Revista Brasileira de Otorrinolaringologia
Print ISSN 0034-7299
Abstract

AZEVEDO, Andréia A. and FIGUEIREDO, Ricardo R. Tinnitus treatment with
acamprosate: double-blind study. Rev. Bras. Otorrinolaringol., Sept./Oct.
2005, vol.71, no.5, p.618-623. ISSN 0034-7299.

Nowadays, the treatment of tinnitus is still a great challenge for the
otolaryngologists. Many facts remain unknown in its pathophysiology, leading
to many different therapies, with irregular results. Acamprosate is a drug
used in alcoholism treatment, due to its regulating effects in glutamatergic
and GABA neurotransmission, and has never been used before in the treatment
of tinnitus AIM: To evaluate efficacy and safety of the acamprosate in the
treatment of sensorineural tinnitus. STUDY DESIGN: randomized clinical
trial. MATERIAL AND METHOD: 50 patients with sensorineural tinnitus were
divided into two groups: 25 received acamprosate and 25 placebo, for a
period of 3 months, in a prospective double-blind study, being analyzed for
its efficacy and safety by the subjective score from 1 to 10 given by the
patient. RESULTS: We found a high index of success in the relief of
tinnitus, about 86.9%. In 47.8% of the cases we found more than 50% relief.
The incidence of side effects was low, 12%, all of them mild. CONCLUSION:
Acamprosate, a drug used in the treatment of alcoholism, is a safe and
successful alternative for sensorineural tinnitus' treatment.

What to think about this (small as it is) study?
Jamffer