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Medical Forum / General / Vision / October 2005

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botulism injections for lazy eye?

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Susan - 20 Oct 2005 04:04 GMT
Has any one had botulism injections for lazy eye muscles?  I have
amblyopia, strabismus, farsightedness, and glaucoma.  The strabismus
was corrected with glasses or contacts until I turned 33 and then my
eye began to cross even with my glasses.  I had a fodden procedure in
1997 which worked for a while but now I'm turning in again a little
bit.  Would botulism injections be a possible treatment for me?
Please help!  Susan
David Robins, MD - 20 Oct 2005 06:04 GMT
On 10/19/05 8:04 PM, in article
1129777459.410880.155080@o13g2000cwo.googlegroups.com, "Susan"
<snewman@knology.net> wrote:

> Has any one had botulism injections for lazy eye muscles?  I have
> amblyopia, strabismus, farsightedness, and glaucoma.  The strabismus
[quoted text clipped - 3 lines]
> bit.  Would botulism injections be a possible treatment for me?
> Please help!  Susan

If you had a faden procedure, this is usually used to reduce the eye turn at
far without affecting the far angle. So, it is used when the eyes are
stright in the distance, and turn in with accommodation at near.

Are you turning in now just at near, again, or is the angle about the same
for distance and near?

BOTOX (botulinum toxin) (not botulism, which is a fatal disease) helps some
angles, but mainly if the angle is not specifically at near. It is not as
predictable nor controllable as surgery. When used for crossing, one inner
muscle (medial recuts) is injected, and this basically paralyzes the muscle
for at least a few weeks. The eye then turns way outwards (exotropic),
causing the medial to lengthen, and the lateral rectus to tighten somewhat.
As the toxin "wears off", the eye starts to turn in, but the msucle changes
that have happened may reduce the angle, or make it straight. Lasts a long
time IF there is fusion lock to hold the eyes in alignment. If not, the
effect is temporary. "Temporary" may mean a few weeks in some cases, to a
few years in other cases.

In any case, risk is low, and if it doesn't work, it does not preclude
having surgery. Can also be repeated if it works


David Robins, MD
Board certified Ophthalmologist
Pediatric and adult strabismus subspecialty
Member of AAPOS
(American Association of Pediatric Ophthalmology and Strabismus).
Neil Brooks - 20 Oct 2005 15:45 GMT
>On 10/19/05 8:04 PM, in article
>1129777459.410880.155080@o13g2000cwo.googlegroups.com, "Susan"
[quoted text clipped - 29 lines]
>In any case, risk is low, and if it doesn't work, it does not preclude
>having surgery. Can also be repeated if it works

[when your only tool is a hammer, the world tends to look like a nail]

Dr. Robins-

What about a trial of phospholine iodide in a case like this??

TIA,

Neil
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David Robins, MD - 21 Oct 2005 06:12 GMT
On 10/20/05 7:45 AM, in article s1bfl1t7ae89dcgdhkff7real9f8ice5kf@4ax.com,

>> On 10/19/05 8:04 PM, in article
>> 1129777459.410880.155080@o13g2000cwo.googlegroups.com, "Susan"
[quoted text clipped - 39 lines]
>
> Neil

Phospholine iodide is useful in children, where the accommodation induced by
the drug will not cause undue asthenopia symptoms. I've peronally never
heard of it used in adults.

Also, would only be useful in any case if the crossing is strictly at near
when accommodating. Won't do anything if distance, fully-relaxed
accommodation, angle is still esotropic.
 
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