This is good for a giggle.
This is the same gang that prevously threw out all the studies using
Zithromax and Clindiamycian and Euthromycian on chronic sinusitis.
They considered three studies using Amoxicillian, and when little
benifit was shown concluded NOT that Amoxicillian was not an
approperate antibiotic for chronic sinusitis but that
Antibotics were useless in chronic sinusitis. Their conclusion was far
more sweeping than the evidence they considered. Irresponsibily so.
So below they show that surgery is no better than "medical treatment".
IN light of their previous studies I would really like to know what
'medical treatment" they refer to.
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Functional endoscopic sinus surgery for chronic rhinosinusitis.Khalil
HS, Nunez DA.
Derriford Hospital, Department of Otolaryngology, Derriford Road,
Plymouth, UK PL6 8DH. khalil@entplymouth.com
BACKGROUND: Rhinosinusitis is a well-recognised clinical syndrome
affecting patients of all ages and gender. FESS has now become a well-
established strategy, comprising several techniques, for the treatment
of chronic rhinosinusitis refractory to medical treatment. OBJECTIVES:
The aim of this review was to assess the effectiveness of functional
endoscopic sinus surgery as a treatment for patients with chronic
rhinosinusitis. SEARCH STRATEGY: The Cochrane Ear, Nose and Throat
Disorders Group Trials Register, the Cochrane Central Register of
Controlled Trials (CENTRAL), MEDLINE (1966 to January 2006) and EMBASE
(1974 to January 2006) were searched. Reference lists were
handsearched and experts in the field contacted to identify further
studies. SELECTION CRITERIA: Randomised controlled trials. Inclusion
criteria were any of the following criteria singly or in combination:
patients with chronic rhinosinusitis diagnosed by a health
professional; patients with sinusitis symptoms for more than 12 weeks;
endoscopic evidence of sinusitis or radiological evidence of
sinusitis. Exclusion criteria were immune suppression; cystic
fibrosis; Wegener's disease; previous sinus surgery or sinonasal
malignancy. DATA COLLECTION AND ANALYSIS: All studies meeting the
inclusion criteria underwent validity assessment and the data were
extracted independently by the two authors.Comparisons were:FESS
versus medical treatmentFESS versus conventional sinus surgeryFESS +
medical treatment versus medical treatmentFESS + medical treatment
versus conventional sinus surgery + medical treatment MAIN RESULTS:
The three included studies were randomised controlled trials.The
evidence available does not demonstrate that FESS, as practiced in the
included trials, is superior to medical treatment with or without
sinus irrigation in patients with chronic rhinosinusitis. A middle
meatal antrostomy fashioned by FESS was also not shown to be superior
to an inferior meatal antrostomy formed by traditional sinus surgery
techniques, although the small sample size in the study does not
exclude a type II error.In one study there was a relapse rate of 2.4%
in the FESS and sinus irrigation group compared to 5.6% in the sinus
irrigation only group. The relapse rates were not mentioned in the
other studies.There were no major complications such as orbital injury
or cerebrospinal fluid leak reported in any of the included trials.
AUTHORS' CONCLUSIONS: FESS as currently practiced is a safe surgical
procedure. The limited evidence available suggests that FESS as
practiced in the included trials does not confer additional benefit to
that obtained by medical treatment (+/- sinus irrigation) in chronic
rhinosinusitis. More randomised controlled trials comparing FESS with
medical and other treatments, with long-term follow up, are required.
I would need to read the "long version" of the Cochrane analysis to
find the fatal error: already they cite small sample size, so as they
typically have done, they take a large number of studies, create a
criteria for inclusion that usually is, unfortunately, flawed, and
then look at a few studies.
Any ENT would disagree that FESS which works with anatomy and
ciliary mucous flow is superior to inferior antrostomies, which create
a low opening that can actually introduce infection, and is not
anatomically effective. Inferior antrostomies have been abandoned for
decades. Unfortunately, I had one of the last ones in the late 1980's.
You know that I've written an article that looked at Cochrane
Reviews, and many physicians who embrace evidence based medicine find
the Cochrane Collaborative flawed, as I do. Unfortunately, only their
abstracts are usually published without a subscription: it's when you
look at the full review that you find that the study criteria are
flawed and that they will gather large amounts of studies and review
only a tiny fraction of them to come to a conclusion that a medical or
surgical therapy is not beneficial.
It's the flaw of evidence based medicine. Garbage in: garbage out.
But, it will be picked up by media, and clinical guidelines--which
are used to determine insurance benefits, and used to deny sinus
surgeries. That's the real risk of the Cochrane guidelines.
Judy
> This is good for a giggle.
> This is the same gang that prevously threw out all the studies using
[quoted text clipped - 59 lines]
> rhinosinusitis. More randomised controlled trials comparing FESS with
> medical and other treatments, with long-term follow up, are required.
Murray Grossan - 20 Apr 2007 17:49 GMT
On 4/20/07 5:31 AM, in article
1177072262.046363.265000@n59g2000hsh.googlegroups.com, "judy.n"
> Any ENT would disagree that FESS which works with anatomy and
> ciliary mucous flow is superior to inferior antrostomies, which create
> a low opening that can actually introduce infection, and is not
> anatomically effective. Inferior antrostomies have been abandoned for
> decades.
I think you mean that any ENT would agree that FESS works better than
antrostomy.
Medical treatment works better than surgery???? We do surgery every day -
after all medical treatment has failed. Of course our group gets referred
the patients who fail good medical management. To make a broad statement
that medical management is the only best treatment for ALL sinus conditions
is silly.
On the other hand there have been some interesting studies comparing placebo
vs antibiotic.
judy.n - 20 Apr 2007 18:51 GMT
Does anyone even do anstrostomies any more? I believe I did say that
FESS is superior to antrostomy.
Medical therapy--what exactly does that mean? There is no standard of
medical therapy for sinusitis: no standard course of antibiotics, oral
or intranasal steroids, one type or solution of nasal irrigation--so
they've wrongly concluded that FESS is equivalent in efficacy to
anstrostomies (what were their endpoint criteria?) and no surgery is
better than medical therapy. Clearly this is a sweeping and incorrect
generalization and conclusion.
I agree that many sinusitis episodes will ultimately resolve without
antibiotics, but there are clearly a subset of patients who require
antibiotics and can get quite ill without them.
There was a study that compared sham knee surgery for arthritis
against arthroscopic surgery, and found no difference. Who is going to
do a study where patients get sham sinus surgery vs. actual surgery?
Also, as I understand it, there is no one FESS approach, it is
individualized to the patient's anatomy.
Judy
> On 4/20/07 5:31 AM, in article
> 1177072262.046363.265...@n59g2000hsh.googlegroups.com, "judy.n"
[quoted text clipped - 16 lines]
> On the other hand there have been some interesting studies comparing placebo
> vs antibiotic.