The FDA completed their safety review of ketek--it caused several cases
of liver failure, leading to deaths and liver transplants, and
concluded that the risk was not excessive, but they have to put a
warning on the label that if your eyes turn yellow, or your urine turns
dark, or you feel ill (hard to tell when you're taking it because
you're ill), to stop the drug and get liver function tests.
 Ketek was held up for years due to safety concerns. Some of the
additional studies were found to be poorly performed in private
clinical sites.
 For the last 4 years the drug company has been giving lectures about
how ketek is going to be the answer to drug resistance.
 Maybe they'll develop another drug in it's class--modified
macrolide--that's safer.
Judy