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Medical Forum / Diseases and Disorders / Tinnitus / May 2006What is the maximal dose for Ginkgo Biloba?
What is the maximal dose for Ginkgo Biloba? I have seen a medical artical saying that Gingko Biloba when tried on mice with tinnitus in doses of 0-100mg/kg/day showed to have benefit in the mice tinnitus behaviour only for doses of 25mg/kg/day and higher. Then the writer said, but that kind of a dose in humans will have significant side effect... but he didn't elaborate on that. So... for 25/kg/day I would need about 1500mg/day, of standardized extract. Is that safe to take? kaltufas@netscape.net wrote in part: >What is the maximal dose for Ginkgo Biloba? > [quoted text clipped - 5 lines] >25/kg/day I would need about 1500mg/day, of standardized extract. Is >that safe to take? I'm pretty sure it has never been tested in humans at that dose. You would be acting as a guinea pig with an herb known to have potentially fatal side effects.  SignatureJim Chinnis / Warrenton, Virginia, USA Want to discuss Meniere's? See http://groups.yahoo.com/group/MenieresDG Your 450 mg a day taken at the manufacturer's prescription is enough. Why do you want to maximize it? You should use as little med as possible to bring about as much result as possible. > Your 450 mg a day taken at the manufacturer's prescription is enough. > Why do you want to maximize it? You should use as little med as > possible to bring about as much result as possible. Because I read about the article titled: "Attenuation of salicylate-induced tinnitus by Ginkgo biloba extract in rats." Which abstract is quoted below, and I see there that 10mg/kg/day which is equal to a dose of 600mg/day didn't work on rats. The abstract qutoe: ----------------------------- "Audiol Neurootol. 1997 Jul-Aug;2(4):197-212. Related Articles, Links Attenuation of salicylate-induced tinnitus by Ginkgo biloba extract in rats. Jastreboff PJ, Zhou S, Jastreboff MM, Kwapisz U, Gryczynska U. Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA. pjastreboff@surgery2.ab.umd.edu The effects of an extract from Ginkgo biloba, EGb 761, on tinnitus were tested using an animal model of tinnitus. Daily oral administration of EGb 761 in doses from 10 to 100 mg/ kg/day began 2 weeks before behavioral procedures and continued until the end of the experiment. Tinnitus was induced by daily administration of 321 mg/kg sodium salicylate s.c. (corresponding to 275 mg/kg/day of salicylate acid) in fourteen groups of pigmented rats, 6 animals/group. The results from salicylate- and EGb-761-treated animals were compared to control groups receiving either salicylate, saline, or EGb 761 only in doses of 100 mg/kg. Administration of EGb 761 resulted in a statistically significant decrease of the behavioral manifestation of tinnitus for doses of 25, 50 and 100 mg/kg/ day. PMID: 9390833 [PubMed - indexed for MEDLINE]" My doctor who prescribed gingko to me advised me against using gingko pills made from extracts. This is why I am using the ones made of dried leafs. I am taking the ones made by 21st Century in Arizona. They are very well made. Use them and forget all that over-analysis of the situation. The medical experiments are done with the standardized extract. The extract have active ingredients which are 50 times more concentrated. So for example: The Germans recomend 240mg x 2 per day = 480mg/day extract. In dried leaf you would have to take 50 times that amount = 480mg x 50 = 24,000mg = 24g per day, in order to get the same amount of active ingredients. In order to take 1,500mg/day of extract one would have to eat 75g of dried leaf. This might have an adverse effect on me, like I might end up being a vegetarian, and I am not willing to take that risk ;) On 5/16/06 6:42 AM, in article 1147786973.863227.159400@g10g2000cwb.googlegroups.com, > What is the maximal dose for Ginkgo Biloba? > [quoted text clipped - 5 lines] > 25/kg/day I would need about 1500mg/day, of standardized extract. Is > that safe to take? Excuse me, how do you diagnose tinnius in a mouse? Murray Grossan <hydromed@adelphia.net> wrote in part: >On 5/16/06 6:42 AM, in article >1147786973.863227.159400@g10g2000cwb.googlegroups.com, [quoted text clipped - 10 lines] >> >Excuse me, how do you diagnose tinnius in a mouse? It's hard, but done in research. I don't think Jastreboff's studies were detailed enough to measure loudness, though. That would take a huge sample of mice and a huge budget. He was able to determine ("diagnose") the presence of tinnitus and the strength of animals' aversion to it. Ask any experimental psychologist. SignatureJim Chinnis / Warrenton, Virginia, USA Want to discuss Meniere's? See http://groups.yahoo.com/group/MenieresDG |
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