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Medical Forum / General / Vision / June 2006Pirenzepine / Atropine for myopia prevention
Hi, I am just wondering if these two topical eye drop / gels are already available in the US or Canada ? If not does anybody know if they are available in other parts of the world ? I am highly myopic and recently my 8 year old son was found to have begun his 'myopia journey". Really want to do something about it and read about these two drugs on the Internet. Thanks in advance. >I am just wondering if these two topical eye drop / gels are already >available in the US Topical ophthalmic atropine sulfate is available in both drop and ointment form as a prescription medication, and has been for dozens of years, in most (if not all) countries. As far as pirenzepine... <http://www.valleyforgepharmaceuticals.com/What_is_the_study_medication.htm> [...] Pirenzepine ophthalmic gel is not approved anywhere in the world and is available only through sponsored investigational trials. [...] [snip] >I am highly myopic and recently my 8 year old son was found to have >begun his 'myopia journey". Really want to do something about it A good start would be to get him some glasses. [snip] Dear Myopic Friend, If you child is not yet too deep into myopia -- you may find an anternative method discussed at: www.chinamyopia.org Some people have a serious adverse reaction to atropine sulfate. The preventive method is less drastic that a drug. You also might want to consult with a behavioral optometrist -- as they support preventive methods as the second-opinion. Best, Otis > Hi, > [quoted text clipped - 7 lines] > > Thanks in advance. > Some people have a serious adverse reaction to > atropine sulfate. The preventive method is less > drastic that a drug. Valley Forge Pharmaceuticals has data showing that pirenzipine works, slowing myopia by as much as 50%. Where is the data showing that your "preventive method" works? -MT Back to my original question: Is Pirenzepine commercially available yet ? > > Some people have a serious adverse reaction to > > atropine sulfate. The preventive method is less [quoted text clipped - 6 lines] > > -MT > Back to my original question: Is Pirenzepine commercially available yet > ? For what it's worth ... 1) I could only find the standard truckload of information about its being in clinical trials, but most of that was from 2003. I would think that--if it HAD been approved--then either Novartis or Valley Forge would be touting it fairly strongly. I don't see that; 2) You asked about Pirenzepine AND Atropine. At least the Atropine part of the questions WAS answered.... Best of luck in your quest. > Back to my original question: Is Pirenzepine commercially available yet Not in the gel form used in the clinical trials. I believe you could sign up for the clinical trials but not all participants will get the treatment. Atropine has been used in the eye for a long time but the side effects are debilitating. -MT Dear Mike, That issue would be resolved with Steve Leung's consultation with the person in question. See: www.chinamyopia.org for details. The method is less risky than atropine sulfate. But as always, prevention is the second-opinion -- and should be UNDERSTOOD THAT WAY. Otis > > Some people have a serious adverse reaction to > > atropine sulfate. The preventive method is less [quoted text clipped - 6 lines] > > -MT > Dear Mike, > > That issue would be resolved with Steve Leung's consultation > with the person in question. See: > > www.chinamyopia.org Mike, The answer to your question: "Where is the data showing that your "preventive method" works?" Would then be ... there isn't any..... > The method is less risky than atropine sulfate. Not to mention ineffective. We asked how you know it works. You haven't provided a satisfactory answer. And atropine sulfate will not likely be used for myopia control. -MT disregard any myopia treatments recommended by Otis Brown. he is currently under investigation by the state of pennsylvania for practicing medicine without a license. sometimes his recommended treatment of using plus reading glasses can cause harm. one child developed diplopia (double-vision) after using it for a while. it has been tested already in clinical studies and found to be ineffective. Otis doesn't care about the outcome of scientifically-controlled studies so he recommends it anyway. nothing, aside from pirenzepine/atropine, has been found to be effective in preventing nearsightedness. unfortunately, those compounds are still in clinical trials at the present time. atropine will likely never be used for preventative purposes at least in this country (side-effects, undesirable dilation and profound cycloplegia). a milder form like pirenzepine is more likely. until then, correct myopia with glasses and contact lenses is the recommended treatment. minus lenses do not increase myopia development-- that has been proven too. regards, =============================== > Hi, > [quoted text clipped - 7 lines] > > Thanks in advance. |
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