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Medical Forum / Diseases and Disorders / Sinusitis / February 2004

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flue brought back sense smell?

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Tony - 23 Feb 2004 03:40 GMT
When I had my nose polyps removed back in Sept, I lost the ability to
smell. I could no longer smell anything.

But that all changed a week ago when I got the flue. On Feb 13th I
noticed I was getting a minor infection in the lungs that was aggravating
my asthma. A doctor prescribed Doxycline 100MG (one capsule twice a day)
to be taken with Apo Prednisone 50mg (one tablet daily). I started taking
them but ended up getting worse anyway. And on Sunday the 15th I was in
bed with the flue and slight fever.

Feeling better on the 16th, I walked out to a restaurant and was surprised
that I could smell something! I couldn't tell what it was I was smelling
exactly because I was overwhelmed by so much scents, perfumes that people
wore, cigarette smell and so on! It seemed every smell was being amplified
a thousand times - it was almost too much to handle. I had to get off a bus
and walk the rest of the way to get fresh air. I can't believe how much
scents there are.

What caused my sense of smell to come back? Was it the flue, fever or the
medication? I have since finished the medication but I still smell.  

Tony
t2k@vcn.bc.ca
ttony_at@yahoo.com
DMF - 23 Feb 2004 04:03 GMT
Tony wrote...
> What caused my sense of smell to come back? Was it the flue,
> fever or the  medication? I have since finished the medication
> but I still smell.

I experienced the same thing recently when I was on Pred and
antibiotics for a sinus infection (no surgeries).  I don't know how
long my sense of smell was diminished, months perhaps. When
it first cleared I could smell someone cooking or the manager
cleaning the hall carpets three floors down in my apartment
building.  At Starbucks sometimes I would have to leave when
someone came in with heavy perfume, even from across the
room. Things have settled down a bit but I still have a stronger
sense of smell than I can ever recall.

Regards,
David
Don Brady - 23 Feb 2004 06:41 GMT
Tony wrote...
> What caused my sense of smell to come back? Was it the flue,
> fever or the  medication? I have since finished the medication
> but I still smell.

The prednisone often brings back sense of smell.

Sometimes it stays and sometimes it goes away again.

Try to minimize irritation from allergens and irritants, as well as avoiding
infections....
Dali - 23 Feb 2004 04:41 GMT
This shows again that what you and others have was an infection in
your sinus. The antibiotics were the cure. A possible canidate is
mycoplasm because doxy is good against it. ENT's will not treat
inflamation with antibiotics. alzeimers, fibromyalgia, chronic
fatigue, MS are all infections that are not being treated today. The
Dr's think it's the inflamation causing the problem. Ugh! Again top
Dr's know this. It is not only my opinion. One was a pulitzer prize
winning Dr. They laughed at him though.

>When I had my nose polyps removed back in Sept, I lost the ability to
>smell. I could no longer smell anything.
[quoted text clipped - 20 lines]
>t2k@vcn.bc.ca
>ttony_at@yahoo.com
knob - 24 Feb 2004 02:47 GMT
I think I posted this once already but I'll do it again.
10-15 years ago my wife wrote a research paper for
pharmacy school that concluded that antibiotics could
cure stomach ulcers.  She was lambasted by her professor
for her "incorrect" conclusion but guess how stomach
ulcers are cured today?

> This shows again that what you and others have was an infection in
> your sinus. The antibiotics were the cure. A possible canidate is
[quoted text clipped - 29 lines]
>>t2k@vcn.bc.ca
>>ttony_at@yahoo.com
Dali - 24 Feb 2004 04:16 GMT
You hit the nail on the head there. smart lady. I'd keep her if i were
you :)

>I think I posted this once already but I'll do it again.
>10-15 years ago my wife wrote a research paper for
>pharmacy school that concluded that antibiotics could
>cure stomach ulcers.  She was lambasted by her professor
>for her "incorrect" conclusion but guess how stomach
>ulcers are cured today?
Steven Litvintchouk - 23 Feb 2004 15:09 GMT
> When I had my nose polyps removed back in Sept, I lost the ability to
> smell. I could no longer smell anything.
[quoted text clipped - 15 lines]
>
> What caused my sense of smell to come back?

I'll bet it was the Prednisone.
It may have reduced the inflammation in your sinuses.
If so, then this might be a good time to ask your doctor for a
prescription corticosteroid nasal spray, and start using it a day or two
before you run out of the Prednisone.  Let's see if we can make your
restored sense of smell permanent.

-- Steven L.
Dali - 24 Feb 2004 00:20 GMT
Lets do an experiment. If he quits the prednisone and still has smell
we must conclude that antibiotics were the cure. right?

