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Medical Forum / General / Vision / February 2006

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Interesting article - Adaptive Optics

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The Central Scrutinizer - 09 Feb 2006 18:08 GMT
Never heard of this before, but it sounds fascinating...

>From  http://www.dailytech.com/article.aspx?newsid=693

PixelOptics is currently just one of several companies trying to
develop "supervision" for everyone -- including the Department of
Defense

PixelOptics just won a $3.5M USD grant from the Department of Defense
for research to perfect "supervision" technology.  The company claims
that it can double the quality of a client's eyesight by using
extremely sensitive lasers capable of detecting the slightest anomalies
on the surface of the eye - then compensating for those defects using
a powered optoelectronic lens.  PixelOptics uses electronically
controlled pixels that are embedded inside of traditional eyeglass lens
to bend and manipulate light as it enters the lens..  After the
software makes some adjustments, the pixel will then be programmed to
fix any problems that a person may have.

Since PixelOptics hardware is dynamic, the company also envisions
future systems to adapt to light levels and ambient conditions to
further improve vision.  Adaptive optics are hardly a new concept;
researchers and the military have been using adaptive optics on
telescopes and spy satellites to compensate for irregularities in the
atmosphere.  Using such small scale adaptive optics for human eyes, on
the other hand, is certainly a new concept that we will see a lot more
of in the future.
Glenn - USAEyes.org - 09 Feb 2006 18:42 GMT
Scott MacRae, MD at the University of Rochester Medical Center did a
lot of research in adaptive optics as a part of development of
wavefront-guided excimer laser ablations for refractive surgery. They
were able to measure and adjust lower order aberrations (sphere and
cylinder) as well as higher order aberrations with patients.

Interestingly, it was found that when all aberrations were removed and
the patient had "pure optics", the patients subjectively complained of
poor vision quality. Induce some aberrations, and the vision quality
improved. Apparently human vision is designed to accept and enhance
some higher order aberrations.

Glenn Hagele
Executive Director
USAEyes.org

"Consider and Choose With Confidence"

Email to glenn dot hagele at usaeyes dot org

http://www.USAEyes.org
http://www.ComplicatedEyes.org

I am not a doctor.
Neil Brooks - 09 Feb 2006 18:53 GMT
>Scott MacRae, MD at the University of Rochester Medical Center did a
>lot of research in adaptive optics as a part of development of
[quoted text clipped - 7 lines]
>improved. Apparently human vision is designed to accept and enhance
>some higher order aberrations.

I find things like this fascinating, if maddening ;-)

In my case--congenital/infantile esotropia--three subsequent
strabismus surgeries have failed to achieve stable orthotropia or
reasonable stereopsis.  The (my) theory is: fusion is a heavily
neurologic process.  Though the mechanical alignment may be perfect,
the fusion center may be underdeveloped, providing little 'detent' to
encourage long-term stability in alignment.

Further, the mind has adapted somewhat to seeing a certain way,
providing an apparent tendency to restore alignment to what it finds
most comfortable.

Another example from my story: accommodative spasm.  Despite the fact
that I now wear full plus contact lenses--the Rx derived from
Atropinised wavefront aberrometry--and appropriate near-vision add
over-Rx, my eyes still have a dramatic tendency toward pseudomyopia,
even without apparent provocation.

While some of this can be ascribed to ciliary hypertonicity and/or
'instrument myopia,' it's also possible that a portion is due to a
neurologic predisposition--something that refractive surgery, extra
plus, clear lens exchange, etc. likely won't change.

If only I had worn a minus lens ... you know ... at the threshold ....
maybe I wouldn't have developed this stair-case hyperopia.  

Sigh.
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Live simply so that others may simply live

The Central Scrutinizer - 09 Feb 2006 20:18 GMT
>If only I had worn a minus lens ... you know ... at the threshold .... maybe I wouldn't have developed this stair-case hyperopia.

Hey Neil - *WHAP!* ;)
acemanvx@yahoo.com - 09 Feb 2006 20:30 GMT
posted a reply but it didnt show up so heres it again. high order
aberrations prevent the eye from seeing its best. I get 20/30 with
conventional glasses. Looking forward to 20/15 or even 20/10!
acemanvx@yahoo.com - 09 Feb 2006 20:45 GMT
By the way, I have more to say!

http://www.dailytech.com/article.aspx?newsid=693

a recent article about how adaptive optics may be materalizing! Imagine
glasses that correct your higher order aberrations too! I have the
feeling alot more people will be wearing glasses, even those seeing
20/20 when they find out what 20/10 is like! Suddenly those 20/40 very
low myopes that dont bother with glasses because it doesnt make much of
a difference will suddenly embrace glasses because now that their high
order aberrations get corrected in addition to their refractive error,
they will really see clear!

