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Medical Forum / General / Vision / July 2005

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Spherical aberration

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William Stacy - 29 Jul 2005 17:20 GMT
I've done a little boning up on this subject and on the larger area of
wave front optics.  I certainly am not an expert in this area. Also,
wave front optics is still a young area scientifically, and there
remains considerable variation in opinions among the experts.

Having said that, I have a few observations.

1. If all aberrations were eliminated, the healthy young human vision
system is capable of 20/8 vision, which is actually a modest theoretical
improvement over the 20/10 commonly found in that group.

2. Wave front LASIK is useful for some patients (mostly those pre and
post op myopes with large pupils) in the reduction (not elimination) of
higher order aberrations. It does not routinely result in 20/8 vision,
because it is not perfect.

3. The "super human" vision envisioned by some is completely spun
unscientific hype.

4. The relationship between high order aberrations and vision has not
been adequately studied and, due to the highly subjective nature of the
visual effects produced by the former on the latter, have not been well
quantified. Indeed, there is not yet even a standard system for
specifying those visual effects.

w.stacy, o.d.
Scott Seidman - 29 Jul 2005 17:44 GMT
William Stacy <wstacy@obase.net> wrote in news:UGsGe.2421$kk6.1476
@newssvr13.news.prodigy.com:

A lot of the science is coming out of Rochester, and I've sat on some
committees for students who are working in this area.

> 4. The relationship between high order aberrations and vision has not
> been adequately studied and, due to the highly subjective nature of the
> visual effects produced by the former on the latter, have not been well
> quantified.

You don't necessarily need to quantify the effects to know they're
disturbing, like the trefoil induced by corneal sutures from certain
procedures.

> Indeed, there is not yet even a standard system for
> specifying those visual effects.
>
> w.stacy, o.d.

I can see your point, but I'm not sure its important.  I would think that
the high-order aberrations can be removed during a preop exam using
adaptive optics techniques like moving mirror arrays (used here to
optically image living photoreceptors in vivo), and you can ask the
patient the "which is better" type questions.

I'm not sure that the higher order corrections will serve your run of the
mill patient much better that current treatments, but for those patients
with severe high order problems, this technology will likely be a vast
improvement.

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Scott
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William Stacy - 29 Jul 2005 18:20 GMT
The only practical use I can see for this stuff is in fixing corneal
damage with a wave guided laser.  There is a company that claims they
have invented wave front corrected spectacles (I'll believe it when I
see it) and another that has similar contacts (theoretically possible,
but why bother, when regular optics RGPs "cover up" most aberrations
anyway due to that dandy little tear film lens.

w.stacy, o.d.

> I can see your point, but I'm not sure its important.  I would think that
> the high-order aberrations can be removed during a preop exam using
> adaptive optics techniques like moving mirror arrays (used here to
> optically image living photoreceptors in vivo), and you can ask the
> patient the "which is better" type questions.

> I'm not sure that the higher order corrections will serve your run of the
> mill patient much better that current treatments, but for those patients
> with severe high order problems, this technology will likely be a vast
> improvement.
Glenn - USAEyes.org - 29 Jul 2005 18:32 GMT
>1. If all aberrations were eliminated, the healthy young human vision
>system is capable of 20/8 vision, which is actually a modest theoretical
>improvement over the 20/10 commonly found in that group.

That is what the industry thought, but that is not the reality. The
reality is that the lack of optical aberrations does not necessarily
improve the quality of human vision. This is because of the
neurological process of vision.

Doctors at the university in Rochester created an adaptive optics
device that could be adjusted to eliminate all wavefront error using
corrective lenses and adjustable mirrors. The problem is that when a
patient had "perfect" optics, they complained of poor vision quality.
Reintroduce the aberrations and the patients are able to see again.

The bottom line is that some aberrations are "good"; not because they
improve optics, but because throughout a lifetime the brain learns to
use those aberrations to its advantage. Change them, and the vision
system becomes confused. This is sometimes called aberration
adaptation.

>2. Wave front LASIK is useful for some patients (mostly those pre and
>post op myopes with large pupils) in the reduction (not elimination) of
>higher order aberrations. It does not routinely result in 20/8 vision,
>because it is not perfect.

You are talking about ablation on biological tissue, not incision on
plastic. There is the whole flap variable with LASIK, and the exact
wound response of an individual's cornea cannot be precisely predicted
- only generally predicted. As a simple example, a 10% difference in
corneal hydration can cause as much as a diopter of
over/undercorrection.

