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Medical Forum / Diseases and Disorders / Sinusitis / April 2008The phage works
http://www.sciencedaily.com/releases/2007/08/070820200004.htm ScienceDaily (Aug. 22, 2007) -- Researchers from Italy have identified a bacteriophage active against Staphylococcus aureus, including methicillin-resistant strains, in mice and possibly humans. See also: Health & Medicine * Infectious Diseases * Tuberculosis * Pharmacology Plants & Animals * Mice * Microbes and More * Bacteria Reference * Antibiotic resistance * Pathogen * Penicillin-like antibiotics * Toxic shock syndrome S. aureus is a highly flexible and potentially dangerous pathogen capable of causing skin abscesses, wound infections, endocarditis, osteomyelitis, pneumonia and toxic shock syndrome. Due to the organism's ability to live inside cells, emerging strains are increasingly resistant to antibiotics. Currently, forty to sixty percent of reported nosocomial S. aureus infections in the United States and the United Kingdom are multi-drug resistant with methicillin-resistant S. aureus carrying a significantly higher mortality rate. A bacteriophage, or phage for short, is a virus that infects bacteria. In the study researchers identified the phage, MSa, and tested its activity against S. aureus in mice. Following simultaneous inoculation with both MSa and lethal and non-lethal doses of S. aureus results showed MSa rescued ninety-seven percent of mice from death and fully cleared mice of non-lethal bacterial infections. "These results suggest a potential use of the phage for the control of both local and systemic human S. aureus infections," say the researchers. These findings are reported in the August 2007 issue of the journal Antimicrobial Agents and Chemotherapy. Reference: R. Capparelli, M. Parlato, G. Borriello, P. Salvatore, D. Iannelli. 2007. Experimental phage therapy against Staphylococcus aureus in mice. Antimicrobial Agents and Chemotherapy, 51. 8: 2765-2773. Adapted from materials provided by American Society for Microbiology, via EurekAlert!, a service of AAAS. Is this the same methods they use at the Phage clinic in the Republic of Georgia? Can't find the site right now, but I'm sure you know the one I speak of. On Mar 28, 1:13 pm, dyger...@gmail.com wrote: > Is this the same methods they use at the Phage clinic in the Republic > of Georgia? Can't find the site right now, but I'm sure you know the > one I speak of. The phage therapy center? Yeah. This is the Italian version. http://www.phagetherapycenter.com/pii/PatientServlet?command=static_home As I understand it the Ruskis do not have an adequate body of work, double blind placebo controlled studies with documentation, that their phage therapy works with humans. Doing a little more investigation, the problem seems to have been that when the original work was done, the people that they gave the phages to recovered, and so did the controls. Everyone got well. Which either says something about the compassion of the Russian research Drs, or the ability of the phages to slip their leash. The fact that staph infections cleared up in 2 or 3 days in people that were given the anti-staph phages was enough proof for the Russians, because they went into production and have been at it for the last 50 years. Found an article that gives a good overview of the "situtation." http://www.usatoday.com/tech/columnist/andrewkantor/2006-07-06-phage-therapy_x.htm On Mar 31, 1:54 pm, dyger...@gmail.com wrote: > Found an article that gives a good overview of the "situtation." > > http://www.usatoday.com/tech/columnist/andrewkantor/2006-07-06-phage-... Yes it is hard to make a profit from a treatment where they treated people on one side of the street, and people on both sides of the street got well, which is what happened. It would require something like the development by a charity for the public good. But then is that not what government supposed to be for. A way for citizens to pool their resources to provide for the public good? I corresponded with Phage International's information guy a bit in 2006, as I was hot to go to T for treatment. They were not allowed to open the clinic in Mexico. I think the Mexican govt finally told them that they considered the Soviet phages too dangerous. Then the head microbiologist form the Elvira lab offered to visit and segregate phages from the local environment to purify and use for treatment, but the officials would not approve that either. I believe that Indian Reservations might want to look at this, since diabetic foot is a frequent cause of amputation and phages rout those infections. And it would be profitable at least for a while until a critical mass of everyone carried anti-staph and anti e-coli phages. It would also be instructive to look at the incidence of sinusitis and the incidence of Alzheimer's disease in areas where phages are commonly used vs the United States. I have heard comments to the effect that both are low in Eastern Europe, and the reason ascribed to several different causes, but I have seen no formal epidemiological studies, much less ones that considered phages as one of the factors. > I believe that Indian Reservations might want to look at this, since > diabetic foot is a frequent cause of amputation and phages rout those > infections. In the case of diabetes, those infections have a way of becoming readily healed once blood glucose is very tightly managed by cutting dietary carbs to a near minimum, and background insulin added if beta cell die off is very advanced. They are SO easy to prevent and no treatment will ultimately work in the environment of glucose spikes and resultant endogenous or exogenous high insulin. Susan > x-no-archive: yes > [quoted text clipped - 12 lines] > > Susan And yet many people with non-healing foot ulcers have been healed with phages. The main investors in phage therapy are doctors who treat this type of wound who have sent patients there when amputation was the only other alternative. And sometimes the diabetes itself disappears as well. > And yet many people with non-healing foot ulcers have been healed with > phages. > The main investors in phage therapy are doctors who treat this type of > wound who have sent patients there when amputation was the only other > alternative. > And sometimes the diabetes itself disappears as well. Infections are well known to raise blood glucose, but I can promise you that the diabetes doesn't disappear. It may seemt that way because DM begins at bg levels FAR below the currently used diagnostic ranges, and because almost all DM diagnoses are missed until many years progressed, due to use of fasting tests for screening. Post meal numbers spike and do damage for many years before fasting even begins to rise. I'm sure treating infections lowers bg, but does not cure DM. Susan |
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