>> When I had my nose polyps removed back in Sept, I lost the ability to
>> smell. I could no longer smell anything.
[quoted text clipped - 24 lines]
>
>-- Steven L.
Don Brady - 24 Feb 2004 01:13 GMT
>Lets do an experiment. If he quits the prednisone and still has smell
>we must conclude that antibiotics were the cure. right?

Not at all.  He said he had already stopped all medications.

Prednisone has much more powerful anti-inflammatory characteristics than
antibiotics.
Dali - 24 Feb 2004 04:20 GMT
You missed the point. The inflamation is caused by an infection. The
antibiotics stop the inflamation because it eradicates the bacteria.
There are many bacteria that cause this type of inflamation, not to
mention mycoplasm and viruses too.

>>Lets do an experiment. If he quits the prednisone and still has smell
>>we must conclude that antibiotics were the cure. right?
[quoted text clipped - 3 lines]
>Prednisone has much more powerful anti-inflammatory characteristics than
>antibiotics.
Don Brady - 24 Feb 2004 05:01 GMT
>You missed the point. The inflamation is caused by an infection. The
>antibiotics stop the inflamation because it eradicates the bacteria.
>There are many bacteria that cause this type of inflamation, not to
>mention mycoplasm and viruses too.

You're inventing you own science....
Dali - 24 Feb 2004 15:04 GMT
Sorry I know it goes against what you may have been taught but it's
fact. The hardest thing to do is unlearn what one has been doing and
learn something simple like ulcers are caused by bacteria Look up
strep pyogene at the CDC and tell me im inventing my own science.
Again A Pulitzer prize Dr. first stated this. I also am being treated
by a Lyme pioneer Dr. William Harvey who agrees with this idea. exerpt
from Dr. Mirkin (drmirkin.com) not inflamation in joint or sinus is
same thing.

REACTIVE ARTHRITIS

Gabe Mirkin, M.D.

I am absolutely amazed that more doctors do not treat at least some of
their arthritis patient with antibiotics because there are hundreds of
papers showing that hundreds of different infections cause arthritis.
Doctors do not have laboratory tests to diagnose many of the germs
that cause arthritis. Failure to treat arthritis early can cause
permanent cartilaginous damage so that no treatment can be effective
later. The most common cause of arthritis, particularly in people
under 50, is reactive arthritis that often follows an infection.

If you develop sudden unexplained pain in one or more joints, your
doctor should check you for an infection. You should be asked if you
have a urinary tract infection: burning on urination, discomfort when
your bladder is full, a feeling that you have to urinate all the time,
getting up in the middle of the night to urinate. Check for a stomach
infection: belching and burning in stomach or chest. Check for a lung
infection: chronic cough, shortness of breath, wheezing, burning in
your nose or soreness in your throat. Check for intestinal infection:
diarrhea, belly cramps or blood in stool. Also check for gum disease,
chronic stuffy nose, chills or fever.

The following can cause reactive arthritis: Salmonella intestinal
infection (1), mononucleosis (2,21,25), parvovirus, chronic hepatitis
B virus and hepatitis C) virus infections (3), Retroviruses (4,5).
Venereal diseases, such as chlamydia, mycoplasma, ureaplasma,
gonorrhea and Gardnerella cause arthritis (6,7,8), mycoplasma (9),
Human T Cell Leukemia Virus-1 (10,33), chlamydia
(11,15,16,17,18,24,34), urinary infections with chlamydia, ureaplasma
and mycoplasma (12,26,27,39), many different intestinal infections
(13,35,41,42,43,44,45,46), ureaplasma (14,27), Lyme disease (19,23),
Salmonella diarrhea (20), parvovirus B19 (22,36), cytomegalovirus
(25,26,32), streptococcal sore throat (28), cat scratch disease (29),
human herpes virus-6 (30), hemophilus influenza bacteria (31), AIDS
(HIV) (33), hepatitis B and C (36). staph aureus bacterial infections
(37,38). Additional references are provided below.

I treat my reactive arthritis patients with Minocycline 100 mg twice a
day, but this must still be considered experimental; many doctors are
not yet ready to accept antibiotics as a treatment for reactive
arthritis. Many patients with rheumatoid arthritis do not feel better
for the first few months after they start taking minocycline. If a
patient does nor feel better after taking 100 mg of minocycline twice
day for 2 months, I add Zithromax 500 mg twice a week. If the patient
does not feel better after taking the two antibiotics for 6 months, I
do add the immune suppressants that most rheumatologists prescribe.
But as soon as they feel better, I stop the immune suppressants and
continue the antibiotics. The treatment of reactive arthritis with
antibiotics is controversial and not accepted by many doctors; discuss
this with your doctor.

