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Medical Forum / General / Vision / August 2005

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Pigment clumping

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auriganews - 12 Jul 2005 14:05 GMT
My optometrist recently told me I had pigment clumping on and around my
macula in the left eye. I am 45 years old with a history of retinal
problems. Over twenty years ago, I had a retinal detachment repaired with a
buckle. This caused a cataract, which was removed 10 years ago. Shortly
after that, I had cystoid macular edema. The surgeon inserted a steroid bag
into my eye which was succesful in clearing my vision. I also have a macular
pucker now which is not affecting my vision too badly. When I do a google
seach for pigment clumping, the results I get are all for macular
degeneration. I have an appointment with my retinal specialist in 6 weeks,
but the waiting is driving me crazy. Is there anything else that could cause
this clumping? I'm thinking maybe it's caused by all my past surgeries.
Could that be a factor? Any answers would be appreciated, as I am a nervous
wreck waiting for my appointment. Thank you.
William Stacy - 12 Jul 2005 15:34 GMT
Pigment clumping is a fairly ambiguous term that may or may not be a
significant factor for eventual macular degeneration.  It could simply
be an after effect of the CME. So relax and wait for the retinologist.

w.stacy, o.d.

> My optometrist recently told me I had pigment clumping on and around my
> macula in the left eye. I am 45 years old with a history of retinal
[quoted text clipped - 9 lines]
> Could that be a factor? Any answers would be appreciated, as I am a nervous
> wreck waiting for my appointment. Thank you.
RM - 13 Jul 2005 00:19 GMT

As Dr. Stacy mentioned, pigment clumping may be totally innocuous or it may
be related to several things, e.g. onset of macular degeneration (rather
early in your case), scarring of the retina (possibly related to the retinal
problems you have had).

In the end, there is nothing you can proactively do about it.  Try not to
worry.  Your retinal specialist will things for you.  If your vision is
unaffected then it's of little concern.

=============

> My optometrist recently told me I had pigment clumping on and around my
> macula in the left eye. I am 45 years old with a history of retinal
[quoted text clipped - 9 lines]
> surgeries. Could that be a factor? Any answers would be appreciated, as I
> am a nervous wreck waiting for my appointment. Thank you.
auriganews - 13 Jul 2005 14:37 GMT
Thank you for your quick replies. Your answers have helped to calm me down
somewhat. It is nice to know it could be related to my earlier problems. I'm
hoping my retinal specialist will be able to put my fears totally to rest.
Thanks again.
David Robins, MD - 14 Jul 2005 06:15 GMT
Retinal detachment, repaired with buckle (usually using cryopexy with that)
can cause pigment clumping, particularly if it was a macula-off detachment.

Even if not, pigment from the detachment healing process can migrate, and
end up under/around the macula later on. Nothing to do about it.

On 7/12/05 6:05 AM, in article
OePAe.2246$oZ.366@newsread2.news.atl.earthlink.net, "auriganews"
<auriga2@REMOVEmindspring.com> wrote:

> My optometrist recently told me I had pigment clumping on and around my
> macula in the left eye. I am 45 years old with a history of retinal
[quoted text clipped - 9 lines]
> Could that be a factor? Any answers would be appreciated, as I am a nervous
> wreck waiting for my appointment. Thank you.
auriganews - 14 Jul 2005 17:42 GMT
Thank you so much for your reply, Dr. Robins. It has helped me tremendously.
My detachment did not include the macula, although the doctor said it came
very close to it. I have noticed some dimming of my vision, especially at
night, but I'm sure just the clumping itself could cause that. Sounds like I
might be stressing out unnecessarily. Thanks for helping me to calm down. I
appreciate it very much.
auriganews - 21 Aug 2005 19:09 GMT
Well, I finally saw my retinal specialist, and he said that I do have
macular degeneration in both eyes. He said it was mild in my left eye, and
microscopic in my right. However, at this point, it is only drusen, and some
pigment clumping. He noticed the drusen a year ago, but now it has become
more numerous, I guess. I understand the rate of progression is slow, but
given that mine progressed already in only a year, is this indicative of
it's rate of progress? I have no idea when to expect severe vision problems.
10 years? 5 years? I also have normal tension glaucoma which attacks the
peripheral vision, so I am concerned that I will be left with hardly any
vision at all. Also, I have been reading that the pigment clumping could be
a sign that it will turn to the wet MD. Is this true? I am only 45 years
old. I am starting to think I will be blind before I turn 50. If anyone has
any answers, I would appreciate it.
Mike Tyner - 21 Aug 2005 20:24 GMT
> Well, I finally saw my retinal specialist, and he said that I do have
> macular degeneration in both eyes. He said it was mild in my left eye, and
> microscopic in my right. However, at this point, it is only drusen, and
> some pigment clumping. He noticed the drusen a year ago, but now it has
> become more numerous, I guess.

