On Jun 3, 10:51 pm, kmf...@yahoo.com wrote:

Chronic sinusitis is most commonly the result of a multi-species
microbal community that moves into the lining of the sinuses after the
goblet cells and cilia have been paralyzed or killed by a virus.
This community, once it is formed is 100 to 1000 times as resistant to
antibiotics as the individual bacterial and fungal species within
it.
Go to pubmed.gov and type "biofilm, biofilm sinusitis, and biofilm
antibiotic" into the search window and .
There is no really effective curative therapy in the long term. That
is why we are chronic sinusisit suffers not ex
There are combinations of antibiotics, biofilm breakers and
antifungals that hold it at bay.

Since it attaches to the sinuses with fibrin in the case of staph, or
amyloid fibrils in the case of e-coli and other related bacteria,
agents that break up this type of protein film allow the mat to become
sensitive to antibiotics again.
Macrolide antibiotics such as Biaxin directly down-regulate the genes
for biofilm production in some, but not all species, in sub-
inhibitory  doses. There are usually multiple strains of each bacteria
present, with those cultivars  within as species that form biofilms
tending to have a competitive advantage. Down-regulating biofilm
production may give the more benign bacteria a chance to compete with
the goo formers.
No one to my knowledge has ever cured sinusitis with amoxicillian by
itself after the infection is established. This antibiotic is only
effective against rapidly dividing platonic bacteria. If prescribed
early in the course of a viral infection it can prevent biofilm
invasion, but it can not kill it once the film is organized, which
take a week or so.
The most effective therapies are combinations of antibiotics, such as
those used to treat TB along with sporanox an anti-fungal, and
prilosec another azole, to manage the gastritis

Using this type of therapy we have been able to reclaim most of the
space so that I can eat and sleep and what is left in my sinuses if
confined to one spot, but if I do not treat it for a couple of days it
comes back with a vengeance.

This therapy is rarely employed because:
1. most ENTS are unaware of the presence of biofilms in the sinuses,
or if they are aware, they also know that everyone has some level of
the same species and no stageing protcol has been developed that
quantifys sinusitis on the bases of area involved, the characteristics
of the mucin and the quanity of toxins/degestive enzymes present in
the mucin.
It is not qualitative bio and chemistry, it is quanative that is
called for.
2. The insurance companies will only very grudgingly pay for
antifungals.

A lot of sinusitis involves HI and HPV and variants of herpes.
Vaccines are available for those, but there are side effects.
Of course there are IMO side effects of CS, like the brown out due to
amyloid intoxication, that can steal your quality of life.

Read up and decide what is right for you.