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Medical Forum / Diseases and Disorders / Arthritis / July 2005

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Adalimumab (Humira) Failure

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baino - 11 Jul 2005 15:56 GMT
Hi Everyone,
                 Well I have just returned home after spending the last 5
weeks in hospital. I was accepted onto the anti-tnf progam in February and
decided to choose Humira as it was 1 injection fortnightly, However, things
went from bad to worse and I had a severe flare up of my RA and ended up
back in hospital. As it turns out the Humira failed to work and my RA hit me
like wildfire again. I think it was due to the body not absorbing it, but it
was'nt confirmed and I didn't ask. I could'nt move in bed as I was in so
much pain and had to have morphine injections to ease the pain and try and
let me have some sleep. I could'nt wash myself or feed myself and the nurses
were having to do all these simple things for me. I was in quite a bad way
and they told me that I was one of the worst cases they had seen for quite
some time. The first 2 weeks in hospital were a nightmare with morphine
injections and having an allergic reaction to Tramadol painkillers as well.
I also had 3 methyl prednisilone infusions to control the inflammation, this
had a knock on effect in as much as my liver function went through the roof
and they had to suspend some of my drugs inc MTX. They decided to stop the
Humira and start me on etanercept (enbrel) and bearing in mind I've only
been on it for 3 weeks it has made so much difference. I am relatively pain
free apart from a few niggles I can live with. I have been having intensive
physio and occupational therapy in hospital and will still have these at
home also but I know its going to be a hard slog to get back to where I was
but now I think I have the correct tools in the toolbox to continue in life
so much happier and so much less in pain. Its a case of onwards and upwards
from now on. I just wish that I had chosen etanercept in the beginning
instead of humira but you just don't know. Another point worth mentioning is
that Infliximab and Humira have the same chemical make up where as
etanercept has  a different chemical make up. This was confirmed by my
consultant who told me that the failure rate for Humira was 1 in 7 and
because i'd failed on that, that the failure rate if i'd been changed to
infliximab would have been 1 in 3 so it was best to avoid that as well, that
left only etanercept which has been a life saver. I'm on twice weekly
injections at te moment but hopefuly will be changing to once a week after
the weekly trials have been evaluated. Drugs work in different ways with
different people but my advice for somebody faced with the decision of
choice of anti-tnf would be to chose etanercept ahead of the others as it
works wonders.

robert

NDO Best For Broadband
On Sunday, 10th July, Your bandwidth measured as:

526.30kbps

which means you can download at 65.79 KB/sec.
diclidophora@yahoo.co.uk - 11 Jul 2005 17:39 GMT
Robert.

You have certainly been thr the mill. My sympathies and best wishes for
the future.
I think it is very interesting that you found there was such a
difference between the anti tnf drugs which are often regarded as being
very similar, at least in their disease modifying actions.

Peter
Jayne - 11 Jul 2005 17:48 GMT
Hi Robert

I've never experienced what you've been through - have never been bad enough
to be hospitalised, and your ordeal sounds dreadful.

I am really pleased that you have found some relief with Enbrel.   I've been
taking it for two years, and it has made a big difference to me.  I had to
add a little mtx in with it, but nowhere near a full dose.  For me it works,
but I've never tried the remicade or humira.

Fingers crossed that it continues to work for you!

Jayne
Jayne - 12 Jul 2005 19:38 GMT
> Hi Robert
>
[quoted text clipped - 9 lines]
>
> Jayne

I meant to add to my post last night but forgot!

After my 6 month monitoring visit a few weeks ago, I am changing over the
the 50mg once a week injection.  My rheumatology dept hasn't got anyone on
the once a week schedule, so I said I'd try it out to see how it goes.

Will post results!

Jayne
Jayne - 12 Jul 2005 19:38 GMT
> Hi Robert
>
[quoted text clipped - 9 lines]
>
> Jayne

I meant to add to my post last night but forgot!

After my 6 month monitoring visit a few weeks ago, I am changing over the
the 50mg once a week injection.  My rheumatology dept hasn't got anyone on
the once a week schedule, so I said I'd try it out to see how it goes.

