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Medical Forum / Diseases and Disorders / Sinusitis / October 2006

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continuing problems--need advice--zithromax????

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MZB - 28 Oct 2006 05:45 GMT
I've been having sinus problems since 9/1.

It seems to just ping-pong from sinus area to sore throat to bronchitis.

Amoxicillan (10 days in Sept) took care of bronchitis but still having
sinus/throat/tonsilitis type problems. No fever but feeling totallyworn
out/fatigued.

Was going to do avelox but did not when chest x-ray and sinus x-rays came
back normal.

(Does this mean there is no infection per se?????)

Nasonex might be working. Not sure yet.

Have doc. appointment on Monday. Not sure what result will be. If we go
antibiotic route, I'm thinking of suggesting zithromax (afrain of the
quinilones; hesitant to go with avelox big gun)

Any thoughts??/Advice??

Mel
Steven L. - 28 Oct 2006 14:41 GMT
> I've been having sinus problems since 9/1.
>
[quoted text clipped - 16 lines]
>
> Any thoughts??/Advice??

Sinus X-rays (as opposed to CT scans) are known to have a high
percentage of false negatives; they often fail to find pockets of
infection.  That's why CT scans have become the diagnostic tool of
choice for sinusitis.

So you might have a continuing low-level sinus infection even with a
normal-looking sinus X-ray.

Zithromax, an antibiotic in the macrolide class, is often a good
second-line antibiotic and is worth a try.  However, macrolides seem to
be ineffective against sinus infections caused by Staph aureus and if
you've got one of those, then you may have to go with a quinolone like
Avelox.

The biggest problem with Zithromax is the dosing.  The manufacturer
claims that because of its long half-life, you only need to take 5 days
worth (the infamous "Z-pak" package it comes in).  That is simply false
for stubborn sinus infections.  Finding a doctor willing to prescribe 2
or 3 weeks worth of Zithromax has been a problem for me.

Signature

Steven D. Litvintchouk
Email:  sdlitvin@earthlinkNOSPAM.net
Remove the NOSPAM before replying to me.

judy.n - 28 Oct 2006 17:45 GMT
What my allergist suggests and does is: prescribe the zithromax at one
of the standard schedules: they vary from 500 day 1 and 250 day 2-5, to
500 for three days, or 500 for 5 days, then he repeats the course on
day 10.
 The standard dosing for chlymidia pneumonia is a 5 day course of
either the 500mg or 600mg zithromax, with a once weekly dose of the 500
mg or 600mg pill for a total of 12 weeks. (There is a Wisconsin family
medicine doctor who promotes this to cure/reduce asthma--I believe it's
on a website: http://www.asthmastory.com/
 There are lots of debates about how to prescribe a drug with a 60+
hour half-life that's taken up extensively in the tissues. There was a
dermatology forum about it, because it's used for asthma, and one
doctor wrote he uses it daily, and the response was that that dosing
schedule would lead to very high, possibly toxic levels, and they
promoted a standard z-pak 5 day dosiing with a weekly 250mg pill.
 My daughter takes one a week to as a low dose macrolide, per her ENT,
he empirically uses either twice weekly or one weekly dosing. She does
have a sinus infection now, but she lives in a dorm, and she got a long
break between infections, and this one is responding promptly to
Augmentin.
 Macrolides, and ketek (a macrolide derivative--with some safety
issues) have anti-inflammatory effects beside their anti-bacterial
effects, that are very helpful with respiratory infections.
Judy
> > I've been having sinus problems since 9/1.
> >
[quoted text clipped - 41 lines]
> Email:  sdlitvin@earthlinkNOSPAM.net
> Remove the NOSPAM before replying to me.
judy.n - 28 Oct 2006 17:48 GMT
Oops, the dermatologists use it for acne.
Regarding dermatology, there is a new form of doxycyline, 40mg
sustained release, for roseacea, that has no antibacterial effect, just
anti-inflammatory.
Judy
> What my allergist suggests and does is: prescribe the zithromax at one
> of the standard schedules: they vary from 500 day 1 and 250 day 2-5, to
[quoted text clipped - 65 lines]
> > Email:  sdlitvin@earthlinkNOSPAM.net
> > Remove the NOSPAM before replying to me.
rick@spamgmail.com - 29 Oct 2006 07:11 GMT
>I've been having sinus problems since 9/1.
>
[quoted text clipped - 18 lines]
>
>Mel

Mel,

Until you use something powerful enough to get rid of the bug that's
bugging you, you won't get rid of it.  It'll just lie dormant, and
it's been my experience that it comes back worse the next time.

I would stay away from Zithromax.  I'd rather take nothing than take
that.  I guess doctors still prescribe it, but I'll never ever take
it.  If you don't want to take something as strong as Levaquin, or to
a lesser extent, Biaxin XL, you could ask your doc about Cipro, and if
you live in Texas or Florida or somewhere, you can get the generic
form of it for $4 at Wal-Mart.  Cipro has worked for me in the past.
But sometimes it hasn't, so I don't ask for it anymore.  

You had x-rays.  But you didn't have a CT scan, which seems

In any case, make sure you ask your doctor for AT LEAST a 14 day
supply, and make sure you take every last bit of it, even on the last
few days when you feel considerably better.  Irrigate also, and if
you're congested, try a Sudafed-type decongestant, or Musinex to try
to get phlegm up.

Is it a regular GP you're going to?  One of them told me that the
recommendation was that only 7 days worth of antibiotics is necessary.
They can't know everything, I guess.   I can tell you from experience,
they really don't know what to do when it comes to a chronic sinus
problem that lasts as long as yours.  A good ENT might put you on a
longer course of antibiotics.  At least that's been my experience.
Good luck and report back to us as to what your doc said.

Rick
MZB - 29 Oct 2006 21:18 GMT
Thanks. This sure is stubborn. I don't think the nasonex is helping.

I have problems with assorted drugs, sadly.

Antihistamines cause severe prostate problems (can't urinate), so that's
out.

Biaxin caused hives last time, so no sulfa-based drugs.

Levaquin MAY have caused a frozen shoulder (rotator cuff) problem, so I'm
hesitant to take the quinolones.

Doesn't leave me with a whole lot of options (tried amoxicillan, it didn;t
do the job). That's why I mentioned zithromax.

Mel

>>I've been having sinus problems since 9/1.
>>
[quoted text clipped - 50 lines]
>
> Rick
kathywb2001@yahoo.com - 30 Oct 2006 22:05 GMT
> Thanks. This sure is stubborn. I don't think the nasonex is helping.
>
[quoted text clipped - 12 lines]
>
> Mel

Have you tried Augmentin?  It is sometimes useful for stubborn
infections.  Actually zithromax worked prettry well at one time.  BTW,
I don't think Biaxin is a sulfa drug;  could you have menat Bactrim?  I
believe Biaxin is a macrolide in the same category as Zithromax.

Kathy
MZB - 31 Oct 2006 03:12 GMT
Kathy:

You are correct.

I meant bactrim.

Augmentin was BAD for me. Tried it a few years ago. Got the worst D in my
life and had to stop it.

Doc prescribed Biaxin XL (see my new post)

Mel

>> Thanks. This sure is stubborn. I don't think the nasonex is helping.
>>
[quoted text clipped - 20 lines]
>
> Kathy
 
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