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Medical Forum / General / Vision / September 2007

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SLT for Glaucoma

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Jim T. - 06 Sep 2007 00:32 GMT
My doc is suggesting that the SLT treatment might be helpful for my
glaucoma - it is pretty well controlled with just Timolol.
What experience with this is out there?
Don W - 06 Sep 2007 20:13 GMT
> My doc is suggesting that the SLT treatment might be helpful for my
> glaucoma - it is pretty well controlled with just Timolol.
> What experience with this is out there?

Not a direct negative experience by me, but I had met a person who was
talked into a SLT treatment for his eyes.  He was doing well with
drops, I had presumed.  One eye was to be done at time.  After the
operation, there was a problem with the corneal flap healing
correctly, so his eyelid hung up at that point.  (A mechanical
problem, would you believe).  As a consequence he had to use dry eye
drops in addition to the glaucoma drops.  Other eye was just on
glaucoma drops.

I too would be interested with what the professional here say about
this.

Good luck,
Don W.
p.clarkii@gmail.com - 07 Sep 2007 04:56 GMT
> Not a direct negative experience by me, but I had met a person who was
> talked into a SLT treatment for his eyes.  He was doing well with
> drops, I had presumed.  One eye was to be done at time.  After the
> operation, there was a problem with the corneal flap healing
> correctly, so his eyelid hung up at that point.  (A mechanical

i'm not sure exactly what type of surgery you are describing but it
sounds like a form of filtering surgery or perhaps implanting a
drain.  Regardless, it is not SLT.  SLT (Selective Laser
Trabeculoplasty) is a type of laser procedure using optimized
wavelengths power levels.  There are no flaps involved since there
isn't actually any surgical cutting that occurs during the procedure.
SLT is relatively new, but it seems like a promising technique.  It is
proven to be as effective as the best 1st line glaucoma medication
available (e.g. prostaglandins @ ~25 - 35% reduction in IOP).  There
are fewer side-effects compared to ALT, a related procedure.  Read
more about it at http://www.glaucoma.org/treating/surgery.html.
Don W - 07 Sep 2007 17:58 GMT
Unfortunately, I cannot re-question the person that described that
condition and the procedure used.  And reviewing the links provided,
it does not appear that it was a SLT, but it was a glaucoma operation
(if I can use that word) specifically to reduce the need for drops and
to reduce pressure.

 In the link that Irv Arons provided, in the "Review of
Ophthalmology", there is one paragraph that caught my eye describing
the SLT: "Lack of reversability.  Dr. Heuer notes that medical therapy
appears to be completely reversable, which SLT is not".  And that
medical therapy is of course, drops.

 But if I were to make this decision, with the drops working well, I
would choose the drops.  I like the word "reversable".

Don W.
gudrun17 - 11 Sep 2007 16:16 GMT
>   Unfortunately, I cannot re-question the person that described that
> condition and the procedure used.  And reviewing the links provided,
[quoted text clipped - 12 lines]
>
> Don W.

While I suppose you could say SLT is not reversible, if I understand
the process correctly, targeting the melanin-containing cells
stimulates a healing response. Since the effect of SLT wears off, it
is my understanding that the trabecular meshwork eventually rebuilds
these cells, so in time you are back to where you started. ALT, on the
other hand, does produce irreversible scarring. I'm sure some of the
doctors here can explain this if I have misunderstood.
-Gudrun
Dr. Leukoma - 11 Sep 2007 16:25 GMT
> While I suppose you could say SLT is not reversible, if I understand
> the process correctly, targeting the melanin-containing cells
[quoted text clipped - 3 lines]
> other hand, does produce irreversible scarring. I'm sure some of the
> doctors here can explain this if I have misunderstood.

That's pretty much how I understand it, too, Gudrun.  The chief
question appears to be how many times can SLT be repeated, and what is
the effect after each retreatment.  It seems as though there are still
some questions about the long-term.
Irv Arons - 06 Sep 2007 22:55 GMT
> My doc is suggesting that the SLT treatment might be helpful for my
> glaucoma - it is pretty well controlled with just Timolol.
> What experience with this is out there?

Jim, over on the Glaucoma board, I posted about SLT becoming a front
line treatment for glaucoma.

the link to my web Journal article about this is:

http://irvaronsjournal.blogspot.com/2006/11/update-on-use-of-slt-for-treating.html

Also, the June 2007 issue of Review of Ophthalmology has a "cover
focus" article on this subject, titled:

"Laser First: SLT as Primary Therapy".

I'll try and get a link to the article and post it here if I can find
it.

Irv Arons
Irv Arons - 06 Sep 2007 22:56 GMT
> My doc is suggesting that the SLT treatment might be helpful for my
> glaucoma - it is pretty well controlled with just Timolol.
> What experience with this is out there?

Jim,

I found the reference, here it is:

http://www.revophth.com/index.asp?page=1_13396.htm

Irv Arons
VA eye doc - 08 Sep 2007 18:16 GMT
> My doc is suggesting that the SLT treatment might be helpful for my
> glaucoma - it is pretty well controlled with just Timolol.
> What experience with this is out there?

SLT is a laser procedure designed to increase the outflow area of the
eye so that the fluid will drain out more efficiently and thereby
reduce the pressure in the eye.  There is constantly fluid being
produced in the eye & fluid draining from the eye.  When you have
glaucoma you usually have a problem either with too much fluid being
produced or not enough draining or not draining quickly enough to keep
up with the production.  All treatments whether drops, laser (ALT or
SLT), or surgery (filter, trabeculectomy, trabeculoplasty, etc.) are
designed to work on one or both of these areas.  Until relatively
recently ALT was the laser procedure of choice, now SLT is most
preferred as it causes less structural damage to the eye than ALT and
it can be repeated.  When to have SLT or surgery depends on the status
of your glaucoma and your doctor's preferences.  The more advanced
your glaucoma is (the more damage you have), the lower your pressure
needs to be.  Many doctors will recommend 2 or 3 different drops to
control the pressure before recommending laser.  Laser is usually
recommended before the surgical procedures.  If your pressure has been
controlled with only 1 medication and your doctor is recommending SLT
it is possible that if the SLT works, you may not need to continue
with the medication-at least for a period of time.
 
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