Will post results!

Jayne
diclidophora@yahoo.co.uk - 13 Jul 2005 17:50 GMT
I see mine on Monday and have requested once a week. It seems there is
nobody here on it either.

He won't inject my swollen knee, so I don't know how this daring
request will fare !

Peter
Jayne - 13 Jul 2005 21:24 GMT
>I see mine on Monday and have requested once a week. It seems there is
> nobody here on it either.
[quoted text clipped - 3 lines]
>
> Peter

I've never had a joint injected Peter - have you had it done before?

Jayne
Harvey R. Stone - 14 Jul 2005 15:17 GMT
>>I see mine on Monday and have requested once a week. It seems there is
>> nobody here on it either.
[quoted text clipped - 7 lines]
>
> Jayne

Hi Jayne,      I have had several.   The skill of the person giving the shot
means a great deal.   I have asked the doc when is he going to start when he
was done and other shots that made me cry like a baby.  The shot may be
needed to remove fluid from a joint and test it for infection or just to put
steroid in to control what is taking place.
Harv
Jayne - 14 Jul 2005 18:01 GMT
> Hi Jayne,      I have had several.   The skill of the person giving the
> shot
[quoted text clipped - 3 lines]
> put steroid in to control what is taking place.
> Harv

Hi Harv (nice to see new posters!)

It isn't something that my doctor has ever offered, to be honest.  I've had
the steroid depo shot in the rear end when I was flaring badly once, but I
think by the time my knees were bad enough to do something about, they
considered that the "something" was a replacement or nothing.

Joint injections are one of those things that my mind sees as being
"cringey", so it is reassuring that you have experiences ones which aren't.

Jayne
baino - 14 Jul 2005 23:44 GMT
I'd like to add that I've had lots of steroid injections ranging from
cortisone to kenelog etc in my elbows, knees, ankles, shoulders etc with
varying degrees of success. I've also had fluid drained from my knees. My
experience is that its painful only if the doctor giving it dosen't hit the
sweet spot in the joint, also the initial injection is'nt sore but the
actual injecting of the cortisone etc can be uncomfortable. I'd also like to
add that in my experience the more times its been done the lesser the pain
relief is, by that I mean it is'nt as effective as it was the first time.
I've also had the intra-muscular (in the bum) ones with some success
although in hospital I had 2 in 3 days with little effect. My advice to
anyone is to have it done because it will alleviate the pain for a time
however the more times its done the lesser the pain relief. I used to get up
to 3 months relief but now if I'm lucky I maybe get a week or perhaps two.
Thank god I've been put onto enbrel as its proving to be the best medication
I've been prescribed since I was diagnosed with RA.

>> Hi Jayne,      I have had several.   The skill of the person giving the
>> shot
[quoted text clipped - 16 lines]
>
> Jayne
Alison - 11 Jul 2005 22:02 GMT
$0$2883$ed2e19e4@ptn-nntp-reader04.plus.net...
> Hi Everyone,
>                   Well I have just returned home after spending the last 5
[quoted text clipped - 35 lines]
>
> robert>>

Sorry  you've had such a bad time but glad to hear the enbrel has made
such a big
difference. I'm on Enbrel and MTX .
Alison
Robin Fairbairns - 11 Jul 2005 22:40 GMT
>[horror story omitted.]  Drugs work in different ways with
>different people but my advice for somebody faced with the decision of
>choice of anti-tnf would be to chose etanercept ahead of the others as it
>works wonders.

poor old you!  here's to continued stability on etanercept, eh!

best wishes...
Signature

Robin (http://www.tex.ac.uk/faq) Fairbairns, Cambridge

baino - 12 Jul 2005 00:56 GMT
Thank you everyone for your kind wishes, I know i've been through the mill
and the doctors told me it would take possibly a couple of years to get back
to where i was originally but i'm going to try and prove them wrong, however
at the same time i'm going to be sensible and not overdo things. I still
have to have lots of physio and OT for the foreseeable future but with 100%
determination, i aim to improve. Another intresting point i'd like to make
with regard to the humira is weight gain. I know this isn't a recognised
side effect but i gained a little weight whilst on it and it wasn't a
coincidence as i'd lost weight for 15 consecutive months then started humira
and then began gaining weight for the next 3 months. The consultant was
interested in this as quite a few others had been telling him the same
thing. Anyway looking forward to another injection tomorrow, at least i'm
getting a tattoo on my belly free of charge with the bruising.

