Honey

Go to pubmed.gov and type in "biofilm sinusitis", and read what you
find there. Then type in "staph and fibrin" and read what you find.
Finally type in  "biofilm antibiotic sensitivity" and you will see 300
odd enteries come up, include "Calgary" in your search and you will
come up with studies at the University of Calgary on antibiotic
sensitivities for bacteria in a biofilm, vs the same bacteria in it's
"Planktonic"  or free swimming state.

Like the one below, and you will see that the bug does not have to be
resistant to exhibit functional resistance because it has formed
Voltron with a couple of millions of it's friends.

To deal with the legal niceties, I am an engineer, not a doctor, and
as such I can only comment in terms of what works for me, and post
articals, you have to take responsibility for doing some research for
yourself.
If you read the threads down list you will find a pretty good sample
of things that have antibiotic and antibiofilm action, including
canada balsam, tannins, prilosec, licorice, splenda, xylitol, St
John's Wart, Sage, mustard, bismuth (pepto bismol), pineapple, coconut
oil  etc, and some anecdotal discriptions of their use.
You will find that a great many of the items on the spice shelf are
antibiotic.

All of these things work better if you do not swallow them but rather
let them diffuse into your sinuses by holding them in your mouth, or
use them as a sinus wash. With the exception of Advil, which you can
only take if you have no allergy to asprin,  most of these compounds
work topically rather than systemically, so swallowing them will not
do a lot of good getting them where they need to go.

Pecan tannin from the center membrane between the nutmeats of the
pecan is the most effective thing for me, along with prilosec OTC.
Michael uses penta tea. Evidently 4 bags of black, one of green, 1/8th
teaspoon of salt, and (maybe) several bags of splenda to a cup of
water, and reports it to be effective in slowly regaining area from
the 'film.
There are also several reports of very fine emulsions (nanometer size
droplets) of soybean or olive oil being able to disrupt bacterial cell
walls and detach biofilms.  Maybe one day these emulsions will be
marketed.

Biofilm bacteria: formation and comparative susceptibility to
antibiotics.
Olson ME, Ceri H, Morck DW, Buret AG, Read RR.

Department of Biological Sciences, University of Calgary, Alberta.
molson@ucalgary.ca

The Calgary Biofilm Device (CBD) was used to form bacterial biofilms
of selected veterinary gram-negative and gram-positive pathogenic
bacteria from cattle, sheep, pigs, chicken, and turkeys. The minimum
inhibitory concentration (MIC) and minimum biofilm eradication
concentration (MBEC) of ampicillin, ceftiofur, cloxacillin,
oxytetracycline, penicillin G, streptomycin, tetracycline,
enrofloxacin, erythromycin, gentamicin, tilmicosin, and trimethoprim-
sulfadoxine for gram-positive and -negative bacteria were determined.
Bacterial biofilms were readily formed on the CBD under selected
conditions. The biofilms consisted of micro-colonies encased in
extracellular polysaccharide material. Biofilms composed of
Arcanobacterium (Actinomyces) pyogenes, Staphylococcus aureus,
Staphylococcus hyicus, Streptococcus agalactiae, Corynebacterium
renale, or Corynebacterium pseudotuberculosis were not killed by the
antibiotics tested but as planktonic bacteria they were sensitive at
low concentrations. Biofilm and planktonic Streptococcus dysgalactiae
and Streptococcus suis were sensitive to penicillin, ceftiofur,
cloxacillin, ampicillin, and oxytetracycline. Planktonic Escherichia
coli were sensitive to enrofloxacin, gentamicin, oxytetracycline and
trimethoprim/ sulfadoxine. Enrofloxacin and gentamicin were the most
effective antibiotics against E. coli growing as a biofilm. Salmonella
spp. and Pseudomonas aeruginosa isolates growing as planktonic
populations were sensitive to enrofloxacin, gentamicin, ampicillin,
oxytetracycline, and trimethoprim/sulfadoxine, but as a biofilm, these
bacteria were only sensitive to enrofloxacin. Planktonic and biofilm
Pasteurella multocida and Mannheimia haemolytica had similar
antibiotic sensitivity profiles and were sensitive to most of the
antibiotics tested. The CBD provides a valuable new technology that
can be used to select antibiotics that are able to kill bacteria
growing as biofilms.

PMID: 11989739 [PubMed - indexed for