2008 00:41 GMT
In article
<fe719273-46fe-4e76-94e6-8cd4fda5a294@w8g2000prd.googlegroups.com>,

> > In article
> > <919b4807-74e1-4187-947f-940867e9d...@h1g2000prh.googlegroups.com>,
[quoted text clipped - 8 lines]
>
> a) what caused his monocular blindness?

His good luck.  Some of these preemies ended up blind in *both* eyes.

>  Was it the fact that he was
> born premature?

With oxygen therapy.


> b) Is what a good plan -- looking into something?  Sure.

Guess what?  They don't do this anymore.

...

So I did the Google.  Choice between dead baby and blind baby.  Not a
good choice:

http://www.cbsnews.com/stories/2002/10/22/health/main526526.shtml

Signature

Dan Abel
Petaluma, California USA
dabel@sonic.net

Rich - 27 Jun 2008 01:41 GMT
> Look into intravenous food-grade hydrogen peroxide.
>
> I make no claims, and it has its own risks, but ... since you're
> already playing with hyperoxygenation as a concept....

Neil,

Thanks for your response. I had planned to include hydrogen peroxide
as an additional method of oxygenation but my post was already too
long. Hydrogen peroxide therapy is mentioned in Majid Ali's book,
"Oxygen and Aging".
Mike Tyner - 27 Jun 2008 00:48 GMT
>retinopathy. There is the possibility that these conditions could be
>prevented, stopped, or even reversed, with oxygen therapy. It
>certainly deserves to be studied much more than has been the case to
>date.

There is also the possibility that your tissues grow accustomed to increased
oxygen, then when you return to room air, they rebel by secreting VEGF and
growing new vessels that break and bleed and scar.

No? Isn't that how we get retinopathy of prematurity?

-MT
Rich - 27 Jun 2008 01:47 GMT
> >retinopathy. There is the possibility that these conditions could be
> >prevented, stopped, or even reversed, with oxygen therapy. It
[quoted text clipped - 8 lines]
>
> -MT

Re premature infant blindness, it runs out that blindness in premature
babies may be caused by doctors WITHHOLDING oxygen!  In any case,
we're talking apples and oranges here: premature babies vs. adults.

"Many premature babies die or suffer major permanent injuries because
they do not receive enough oxygen in their first few days when they
need it most1,2,3.

"Until the often still immature lungs of these preemies can extract
enough of this life- sustaining gas from the air they breathe, they
need this essential nourishment in higher concentrations than babies
more ready for the transition to life outside the womb.

"Their need for more concentrated oxygen is similar to their need for
the higher concentrations of essential food proteins which mothers of
preemies provide in their milk as compared to that from mothers who
carried their babies to term4.  The difference is that Nature tailors
their food to their needs, but not their air.

"Physicians have thus recommended since the turn of the century to
help premature babies with higher- than- normal concentrations of
oxygen, and many have fed them such enriched baby- fare of the lungs
with consistent success and no harmful side effects5, 6.

""This retinal disease common in intensive care nurseries affects now
to some degree up to two thirds of the smallest premature babies and
up to one third of the larger ones. Most of the affected infants
recover with minor or no immediately noticeable damage to their eyes,
but many do not. Among the most susceptible babies, those with birth
weights around three pounds or less, ROP was said to have in 1985
severely impaired the vision of about one in ten, and to have
completely blinded up to about one in fifty7.

"Back in 1952, shortly before the oxygen starvation regimen was
introduced, and a dozen years after the sudden appearance of the
disease, the incidence of "gross visual defects" from ROP among the
babies born in the same birth weight group in the state of New York
was reported as about one in eighteen8.

If this is true, then this monstrous medical error has been enormously
tragic, Extrapolating from the New York data, from the same site:
"This calculation yields roughly 16,000 extra deaths per year in the
United States from the oxygen withholding". .

More at  http://www.recoveredscience.com/Oxygenwithholding01.htm
Mike Tyner - 27 Jun 2008 02:25 GMT
> Re premature infant blindness, it runs out that blindness in premature
> babies may be caused by doctors WITHHOLDING oxygen!  In any case,
> we're talking apples and oranges here: premature babies vs. adults.

1) I don't recall any neonatologists making babies turn blue.

2) Many more adults than babies lose vision due to neovascularization.