robert
> Hi Everyone,
>                  Well I have just returned home after spending the last 5
[quoted text clipped - 43 lines]
>
> which means you can download at 65.79 KB/sec.
Ian - 12 Jul 2005 10:56 GMT
trawlman@yahoo.co.uk wrote:

> Thank you everyone for your kind wishes, I know i've been through the mill
> and the doctors told me it would take possibly a couple of years to get back
> to where i was originally but i'm going to try and prove them wrong, however

That's  the right attitude!  I was horrified to read your account,
being a new comer to this arthritis thing; I had no idea it can be so
bad.
Free tattoo on your belly ....!  Like it.
Signature

Ian
Ft Worth, TX

me2@dn14.net - 12 Jul 2005 17:29 GMT
>I had no idea it can be so
>bad.

Ian,
In just the same way as different drugs can be effective or less so if
different people, arthritis can "be bad" or less so on different
individuals. I really feel for the orignal poster and am glad that
Enbrel seems to be working now.

There are over 170+ types of arthritis:

Achilles tendinitis, Achondroplasia, Amyloidosis, Acromegalic
arthropathy, Adhesive capsulitis, Adult onset Still's disease,
Ankylosing spondylitis, Anserine bursitis, Arthrochalasis multiplex
congenita, Aseptic necrosis, Asymptomatic hyperuricemia, Avascular
necrosis, Bacterial arthritis, Baker's cysts, Behcet's syndrome,
Bicipital tendinitis, Blount's disease, Bouchard's nodes, Boutonniere
deformity, Buchman's disease, Buerger's disease, Bursitis,
Calcaneal bursitis, Calcium pyrophosphate dehydrate (CPPD) crystal
deposition disease, Caplan's syndrome, Carpal tunnel syndrome,
Charcot-Marie-Tooth disease Childhood dermatomyositis,
Chondrocalcinosis, Chondroma, Chondromalacia patellae, Chondromatosis,
Chronic overuse syndrome, Chronic polymyositis, Chronic recurrent
multifocal osteomyelitis, Churg-Strauss syndrome, Clawfoot, Clutton's
joints, Cogan's syndrome, Connective tissue disease,
Corticosteroid-induced osteoporosis, Costosternal syndrome, CREST
syndrome, Crohn's disease, Cryoglobulinemia, Degenerative joint
disease, Dermatomyositis, Diabetic finger sclerosis, Diffuse articular
lipomatosis, Diffuse idiopathic skeletal hyperostosis (DISH),
Discitis,Discoid lupus erythematosus, Drug-induced lupus, Drug-induced
scleroderma-like disease, Duchenne's muscular dystrophy, Dupuytren's
contracture, Dwarfism, Ehlers-Danlos syndrome, Enteropathic arthritis,
Epicondylitis, Erosive inflammatory osteoarthritis, Exercise-induced
compartment syndrome, Fabry's disease, Familial amyloidosis, Familial
Mediterranean fever,Farber's lipogranulomatosis, Felty's syndrome,
Fibromyalgia, Fifth's disease, Flatfeet, Foreign body synovitis,
Freiberg's disease, Frozen shoulder, Fungal arthritis,
Gaucher's disease, Giant cell arteritis, Gonococcal arthritis,
Goodpasture's syndrome, Gout, Granulomatous arteritis,
Heberden's nodes, Hemarthrosis, Hemochromatosis, Henoch-Schonlein
purpura, Hepatitis B surface antigen disease, Hidradenitis
suppurative, Hip dysplasia, Hurler syndrome, Hypermobility syndrome,
Hypersensitvity vasculitis, Hypertrophic osteoarthropathy,
Idiopathic osteonecrosis, Immune complex disease, Impingement
syndrome, Jaccoud's arthropathy, Juvenile ankylosing spondylitis,
