Intravitreal injections of angiopoietin-1 or AcSKDP a possible treatment for ROP?

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douglas - 06 May 2008 04:03 GMT

Could intravitreal injections of angiopoietin-1 or AcSKDP --
http://bloodjournal.hematologylibrary.org/cgi/reprint/101/8/3014.pdf--
be a possible treatment for ROP? Since ROP is caused presumably by the
iatrogenically high oxygen levels given to premature babies causing
the angiogenesis system in the eyes to think "the retina's oxygenated
enough, no need to create more blood vessels", shouldn't
intravitreally injecting either angiopoietin-1 or AcSKDP be a possible
treatment for neonates afflicted w/ this potentially blinding
condition? Or would this work *too* well, and cause a retinal
hemangioma?

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Zetsu - 06 May 2008 13:17 GMT

I don't understand. Isn't retinopathy of prematurity caused by /too
much/ blood vessels rapidly growing in the eye? So why would you want
to exacerbate the condition by stimulating the body with an injection
fooling the mind into believing that that there is a lack of oxygen
when there's already too much? And the link you provided is dead, or
it didn't work for me.

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