>>You missed the point. The inflamation is caused by an infection. The
>>antibiotics stop the inflamation because it eradicates the bacteria.
>>There are many bacteria that cause this type of inflamation, not to
>>mention mycoplasm and viruses too.
>
>You're inventing you own science....
Steven Litvintchouk - 24 Feb 2004 15:24 GMT
> Sorry I know it goes against what you may have been taught but it's
> fact. The hardest thing to do is unlearn what one has been doing and
> learn something simple like ulcers are caused by bacteria.

No, the hardest thing to do is wait until medical science has confirmed
the finding using the scientific method.

Many theories that look promising turn out to be duds.  You can't go
chasing after every promising theory to be a guinea pig for them all.

> same thing.
>
[quoted text clipped - 5 lines]
> their arthritis patient with antibiotics because there are hundreds of
> papers showing that hundreds of different infections cause arthritis.

If Dr. Mirkin can publish his findings in a peer-reviewed journal, then
his theories will be worthy of discussion.

-- Steven L.
Dali - 24 Feb 2004 17:49 GMT
True but if I waited longer Id be dead. William Harvey is publishing
in the journals. (Again he is a Lyme expert with over 500 patients
because other Dr's dont think Lyme is in Texas).The facts are in and
trials have already been done. The CDC is even getting on Dr's for not
treating these infections. The patients are given steroids until
something like TB comes along because the immune system is not
working. Dead people are in the morgue with these bacteria(thats were
all the answers are)
drmirkin only show articles that have been puplished. this is not
quakery! I am an example of Lyme and strep a. STSS strep toxic shock
syndrome is in the CDC. I've experienced it and KNOW it's real.
STSS is what happens when it fights back against antibiotics. Kinda
like MRSA. You do believe in MRSA right? meth resistant staph.

>> Sorry I know it goes against what you may have been taught but it's
>> fact. The hardest thing to do is unlearn what one has been doing and
[quoted text clipped - 20 lines]
>
>-- Steven L.
Dali - 24 Feb 2004 18:02 GMT
Some infection are now being treated by the internet. Dr Harvey is
working with other top Lyme specialist by the internet. It is a much
quicker way to operate. After bouncing of ideas they then publish.
Look how efficient this group is.

>If Dr. Mirkin can publish his findings in a peer-reviewed journal, then
>his theories will be worthy of discussion.
Dali - 24 Feb 2004 18:07 GMT
I say this bacause the Dr's I have been involved with will not even
read articles published by the CDC. Because, I'm guessing, it doesn't
fall into the way they have always done things. It's a big problem in
my experince.

>No, the hardest thing to do is wait until medical science has confirmed
>the finding using the scientific method.
Dali - 24 Feb 2004 18:12 GMT
I am sorry. I should have put this at the end but I thought it might
be to long. You are right in being skeptical.  It's his sources.

1) F Kanakouditsakalidou, G Pardalos, P Pratsidougertsi, A
Kansouzidoukanakoudi, H Tsangaropouloustinga. Persistent or severe
course of reactive arthritis following Salmonella enteritidis
infection - A Prospective study of 9 cases. Scandinavian Journal of
Rheumatology 27: 6 (1998):431-434.

2) T Schifter, UH Lewinski. Adult onset Still's disease associated
with Epstein-Barr virus infection in a 66-year-old woman. Scandinavian
Journal of Rheumatology 27: 6 (1998):458-460.

3) LB Siegel, EP Gall. Viral infection as a cause of arthritis.
American Family Physician 54: 6 (NOV 1 1996):2009-2015. (parvovirus,
chronic hepatitis B virus and hepatitis C) virus infections.

4) K Nakagawa, V Brusic, G Mccoll, LC Harrison. Direct evidence for
the expression of multiple endogenous retroviruses in the synovial
compartment in rheumatoid arthritis. Arthritis and Rheumatism 40: 4
(APR 1997):627-638.

5) K Eguchi, T Origuchi, H Takashima, K Iwata, S Katamine, S Nagataki.
High seroprevalence of anti-HTLV-I antibody in rheumatoid arthritis.
Arthritis and Rheumatism 39: 3 (MAR 1996):463-466.

6)S Francois, G Guyadiersouquieres, C Marcelli. Reactive arthritis due
to Gardnerella vaginalis - A case-report. Revue du Rhumatisme 64: 2
(FEB 1997):138-139.