-MT
Don W - 27 Jun 2008 04:44 GMT
By any chance are you the same as the Rich in:

http://www.i-see.org/optifuge.html

Don W.

…that’s the only kind I do  :-) …but this one is not as crazy as the
one that could have killed me, the “Optifuge” experiment (1)), but
quite unusual.

It’s the application of oxygen to the eye. I used a device called an
oxygen concentrator. By removing nitrogen from ambient air, it
delivers 90% pure oxygen, which I breathe at a rate of 5 liters per
minute through a nasal tube. (2).

So, what does this have to do with vision?  Just this: my previous
experiments have always involved myopia, but a couple of years ago I
was diagnosed with glaucoma (I didn’t know I had it), and my
ophthalmologist of course did what they all do, prescribed a
medication to lower my IOP (Intraocular Pressure), in my case, a Beta
blocker, Timolol.. Never mind that my IOP was within normal limits, he
went along with the hypothesis that glaucoma is the result of raised
IOP that damages the optic nerve.

When I asked about possible side effects, he dismissed them: “They
only occur in a small proportion of patients” (about 1 or 2 percent as
I recall). These include blurred vision, dizziness and dry eyes, as
well as more serious effects such as chest pain, fainting, and
irregular heartbeat (all these from the brochure accompanying the
medication).. Strange that they didn’t include others, such as
alopecia (hair loss)—just what I need! and impotence—Oh, great! but
then the brochure was written by the manufacturer. They didn’t include
the possibility of severe reactions like …death! (3).

Although I wasn’t bothered by the glaucoma, I also had to consider
the possibility that it could progress.

In researching the literature I kept coming across intriguing
references to the importance of oxygen to the eye. For example, how
many people are aware of the astonishing fact that the retina has “…
the highest oxygen demand of any tissue in the body.”?

Other papers dealt with the question of retinal hypoxia (def.:
deficiency in the amount of oxygen reaching body tissues) and its
possible effect on vision. For example, “…damage to the cells of the
optic nerve is now known to occur during migraine headaches, when
blood vessels constrict the flow of oxygen and other nutrients to the
cells”; “,.,neovascular glaucoma occurs in individuals in whom there
is poor blood flow to the eye. Blood supplies much of the eye with
nourishment, including oxygen, and removes waste from it”; “Decreased
blood flow to the eye causes structural changes over time that results
in increased IOP.” “Glaucoma patients have narrowed retinal blood
vessels compared to normals”.

These citations and others persuaded me that a much more convincing
case could be made that glaucoma was caused by reduced blood flow to
the eye that damaged retinal and optic nerve cells, not high
intraocular pressure.

After just a few days of breathing the 90% oxygen I noticed that
colors had become much brighter, and print appeared blacker.This
suggested that increasing the blood supply to the retina had improved
my contrast sensitivity. I later found a report on precisely this
effect. (4)

I also noticed improved visual acuity as shown on a Snellen chart, but
it is unclear whether this was due simply to the improved contrast
sensitivity or some other effect (change in the lens?,  axial
length?).

From reading hundreds of papers in the ophthalmology journals I
discovered a few that, in effect, dismiss the Glaucoma/IOP hypothesis
as nonsense. I could cite these papers, but it may be sufficient to
show the illogic of this hypothesis is by considering this: large
numbers of people with high IOP don’t have glaucoma; large numbers of
people with normal IOP have glaucoma; and of the large number of
people who lower their IOP with medication, their glaucoma continues
to progress.

Exercising, while breathing oxygen, dramatically increases the amount
of oxygen in the blood plasma, i.e., the portion of the blood outside
the red and white ells. This can be determined by testing the blood
oxygen level in the arteries and veins.

Doctors will say that you can't increase the oxygen in your blood by
breathing oxygen. But what they mean is that you can't increase the
amount of oxygen in your red blood cells, which are responsible for
transporting oxygen to the tissues. The reason the amount of oxygen in
the red cells cannot be increased is because, under most
circumstances, they are already 97 percent saturated with oxygen. So,
they say, a three percent increase will make little difference and the
red cells won't accept the extra oxygen, anyway.

      While this is true, they ignore the role of oxygen in the
plasma, the "juice" within which the red cells flow. The oxygen
content of this fluid can be dramatically increased and thus oxygen
will be "pushed" into the body's cells without the aid of the red
cells. It's called the Law of Mass Action. If you build up the
concentration of a certain component in a chemical mixture high
enough, chemical combining will take place with other elements of the
mixture that ordinarily wouldn't happen.