I have the feeling millions who got laser or other refractive surgury
will be disapointed to be back in glasses in order to enjoy good, crisp
vision. All forms of refractive surgury, especially laser induces more
aberrations so they arent seeing as good as they should. I can see RS
being alot less popular because it cant give you vision as clear as
conventional glasses, much less wavefront glasses! If someone was given
the choice of getting 20/20 with lasik or 20/10 with wavefront glasses,
almost all will choose wavefront glasses! Lasik would be a complete
waste for me since ill still need glasses to see clearly and may in
fact also need reading glasses.
acemanvx@yahoo.com - 09 Feb 2006 21:01 GMT
One more comment: I read that true wavefront glasses needs to be
dynamic because your eyes are constantly moving and shifting focus so
youll need glasses with tiny sensors that follow your every eye
movement. Stationary wavefront only works if you keep your eyes
perfectly still and centered so they align with the aberrations. We
need something that follows the movement of your eyes to keep the
aberrations aligned at all times. This poses many technological
challenges and may be some 15 to 20 years away from reaching the
market. There already is (stationary) wavefront glasses out but my
friends say 9 out of 10 people see no difference or they actually see a
little worse! The 1 in 10 who do see a difference have a large number
of aberrations, usually from a bad lasik experience. One guy had lots
of glare and his wavefront glasses reduced the glare.
p.clarkii@gmail.com - 10 Feb 2006 03:00 GMT
> By the way, I have more to say!

we all wait with baited breath to hear what aceman has to say.
Mike Tyner - 09 Feb 2006 22:09 GMT
> posted a reply but it didnt show up so heres it again. high order
> aberrations prevent the eye from seeing its best. I get 20/30 with
> conventional glasses. Looking forward to 20/15 or even 20/10!

Here's hoping your 20/30 limitation is optical, and not neurological.

-MT
acemanvx@yahoo.com - 09 Feb 2006 23:53 GMT
I pinhole to a full 20/25 and I can almost see the 20/20 line but its
too small because of my minus glasses which minify. Because alot of my
aberrations are located on the center, the pinhole cant help me 100%.
With tomorrows glasses I may be like 20/15 WITH minification(which
would make me a little better than 20/15 in fact) I also got
topographies and have already been commented by several about my
aberrations and astigmastim. The fact pinhole makes a difference is a
good indicator my limit is optical. Wavefront glasses work better than
pinhole. By the way about a third of people cant correct to 20/20, not
even with contacts.
otisbrown@pa.net - 10 Feb 2006 01:31 GMT
Dear Central,

In fact, there is a "school of thought" (i.e., second opinion) that
when a child's refractive state is +3 or so (and he is young
and "adaptive) the "plus" should be kept off his face, until
his eyes "adapt" down to a normal zero to +2 diopters.

On a optical control-system the effect of putting a +3 on
a child at +3 diopters, is that his refractive state
will not only stay at +3 but will "move positive" -- as
was the case for Neil Brooks.

There is no "magic pill" here -- just an honest difference
of opinion.

But, "Central" many a truth is said in jest.

Best,

Otis
Mike Tyner - 10 Feb 2006 03:20 GMT
> In fact, there is a "school of thought" (i.e., second opinion) that
> when a child's refractive state is +3 or so (and he is young
> and "adaptive)

Be still my heart! Are _you_ admitting they aren't "adaptive" after some
age?

The standard deviation of human refractive error DECREASES from birth to a
certain age, then it INCREASES again.

What age would that be, Otis?

-MT
Neil Brooks - 10 Feb 2006 03:30 GMT
>> In fact, there is a "school of thought" (i.e., second opinion) that
>> when a child's refractive state is +3 or so (and he is young
[quoted text clipped - 7 lines]
>
>What age would that be, Otis?

What is ... the threshold, Alex?
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Live simply so that others may simply live

otisbrown@pa.net - 10 Feb 2006 03:16 GMT
Dear "Central",

Subject:  Adaptive optics -- Adaptive Eye to A lens.

Re:  The second opinion on the plus lens.

Looks like you were correct about Neil Brooks.  An over-prescribed
plus can certainly make a monkey-primate eye "more positive".
It is possible that the same "adaptiveness" also occurs
for the human-primate eye.