Wavefront refractive surgery does not reliably and predictably reduce
higher order aberrations. Wavefront tends to increase HOA less than
conventional ablation.

On the whole, wavefront-guided ablations provide vision outcomes
superior to conventional ablation, but are not perfect and never will
be perfect.

>3. The "super human" vision envisioned by some is completely spun
>unscientific hype.

The hype is that doctors can predictably provide "supervision". The
reality is that it does occur on occasion but not predictably.

>4. The relationship between high order aberrations and vision has not
>been adequately studied and, due to the highly subjective nature of the
>visual effects produced by the former on the latter, have not been well
>quantified. Indeed, there is not yet even a standard system for
>specifying those visual effects.

I'm not exactly sure how you mean this statement. Wavefront is not a
new technology. It has been around since the 1600s. Its application to
human vision is new and that does need a tremendous amount of study,
however not knowing everything about something does not mean you
cannot use what you know.  We don't know what electricity is, but that
does not mean we need to sit in the dark.

The standard system for specifying visual effects is somewhat self
contained. Wavefront aberration mapping is the standard system for
evaluation HOA changes.

Glenn Hagele
Executive Director
USAEyes.org

"Consider and Choose With Confidence"

Email to glenn dot hagele at usaeyes dot org

http://www.USAEyes.org
http://www.ComplicatedEyes.org

I am not a doctor.
Repeating Rifle - 29 Jul 2005 19:29 GMT
On 7/29/05 10:32 AM, in article huoke15t6d7omejmbcscsfgde6v6e967u0@4ax.com,

>> 1. If all aberrations were eliminated, the healthy young human vision
>> system is capable of 20/8 vision, which is actually a modest theoretical
[quoted text clipped - 16 lines]
> system becomes confused. This is sometimes called aberration
> adaptation.

I find that very interesting. Were the experimenters able to remove off-axis
aberrations such as coma and true astigmatism? I certainly would not expect
that to have been done. In that case, the on-axis correction causes off-axis
vision deterioration.

Bill
William Stacy - 29 Jul 2005 20:43 GMT
> I find that very interesting. Were the experimenters able to remove off-axis
> aberrations such as coma and true astigmatism? I certainly would not expect
> that to have been done. In that case, the on-axis correction causes off-axis
> vision deterioration.

It is being done clinically now.  Not perfectly, as Glenn pointed out,
but is being done.  Any off axis (peripheral) deterioration may or may
not be noticed by the patient as mentioned in my last post, and is
probably insignificant.

What works for human vision certainly won't work for cameras, because
the granularity of film/digital pickups is uniform, while the human
retina has a huge variation.  You can easily visualize this variation by
looking at the "x" below and trying to read anything on else on your
monitor while doing so...

                x

w.stacy, o.d.
Scott Seidman - 29 Jul 2005 22:36 GMT
> I find that very interesting. Were the experimenters able to remove
> off-axis aberrations such as coma and true astigmatism? I certainly
> would not expect that to have been done. In that case, the on-axis
> correction causes off-axis vision deterioration.
>
> Bill

http://www.journalofvision.org/4/4/4/

They remove ALL aberrations.  They use the same adaptive optics sytems that
the telescope guys use to correct for irregularities in the atmosphere.  
When turned around the other way (i.e., for an observer to view the
retina), which is what the system they use was actually designed for, it
lets them correct for any irregularities along the light path and view
photoreceptors at the single-cell level.

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Scott
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William Stacy - 29 Jul 2005 20:11 GMT
> I'm not exactly sure how you mean this statement. Wavefront is not a
> new technology. It has been around since the 1600s.

ok so maybe my terminology was a bit loose.  Most people understand the
current discussion to be about the new wave front LASER applications,
esp. as they relate to vision, which is quite recent.
Repeating Rifle - 29 Jul 2005 23:46 GMT
On 7/29/05 12:11 PM, in article
rbvGe.1842$iM7.64@newssvr21.news.prodigy.com, "William Stacy"
<wstacy@obase.net> wrote:

>> I'm not exactly sure how you mean this statement. Wavefront is not a
>> new technology. It has been around since the 1600s.
>
> ok so maybe my terminology was a bit loose.  Most people understand the
> current discussion to be about the new wave front LASER applications,
> esp. as they relate to vision, which is quite recent.

