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Medical Forum / Diseases and Disorders / Sinusitis / March 2008Cuppa
http://www.sciencedaily.com/releases/2008/03/080312100045.htm > http://www.sciencedaily.com/releases/2008/03/080312100045.htm Cup Of Black Tea Could Defend Against Athrax Threat, Research Suggests ScienceDaily (Mar. 16, 2008) -- A cup of black tea could be the next line of defence in the threat of bio-terrorism according to new international research. ... and also, from a link in the right sidebar:- ".... Now researchers from the National institute of Chemistry in Ljubljana, Slovenia discovered that the main ingredients of green tea are able to perform other tricks. They found out that green tea catechins inhibit essential bacterial enzyme DNA gyrase, which is the target of several existing clinically used drugs. By the use of NMR spectroscopy, researchers from Slovenia have now pinpointed the ATP- binding site of DNA gyrase as target of EGCG, the most abundant catechin from the green tea extract. Up to now several compounds targeted against the ATP-binding site of bacteria gyrase have been known but couldn't be used as drugs due to their side effects on mammalian cells. ..." http://www.sciencedaily.com/releases/2007/01/070116132946.htm Well I never, who would have thought,with the nasal lavage (4 bags black, 1 bag green), we aren't just a bunch of (pecan) nut cases but may well be onto something potentially acceptable by the 'main stream.' Have to make myself a cup of tea to drink to recover from the shock ... [Black Tea Soothes Away Stress ScienceDaily (Oct. 4, 2006) -- Daily cups of tea can help you recover more quickly from the stresses of everyday life, according to a new study by UCL (University College London) researchers. New scientific evidence shows that black tea has an effect on stress hormone levels in the body. ] Michael On 3/16/08 11:23 PM, in article 0172b70b-5f0e-45f8-9da9-4ffc0d8114c2@f63g2000hsf.googlegroups.com, "Michael" <mfrpersonal@gmail.com> wrote: >> http://www.sciencedaily.com/releases/2008/03/080312100045.htm > [quoted text clipped - 31 lines] > > Michael THANK goodness you pointed out the value of black/green tea. Now maybe I won't be criticized so severely when I make recommendations based on my experience and observation by her. By the way the green/black tea for sinus has been in my book since the first edition - > On 3/16/08 11:23 PM, in article > 0172b70b-5f0e-45f8-9da9-4ffc0d811...@f63g2000hsf.googlegroups.com, "Michael" [quoted text clipped - 43 lines] > By the way the green/black tea for sinus has been in my book since the > first edition - Murray: You advised tea as a sinus lavage medium? Elizabeth > > On 3/16/08 11:23 PM, in article > > 0172b70b-5f0e-45f8-9da9-4ffc0d811...@f63g2000hsf.googlegroups.com, "Michael" [quoted text clipped - 48 lines] > > Elizabeth Another reason to drink tea / lower stress:- Microbial endocrinology: how stress influences susceptibility to infection. Freestone PP, Sandrini SM, Haigh RD, Lyte M. Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester, LE1 7RH, UK. Trends Microbiol. 2008 Feb;16(2):55-64. Epub 2008 Jan 10. A holistic approach to understanding the mechanisms by which stress influences the pathogenesis of infectious disease has resulted in the development of the field of microbial endocrinology. This transdisciplinary field represents the intersection of microbiology with mammalian endocrinology and neurophysiology, and is based on the tenet that microorganisms have evolved systems for using neurohormones, which are widely distributed throughout nature, as environmental cues to initiate growth and pathogenic processes. This review reveals that responsiveness to human stress hormones is widespread in the microbial world and documents recent advances in microbial endocrinology. PMID: 18191570 [PubMed - in process] See also:- http://microbiologybytes.wordpress.com/2008/03/21/bacteria-can-sense-when-we-are -stressed/ > > > On 3/16/08 11:23 PM, in article > > > 0172b70b-5f0e-45f8-9da9-4ffc0d811...@f63g2000hsf.googlegroups.com, "Michael" [quoted text clipped - 73 lines] > > See also:-http://microbiologybytes.wordpress.com/2008/03/21/bacteria-can-sense-... Interesting. Especially where it says: "Stress hormones may not only affect the competence of the immune system. We have found that they also act directly on bacteria to increase both their growth and virulence (ability to cause an infection). In fact, we and others have now shown that for dozens of infectious bacteria the presence of human stress hormones is a signal for the bacteria that they are inside a potential host, and that this host is stressed, its immune defences weakened, and the time is opportune to begin their attack. The stress hormones adrenaline and noradrenaline can turn blood that is normally very hostile to bacteria into a kind of bacterial tomato soup. Addition of these stress hormones to blood or serum will enable 10 bacteria to grow to 100 million cells in less than a