Dr. Allen supports the second-opinion which is to "go slow" about
putting a young child in a full-strength plus lens.

You suggestion about stair-case hyperopia is correct.

Best,

Otis

==========================

            How to Eliminate Hyperopia

            (A HIGH positive refractive state of the fundamental eye.)

          by Merrill Allen, OD, PhD, FAAO, FCOVD

              PROFESSOR of OPTOMETRY

            Indiana University.

Summary:  The young eye should be given time to move towards zero
     diopters refractive state (emmetropiia).  A strong plus
     lens will interfere with the "normalization" process
     (i.e,, interfere with "emmetropization".) This statement
     is the "second-opinion" by a highly qualified experts.

Re:  When I'm in the mall, I see thick glasses on small children
    and I have to control myself.  I know that wearing those
    glasses blocks emmetropization.  (i.e., blocks the
    process of normal vision growth.  Subsequently, a
    proven characteristic of the primate eye.    OSB) If Mom
    would put the glasses on the child only in the
    afternoon, the child would grow out of his/her hyperopia
    and require several spectacle power reductions.  If the
    child's correction is less than the refractive error,
    he/she will grow out of the need for those glasses and
    soon weaker lenses will be needed.  Dr.  M.  Allen

       __________________________________

    Humans are adaptable.  The refractive error distribution in
the population of newborns is almost a normal curve.  By the first
grade the distribution has become leptokurtic with the great
majority of the population falling within -0.5 and +2.00 diopters
of error.  The babies have grown out of their refractive errors!

    Graduate Students at Indiana University did a study of babies
at 2 weeks of age who performed as well on focusing tests as
college students.  The one baby who did not was about 5 D
hyperopic.  After 6 weeks or so it was clearly withdrawn and
abnormal in personality.  The baby could not respond to the test.
Application of +4 D glasses changed the baby's personality
overnight!  Regarding the overcoming of hyperopia by optometric
intervention, the baby above was not followed, but if the baby
continued to wear those glasses, now as an adult, he/she will
still be +4 hyperopic.

    I worked with an 18 month old esotropic girl whose eyes were
so crossed I thought she had convergence fixus.  However when I
held her at arms length and turned my body through 360 degrees her
vestibulars took over and her eyes straightened and she showed
nystagmus.  At each of the three visits I increased the plus to
take home.  Her eyes straightened with +11D.  Then at the age of
three years while moving to another city she lost her glasses and
went without them for 3 months.  The new eye examination showed
her Rx to be +4.  She had lost 7 diopters in three months!

    I did not realize the significance and was not smart enough
to say to Mom:    "Let's leave the glasses off for another 3
months," or "Let's wear plano glasses with binasal occluders for 3
months." The last checkup of this patient was at age 18 years when
she was wearing +4D contact lenses!  We cured her of esotropia and
reduced 7 diopters of hyperopia!  She has of course continued to
be straight eyed.

    Wild monkeys have low hyperopia or emmetropia and no myopia.
Caged monkeys have less hyperopia and much more myopia.  Because
the evidence for emmetropization is so strong, I suggest a couple
of approaches on how to emmetropize young hyperopes.

    Only prescribe as much plus as needed to keep the eyes
straight.  (In the case of our baby that couldn't focus and had
personality problems, the plus probably wouldn't be needed for
more than a week or two as the child figured out how to use his
eyes.

    At most the Rx should only be about half of the retinoscopic
Rx and then reduced in power as the eyes change.  With esotropia,
more plus power may be needed at first to establish normal
binocular vision, after which treatment of hyperopia may proceed.
Alternatively for esotropia, the no Rx, binasal approach, see
below, is highly recommended.  Use no lens power but provide
binasal occluders such as frosty Scotch tape applied with the
outer edges placed at the distance apart of the centers of the
pupils, minus 4mm.

    A growing child will require frequent occluder adjustments as
his/her pupillary distance increases.  The binasals will
straighten crossed or exotropic eyes as well as cause
emmetropization.  Within 6 months the occluders can be removed.
Strabismus and refractive error should be cured in that time!  if
you or the parents forget, the child will grow out of the binasals
[they will cover less and less of the visual field] and will be
cured.

    We know that older people grow into myopia, so I would not
put an upper age on when a person can grow out of hyperopia.  The
important condition is that they be able to intensively pursue
visual tasks requiring accommodation.  If they are not visually
involved, and if we eliminate the need to emmetropize, they will
not emmetropize!

