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Medical Forum / Diseases and Disorders / Sinusitis / December 2007

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I Kan Jang.  Kan you?

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neil0502@yahoo.com - 12 Dec 2007 22:48 GMT
I found three references to this on this site.  All of them received
zero replies and zero attention.  They went out with whimpers, not
bangs.

But ... PubMed's got more than a few POSITIVE RCCT's on it for URI's,
sinusitis, etc.

I just shelled out sixty large (I'm such a mobster) for three boxes
(90 pills).

BTW, it also seems to have a salutary effect on "spermatogenesis and
quality of semen."  Please.  Let's not belabor /that/ particular
point.... ;-)

Yet another mini-rant:

There really DOES seem to be clinical testing done on commercially
available, OTC (or simple botanicals, supplements, etc.) stuff.  Much
of it incredibly cheap.  Much of it appears incredibly safe (today)
and incredibly effective at stuff we might want.

Of course, it won't get any press until/unless BigPharma can patent,
synthesize, control, and profit hugely from it, but ... I'm interested
in the idea that this particular one made three appearances and never
got a callback.

Anyway, I'm in.  We'll see what happens.
judy.n - 13 Dec 2007 01:57 GMT
What supplement? I swear by beta 1,3 glucan. I buy it at wholesale
prices. It was recommended to a patient whose daughter is an MD at
Stanford.
Judy

On Dec 12, 5:48 pm, neil0...@yahoo.com wrote:
> I found three references to this on this site.  All of them received
> zero replies and zero attention.  They went out with whimpers, not
[quoted text clipped - 23 lines]
>
> Anyway, I'm in.  We'll see what happens.
neil0502@yahoo.com - 13 Dec 2007 02:25 GMT
> What supplement? I swear by beta 1,3 glucan. I buy it at wholesale
> prices. It was recommended to a patient whose daughter is an MD at
> Stanford.

I'm sorry.  It wasn't really clear, was it.

The supplement is called "Kan Jang."

Here's a link.  Don't be afraid to plug the supp's name into PubMed:

 http://www.proactivebio.com/viewproduct.php?id_product=8

Thanks for the lead on Beta-Glucan.  Didn't know that one.

Wow!  Quick RCCT PubMed search really yields really good info on that
one ... on all sorts of fronts: LDL, FBG, immune ....!  [reaches for
credit card ... yet again.  This stuff is SO much cheaper than ONE
darned co-pay :-)]

I KNOW that supplements are NOT zero risk, but ... I gotta tell you:
I'm not aware of any harm that any has ever caused me.  OTOH, I do
make sure to let anybody who might give me an Rx know what I'm
taking ... just in case.
august - 13 Dec 2007 23:37 GMT
>> What supplement? I swear by beta 1,3 glucan. I buy it at wholesale
>> prices. It was recommended to a patient whose daughter is an MD at
[quoted text clipped - 19 lines]
> make sure to let anybody who might give me an Rx know what I'm
> taking ... just in case.

Unfortunately the only criteria for getting an abstract added to PubMed is
getting published in a journal.  The journal does not have a real readership
or to verify the truthfulness of any of the claims being made in their
articles. In my opinion there are numerous quasi legitimate journals that
exploit these loose qualifications for getting abstracts listed in Pubmed
just so as to use these listings for advertising purposes.  It's not like
getting an article published in the NEJM.

Neil, I'm not familiar with the supplement you mentioned.
AW
Susan - 13 Dec 2007 23:49 GMT
> Unfortunately the only criteria for getting an abstract added to PubMed is
> getting published in a journal.  The journal does not have a real readership
[quoted text clipped - 3 lines]
> just so as to use these listings for advertising purposes.  It's not like
> getting an article published in the NEJM.

It's not as if getting published in the NEJM is any assurance of
integrity or quality of publications.  Not if you believe the publisher,
or former publisher, wrt the influence of corporate grants and
advertising dollars on researcher's stated conclusions and choices about
what to publish.

Caveat emptor in all things, and don't be fooled by the veneer of
respectability; it's quite thin.

Susan
neil0502@yahoo.com - 14 Dec 2007 00:02 GMT
> <neil0...@yahoo.com> wrote in message
>
[quoted text clipped - 31 lines]
> just so as to use these listings for advertising purposes.  It's not like
> getting an article published in the NEJM.