I think that wavefront as used for LASIK is just recent application of
interferometric measurement. The deviation of the surface from that required
for ideal imaging, in this case the corneal surface, is measured in
wavelengths. Subsequently, that tells you how much material to remove to
compensate for the structural optical error.

In other words, using the measurement technique, it is now possible to find
out how much of the cornea to remove at any point to correct refractive
error. The laser lets you remove it. That is, it is now possible to figure a
living cornea to compensate for error.

Bill
Repeating Rifle - 29 Jul 2005 19:21 GMT
On 7/29/05 9:20 AM, in article
UGsGe.2421$kk6.1476@newssvr13.news.prodigy.com, "William Stacy"
<wstacy@obase.net> wrote:

> I've done a little boning up on this subject and on the larger area of
> wave front optics.  I certainly am not an expert in this area. Also,
> wave front optics is still a young area scientifically, and there
> remains considerable variation in opinions among the experts.

The study of aberrations has a history going back over a century. Studying
aberrations in terms of wavefronts is somewhat newer but still old. See the
classic by Born and Wolf. Wavefront technique applied to ophthalmology is
relatively recent. Optical shops outside the vision trade have long used
wavefront correction to improve the performance of components. The process
is called "figuring." After measurement, small errors are removed by local
polishing. The Hubble telescope mirror was figured incorrectly when made.

> Having said that, I have a few observations.
>
> 1. If all aberrations were eliminated, the healthy young human vision
> system is capable of 20/8 vision, which is actually a modest theoretical
> improvement over the 20/10 commonly found in that group.

I find it hard to believe that any any aberration other than spherical or
chromatic is important to human vision. What optometry calls "astigmatism"
does not correspond to astigmatism as used in other optical fields. In a
camera lens, astigmatism is an off-axis aberration. Nevertheless, optometric
astigmatism contributes a cylindrical wavefront component that can be
corrected with a cylindrical lens or figuring.

> 2. Wave front LASIK is useful for some patients (mostly those pre and
> post op myopes with large pupils) in the reduction (not elimination) of
> higher order aberrations. It does not routinely result in 20/8 vision,
> because it is not perfect.

I am not sure what you mean by higher order aberration. From the little I
know of LASIK, its primary goal is to get rid of refractive errors that are
ordinarily not considered aberrations in other fields of optics. That is,
the corrections remove spherical focus error and cylindrical focus error. It
cannot do anything about chromatic aberration which is not a wavefront error
per se.

My guess is, that for most people, true aberration, especially high order
aberration, is not a big problem. I suppose a conical cornea could be
largely corrected using wavefront techniques.

> 3. The "super human" vision envisioned by some is completely spun
> unscientific hype.
[quoted text clipped - 4 lines]
> quantified. Indeed, there is not yet even a standard system for
> specifying those visual effects.

My guess is that any wavefront correction for off-axis vision is unnecessary
and will cause on-axis vision to deteriorate. Pilots, for example, primarily
use their central vision.  Off-axis vision is used primarily to know where
to look with central vision. Thus, if I were in the market for LASIK I would
go for the best possible on-axis correction with a large pupil. Even so,
when it gets dark enough, good central vision will disappear anyway. In that
case, off-axis vision will have been degraded by the correction for central
vision.

> w.stacy, o.d.
Bill
William Stacy - 29 Jul 2005 20:36 GMT
> I find it hard to believe that any any aberration other than spherical or
> chromatic is important to human vision.

In normal, healthy eyes neither of those types is very important either,
which is kind of where this whole discussion started.

> I am not sure what you mean by higher order aberration.

The wave front LASER people have created a paradigm that calls dioptric
errors (defocus, regular astigmatism, and chromatic aberration) lower
order aberration, since they can be expressed in ordinary diopters.
They call all other aberrations higher order because they can only be
expressed in terms of zernicke polynomials, complex curve fitting
formulas.  These include spherical aberration, coma, irregular
astigmatism, field distortion, trefoil, quadrafoil and others that don't
even have names because they are pretty insignificant.   Astigmatism and
 spherical aberration are odd in that the classic optical definitions
of those terms are not the same as the wave front definitions.

 From the little I
> know of LASIK, its primary goal is to get rid of refractive errors that are
> ordinarily not considered aberrations in other fields of optics. That is,
> the corrections remove spherical focus error and cylindrical focus error.

