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Medical Forum / Diseases and Disorders / Sinusitis / October 2007

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New Study Casts Doubt on Irrigation For Chronic Sinusitis

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Steven L. - 03 Oct 2007 07:00 GMT
Effectiveness of sinus irrigation in chronic sinusitis
Medical Studies/Trials
Published: Tuesday, 18-Sep-2007

Nasal irrigation has been widely used by rhinologists in treating
sinonasal diseases.

It not only removes static secretion and promotes mucociliary clearance,
but in chronic rhinosinusitis, nasal flush is also a route for topical
drug administration into paranasal sinuses.

But a new study presented at the 2007 AAO-HNSF Annual Meeting & OTO EXPO
raises concerns that nasal irrigation techniques are not as effective as
previously thought. The prospective study included 14 patients
presenting with bilateral chronic rhinosinusitis. Patients underwent
nasal irrigation using either a douche irrigation syringe or a spray.
For each patient, a computed tomography scan was undertaken to determine
the volume and the distribution of staining in the nose and the
paranasal sinuses.The results showed that neither nasal douche nor spray
effectively delivers nasal irrigation solution into paranasal sinuses in
chronic rhinosinusitis.

Results from the study could impact future research into delivery
methods for medications intended to treat sinus conditions.

http://www.entnet.org/

http://www.news-medical.net/?id=29982

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Steven L.
Email:  sdlitvin@earthlinkNOSPAM.net
Remove the NOSPAM before replying to me.

judy.n - 03 Oct 2007 20:05 GMT
And yet the Cochrane Collaborative looked at a large number of studies
and decided irrigation was beneficial.
I personally think this is interesting as a "syringe" and a "spray"
bottle didn't disseminate saline beyond the nose, but first I'd want
to know what exact method was used, and the actual penetration of the
saline isn't the essential mechanism: it's promoting ciliary action,
and clearing nasal crusts, and helping non-self-cleansing noses
cleanse. As the sinuses are supposed to be sterie, I don't think we
want the saline in them. Just in the nose. Then the cilia can kick in
and pump the mucous out.
 I posted the Cochrane meta-analysis earlier. And they never tend to
support any therapy.
Judy

> Effectiveness of sinus irrigation in chronic sinusitis
> Medical Studies/Trials
[quoted text clipped - 29 lines]
> Email:  sdlit...@earthlinkNOSPAM.net
> Remove the NOSPAM before replying to me.
Steven L. - 03 Oct 2007 20:39 GMT
> And yet the Cochrane Collaborative looked at a large number of studies
> and decided irrigation was beneficial.
[quoted text clipped - 4 lines]
> and clearing nasal crusts, and helping non-self-cleansing noses
> cleanse.

This latest study was more interested in the use of irrigation as a
method for delivering topical medication than in the use of irrigation
for clearing mucous.  That's why they used dye to see exactly where the
irrigation solution was going.

Many physicians, including Dr. Grossan, have prescribed topical
antibiotics, such as gentamicin and tobramycin, delivered via
irrigation.  But this study suggests that the antibiotics won't reach
deep into blocked sinuses to do any good there.

Signature

Steven L.
Email:  sdlitvin@earthlinkNOSPAM.net
Remove the NOSPAM before replying to me.

judy.n - 04 Oct 2007 03:09 GMT
With a syringe and a spray--I just wonder what they actually used.
Again, it may not be necessary to force antibiotics into the far
depths of the sinuses to successfully treat infection. This study
reminds me of the dye studies that demonstrated just how little active
medication an inhaler delivers to the lungs. Yet, they work. Better
with a spacer.
Judy

> > And yet the Cochrane Collaborative looked at a large number of studies
> > and decided irrigation was beneficial.
[quoted text clipped - 19 lines]
> Email:  sdlit...@earthlinkNOSPAM.net
> Remove the NOSPAM before replying to me.
Steven L. - 05 Oct 2007 00:19 GMT
> With a syringe and a spray--I just wonder what they actually used.
> Again, it may not be necessary to force antibiotics into the far
> depths of the sinuses to successfully treat infection. This study
> reminds me of the dye studies that demonstrated just how little active
> medication an inhaler delivers to the lungs. Yet, they work. Better
> with a spacer.

The bronchi of the lungs are much wider open than a sinus cavity that is
physically blocked by a polyp or cyst or mucocele.  The sinus ostia is
only 2 mm wide to begin with and it doesn't take much to close it off
completely.  Plus, blood supply in the lungs is much richer than in the
sinuses, which aids the further circulation of medication and antibodies.

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Steven L.
Email:  sdlitvin@earthlinkNOSPAM.net
Remove the NOSPAM before replying to me.

judy.n - 05 Oct 2007 21:19 GMT
One pulmonologist said in a lecture: "the nose is the portion of the
respiratory tract accessible to the finger"--I'm not debating that
sinuses and lung structure are different, I'm just sayiing that
topical medication is used in the respiratory tract--both lung and
sinuses.
Here's a summary of the cochrane review: the guru's of effidence based
medicine
Nasal saline irrigations relieve chronic rhinosinusitis

By Will Boggs, MD

Nasal saline irrigation improves symptoms in patients with chronic
rhinosinusitis, according to a report in the July 18th issue of the
Cochrane Database of Systematic Reviews.