Sigh.

Too, too true.  Susan's points, too.

> Neil, I'm not familiar with the supplement you mentioned.

Can't even remember where I came across it.

I tend to evaluate these things in light of /numerous/ published
studies.  Just like anything else, a larger sample size has a /
somewhat/ reduced chance of being a ripoff/backdoor method into
PubMed, like you described.

Like believing the rave review, by a SINGLE reviewer, of a restaurant
(usually written by the owner's teen-aged son).

Or not.

WFK?
b_todten@yahoo.com - 18 Dec 2007 21:19 GMT
On Dec 12, 7:25 pm, neil0...@yahoo.com wrote:

> > What supplement? I swear by beta 1,3 glucan. I buy it at wholesale
> > prices. It was recommended to a patient whose daughter is an MD at
[quoted text clipped - 19 lines]
> make sure to let anybody who might give me an Rx know what I'm
> taking ... just in case.

I've used Kan Jang for years. It's a big seller in the Nordic
countries (made in Sweden by Swedish Herbal Institute and sold here in
the USA by their company ProActive BioProducts Inc.). This one has
science behind it, and lots of it. As stated here, Pubmed has a number
of them, and they are generally first class research in good journals.
Remember that botanicals go into different journals than do pharma
products, but the peer reviewers behind a journal like Phytomedicine
are just as fussy as the peer reviews behind an MD publication.

The guy who heads up the American Botanical Council, Mark Blumenthal,
is always talking about this product Kan Jang (for sinusitis, colds,
etc) whenever someone says something about the lack of science behind
so many dietary supplements.

B.
judy.n - 18 Dec 2007 22:23 GMT
Do you use it daily, or as needed with cold symptoms?
Judy

On Dec 18, 4:19 pm, b_tod...@yahoo.com wrote:
> On Dec 12, 7:25 pm, neil0...@yahoo.com wrote:
>
[quoted text clipped - 37 lines]
>
> B.
judy.n - 18 Dec 2007 22:30 GMT
Just on a google search, found a decent discussion of andrographis
http://www.raysahelian.com/andrographis.html
Judy

On Dec 13, 8:11 am, "Steven L." <sdlit...@earthlink.net> wrote:
> Do you use it daily, or as needed with cold symptoms?
> Judy
[quoted text clipped - 42 lines]
>
> > B.
Steven L. - 13 Dec 2007 13:11 GMT
> There really DOES seem to be clinical testing done on commercially
> available, OTC (or simple botanicals, supplements, etc.) stuff.  Much
> of it incredibly cheap.  Much of it appears incredibly safe (today)
> and incredibly effective at stuff we might want.

No, these alternative preparations vary widely in both safety and
effectiveness.  The vast majority can have major side effects that the
labels don't warn you about.  And they're not "incredibly effective"
either.

Colloidal silver is irreversibly toxic, yet it's still sold.
The FDA had to intervene to pull ephedra off the market.
Goldenseal can cause cross-allergic reactions to people who have hay
fever.  (If you're allergic to some kinds of pollen, you're often
allergic to others.)
Licorice, widely used for peptic ulcers, can raise blood pressure.
Homeopathy is ineffective quackery.
Clinical trials on echinacea for colds have been inconclusive.
While clinical trials of glucosamine for arthritis showed some benefit,
clinical trials of chondroitin did not.  Yet these are commonly packaged
together in one supplement, and you end up paying for both.

The difference with Big Pharma, as you put it, is that if the FDA finds
the medication is either unsafe or ineffective, the pharma company is no
longer able to market it.

But these alternative remedies (with the exception of homeopathy) got
themselves listed as "dietary supplements," and so the legal requirement
that a medication has to be proven effective doesn't apply to these
alternative remedies.

AFAIK, there has NEVER been a single instance of an alternative remedy
ever being withdrawn from the market voluntarily, either because it was
shown to be unsafe or shown to be ineffective.  That should tell you
something about the standards and ethics of the alternative remedy
industry.  Colloidal silver has continued to be sold over the market,
100 years after its toxicity was proven scientifically.  That's
disgraceful, and would never happen with mainstream medicine.

> Of course, it won't get any press until/unless BigPharma can patent,
> synthesize, control, and profit hugely from it, but ...

