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Medical Forum / General / Vision / December 2004

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Age-Related Macular Degeneration / Photodynamic Therapy

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doe - 22 Nov 2003 20:53 GMT
http://www.islamonline.net/English/Science/2003/09/article08.shtml

<<snip>>
But one of the most promising uses is in the treatment of Age-Related Macular
Degeneration (AMD or ARMD). Results are nothing short of exceptional!

ARMD affects 40% of individuals 75 years or older and is the leading cause of
blindness in developed countries. One form of ARMD, the “wet” form, is the
result of new blood vessels formation. Termed “choroidal
neovascularisation” (CNV), these vessels grow under the center of the retina,
in an area known as the macula. There, these vessels can leak fluid and bleed,
causing scar tissue to form. That scarring can destroy vision in as little as
three months!

In ARMD, the photosensitizing agent is also injected into the patient’s
bloodstream. The light sensitive dye sticks to the inner lining of the new
vessels. Then, the macula of the patient’s eye is subjected to the dose of
light, which activates the photosensitive agent resulting in damage to the
blood vessels, causing them to close, preventing the leaking vessels from doing
further damage.

The procedure is done on an outpatient basis and takes about 30 minutes.

A study for the treatment of Age-Related Macular Degeneration with Photodynamic
Therapy was performed in 22 centers in Europe and the United States. Vision was
stable or improved in 61% of patients treated with photodynamic therapy with
virtually no side effects!

As research continues, the application of light as a treatment modality will
expand and provide a safe and effective means of treating a large variety of
diseases.

Amazing, this thing we call light!
<<snip>>

Who loves ya.
Tom

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The Real Bev - 23 Nov 2003 03:00 GMT
> The procedure is done on an outpatient basis and takes about 30 minutes.
>
> A study for the treatment of Age-Related Macular Degeneration with Photodynamic
> Therapy was performed in 22 centers in Europe and the United States. Vision was
> stable or improved in 61% of patients treated with photodynamic therapy with
> virtually no side effects!

Which means that 39% of the patients received no benefit whatsoever
except for lightening their wallets.  My MIL was given two of the
treatments during the study phase with no benefit whatsoever, but was
included in the "improved" category because she recognized her own face
in the mirror for a few hours after the first treatment.  It was
shocking how they fudged her Snellen test to include her in the study
population.

She was functionally blind going in and equivalently functionally blind
going out.  Just another data point.

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Cheers,
Bev
==========================================================
There is a fine line between 'hobby' and 'mental illness.'

Ann - 23 Nov 2003 12:56 GMT
>> The procedure is done on an outpatient basis and takes about 30 minutes.
>>
[quoted text clipped - 13 lines]
>She was functionally blind going in and equivalently functionally blind
>going out.  Just another data point.

I would also wonder what they mean by saying that some of the 61% were
'stable'.  Makes it sound as though there was no change.  What then
happened to the 39%.  Deterioration one assumes.

Ann
LarryDoc - 26 Nov 2003 05:09 GMT
I could post other, more detailed statistical findings on the results of
PDT and some of the other recent treatments for macula degen. (And
there's even more new stuff in development to work with, or instead of
PDT.)  I've attended a number of presentations on the subject and a
research site, including some of my patients is right here in town.
There's quite a bit of data and, as you might imagine, you can interpret
the findings to quantify successful treatment in a number of ways. To be
brief, the ability of the treatment to (1) reverse the damage, (2) halt
the damage and stablize the vision, (3) limit the damage and slow down
the progress and vision loss, or (4) have little or no effect depends
upon a number of specific factors. We understand most, but not all of
the issues---but that means we can identify good patient candidates and
not so good patient candidates and people who would not benefit at all.

At least not yet.

The bottom line is that PDT is not a perfect answer and the numbers
really aren't all that great, but that's not always the information that
is meaningful.  What is, is that if you're someone who is inevitably
loosing the ability to see and the treatment has a reasonable chance of
preserving what vision remains, then 30-40% chance of stablizing the
disease is a great number. 70-80% is better and for some people, that's
the correct number.  Sadly, for others, it's close to zero.

Anyway, if we can save some vision and improve the quality of life, no
matter for how much time remaining, that's pretty exciting. Also, one
person's concept of "good vision" is not that of another's.

You need also to keep in mind that this is a very new medicine and, as
we learn more about the underlying causes of mac degen and the resulting
visible tissue damage, treatment will likely improve.  And that's a good
thing, considering that each year there are more and more older people
and therefore more and more people who develope mac degen, and the
medical industry is seeing, very clearly, big dollar signs.

Hopefully it will cost patients less, too. It *is* a big expense. (And
don't forget nutritional supplement therapy.)

--LB
 

  `                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
`````

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Dr. Larry Bickford, O.D.
Family Practice Eye Health & Vision Care

The Eyecare Connection
http//www.eyecarecontacts.com
larrydoc at eye-care-contacts dot com (remove -)

ronen toker - 08 Dec 2004 17:49 GMT
> I could post other, more detailed statistical findings on the results of
> PDT and some of the other recent treatments for macula degen. (And
[quoted text clipped - 6 lines]
> the damage and stablize the vision, (3) limit the damage and slow down
> the progress and vision loss, or (4) have little or no effect depends

> upon a number of specific factors. We understand most, but not all of

> the issues---but that means we can identify good patient candidates and
> not so good patient candidates and people who would not benefit at all.
[quoted text clipped - 11 lines]
> Anyway, if we can save some vision and improve the quality of life, no
> matter for how much time remaining, that's pretty exciting. Also, one

> person's concept of "good vision" is not that of another's.
>
[quoted text clipped - 11 lines]
>
>    `

> `````
>
[quoted text clipped - 5 lines]
> http//www.eyecarecontacts.com
> larrydoc at eye-care-contacts dot com (remove -)
 
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