The only missing detail is the quality of the drusen. Hard, discrete dots
are less significant.

Softer, confluent, larger drusen are a pretty big risk factor. So is pigment
migration.

I think you should get in the habit of checking your central fields with a
printed page or quadrille pad, once a month or so.

I also think you should have a "PHP" visual field, and a macular OCT every
year or two. You'll need a baseline flourescein angiogram in the near
future.

----------

Dr. Stuart Richer's lifestyle recommendations, adapted from yesterday's
lecture:

---------

Avoid smoking

Avoid exposure to bright sunlight.

Increase antioxidant nutrients, especially spinach or kale, cooked tomatoes,
oranges & bananas, blueberries, moderate red wine

Avoid or control hypertension and cardiovascular risk factors

Avoid high iron intake, give blood 3x/year

Lutein (60 mg) plus a daily multivitamin with zinc

Omega-3 fatty acids:  sardines, salmon, tuna, herring, nuts

1 cup soy milk/day, extra vitamin D

--------

> I understand the rate of progression is slow, but given that mine
> progressed already in only a year, is this indicative of it's rate of
> progress? I have no idea when to expect severe vision problems.

90% of macular degeneration is "dry" or atrophic, with less severe effect on
vision.

10% of macular degeneration is "wet" or exudative.

With wet MD, on average it takes about 10 years to go from 20/40 to 20/200.

The most promising treatment approaching FDA approval is Lucentis.

-MT, OD
Don W - 22 Aug 2005 08:11 GMT
 The grid Mike is referring to is termed an "Amsler grid" and there are
various sites this could be downloaded from.  Basically the grid has high
contrast and has a centered dot which is fixated upon while testing.  One is
to look for waviness in the lines (any one) and note if parts of the grid
are "foggy".

 Good luck.

Don W

> Well, I finally saw my retinal specialist, and he said that I do have
> macular degeneration in both eyes. He said it was mild in my left eye, and
[quoted text clipped - 9 lines]
> am only 45 years old. I am starting to think I will be blind before I turn
> 50. If anyone has any answers, I would appreciate it.
auriganews - 22 Aug 2005 17:16 GMT
Thank you both for your suggestions. I already have an Amsler grid that I
was given 20 years ago after my retinal detachment. The lines on that are
somewhat wavy, due, I am told to an epirentinal membrane. I check it every
so often to see if the waviness is getting worse. So far, so good.

He did not tell me what kind of drusen I have. He only mentioned they were
quite small. I am assuming they were the soft kind, but I really don't know.
I don't know what a PHP visual field test is, but  I did have a visual field
test done on Friday. I get them yearly to check the glaucoma. Only slight
peripheal loss so far. My pressure stays at between 10 and 12, so he said
eye drops would be useless in this case.

I also don't know what a macular OCT is, either. I have never heard of that.
But, I do get a flourescein angiogram yearly, because of all my other
retinal problems, I assume. Basically, my eyes are a mess. I'm thankful I
see as well as I do.

I have been reading up on the diet and nutrition advice for macular
degneration, and I will paying closer attention to what  I eat. And quitting
smoking too. Hopefully. Thank you for your advice. I guess there is not much
I can do, except wait and see what happens. This is so frustrating.
Don W - 22 Aug 2005 18:17 GMT
> I also don't know what a macular OCT is, either. I have never heard of
> that. But, I do get a flourescein angiogram yearly, because of all my
> other retinal problems, I assume. Basically, my eyes are a mess. I'm
> thankful I see as well as I do.

The OCT is optical coherence tomography which give data as to the depth of
the retina.  Seems like if you are getting angiograms the OCT would be a
complement to this test.

Don W
 
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