That's a bunch of baloney.  These remedies get huge amounts of
uncritical press adulation and talk-show publicity that the mainstream
drugs don't get.  Millions of people take echinacea, saw palmetto,
glucosamine/chondroitin, garlic, etc..  How do you suppose they found
out about these medications?

What Big Pharma could do legitimately is a) identify the specific
chemical(s) in these preparations that have the desired effect, b)
purify those chemicals into higher concentrations so they're more
effective, c) filter out those chemicals that are identified to have
undesirable side effects.  Because any herb has dozens of
phytochemicals.  Some good, some bad, some neither.

Signature

Steven L.
Email:  sdlitvin@earthlinkNOSPAM.net
Remove the NOSPAM before replying to me.

neil0502@yahoo.com - 13 Dec 2007 15:53 GMT
> neil0...@yahoo.com wrote:
> > There really DOES seem to be clinical testing done on commercially
[quoted text clipped - 6 lines]
> labels don't warn you about.  And they're not "incredibly effective"
> either.

Some are ... at least according to PubMed-published RCCT trials.  You
simply may put that bar in a different place than do I.

> Colloidal silver is irreversibly toxic, yet it's still sold.

I know people who've used it for decades, with no apparent ill
effects.  You and I both know (of) people who've used Afrin (or
corticosteroids up their noses) for years, similarly, with "no
apparent ill effects."  I don't know that your over-simplification, in
the case of colloidal silver, holds up to closer scrutiny.  I simply
don't know.

> The FDA had to intervene to pull ephedra off the market.
> Goldenseal can cause cross-allergic reactions to people who have hay
[quoted text clipped - 21 lines]
> something about the standards and ethics of the alternative remedy
> industry.

Well, Google turned up a couple of instances right away, so ... I
dunno.

I call "post hoc ergo propter hoc" on that one, Steven.  Maybe the
"unsafe or ineffective" standard simply wasn't there.  I don't know
anything about the ephedra specifics, for example, but what I remember
is that people died by basically OD'ing .... as they well could on
aspirin.

I don't necessarily expect that -- given /only/ what I stated above
(let's call it a hypothetical) -- they /should/ recall, without
evidence of a widespread issue when "safe as directed" isn't the case.

> Colloidal silver has continued to be sold over the market,
> 100 years after its toxicity was proven scientifically.  That's
[quoted text clipped - 15 lines]
> undesirable side effects.  Because any herb has dozens of
> phytochemicals.  Some good, some bad, some neither.

I guess ... in a way ... we have to agree to disagree, though quite
mildly.

1) If BigPharma could "filter out those chemicals that are identified
to have
> undesirable side effects," then it seems rather intuitive that EVERY drug they manufacture and market would NOT have "pages and pages" of horrifying "Adverse Events" listed in its prescribing information (where incidence > X and > Y times that of placebo).

They do.

2) While it's not tough to find people, in the literature, who look
like Soviet Era Eastern Europe because of colloidal silver, how much
different is the incidence of that than is the incidence of death by
BigPharma products?  Besides, what's "toxicity," anyway, and where do
you create /that/ line.  Anybody know what all these pills that they
hand us are doing to /our/ bodies over, say, a ten-year period?

3) In my opinion, and (biasing and un-representative) experience,
Western Med really has virtually no clue, broadly, about WHO gets
WHICH "adverse events" to the degree that they can exclude on the
front end.  At one very high level (monitoring LFT's, and the like),
they do, but ... we're back to sample size issues.  "Postmarketing
data" (when they try it out on NON-volunteer humans, for profit) is
their first look at reasonable sample sizes.

4) Just like the arguments about medical marijuana, or legalization
vs. not: I'm more concerned that consistency and standardization be
brought to the dietary supplement industry, so that you know /what/
you're getting and /how much/ of it, in every capsule.  I'm not sold
on the notion that the FDA needs to protect me from those products.
Not yet.

5) As to "identify the specific chemical(s) in these preparations that
have the desired effect, and purify those chemicals into higher
concentrations so they're more effective"

Okay.  Maybe.  But if smoking a joint removed a chemo patient's pain
and stimulates their appetite, and Marinol is proven far less
effective, then ... what was the gain?  The losses are easy to
characterize: access, cost, efficacy.

If garlic /really/ works to lower cholesterol, or as a mild
antimicrobial, or if raw sauerkraut (or yogurt) is loaded with
probiotics, then ... what's the gain, really?

