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Medical Forum / Diseases and Disorders / Tinnitus / March 2007

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Ginkgo Biloba multiple studies: NOT a benefit for T

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jga.socal - 26 Mar 2007 05:52 GMT
I've taken Ginko  50mg/day for a year and have not noticed a benefit
to my T.  I take it for other reasons.  Well, thats the extent of my
anecdotal evidence concerning Ginkgo and T.

A little research may find a small study or two that seem to support
the efficacy of Ginkgo for alleviating Tinnitus.  However, A little
more 'honest' research will reveal that the majority of studies
conclude that Ginkgo does NOT help Tinnitus.

Lesson here? If a person is simply determined to obtain confirmation
of their opinion on something, there is a decent chance they can find
a study somewhere by someone who's conclusion may seem to lend
support. If more studies are available, as they are in this case, a
survey of the conclusions should be sought by the truly inquisitive
mind.  Before I quote such a survey I have a ....

Commentary: As for the deaf,dumb, & blind 'Tommy' who finds his
salvation, speech, and vision by playing a mean game of pinball, the
rest of us should be wary of his claims when he proselytizes that
playing pinball will help us too. Ginkgo biloba is contraindicated for
dozens of drugs and conditions. I hope no one gets hurt by acting upon
the Ginkgo hype from Tommy.  If Ginkgo works for you and you report
that here, you will be the second reported success!  If you get
seriously ill from it, we probably wont hear from you. :-(

On to the plethora of not-so-anecdotal evidence.  One survey of many
Ginkgo-Tinnitus studies can be found for 'Tinnitus Aurium' at
http://healthlibrary.epnet.com.  It concludes that, "the evidence is
strong enough to state that ginkgo does NOT benefit tinnitus".

"Several studies have evaluated Ginkgo biloba extract for treating
tinnitus, but the results have been conflicting. (2-7,18).  While some
small studies found benefit, by far the largest and best-designed of
these trials found no benefit. In this double-blind, placebo-
controlled trial, 1,121 individuals with tinnitus were given 12 weeks
of treatment with standardized ginkgo at a dose of 50 mg 3 times daily
(8).
The results showed no difference between the treated and the placebo
group.
A separate set of researchers performed an additional study on ginkgo
for tinnitus, and then additionally conducted a meta-analysis
(statistically rigorous review) of the published data. Their
conclusion: the evidence is strong enough to state that ginkgo does
NOT benefit tinnitus. (20)"

2.  Holgers KM, Axelsson A, Pringle I. Ginkgo biloba extract for the
treatment of tinnitus. Audiology. 1994;33:85-92.
3. Ernst E, Stevinson C. Ginkgo biloba for tinnitus: a review. Clin
Otolaryngol. 1999;24:164-167.
4. Coles R. Trial of an extract of Ginkgo biloba (EGB) for tinnitus
and hearing loss [letter]. Clin Otolaryngol. 1988;13:501-502.
5. Meyer B. Multicenter randomized double-blind drug vs. placebo study
of the treatment of tinnitus with Ginkgo biloba extract [translated
from French]. Presse Med. 1986;15:1562-1564.
6. Morgenstern C, Biermann E. Long-term tinnitus therapy with ginkgo
special extract EGb 761 [translated from German]. Fortschr Med.
1997;115(29):57-58.
7. Drew S, Davies E. Effectiveness of Ginkgo biloba in treating
tinnitus: double blind, placebo controlled trial. BMJ. 2001;322:1-6."
8.  Drew S, Davies E. Effectiveness of Ginkgo biloba in treating
tinnitus: double blind, placebo controlled trial. BMJ. 2001;322:1-6.
18. Morgenstern C, Biermann E. The efficacy of Ginkgo special extract
EGb 761 in patients with tinnitus. Int J Clin Pharmacol Ther.
2002;40:188-197.
20. Rejali D, Sivakumar A, Balaji N. Ginkgo biloba does not benefit
patients with tinnitus: a randomized placebo-controlled double-blind
trial and meta-analysis of randomized trials. Clin Otolaryngol. 2004
Jun;29(3):226-31.
fyfpoon@gmail.com - 26 Mar 2007 08:20 GMT
> I've taken Ginko  50mg/day for a year and have not noticed a benefit
> to my T.  I take it for other reasons.  Well, thats the extent of my
[quoted text clipped - 4 lines]
> more 'honest' research will reveal that the majority of studies
> conclude that Ginkgo does NOT help Tinnitus.

(1)Kindly cite the survey figures related to the studies.  That is to
say, have you done a survey _all over the world_ to decide that the
"majority of studies conclude that Ginkgo does not help tinnitus"
either directly or indirectly?

