 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Sinusitis / April 2008Best antibiotics to use
Sinus infection worsening so it might be doctor time. Last major one was 1-2 years ago and about 4 weeks on Biaxin XL seemed to work pretty good. Just curious so I'm asking this most knowledgeable group: what antibiotics work best? (BTW, I have severe intestinal problems with augmentin and I might be allergic to sulfur based drugs--hives). I found amoxicillan to be useless. Mel > Sinus infection worsening so it might be doctor time. > [quoted text clipped - 9 lines] > > Mel The textbooks say to start with augmentin or ceftin, or the macrolides--biaxin or azithromycin and go on to quinolones and combos if they don't work. Sometimes high dose amoxicillin will work when low dose doesn't ( up to 4 grams/day) The reason that Elizabeth likes macrolides is that they are biofilm disrupters. I agree. Some people will also go to doxycyline or bactrim. If biaxin worked before, I'd give it a shot. It's gone generic as well. With augmentin--make sure to take it with food, but it sounds like it doesn't agree with you, and hives on sulfa mean you should avoid bactrim--that's a true allergy. Hope you feel better. Judy > With augmentin--make sure to take it with food, but it sounds like > it doesn't agree with you, and hives on sulfa mean you should avoid > bactrim--that's a true allergy. > Hope you feel better. > Judy Interesting note: I had giant, puffy hives all over my body, with lip swelling as a kid of 7, after a week on penicillin, so was pronounced allergic. Decades later, I had a milder but similar reaction to a cephalosporin drug. Always thought I was allergic. Then a doctor mistakenly gave my Lorabid, not realizing it was a related drug, and I was fine on it, and told my allergist about it. He said that 90% of the patients he has who've been told that they're allergic to antibiotics due to such reactions are not allergic when he tests them. He tested me, and I didn't react. I take penicillin drugs with no problem, and cephalosporins, ever since. My allergist suspects that most cases mistaken for abx allergy may be die off reactions to endotoxins produced by pathogens in the skin, very likely, in my case, to have been borrelia. Susan > x-no-archive: yes > [quoted text clipped - 15 lines] > them. He tested me, and I didn't react. I take penicillin drugs with > no problem, and cephalosporins, ever since. I got caught that way and learned the following: They have now discovered that if you take some cephalosporin drugs while you have an active *viral* infection, a possible side effect is a hive-like rash that resembles an allergic reaction--but it's not. It's a strange interaction between viruses and cephalosporins. At least it's one way to find out that your sinusitis is viral after all, rather than bacterial. :-) So don't take cephalosporins while you have any kind of viral infection--not even an active cold sore. Sorry, I don't have the reference at my fingertips right now. It's also true that Lorabid's chemical structure is sufficiently different from Ceftin that you could actually react to Ceftin but not to Lorabid. It's really a carbacephem, a modification to cephalosporins.  SignatureSteven L. Email: sdlitvin@earthlinkNOSPAM.net Remove the NOSPAM before replying to me. > > x-no-archive: yes > [quoted text clipped - 37 lines] > Email: sdlit...@earthlinkNOSPAM.net > Remove the NOSPAM before replying to me. At one point I would get a lot of isolated hives, and with nearly chronic sinus infections, they would overlap. I did get some hives while on ceftin, but my allergist made a solution and skin tested me and it was negative. I've gotten an isolated hive on levaquin, once, then took it without hive issues afterward. I also got the rare hive on doxycylcine. I then went to the dermatologist who showed that I was having intense dermatographism--hiving with minimal skin pressure. Definitely infections can cause hives and it's hard to tease the two apart. Now with more MRSA, we're using more bactrim, and seeing those horrible bactrim skin reactions and systemic reactions all over again (used a lot of it when I worked for an HMO, for cost reasons.) Steve, ceclor is a unique skin reactor--the rash on ceclor, which can look like serum sickness with bull's eye rashes is unique to the drug and does not mean generalized cephalosporin allergy. Also, quinolones can cause histamine release and pseudo-anaphylaxis- people get it with their first ever dose of cipro sometimes. There was a wonderful allergist at Mass General--Mariana Castalls (I think) and I heard her talk once, and she was a wealth of knowledge about drug reactions. She