Part of the problem -- /very/ broadly -- is that Western Medicine/Big
Pharma (virtually a unified organism, IMO) doesn't /really/ try to get
ahead of the issues.  It's hard to argue against the notion that there
is .... no .... real .... money .... in .... healthy people.

I heard Bill Maher word it this way: "No money in healthy people.  No
money in dead people.  The money is in the middle."

That's NOT conspiracy theorist talk.  It's an economic fact.
Everybody can draw their own conclusions about whether, and to what
degree, that fact influences policy, marketing, R&D, or overall
business strategy.

If the profit motive were suddenly unimportant (more than a
hypothetical -- simply dreaming out loud -- but ... work with me
here), but the passion, commitment, funds, and fervor were unchanged,
then wouldn't you think that prevention could be HUGELY quantified,
classified, understood, and implemented, at DRAMATICALLY lower cost,
and with incalculable societal benefits?

I've worked at the VP level for two different NYSE companies.  Most of
my friends are, or have been, in biotech (IT geeks mostly, but....).
I understand how business decisions are made.  It's disheartening to
watch, but it rather pokes holes, pre-emptively, in any claim of
"conspiracy theorist" on my part.

I'd rather be healthy (I'm not being intentionally trite or
condescending here).

I think that -- in MY case -- all of the Tx modalities done to me,
over years, have been a BIG net negative.  I hear lots of talk that
leads me to believe that many of you feel similarly.

Hopefully, that all came across as "Socratic," not combative.  I have
much respect for those of you who post on this NG (naso-gastric?), so
I don't mean to degrade that with any differing opinion.

Neil
judy.n - 14 Dec 2007 17:48 GMT
Neil,
 Well put.
 I watched a documentary on PBS about how the state of the art
treatment for heart disease in about the 50's--they showed a cheesy
training film--was to open up the chest and sprinkle abestos on the
pericardium.
 So, if you find that Western medicine has inadvertantly harmed you,
it would be no surprise.
 How about the NEJM article that showed that medical therapy for
heart disease is as good as or better than stents. So much of medicine
is trendy, quickly embraced without much data and slowly abandoned.
 Before a drug comes to market, it is tested on about 2000 subjects.
If popular, millions will be exposed to it in the first year, and then
the post marketing surveliiance is spotty and voluntary.
 I prescribed fen-phen....I worked for an HMO, and followed their
strict guidelines.
 We could go on for a long time here.
 As I wrote Susan: "Just because you're paranoid, doesn't mean
they're not out to get you." The blog I posted earlier is created by
some Brown professors, who have attempted to shine light in some dark
corners of medicine. The founder is a very thoughtful person, he is
purely curious--he has no hidden agenda. We would eat lunch in the
hospital cafeteria, and he would muse about issues in medicine.
 An aside: re supplments--with a wife who is an NP: there are a
couple of very reputable sites for supplements: Emerson Ecologics and
Pure Caps, where a licensed health care provider (and they include
accupuncturists at Emerson) can get access to the site, and get
greatly reduced prices.
 I completely agree with your arguements, and I don't think that they
in any way negate the fact that there are individuals in health care
and pharma who are ethical and trying to help. The system is very
broken, and medicine, in the US, is a business. Business decisions are
not altruistic.
Judy

On Dec 13, 10:53 am, neil0...@yahoo.com wrote:

> > neil0...@yahoo.com wrote:
> > > There really DOES seem to be clinical testing done on commercially
[quoted text clipped - 161 lines]
>
> Neil
neil0502@yahoo.com - 15 Dec 2007 16:26 GMT
> Neil,
>   Well put.
>   I watched a documentary on PBS about how the state of the art
> treatment for heart disease in about the 50's--they showed a cheesy
> training film--was to open up the chest and sprinkle abestos on the
> pericardium.

Wow.  That one, I hadn't heard.

>   So, if you find that Western medicine has inadvertantly harmed you,
> it would be no surprise.
>   How about the NEJM article that showed that medical therapy for
> heart disease is as good as or better than stents.

They billed $500k for a dozen stents (and related care) in my older-
than-dirt grandmother.  They allowed NO talk of "just" giving medical
therapy a chance.

IIRC, it was not long after that  that the NEJM article came out.