    When I'm in the mall, I see thick glasses on small children
and I have to control myself.  I know that wearing those glasses
blocks emmetropization.  If Mom would put the glasses on the child
only in the afternoon, the child would grow out of his/her
hyperopia and require several spectacle power reductions.  If the
child's correction is less than the refractive error, he/she will
grow out of the need for those glasses and soon weaker lenses will
be needed.
Quick - 10 Feb 2006 04:37 GMT
> When I'm in the mall, I see thick glasses on small
> children and I have to control myself.

Wow, I was scanning (read the first 3 or 4 words
every 10 or 20 lines) and this came accross as

> When I'm in the mall, I see thick glasses on small
> chickens and I have to control myself.

=Quick
otisbrown@pa.net - 10 Feb 2006 04:43 GMT
Dear Quck,

That was Dr. Allen's statement.  You should read
the complete paper to understand what
the man was saying -- rather than skimming
and not having a clue.

The majority opinion is indeed to put a full-strength
plus lens on a child (like Neil).  Dr. Allen was
suggesting a "go slow" process because the
eye is indeed "adaptive", and a full strength
"plus" will result in the eye moving in
a positive direction.

Allen simply "objected" to that majority-opinion.

Best,

Otis
Mike Tyner - 10 Feb 2006 04:56 GMT
> Dr. Allen was
> suggesting a "go slow" process because the
> eye is indeed "adaptive"

Until what age, Otis?

-MT
axxx - 10 Feb 2006 06:44 GMT
Glenn

http://www.stronghealth.com/services/strongvision/aboutsv/MacRae.cfm

I have small belief in words if they are said RS surgeon :(

>Interestingly, it was found that when all aberrations were removed and the patient had "pure optics", the patients subjectively complained of poor vision quality.
Glenn ,What symptoms rather "poor vision quality" ???

>Apparently human vision is designed to accept and enhance some higher order aberrations.

These researches are in an initial stage. Why you present it as " the
obvious fact "???

Ace 20/20>20/15>20/10
It is similar: in a computer the graphic editor do " sharpen filter "
at processing a photo.

Ace
>I pinhole to a full 20/25 and I can almost see the 20/20 line but its too small because of my minus glasses which minify. Because alot of my aberrations are located on the center, the pinhole cant help me 100%. With tomorrows glasses I may be like 20/15 WITH minification(which would make me a little better than 20/15 in fact) I also got topographies and have already been commented by several about my aberrations and astigmastim. The fact pinhole makes a difference is a good indicator my limit is optical. Wavefront glasses work better than pinhole..............

You can try good RGP lens.
Why you cannot come to dr. Leukoma???
I am assured that DR will give you greater discount in the price as you
are " the expert of sight " :)
You dont have  time and money for travel to dr. Leukoma???
Problem-money:(    ???
axxx - 10 Feb 2006 07:40 GMT
I wish to correct.
I have small belief in words if they are said RS surgeon :(
And especially in unsubstantiated interpretation Glenn H :)
Neil Brooks - 10 Feb 2006 15:54 GMT
>You can try good RGP lens.
>Why you cannot come to dr. Leukoma???
>I am assured that DR will give you greater discount in the price as you
>are " the expert of sight " :)
>You dont have  time and money for travel to dr. Leukoma???
>Problem-money:(    ???

http://www2.sptimes.com/Treasures/Sounds/007.wav

http://www2.sptimes.com/Treasures/Sounds/001.wav

http://www2.sptimes.com/Treasures/Sounds/002.wav
Signature

Live simply so that others may simply live

otisbrown@pa.net - 10 Feb 2006 15:30 GMT
Dear Mike,

I think that Professor Allen made this
issue quite clear.  Or don't you
like reading second-opinion statements?

I assume you provide full strength "plus",
thus preventing "emmetropization".

Otis
Mike Tyner - 10 Feb 2006 18:33 GMT
> I assume you provide full strength "plus",
> thus preventing "emmetropization".

You assume too much.

-MT
Quick - 10 Feb 2006 05:23 GMT
> Dear Quck,
>
> That was Dr. Allen's statement.

How could one tell from your post?
Scott Seidman - 10 Feb 2006 15:32 GMT
> That was Dr. Allen's statement.  You should read
> the complete paper to understand what
> the man was saying -- rather than skimming
> and not having a clue.

Perhaps we could do that if you posted a reference to the paper.

Signature

Scott
Reverse name to reply

otisbrown@pa.net - 10 Feb 2006 21:22 GMT
Scott>  Perhaps we could do that if you posted a reference to the
paper.