(2)Which method or a drug helps tinnitus for *most* patients?

(3)If a method or a drug helps out tinnitus in the minority of
tinnitus patients, does it mean this method or drug should be
discarded?

(4)If a patient experiences improvement after using ginkgo, can you
categorically say that it is only 'his mind working over matter' or he
is simply feeling 'psychological'?  Then can the same argument be made
that those who don't experience positive effects are also getting
'psychological'?

(5)Should a tinnitus patient try ginkgo biloba in view of the majority
of studies pointing to the contrary?

(6)What happens to the German experience I posted in which the German
doctors concluded ginkgo is "effective and safe" for tinnitus
treatment?  Should it be overthrown by the "majority of studies" you
have had?  Were the patients in the double blind controlled studies in
Germany getting 'psychological'?

> Lesson here? If a person is simply determined to obtain confirmation
> of their opinion on something, there is a decent chance they can find
[quoted text clipped - 54 lines]
> trial and meta-analysis of randomized trials. Clin Otolaryngol. 2004
> Jun;29(3):226-31.
Murray Grossan - 26 Mar 2007 16:36 GMT
On 3/25/07 9:52 PM, in article
1174884727.777280.154790@p77g2000hsh.googlegroups.com, "jga.socal"
<jganders@gmail.com> wrote:

>  If Ginkgo works for you and you report
> that here, you will be the second reported success!  If you get
> seriously ill from it, we probably wont hear from you. :-(

I am in Southern California and I wouldn't dare recommend Gingko. People
here take Chinese herbs, Special Herbs, and "natural whatever" . Since I see
nosebleeds from the interaction of Gingko with "god knows what" they are
taking, a nose bleed is one thing. A stroke is a catastrophy.
Its not that Gignko itself is bad, its just that there are so many things it
can combine with to cause bleeding.
And, the evidence that it helps T is not in. Besides, T can come from Brain,
Nerve etc and not just the ear. And there is serious question about whether
you can increase circulation to the ear and if you can does it help?
fyfpoon@gmail.com - 27 Mar 2007 08:01 GMT
> On 3/25/07 9:52 PM, in article
> 1174884727.777280.154...@p77g2000hsh.googlegroups.com, "jga.socal"
[quoted text clipped - 13 lines]
> Nerve etc and not just the ear. And there is serious question about whether
> you can increase circulation to the ear and if you can does it help?

Do the people in Southern California consult doctors or pharmacists
first before taking any drugs, be they herbs or synthetic?

===========================
Murray Grossan - 27 Mar 2007 20:40 GMT
On 3/27/07 12:01 AM, in article
1174978915.744725.75360@d57g2000hsg.googlegroups.com, "fyfpoon@gmail.com"

> Do the people in Southern California consult doctors or pharmacists
> first before taking any drugs, be they herbs or synthetic?
First they see an herbalist. Then they see a chinese herbalist. Then they
see a nutritionist. Then they see a psychic nutritioinist. At the same time
they get "good" medical advice at the Organic Health Food Store.

Think I am exaggerating? I ask them to bring samples of what they are
taking. Too heavy for me to pick up and I have difficulty translating the
chinese.
fyfpoon@gmail.com - 28 Mar 2007 21:56 GMT
> On 3/27/07 12:01 AM, in article
> 1174978915.744725.75...@d57g2000hsg.googlegroups.com, "fyfp...@gmail.com"
[quoted text clipped - 10 lines]
> taking. Too heavy for me to pick up and I have difficulty translating the
> chinese.

No, i don't think you are exaggerating.  But then again, why do these
people have so much confidence in all that mystical stuff and appear
to lose confidence with what the 'conventional' med can do for them?
Take ginkgo as an example, if the conventional med, with all these
years of high tech development, could have taken care of them, there
would not have been so much commotion of argument over ginkgo.

Perhaps the Western medical establishment should follow the Chinese
example in incorporating both the chemical and the herbal into ONE
balanced synthesis!  The Europeans are doing it, and I frankly don't
see how the American medical establishment can postpone it any
further.  It will certainly put up the last fight though, the market
forces will make it yield eventually.
fyfpoon@gmail.com - 28 Mar 2007 22:03 GMT
> I've taken Ginko  50mg/day for a year and have not noticed a benefit
> to my T.  I take it for other reasons.  Well, thats the extent of my
[quoted text clipped - 63 lines]
> trial and meta-analysis of randomized trials. Clin Otolaryngol. 2004
> Jun;29(3):226-31.

Yes, Jim, i forgot to congraduate you upon this piece of writing which
might have enabled you to graduate from a community high school in
America.

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