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Medical Forum / General / Vision / October 2005

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Ambien(Zolpidem) & Glaucoma

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peg - 29 Oct 2005 00:23 GMT
Does anyone know the mechanism by which Ambien/Zolpidem
(a sleeping med) can sometimes cause glaucoma? It's one
of the mentioned side effect.

Thanks.

Regards,

peg
Neil Brooks - 29 Oct 2005 00:53 GMT
>Does anyone know the mechanism by which Ambien/Zolpidem
>(a sleeping med) can sometimes cause glaucoma? It's one
>of the mentioned side effect.

What I /can/ tell you is:

1) Glaucoma is listed as a "Treatment-emergent adverse events
associated with clinical trial participation."  This is very different
from a side effect.  The former does not necessarily imply that the
medicine /caused/ the problem; the latter does.

2) Glaucoma is further listed as "rare" in the preclinical trial of
3,660 subjects used in clinical trials.  "Rare," in this case, is
defined as "less than one in one thousand patients."

So ... in their trial of 3,660 people taking Ambien for some length of
time, one patient reported having glaucoma.  This patient may or may
not have already /had/ glaucoma that was formerly undiagnosed.  That
glaucoma may or may not have been causally associated with the use of
Ambien.

http://www.sanofi-synthelabo.us/products/pi_ambien/pi_ambien.html#ADVERSE_REACTIONS

OR http://www.ambien.com/hcp/pdf/magnum_pi_key.pdf

Hope that helps....

Neil

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Larry - 29 Oct 2005 05:25 GMT
> Hope that helps....

A remarkably complete answer.  Thanks.
I was told not to use any medicine associated with glaucoma.  That leaves
water, and that is suspect.

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