For ordinary LASIK you are right, but for wave front guided LASIK, the
"higher order" aberrations are attempted to be corrected, especially in
large pupils where they do have an effect. Probably the most promising
use of this new technology is in rehabilitating roughly shaped, diseased
corneas.

> My guess is, that for most people, true aberration, especially high order
> aberration, is not a big problem. I suppose a conical cornea could be
> largely corrected using wavefront techniques.

Right, except keratoconus usually means abnormally thin corneas, so
unfortunately is not a good candidate.

> My guess is that any wavefront correction for off-axis vision is unnecessary
> and will cause on-axis vision to deteriorate. Pilots, for example, primarily
[quoted text clipped - 4 lines]
> case, off-axis vision will have been degraded by the correction for central
> vision.

Actually, wave front LASIK aims at para-central rays.  These are
parallel with the axis, bot not coincident with them, which is why pupil
size is so important. It doesn't really deal with your "off axis" rays
that we call peripheral vision.  Peripheral vision blur is not
considered a big deal because acuity in the periphery is so poor anyway.

w.stacy, o.d.
Scott Seidman - 29 Jul 2005 22:24 GMT
William Stacy <wstacy@obase.net> wrote in news:RyvGe.2499$kk6.1778
@newssvr13.news.prodigy.com:

> Right, except keratoconus usually means abnormally thin corneas, so
> unfortunately is not a good candidate

Believe it or not, I think I've heard that post-op keratoconus patients
with corneal transplants are Lasik candidates

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Glenn - USAEyes.org - 29 Jul 2005 23:09 GMT
Yes, some DLKP and PKP patients have had refractive surgery, but PRK
or LASEK with Mitomycin C would make more sense. There is less IOP
raise and more untouched tissue.

Much depends upon the individual circumstances. I would not say that
refractive surgery on a transplant patient due to keratoconus is
common.

Glenn Hagele
Executive Director
USAEyes.org

"Consider and Choose With Confidence"

Email to glenn dot hagele at usaeyes dot org

http://www.USAEyes.org
http://www.ComplicatedEyes.org

I am not a doctor.
Repeating Rifle - 30 Jul 2005 00:06 GMT
On 7/29/05 12:36 PM, in article
RyvGe.2499$kk6.1778@newssvr13.news.prodigy.com, "William Stacy"
<wstacy@obase.net> wrote:

>> I find it hard to believe that any any aberration other than spherical or
>> chromatic is important to human vision.
[quoted text clipped - 14 lines]
> spherical aberration are odd in that the classic optical definitions
> of those terms are not the same as the wave front definitions.

Unfortunately, it appears too late to avoid another discrepancy between
optometric and optical nomenclature. In my training, defocus would not be
considered an aberration at all because it is correctible using spherical
refractive surfaces.

<snip>

> Actually, wave front LASIK aims at para-central rays.  These are
> parallel with the axis, bot not coincident with them, which is why pupil
> size is so important. It doesn't really deal with your "off axis" rays
> that we call peripheral vision.  Peripheral vision blur is not
> considered a big deal because acuity in the periphery is so poor anyway.

<glenn.hageleSTOPSPAM@USAEyes.org> had an intersting post here on that
subject

Bill
Mike Tyner - 30 Jul 2005 02:01 GMT
> My guess is, that for most people, true aberration, especially high order
> aberration, is not a big problem.

Most people experience a big dose of spherical abb when they get their eyes
dilated.

It's surprising that people with large pupils don't walk in with a special
set of problems.

-MT
Repeating Rifle - 30 Jul 2005 03:04 GMT
On 7/29/05 6:01 PM, in article
bkAGe.10956$oZ.5386@newsread2.news.atl.earthlink.net, "Mike Tyner"
<mtyner@mindspring.com> wrote:

>> My guess is, that for most people, true aberration, especially high order
>> aberration, is not a big problem.
[quoted text clipped - 6 lines]
>
> -MT

I have wondered about that. Apparently, there is insufficient selective
pressure to make aspheric refractive surfaces in real eyes. Diurnal people's
vision probably has other requirements. If there is an intelligent designer,
he/she forgot about aplanatic surfaces.

Are there any nocturnal animals that do have aspheric optical systems? Do
they also have cones for central vision?