      Most of the oxygen in the plasma under these high-saturation
circumstances will be "wasted" in that it will not be absorbed by the
cells which expect to be "fed" oxygen by the red cells. But if only
one-tenth of one percent of the oxygen gets through, and you offer
your cells this extra oxygen every day, there will be an extensive
increase in your total tissue oxygen level.
Ophthalmologists tell their glaucoma patients that the condition can
not be reversed. What they mean, I think, is that the drugs they use
can’t do it. Apparently they are unaware that several studies show
that glaucoma CAN be reversed. Here’s one:

Bojic reports  a double-blind study where subjects who had a
glaucomatous visual field loss were exposed on a daily basis to 2.0
bars of air pressure for 90 minutes. Sixty percent of the subjects
engaged in an oxygen-breathing schedule, while the remainder breathed
only air.

The report summarizes: 1) “In the experimental group there was a
significant improvement of visual fields (p.>0.5), whereas there was
no change in the control group.” 2) “Hyperbaric oxygen did not have
any influence on intraocular pressure”. 3) “…the achieved visual field
improvements [e.g. 30% less blind spot area] remained stable for three
months…4) Our study indirectly  points to the role of a vascular
mechanism in the pathogenesis of glaucoma”. Bojic' 1993 - Bojic' L,
Racvicv G, Gošovic' S, Kovacvevic' H. The effect of hyperbaric oxygen
breathing on the visual field in glaucoma. Acta Ophth 1993; 315-319

There are hundreds of millions of people who suffer serious eye
conditions such as glaucoma, macular degeneration and diabetic
retinopathy. There is the possibility that these conditions could be
prevented, stopped, or even reversed, with oxygen therapy. It
certainly deserves to be studied much more than has been the case to
date.

--Rich
---------------------------------------------
1. www.i-see.org/optifuge.html  Other experiments involved compressing
the globe, and applying vibration to the eye, described at
http://aarcolin4.net

2. The device I used was a Respironics Millenium. Not cheap—around
$1500, but refurbished models are around $550.

  Another method is hyperbaric oxygen therapy (HBOT), which
  involves the breathing of pure oxygen while in a sealed chamber
that has been pressurized at 1.5 to 3 times normal atmospheric
pressure

3. Between 1978 and 1985 there were 450 case reports of serious
respiratory and cardiovascular events, and the FDA and the National
Registry of Drug-Induced Ocular Side Effects received reports of 32
cases of death attributed to ophthalmic Timolol

(4) “Hyperbaric oxygen treatment improves contrast sensitivity
(ability to see shades of gray) when administered to healthy
volunteers”

A useful book on the role of oxygen in human physiology is “Oxygen and
Aging” by Majid, Ali, M.D.

I should note that there are side effects to oxygen therapy for the
eyes, but unlike the drugs sold by Big Pharma, they are beneficial!
For more than 15 years I suffered from fibromyalgia in the form of
sometimes severe calf and ankle pain. After six weeks of oxygen
therapy it is almost gone!
Rich - 27 Jun 2008 06:01 GMT
> By any chance are you the same as the Rich in:
>
> http://www.i-see.org/optifuge.html
>
> Don W.

Don,

Yeah, that's me. As Bob Dylan (or was it Paul Simon?) sang, "Still
Crazy After All These Years" :-)

> …that’s the only kind I do  :-) …but this one is not as crazy as the
> one that could have killed me, the “Optifuge” experiment (1)), but
[quoted text clipped - 156 lines]
> sometimes severe calf and ankle pain. After six weeks of oxygen
> therapy it is almost gone!
Neil Brooks - 27 Jun 2008 06:08 GMT
> > By any chance are you the same as the Rich in:
>
[quoted text clipped - 6 lines]
> Yeah, that's me. As Bob Dylan (or was it Paul Simon?) sang, "Still
> Crazy After All These Years" :-)

We San Diegans can be a wild bunch....
Neil Brooks - 27 Jun 2008 06:10 GMT
> > > By any chance are you the same as the Rich in:
>
[quoted text clipped - 8 lines]
>
> We San Diegans can be a wild bunch....

Though that WAS a bit of a guess....
 
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