7) F Li, R Bulbul, HR Schumacher, T Kieberemmons, PE Callegari, JM
Vonfeldt, D Norden, B Freundlich, B Wang, V Imonitie, CP Chang, I
Nachamkin, DB Weiner, WV Williams. Molecular detection of bacterial
DNA in venereal-associated arthritis. Arthritis and Rheumatism 39: 6
(JUN 1996):950-958.

8) T Schaeverbeke, JP Vernhes, L Lequen, B Bannwarth, C Bebear, J
Dehais. Mycoplasmas and arthritides. Revue du Rhumatisme 64: 2 (FEB
1997):120-128.

9) A Franz, ADB Webster, PM Furr, D Taylorrobinson. Mycoplasmal
arthritis in patients with primary immunoglobulin deficiency: Clinical
features and outcome in 18 patients. British Journal of Rheumatology
36: 6 (JUN 1997):661-668.

10) High seroprevalence of anti-HTLV-I antibody in rheumatoid
arthritis. Arthritis and Rheumatism 39: 3 (MAR 1996):463-466.

11) M Leirisalorepo. Therapeutic aspects of spondyloarthropathies - A
review. Scandinavian Journal of Rheumatology 27: 5 (1998):323-328.

12) U Lange, M Berliner, W Weidner, HG Schiefer, KL Schmidt, K
Federlin. Ankylosing spondylitis and infections of the male urogenital
tract: Exploration of urinary tract infection in correlation to
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1996):249-255.

13) H Mielants, M Devos, C Cuvelier, EM Veys. The role of GUT
inflammation in the pathogenesis of spondyloarthropathies. Acta
Clinica Belgica 51: 5 (OCT 1996):340-349.

14) O Vittecoq, T Schaeverbeke, S Favre, A Daragon, N Biga, C
Cambonmichot, C Bebear, X Leloete. Molecular diagnosis of Ureaplasma
urealyticum in an immunocompetent patient with destructive reactive
polyarthritis. Arthritis and Rheumatism 40: 11 (NOV 1997):2084-2089.

15) L Cirasino, A Marccotti, C Barosi, F Massaro, A Silvani.
Misdiagnosis of post-traumatic splenic rupture in a patient with acute
cold agglutinin disease due to Mycoplasma infection. Scandinavian
Journal of Infectious Diseases 29: 5(1997):522-524.

16) Y Aihara, M Mori, T Kobayashi, S Yokota. A pediatric case of
polymyositis associated with Mycoplasma pneumoniae infection.
Scandinavian Journal of Rheumatology 26: 6 (1997):480-481.

17) Braun et al. Chlamydia pneumoniae- a new causitive agent of
reactive arthritis and undifferentiated arthritis. Ann Rheum Dis
1994;53:100-105.

18) Gerard HC et al. Screening of synovial tissue from reactive
arthritis patients for the presence of chlamydia pneumoniae. Arthritis
Rheum 1995;38:S394.

19) IT Kufko, OM Lesnyak, VG Melnikov, NS Baranova, OF Ryabitseva, ZI
Sokolova. Comparative clinical and laboratory characteristics of Lyme
arthritis and reactive arthritis. Terapevticheskii Arkhiv 69: 5
(1997):12-15.

20) F Kanakouditsakalidou, G Pardalos, P Pratsidougertsi, A
Kansouzidoukanakoudi, H Tsangaropouloustinga. Persistent or severe
course of reactive arthritis following Salmonella enteritidis
infection - A Prospective study of 9 cases. Scandinavian Journal of
Rheumatology 27: 6 (1998):431-434.

21) T Schifter, UH Lewinski. Adult onset Still's disease associated
with Epstein-Barr virus infection in a 66-year-old woman. Scandinavian
Journal of Rheumatology 27: 6 (1998):458-460.

22) P Roblot, F Roblot, A Ramassamy, B Becqgiraudon. Lupus syndrome
after parvovirus B19 infection. Revue du Rhumatisme 64: 12 (DEC
1997):849-851.

23) S Priem, GR Burmester, T Kamradt, K Wolbart, MG Rittig, A Krause.
Detection of Borrelia burgdorferi by polymerase chain reaction in
synovial membrane, but not in synovial fluid from patients with
persisting Lyme arthritis after antibiotic therapy. Annals of the
Rheumatic Diseases 57: 2 (FEB 1998):118-121.

24) HC Gerard, PJ Branigan, HR Schumacher, AP Hudson. Synovial
Chlamydia trachomatis in patients with reactive arthritis/ Reiter's
syndrome are viable but show aberrant gene expression. Journal of
Rheumatology 25: 4 (APR 1998):734-742.

