The inflammatory effect of purulent mucus

Thread view:

Enable EMail Alerts

Start New Thread

Thread rating:

Steven L. - 13 Apr 2008 20:37 GMT

When I get discolored post nasal drip from sinusitis, I can feel it
almost burning in the back of my throat and even my larynx.

Besides the thick mucus being physically irritating, does mucus from
sinusitis contain chemicals or antibodies that are inflammatory to
mucous membranes?

Dr. Grossan, any thoughts on this? Exactly what does mucus from
sinusitis contain that might inflame the tissues of the throat and larynx?

Signature

Steven L.
Email: sdlitvin@earthlinkNOSPAM.net
Remove the NOSPAM before replying to me.

Reply to this Message

Michael - 13 Apr 2008 21:23 GMT

> When I get discolored post nasal drip from sinusitis, I can feel it
> almost burning in the back of my throat and even my larynx.
[quoted text clipped - 10 lines]
> Email: sdlit...@earthlinkNOSPAM.net
> Remove the NOSPAM before replying to me.

Hope the following links might be of some help:-

Proinflammatory effects of Staphylococcus aureus exotoxin B on nasal
epithelial cells.
Damm M, Quante G, Rosenbohm J, Rieckmann R.
Department of Otorhinolaryngology, Head and Neck Surgery, University
of Cologne (Köln), Germany. michael.damm@uni-koeln.de
Otolaryngol Head Neck Surg. 2006 Feb;134(2):245-9.
http://www.ncbi.nlm.nih.gov/pubmed/16455372

Immunoglobulin E to Staphylococcal and Streptococcal Toxins in
Patients with Chronic Sinusitis/Nasal Polyposis.
Laryngoscope. 114(10):1822-1826, October 2004.
Tripathi, Anju MD; Conley, David B. MD; Grammer, Leslie C. MD; Ditto,
Anne M. MD; Lowery, Margaret M. MD; Seiberling, Kristen A. MD;
Yarnold, Paul A. PhD; Zeifer, Barbara MD; Kern, Robert C. MD
http://www.laryngoscope.com/pt/re/laryngoscope/abstract.00005537-200410000-00027
.htm;jsessionid=LCjQ2Tr4MX5FJJGhXvV05QdCglqn4JDhTqcdnbgpL7Jn3wsp7jy4!271346019!1
81195628!8091!-1

Exotoxins of Staphylococcus aureus
Martin M. Dinges, Paul M. Orwin, and Patrick M. Schlievert*
Department of Microbiology, University of Minnesota School of
Medicine, Minneapolis, Minnesota 55455
Clin Microbiol Rev. 2000 January; 13(1): 16-34.
Copyright (c) 2000, American Society for Microbiology
Full text at:-
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=10627489

For bacterial toxins in general:-
http://www.cdc.gov/ncidod/eid/vol5no2/schmitt.htm
http://www.textbookofbacteriology.net/proteintoxins.html

Michael

Reply to this Message

Murray Grossan - 17 Apr 2008 06:35 GMT

On 4/13/08 12:37 PM, in article 4802610F.7040209@earthlink.net, "Steven L."
<sdlitvin@earthlink.net> wrote:

> When I get discolored post nasal drip from sinusitis, I can feel it
> almost burning in the back of my throat and even my larynx.
[quoted text clipped - 5 lines]
> Dr. Grossan, any thoughts on this? Exactly what does mucus from
> sinusitis contain that might inflame the tissues of the throat and larynx?

In addition to the liquid that flows down your throat there is also the
material draining through the lymphatics that swells the throat and causes
these symptoms.
This is why pulsatile irrigation should include the nose and the throat.
When used for snoring, it is the throat irrigation that reduces the throat
edema/swelling as well as clearing the PND.

Reply to this Message