> So much of medicine
> is trendy, quickly embraced without much data and slowly abandoned.
>   Before a drug comes to market, it is tested on about 2000 subjects.
> If popular, millions will be exposed to it in the first year, and then
> the post marketing surveliiance is spotty and voluntary.

And, of course (and -- I might reluctantly argue -- appropriately),
even the postmarketing data is crystal clear to report that causality
has NOT been established.

I understand little about THIS part (haven't had time, ability, nor
inclination to look into it), but ... /even from self-reporting data/,
as you so rightly pointed out, there should be a cursory method of
determining incidence relative to other drugs, relative to placebo,
and/or relative to the general population.

That's how you would figure out which ones seem to be caused by the
drug.  That's how you focus additional testing/research efforts.

Do you know whether anything /significant/ IS done with postmarketing
data??

That reminds me: I think I need to file a report /with/ the FDA about
my reaction to the DPT....

>   I prescribed fen-phen....I worked for an HMO, and followed their
> strict guidelines.

I feel like we've collectively just welcomed you into the Alcoholics
Anonymous communitee :-)

Wow.  Fairly sure that fen-phen (along with a life of gluttony) was
the final straw for my uncle .... but HE knew, and actively ignored,
all of the data that came his way.  He liked to eat!

>   We could go on for a long time here.
>   As I wrote Susan: "Just because you're paranoid, doesn't mean
[quoted text clipped - 3 lines]
> purely curious--he has no hidden agenda. We would eat lunch in the
> hospital cafeteria, and he would muse about issues in medicine.

I've been perusing some of his posts.  Fascinating.  I'm glad folks
like him are out there and vocal.  Maybe the 60's and 70's spirit
hasn't totally disappeared.

>   An aside: re supplments--with a wife who is an NP: there are a
> couple of very reputable sites for supplements: Emerson Ecologics and
> Pure Caps, where a licensed health care provider (and they include
> accupuncturists at Emerson) can get access to the site, and get
> greatly reduced prices.

Thanks for those.  I hadn't known about either.  Do YOU source your
BetaGlucan (or other) through either or both of those?

>   I completely agree with your arguements, and I don't think that they
> in any way negate the fact that there are individuals in health care
> and pharma who are ethical and trying to help. The system is very
> broken, and medicine, in the US, is a business. Business decisions are
> not altruistic.
> Judy

Thank you for highlighting that important distinction.  I didn't mean
to paint every player with the same broad brush of cynicism.  I also
agree: there are certainly individuals who are fighting The Good
Fight.

But the strength and enormity (read: $$$) of what they're (/you're) up
against is a little bit discouraging.

I understand only too well that -- absent the GIGANTIC profit motive
-- much of the med-tech/biotech innovation would simply evaporate.  I
don't quite know how to resolve this paradox.

There ARE a billion moving parts.  It IS a huge piece of our GDP
(roughly 16%.  >4x that of defense!).  It will be /hugely/ resistant
to significant change..

Getting too far afield.  Have to go gobble down some narcs for this
poor excuse for a left arm.....

Wheaties: breakfast of champions?  Nah.  Dilaudid!
judy.n - 15 Dec 2007 17:31 GMT
Neil,
 Re: the beta 1,3,1,6 glucan, I used to buy it at pure caps, but they
stopped selling it, so now I buy it at Emerson Ecologics. Pure caps is
very scientific, Emerson is more complimentary medicine oriented.
 The brand I buy is Life Soure Basics, they have a patented WGP 3-6
Beta Glucan, and when I talked to the rep, when pure caps stopped
marketing it, he told me that the 250 mg is a fine daily dose, and
just to take it on an empty stomach: it supposedly works at the level
of the small bowel, and food decreases the effect.
 Here's Emerson's web page:
http://www.emersonecologics.com/

I can't link you into the ordering page, because it's password
protected: but here's the info
Product Name:    Beta Glucan 250 mg 60 caps
Description:    Beta Glucan 250 mg 60 capsules

A revolutionary immune system activator*

Patented Beta-1,3/1,6-Glucan.

Suggested use: Take one capsule per day on an empty stomach or as
directed by a healthcare provider.