Juvenile chronic polyarthritis, Juvenile dermatomyositis, Juvenile
osteochondroses, Kawasaki disease, Kienbock's disease,
Legg-Calve-Perthes disease, Lesch-Nyhan syndrome, Libman-Sacks
endocarditis, Lightchain disease, Liner scleroderma, Lipoid
dermatoarthritis, Loffler's syndrome, Lofgren's syndrome, Lyme
disease, Malignant synovioma, Marfan's syndrome, Medial plica
syndrome, Metabolic bone disease, Mixed connective tissue disease
(MCTD), Mixed cryoglobulinemia, Morquio syndrome, Morton's neuroma,
Mucha-Habertnan disease, Multiple epiphyseal dysplasia, Munchausen's
syndrome, Myasthenia gravis, Mycoplasmal arthritis, Myofascial pain
syndrome, Neonatal lupus, Neuropathic arthropathy, Nodular
panniculitis, Ochronosis, Olecranon bursitis, Osgood-Schlatter
disease, Osteitis defortnans, Osteoarthritis, Osteochondromatosis,
Osteogenesis imperfecta syndrome, Osteomalacia, Osteomyelitis,
Osteonecrosis, Osteoporosis, Overlap syndrome,
Pachydermoperiostosis, Paget's disease of bone, Palindromic
rheumatism,Patellofemoral pain syndrome, Pellegrini--Stieda syndrome,
Periarticular abnormalities, Peroneal tendinitis, Pigmented
villonodular synovitis, Piriformis syndrome, Plantar fasciitis,
Polyarteritis nodosa, Polymyalgia rheumatica, Polymyositis, Popliteal
cysts, Popliteal tendinitis, Posterior interosseous nerve syndrome,
Posterior tibial tendinitis, Pott's disease, Prepatellar bursitis,
Progressive systemic sclerosis, Prosthetic joint infection,
Pseudogout, Pseudo-Hurler polydystrophy, Pseudohypoparathyroidism,
Pseudoxanthoma elasticum, Psoriatic arthritis, Pyogenic arthritis,
Raynaud's phenomenon, Reactive arthritis/Reiter's syndrome, Reflex
sympathetic dystrophy syndrome, Relapsing polychondritis, Renal
osteodystrophy, Retrocalcaneal bursitis, Rheumatic fever, Rheumatoid
arthritis, Rheumatoid vasculitis, Riley-Day syndrome, Ross River
virus,Rotator cuff tendinitis, Sacroiliitis, Saddle nose deformity,
Salmonella osteomyelitis,Sanfilippo syndrome, Sarcoidosis, Saturnine
gout, Scheie syndrome,Scheuermann's osteochondritis, Scleroderma,
Septic arthritis,Seronegative arthritis, Shigella arthritis,
Shoulder-hand syndrome,Sicca complex, Sickle cell arthropathy,
Sjogren's syndrome, Skeletal dysplasias, Slipped capital femoral
epiphysis, Sly syndrome, Spinal stenosis, Spondylolysis,
Sporotrichosis Arthritis, Stickler syndrome,
Still's disease, Sub-Achilles bursitis, Subacute cutaneous lupus, Swan
neck deformity, Sweet's syndrome, Sydenham's chorea, Syphilitic
arthritis, Systemic lupus erythematosus (SLE),
Takayasu's arteritis, Tarsal tunnel syndrome, Temporal arteritis,
Tendinitis, Tennis elbow, Thoracic outlet syndrome, Tietse's syndrome,
Toxic oil syndrome, Transient osteoporosis, Traumatic arthritis,
Trochanteric bursitis, Tuberculosis arthritis,
Arthritis of Ulcerative colitis, Undifferentiated connective tissue
syndrome (UCTS), Urticarial vasculitis, syndrome,
Vasculitis, Viral arthritis, VonGierke's disease, VonWillebrand's
disease, Weber-Christian disease, Wegener's granulomatosis, Whipple's
disease, Wilson's disease, Yersinial arthritis.

If I missed any have a word with the Rheumatologist about it....

--
Andy
 
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