was the one who told me that my aspirin sensitive daughter-who wheezes with motrin--could take vioxx. Technically if she's on singulair she could chance an NSAID. But she doesn't. Kids do these amazing viral rashes and adults will show up with erythema multforma from viruses (usually herpes simplex) all the times. Makes it hard to figure things out. Judy > There was a wonderful allergist at Mass General--Mariana Castalls (I > think) and I heard her talk once, and she was a wealth of knowledge > about drug reactions. Yes, Dr. Castells is the woman who did my immunological workup! And she's also the one who worked me through that bizarre maculopapular rash I got from Ceftin. I looked like I had chicken pox. She said it could last for up to SIX MONTHS, waxing and waning; my rash faded after two months. But she's at Brigham & Women's now. Yes, she really knows her stuff. > Kids do these amazing viral rashes and adults will show up with > erythema multforma from viruses (usually herpes simplex) all the > times. Well, there is definitely something about Ceftin (but not Lorabid) that can potentiate viral rashes--Ceftin can make you more prone to a rash if you already have an active viral infection. That's what happened to me. But it's so hard to know if a sinus flareup is due to a (subclinical) viral infection that I don't want to chance taking Ceftin again. If I find the reference, I'll post it. SignatureSteven L. Email: sdlitvin@earthlinkNOSPAM.net Remove the NOSPAM before replying to me. > I got caught that way and learned the following: > [quoted text clipped - 12 lines] > different from Ceftin that you could actually react to Ceftin but not to > Lorabid. It's really a carbacephem, a modification to cephalosporins. I was told by the pharmacist that the Lorabid was conidered a penicillin drug, very close to its chemical structure. I had not viral, but Lyme, undiagnosed in 1983 when I had the cephalosporin reaction, which wasn't hives; my lips and fingers swelled and I felt icky. The giant, puffy hives all over with lip swelling was decades before, to penicillin. I actually tolerate these drugs better than others now that my tick borne diseases have been treated with high dose doxycycline. I don't tolerate Biaxin or Zithromax at all since having cortisol problems. Susan > Sinus infection worsening so it might be doctor time. > [quoted text clipped - 9 lines] > > Mel i like avelox....judyj On Apr 17, 2:33 am, "MZB" <m...@noway.prudigy.net> wrote:> Sinus infection worsening so it might be doctor time.> > Last major one was 1-2 years ago and about 4 weeks on Biaxin XL seemed to> work pretty good.> > Just curious so I'm asking this most knowledgeable group:> > what antibiotics work best?> > (BTW, I have severe intestinal problems with augmentin and I might be> allergic to sulfur based drugs--hives). I found amoxicillan to be useless.> > MelYou are right. Amoxicillian is only good for free floating bacteria, but not at all effective when the bacteria settles down to a biofilm. First one gets a virus which kills or disables goblet and cillia, then the bacteria move in and attach themselves to the virally damaged area, and will not allow it to heal. Go here and type in "biofilm sinusitis" for articals which will show you what is going on. http://www.ncbi.nlm.nih.gov/sites/entrezAlso type in "Calgery Biofilm device" to bring up articals about testing antibiotics vs bacteria in biofilms. Bottem line, the sooner that you start to treat it, the more likely to be able to eradicate it. It is a lot easier to prevent the biofilm from being estblished than to try to eradicate it once it has a foothold. From research by Couch at the CDC reported in 1981, virus is followed by the establishment of a staph infection as part of a mixed microbial community in a lot of cases. This staph infection creats the glistening clear fibrin mucus which is associated with chronic sinusitis. Fungus will never turn down a cushy warm place and a meal once the bacteria have made a beachhead. Also there are the Actinomycetes. All will be there and all are inhibited by different drugs. All have presister cells. http://www.ncbi.nlm.nih.gov/pubmed/17143318?ordinalpos=8&itool=EntrezSystem2.PEn trez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumThus a combo is most effective. One such is:Bixian for staph, Sproanox for fungi, ((a real hassle to get insurance to pay for) or Prilosec (opramazole) which is OTC and works pretty well against fungi. )Bactrium for actinomycetes all at once and for a minimum of 4 weeks. Along with washes of 4 bag tea with 2 tsp of splenda and 1/8 tsp of salt per 8 oz.
|
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.