25) M Mousavijazi, L Bostrom, C Lovmark, A Linde, M Brytting, VA
Sundqvist. Infrequent detection of cytomegalovirus and Epstein-Barr
virus DNA in synovial membrane of patients with rheumatoid arthritis.
Journal of Rheumatology 25: 4 (APR 1998):623-628.

26) T Schaeverbeke, M Clerc, L Lequen, A Charron, C Bebear, B
Debarbeyrac, B Bannwarth, J Dehais, C Bebear. Genotypic
characterization of seven strains of Mycoplasma fermentans isolated
from synovial fluids of patients with arthritis. Journal of Clinical
Microbiology 36: 5 (MAY 1998):1226-1231.

27) TV Poggio, N Orlando, L Galanternik, S Grinstein. Microbiology of
acute arthropathies among children in Argentina: Mycoplasma pneumoniae
and hominis and Ureaplasma urealyticum. Pediatric Infectious Disease
Journal 17: 4 (APR 1998):304-308.

28) S Ahmed, EM Ayoub, JC Scornik, CY Wang, JX She. Poststreptococcal
reactive arthritis: Clinical characteristics and association with
HLA-DR alleles. Arthritis and Rheumatism 41: 6 (JUN 1998):1096-1102.

29) MC Jendro, G Weber, T Brabant, H Zeidler, J Wollenhaupt. Reactive
arthritis after cat bite: A rare manifestation of cat scratch disease
- Case report and overview of the literature. Zeitschrift Fur
Rheumatologie 57: 3 (JUN 1998):159-163.

30) A Krause, G Krause. Arthritis in a patient with erythema
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31) C Alba, B Bailly, C Sauviat, B Depernet. Arthritis due to
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32) HJ Anders, FD Goebel. Cytomegalovirus polyradiculopathy in
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33) D Vassilopoulos, LH Calabrese. Rheumatologic manifestations of
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34) B Svenungsson. International Journal of STD & AIDS 6: 3:(MAY-JUN
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35) S Aoki, K Yoshikawa, T Yokoyama, T Nonogaki, S Iwasaki, T Mitsui,
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36) LB Siegel, EP Gall. Viral infection as a cause of arthritis.
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37) D Tabarya, WL Hoffman. Staphylococcus aureus nasal carriage in
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38) T Origuchi, K Eguchi, Y Kawabe, I Yamashita, A Mizokami, H Ida, S
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40) M Wuorela, K Granfors. Infectious agents as triggers of reactive
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>If Dr. Mirkin can publish his findings in a peer-reviewed journal, then
>his theories will be worthy of discussion.
Tony - 27 Feb 2004 04:05 GMT
> >Lets do an experiment. If he quits the prednisone and still has smell
> >we must conclude that antibiotics were the cure. right?
>
> Not at all.  He said he had already stopped all medications.

That's right I stopped it over a week ago and I can still smell.
It's unbelievable how much there is to smell I was missing! I've had to
take more showers, buy underarm deoderents and change socks ect. It's
scary to think that no one bothered to tell me!  

The weird part is I can only smell about 4 hours after getting out of
bed. So if I get up at 8am I start to smell at around 12 noon until I go
to bed around 11pm.

Tony
t2k@vcn.bc.ca

> Prednisone has much more powerful anti-inflammatory characteristics than
> antibiotics.
Tony - 27 Feb 2004 04:00 GMT
I stopped it over a week ago and I can still smell. It's unbelievable how much
there is to smell I was missing! I've had to take more showers, buy underarm
deoderents and change socks ect. It's scary to think that no one bothered to
tell me!  

The weird part is I can only smell about 4 hours after getting out of bed.
So if I get up at 8am I start to smell at around 12 noon.

Tony
t2k@vcn.bc.ca

> Lets do an experiment. If he quits the prednisone and still has smell
> we must conclude that antibiotics were the cure. right?
[quoted text clipped - 27 lines]
> >
> >-- Steven L.
Tony - 24 Feb 2004 04:13 GMT
Yes I've been using Nasonex (Mometasone Furoate) Since after the
surgery in September. But this is the first time I've smelled
anything.

Tony

> > When I had my nose polyps removed back in Sept, I lost the ability to
> > smell. I could no longer smell anything.
[quoted text clipped - 24 lines]
>
> -- Steven L.
Dali - 24 Feb 2004 04:24 GMT
I assume that is a new steroidal drug to stop inflamation? This points
again to a bacterial bug that you accidentally cured. It was the same
with me. I took antibiotics and found my symptoms improved. Then I
read CDC and trails which all pointed to something called reactive
infections or if it's in your joints reactive arthritis.

>Yes I've been using Nasonex (Mometasone Furoate) Since after the
>surgery in September. But this is the first time I've smelled
>anything.
>
>Tony
 
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