Serving Size: 1 capsule

Ingredients:
Beta Glucan Complex 250 mg

Naturally derived from baker's yeast cell wall (Saccharomyces
cerevisiae)

Other ingredients: Chitin, Microcrystalline cellulose, gelatin, water.
Company:    Life Source Basics
Product Code:    BET21
Retail Price:    $49.99
Wholesale Price:    $29.99

Re: the FDA--I used to share my office with a PharmD, and she had the
greatest resource books--including the Natural Compendium of Herbs,
and years ago, she had me get on the listserve for the FDA medwatch.
So, they do take post marketing survelliance, and will pull drugs/
issue black box warnings, etc.

But, I read an article in People magazine about psychiatric side
effects from Chantix, and it took a month for the FDA to issue a
warning. And, if you're not on their listserve, how do you get the
warning? (I was in a quandry: how do you admit that your info is from
the learned journal "People"--read in my husband's office.)

You should definitely report your adverse event to the FDA. There's an
on line form to do that.
http://www.fda.gov/CDER/aers/default.htm

Judy

On Dec 15, 11:26 am, neil0...@yahoo.com wrote:

> > Neil,
> >   Well put.
[quoted text clipped - 99 lines]
>
> Wheaties: breakfast of champions?  Nah.  Dilaudid!
rpautrey2 - 15 Dec 2007 13:51 GMT
The medical establishment has recently admitted that prescription
antibiotics have never been effective for sinus infections. The blood
supply to the area is so poor the antibiotic never makes it to the
infection. Where were the heads of the FDA and the AMA? In The sand?
See my "Sinus Drainage Methods" post in this group. You have also made
several factual inaccuracies in your analysis of orthodox vs.
alternative medicine safety.

Paul

> neil0...@yahoo.com wrote:

> > There really DOES seem to be clinical testing done on commercially
> > available, OTC (or simple botanicals, supplements, etc.) stuff.  Much
> > of it incredibly cheap.  Much of it appears incredibly safe (today)
> > and incredibly effective at stuff we might want.

> No, these alternative preparations vary widely in both safety and
> effectiveness.  The vast majority can have major side effects that the
> labels don't warn you about.  And they're not "incredibly effective"
> either.

> Colloidal silver is irreversibly toxic, yet it's still sold.
> The FDA had to intervene to pull ephedra off the market.
[quoted text clipped - 7 lines]
> clinical trials of chondroitin did not.  Yet these are commonly packaged
> together in one supplement, and you end up paying for both.

> The difference with Big Pharma, as you put it, is that if the FDA finds
> the medication is either unsafe or ineffective, the pharma company is no
> longer able to market it.

> > Of course, it won't get any press until/unless BigPharma can
patent,
> > synthesize, control, and profit hugely from it, but ...
>
[quoted text clipped - 3 lines]
> glucosamine/chondroitin, garlic, etc..  How do you suppose they found
> out about these medications?

> What Big Pharma could do legitimately is a) identify the specific
> chemical(s) in these preparations that have the desired effect, b)
> purify those chemicals into higher concentrations so they're more
> effective, c) filter out those chemicals that are identified to have
> undesirable side effects.  Because any herb has dozens of
> phytochemicals.  Some good, some bad, some neither.

> Steven L.
> Email:  sdlit...@earthlinkNOSPAM.net
judy.n - 15 Dec 2007 17:41 GMT
Read the study more carefully, along with the editorials. They didn't
document a benefit from amoxicillin in all comers: many (or most) of
whom had self limiting viral infections. But, all the ENT's admit that
there are people who require antibiotics, and that is a clinical
decision.
 The AMA is an advocacy group: they don't make scientific decisions.
And, they don't represent that all physicians--you have to pay to
join, and many physicians don't. They are a driving force against
universal health coverage.
 The FDA regulates drugs. Again, they don't evaluate global
therapeutic decisions.
 The people who would take the data, digest it, and issue therapeutic
guidelines would be evidence based medicine collectives, like the
Cochrane Collaborative, or Clinical Societies: like the various
representatives for Otolaryngology.
 Clearly many people with a cold and pussy stuff in their noses will
get better on their own. But some won't. And that decision to treat
should be made by an informed and skillful clinician.
Judy

> The medical establishment has recently admitted that prescription
> antibiotics have never been effective for sinus infections. The blood
[quoted text clipped - 48 lines]
> > Steven L.
> > Email:  sdlit...@earthlinkNOSPAM.net

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