Otolaryngol Head Neck Surg. 2007 Jan;136(1):72-7. Links
A pilot clinical trial of the effects of coenzyme Q10 on chronic
tinnitus aurium.Khan M, Gross J, Haupt H, Jainz A, Niklowitz P,
Scherer H, Schmidt FP, Klapp BF, Reisshauer A, Mazurek B.
Department of Otorhinolaryngology, Charité-University Medicine Berlin,
Berlin, Germany.

OBJECTIVE: To determine the short-term effects of coenzyme Q10 (CoQ10)
on the antioxidative status and tinnitus expression in patients with
chronic tinnitus aurium. STUDY DESIGN: A 16-week prospective
nonrandomized clinical trial (n = 20). Tinnitus and Short Form-36
Questionnaires (TQ/SF-36) were evaluated together with the plasma
concentrations of CoQ10, malondialdehyde, and the total antioxidant
status. RESULTS: The mean plasma CoQ10 concentration rose under
external CoQ10 supply and remained elevated after medication stopped
without overall effects on the tinnitus score. However, in a subgroup
of 7 patients with low initial plasma CoQ10 concentration and
significant increase in the plasma CoQ10 level, a clear decrease in
the TQ score was observed. CONCLUSION: In patients with a low plasma
CoQ10 concentration, CoQ10 supply may decrease the tinnitus
expression. SIGNIFICANCE: This is the first study to examine the
effect of CoQ10 in chronic tinnitus aurium.

PMID: 17210337 [PubMed - indexed for MEDLINE]