thinkarthritis.org - Patients with rheumatoid arthritis (RA), a
chronic inflammatory autoimmune disease, have a high risk of death
from disease - at least double the risk of the general population,
studies overwhelmingly show. Evidence has been less clear on whether
RA patients are exceptionally vulnerable to dying from cancer.

The first study to investigate whether patients with RA who develop
cancer have a decreased rate of survival, featured in the March 2007
issue of Arthritis & Rheumatism, also examined the impact of rheumatic
disease on overall cancer incidence. Conducted by a team of
researchers in the United Kingdom, it focused on 2,105 patients with
recent onset inflammatory polyarthritis (IP). Over time, a large
proportion of new-onset IP cases evolve into RA, meeting the
diagnostic criteria of the American College of Rheumatology.

Researchers followed the IP patients over a 10-year period to detect
the occurrence of cancer. Among the group, they identified 123 cases
of cancer for analysis. These cases included bone, lung, breast,
prostate, urinary, colon, and brain cancers; cancers of the digestive,
respiratory, and central nervous systems; cancers of the blood cells
and cancerous tumors; but excluding non-melanotic skin cancers. Then,
they compared these rates with the rates of cancer in the general
population from the same geographic area, Norfolk, adjusting for
difference in age and sex. Overall, the incidence of cancer was not
increased in the IP subjects compared with the general population.
However, the risk of blood cell cancers was increased among the IP
sample, a finding researchers expected given the association between
RA and lymphoma.

... http://www.thinkarthritis.org/article-2996131.htm

Tim Silva