Bill
William Stacy - 30 Jul 2005 04:23 GMT
> I have wondered about that. Apparently, there is insufficient selective
> pressure to make aspheric refractive surfaces in real eyes. Diurnal people's
> vision probably has other requirements. If there is an intelligent designer,
> he/she forgot about aplanatic surfaces.

Here we go again.  No, the cornea is not spherical and is indeed
aspheric and was definitely "designed" correctly.  It is precisely the
flattening in the normal peripheral cornea that corrects what would be a
horrific amount of ordinary spherical aberration under low light
conditions if we had spherical corneas. We don't, and as a result, have
very little spherical aberration.

w.stacy, o.d.
Repeating Rifle - 30 Jul 2005 07:33 GMT
On 7/29/05 8:23 PM, in article
DoCGe.2721$kk6.2286@newssvr13.news.prodigy.com, "William Stacy"
<wstacy@obase.net> wrote:

>> I have wondered about that. Apparently, there is insufficient selective
>> pressure to make aspheric refractive surfaces in real eyes. Diurnal people's
[quoted text clipped - 7 lines]
> conditions if we had spherical corneas. We don't, and as a result, have
> very little spherical aberration.

Sorry about that. I really should not have implied that the cornea was
spheric. What I do ask is if the eye's optical system is aplanatic or
whatever the correct term is when the image surface, like the retina, is not
plane.

So I will repeat my questions in a different way. Is the human eye close to
being aplanatic because of its aspherity? I doubt it because, as stated in
earlier posts, eye performance degrades with larger pupils. Even with
perfect aplanaticity there is a loss of depth of field that might
subjectively appear to be degraded acuity.

Again, does the typical nocturnal animal such as an owl or cat have better
aplanaticity than a human?

Bill
Dr. Leukoma - 30 Jul 2005 14:54 GMT
I've read that the trilobite had an aplanatic eye.

DrG
William Stacy - 30 Jul 2005 15:18 GMT
> Sorry about that. I really should not have implied that the cornea was
> spheric. What I do ask is if the eye's optical system is aplanatic or
> whatever the correct term is when the image surface, like the retina, is not
> plane.

I'm sure this has been investigated, but not by me, except that it would
make sense, since the retina is concave, the optics would correspond to
that.  I will say that the region of the eye that is most concerned with
focus/defocus and image quality is the macula, which can be considered,
at a first approximation, to be flat.

> So I will repeat my questions in a different way. Is the human eye close to
> being aplanatic because of its aspherity? I doubt it because, as stated in
> earlier posts, eye performance degrades with larger pupils. Even with
> perfect aplanaticity there is a loss of depth of field that might
> subjectively appear to be degraded acuity.

I think it is, within the norms of pupil size.  When you talk about huge
pupils sure, you are bound to encounter the edges of the optical part of
the cornea and get some degradation from the limbal area.  That part was
not designed to be used for vision, just to make the structural
connection to the scleral.  It is thicker and less transparent, so you'd
expect the image to degrade. Like opening up the F stop of a camera so
wide that you get lens edge/housing whatever in the mix.

> Again, does the typical nocturnal animal such as an owl or cat have better
> aplanaticity than a human?

Yes.  They have larger pupils so the optics are better in the areas they
 actually use on a regular basis.  We humans mostly stayed in at night
during our design process.

w.stacy, o.d.
Repeating Rifle - 30 Jul 2005 23:03 GMT
On 7/30/05 7:18 AM, in article
J_LGe.8343$_%4.4223@newssvr14.news.prodigy.com, "William Stacy"
<wstacy@obase.net> wrote:

> I think it is, within the norms of pupil size.  When you talk about huge
> pupils sure, you are bound to encounter the edges of the optical part of
[quoted text clipped - 3 lines]
> expect the image to degrade. Like opening up the F stop of a camera so
> wide that you get lens edge/housing whatever in the mix.

"Apodization" is a term that is probably not used much in optometry. The
transmissivity decreases ("less transparent") toward the periphery of the
pupil. It is used to avoid diffractive ring patterns near focal spots. I do
not expect that eye optical quality is good enough to where apodization cab
be useful. I do not see fringes around text on my computer monitor. The
reduction in transmissivity must serve some other evolutionary purpose. Even
in bright illumination, when pupils shrink, I never see any indication that
apodization could be useful.

Bill
Dr. Leukoma - 31 Jul 2005 00:16 GMT
You gotta be talking huge huge pupil for that to occur.  Just my
opinion.

DrG

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