Otis>  But of course.  You will find it at:

www.i-see.org

under "Library", and then
just find Allen's remarks about "hyperopia", and
its "prevention".

Best,

Otis
Scott Seidman - 10 Feb 2006 22:27 GMT
> Scott>  Perhaps we could do that if you posted a reference to the
> paper.
[quoted text clipped - 10 lines]
>
> Otis

No need.  I thought you were actually trying to cite a peer-reviewed work--
you know, the kind that count.

Signature

Scott
Reverse name to reply

otisbrown@pa.net - 11 Feb 2006 02:49 GMT
Scott>  No need.  I thought you were actually trying to cite a
peer-reviewed work--
you know, the kind that count.

Otis>  OK, Scott, I got it.  A full professor of optometry who
expresses a second opinion is an idiot.

Scott -- you are briliant!

Otis
Dr. Leukoma - 11 Feb 2006 03:32 GMT
The "late" Dr. Merrill Allen.

=================================================================
Professor Emeritus of Optometry Merrill James Allen passed away
December 28, 2003 in Bloomington.  He had a long and distinguished
career on the Indiana University Optometry faculty, joining it when the
first professional optometry students were enrolled in 1953 and
retiring in 1987.
=================================================================

DrG
Mike Tyner - 11 Feb 2006 04:47 GMT
> Otis>  OK, Scott, I got it.  A full professor of optometry who
> expresses a second opinion is an idiot.

Dr. Allen recognized that emmetropization doesn't continue forever.

You, however...

-MT
Scott Seidman - 13 Feb 2006 13:27 GMT
> Otis>  OK, Scott, I got it.  A full professor of optometry who
> expresses a second opinion is an idiot.

No, I'm just saying that the unit of scientific discourse is the published
paper from a peer-reviewed journal.  It's not a perfect standard, but it
serves well enough.

Signature

Scott

The Central Scrutinizer - 10 Feb 2006 16:03 GMT
>Looks like you were correct about Neil Brooks.

Otis, I never said anything about Neil - now, what exactly are you
babbling about, uncle Festus?

BD
acemanvx@yahoo.com - 09 Feb 2006 21:04 GMT
hyperopia is an eye that failed to fully complete emmetropization.
Almost everyone starts out hyperopic in their infancy and early
childhood. I went thru emmetropization too far and ended up myopic.

As for adaptive optics, its the ticket for anyone with a number of high
order aberrations like me. Conventional glasses cant compenstate for
this so I fall a little shy of 20/20 at 20/30. I really wonder what
20/15, or even 20/10 vision looks like! This will also be great for
those post-lasik patients who had their aberrations increased and dont
see well, especially at night.
Scott Seidman - 09 Feb 2006 18:53 GMT
> Scott MacRae, MD at the University of Rochester Medical Center did a
> lot of research in adaptive optics as a part of development of
[quoted text clipped - 20 lines]
>
> I am not a doctor.

Picture the use of such technology to correct post surgical eyes with
suture-induced High-order aberrations like trefoil.  Almost guaranteed
such patients would prefer to get rid of the aberrations.

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Scott
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Scott Seidman - 10 Feb 2006 14:05 GMT
> Interestingly, it was found that when all aberrations were removed and
> the patient had "pure optics", the patients subjectively complained of
[quoted text clipped - 5 lines]
> Executive Director
> USAEyes.org

Glenn, can you post the reference?    Not to argue about the finding about
how the eye/brain deals with high-order aberration (which I have no problem
with), but I'd like to know whether the aberrations were removed optically
at the bench, or with photorefractive surgery.  I think some people might
be getting the wrong impression.
 
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Scott
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Robert Martellaro - 09 Feb 2006 21:20 GMT
>Never heard of this before, but it sounds fascinating...
>
[quoted text clipped - 3 lines]
>develop "supervision" for everyone -- including the Department of
>Defense

This may also be of interest-

http://www.ophthonix.com/

It appears that they are able to produce a lens with a variable index of
refraction. This raises some interesting possibilities regarding multifocal lens
designs. Might an executive progressive lens with minimal surface astigmatism be
right around the corner?

Robert Martellaro
~~~~~~~~~~~~~~~~~~
Optician/Owner
Roberts Optical
robopt@execpc.com
~~~~~~~~~~~~~~~~~~
"An expert is a person who has made all the mistakes that can be made in a very narrow field."
 - Niels Bohr
 
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