"Saline irrigations are not just a 'feel good' treatment," Dr.
Richard
Harvey, currently at the Medical University of South Carolina,
Charleston, told Reuters Health. "In chronic sino-nasal disease, the
use of topical nasal saline, while not more effective than
prescription medications, improves clinical outcomes and can be
included in the treatment plan."

Dr. Harvey and associates assessed the published evidence for the
clinical effectiveness of topical saline therapy in the management of
the symptoms of chronic rhinosinusitis.

Saline irrigation was better than no treatment for improving symptoms
and disease-specific quality-of-life scores in three studies that
investigated this treatment, the authors report, and saline improved
disease-specific quality-of-life as an addition to oral antihistamine
therapy in one study.

In contrast, saline did not improve disease-specific quality-of-life
scores over a reflexology control or over intra-nasal steroid in two
studies.

In the two studies that compared isotonic with hypertonic saline,
there was no difference in benefit between the two concentrations.

"We currently have several studies focused on the efficacy of
different delivery techniques (there are numerous varieties on the
market - pump sprays, pressurized sprays, squeeze bottles, Neti pots
and nebulizers)," Dr. Harvey said.

"Some of the most frequently asked questions involve the optimal
delivery technique, volume, and frequency for using nasal saline," he
added. "While this is an area of ongoing research, my clinical
judgment and experience from working with world leaders in nose and
sinus care suggests that squeeze bottles ... and pressurized sprays
which can deliver high volumes under positive pressure are probably
the most effective."

Cochrane Database Syst Rev 2007;3. [<http://imageb.epocrates.com/
mailbot/links?EdID=34565843&LinkID=11935>Cochrane review]

On Sep 18, 10:50 am, Susan <neverm...@nomail.com> wrote:

Judy

> > With a syringe and a spray--I just wonder what they actually used.
> > Again, it may not be necessary to force antibiotics into the far
[quoted text clipped - 13 lines]
> Email:  sdlit...@earthlinkNOSPAM.net
> Remove the NOSPAM before replying to me.
Ghamph - 08 Oct 2007 01:17 GMT
They should have just asked me or other experienced sinusitis sufferers.  I
thought that most knew that the solution doesn't go up into the sinuses.
It's only to help wash out dirt and or pathogens dried mucus etc..

I stopped irrigating five months ago and there is no remarkable difference.
Only steroid spray helps my attacks.
Jamffer

> Effectiveness of sinus irrigation in chronic sinusitis
> Medical Studies/Trials
[quoted text clipped - 24 lines]
>
> http://www.news-medical.net/?id=29982
jjfjksdf - 08 Oct 2007 03:21 GMT
> They should have just asked me or other experienced sinusitis sufferers.  I
> thought that most knew that the solution doesn't go up into the sinuses.
[quoted text clipped - 3 lines]
> Only steroid spray helps my attacks.
> Jamffer

I posted the same story several weeks before Steven did and I said the
same thing.  I stopped irrigating after doing it for years with first
a neilmed bottle then a grossan.  It's been more than a year now
and nothing changed at all for me better or worse.
Murray Grossan - 08 Oct 2007 07:01 GMT
On 10/7/07 5:17 PM, in article 13gitpsrcdsoj7f@corp.supernews.com, "Ghamph"
<ghamph@localnet.com> wrote:

> They should have just asked me or other experienced sinusitis sufferers.  I
> thought that most knew that the solution doesn't go up into the sinuses.
[quoted text clipped - 32 lines]
>>
>> http://www.news-medical.net/?id=29982

Too bad they didn't study pulsatile irrigation. Because the solution does
end in the sinuses, this is now a preferred method of delivering
antibiotics.
But the primary function of pulsatile irrigation is to restore nasal cilia
action. This can be objectified by Saccharin test or other means and can be
used to "titrate" the pulsatile irrigation. Once the cilia are normal you
don't need further pulsatile irrigation.
However some conditions  need more than  pulsatile irrigation and should
include cilia stimulating products.
Ghamph - 08 Oct 2007 23:21 GMT
> Too bad they didn't study pulsatile irrigation. Because the solution does
> end in the sinuses, this is now a preferred method of delivering
[quoted text clipped - 5 lines]
> However some conditions  need more than  pulsatile irrigation and should
> include cilia stimulating products.

Is there any study to prove your affirmations?
If anyone should study pulsatile irrigation it should be the makers of the
machines.  That is unless they may have already and nothing conclusive
occurred so they lost the results.

Jamffer
Kafir - 09 Oct 2007 01:08 GMT
>> Too bad they didn't study pulsatile irrigation. Because the solution does
>> end in the sinuses, this is now a preferred method of delivering
[quoted text clipped - 14 lines]
>
> Jamffer

He ducks like a quack.
 
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