day. To add to the health issues relating to stress, our work has also shown that drugs which are chemically similar to the catecholamine stress hormones adrenaline and noradrenaline can also have unexpected side effects which may increase the susceptibility to infection of the patient taking them. This includes infections which stem from intravenous lines, and more recently, the discovery that catecholamine stress hormones and structurally similar drugs extensively used in intensive care units to improve function of the heart and kidneys of critically ill patients can in less than a day bring back to active life Staphylococcus aureus bacteria so damaged by antibiotics that they appear to be dead. However, the news is not all bad, as intriguingly, we have also found that the same drugs that counter stress hormone effects in humans (for instance to lower blood pressure) can be used to stop bacteria responding to stress hormones." >>Another reason to drink tea / lower stress:- Or to eat low carb; higher insulin levels suppress adrenal biosynthesis and cortisol binding globulin. >>Microbial endocrinology: how stress influences susceptibility to >>infection. [quoted text clipped - 25 lines] > increase both their growth and virulence (ability to cause an > infection). This is interesting; it's a rare Cushing's patient who doesn't have sinus infections, chronic and unbelievably acute. But our stress hormone levels are typically bouncing all over the place, a moving target for sure. Susan > >http://www.sciencedaily.com/releases/2008/03/080312100045.htm > [quoted text clipped - 30 lines] > > Michael "... may well be onto something potentially acceptable by the 'main stream.' " Eg:- The ATP-binding site of type II topoisomerases as a target for antibacterial drugs. Maxwell A, Lawson DM. Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Colney, UK. tony.maxwell@bbsrc.ac.uk Curr Top Med Chem. 2003;3(3):283-303 DNA topoisomerases are essential enzymes in all cell types and have been found to be valuable drug targets both for antibacterial and anti- cancer chemotherapy. Type II topoisomerases possess a binding site for ATP, which can be exploited as a target for chemo-therapeutic agents. High-resolution structures of protein fragments containing this site complexed with antibiotics or an ATP analogue have provided vital information for the understanding of the action of existing drugs and for the potential development of novel anti-bacterial agents. In this article we have reviewed the structure and function of the ATPase domain of DNA gyrase (bacterial topoisomerase II), particularly highlighting novel information that has been revealed by structural studies. We discuss the efficacy and mode of action of existing drugs and consider the prospects for the development of novel agents. PMID: 12570764 [PubMed - indexed for MEDLINE] Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseases. Tse-Dinh YC. Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA. yuk-ching_tse-dinh@nymc.edu Infect Disord Drug Targets. 2007 Mar;7(1):3-9. DNA topoisomerases are ubiquitous enzymes needed to overcome topological problems encountered during DNA replication, transcription, recombination and maintenance of genomic stability. They have proved to be valuable targets for therapy, in part because some anti-topoisomerase agents act as poisons. Bacterial DNA gyrase and topoisomerase IV (type IIA topoisomerases) are targets of fluoroquinolones while human topoisomerase I (a type IB topoisomerase) and topoisomerase II are targets of various anticancer drugs. Bacterial type IA topoisomerase share little sequence homology to type IB or type IIA topoisomerases, but all topoisomerases have the potential of having the covalent phosphotyrosine DNA cleavage intermediate trapped by drug action. Recent studies have demonstrated that stabilization of the covalent complex formed by bacterial topoisomerase I and cleaved DNA can lead to bacterial cell death, supporting bacterial topoisomerase I as a promising target for the development of novel antibiotics. For current antibacterial therapy, the prevalence of fluoroquinolone-resistant bacterial pathogens has become a major public health concern, and efforts are directed towards identifying novel inhibitors of bacterial type IIA topoisomerases that are not affected by fluoroquinolone resistant mutations on the gyrase or topoisomerase IV genes. For anti-viral therapy, poxviruses encode their own type IB topoisomerases; these enzymes differ in drug sensitivity from human topoisomerase I. To confront potential threat of small pox as a weapon in terrorist attacks, vaccinia virus topoisomerase I has been targeted for discovery of anti-viral agents. These new developments of DNA topoisomerases as targets of novel therapeutic agents being reviewed here represent excellent opportunities for drug discovery in the treatment of infectious diseases. PMID: 17346206 [PubMed - indexed for MEDLINE]
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