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Medical Forum / Diseases and Disorders / Sinusitis / June 2006Another paper on xylitol
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11614-9. Related Articles, Links The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing. Zabner J, Seiler MP, Launspach JL, Karp PH, Kearney WR, Look DC, Smith JJ, Welsh MJ. Howard Hughes Medical Institute, Departments of Internal Medicine, Pediatrics, and Physiology and Biophysics, and Nuclear Magnetic Resonance Facility, University of Iowa College of Medicine, Iowa City, IA 52242, USA. joseph-zabner@uiowa.edu The thin layer of airway surface liquid (ASL) contains antimicrobial substances that kill the small numbers of bacteria that are constantly being deposited in the lungs. An increase in ASL salt concentration inhibits the activity of airway antimicrobial factors and may partially explain the pathogenesis of cystic fibrosis (CF). We tested the hypothesis that an osmolyte with a low transepithelial permeability may lower the ASL salt concentration, thereby enhancing innate immunity. We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro. Furthermore, in a double-blind, randomized, crossover study, xylitol sprayed for 4 days into each nostril of normal volunteers significantly decreased the number of nasal coagulase-negative Staphylococcus compared with saline control. Xylitol may be of value in decreasing ASL salt concentration and enhancing the innate antimicrobial defense at the airway surface. PMID: 11027360 [PubMed - indexed for MEDLINE] > Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11614-9. Related > Articles, Links [quoted text clipped - 28 lines] > > PMID: 11027360 [PubMed - indexed for MEDLINE] Interesting! Maybe I should add it to my saline/bactroban spray? Susan Just want to add! I have used Xylitol for the last 6 months and the funny thing is , I'm the one with the bad nose,but all my kids and wife get the colds?? I have been cold and infection free for the last 6 months! Prior to Xylitol I got an infection or cold about every third month!? I would still like some better breathing but, not having a sinus nfection every few months is a big PLUS!!(side note) I use the Xylitol in my waterpik once a day!( some times everyother day), But it seems to be doing me some good!! :-) give it a try! At what dose do you use it? There was a previous suggestion of 4 tsp/500cc to create a 5% solution. I've seen big containers of it at Whole Foods for a moderate price. I've bought Xlear spray, but it would be so much cheaper to make it up myself in my saline solution. Judy > Just want to add! I have used Xylitol for the last 6 months and the funny > thing is , I'm the one with the bad nose,but all my kids and wife get the [quoted text clipped - 4 lines] > once a day!( some times everyother day), But it seems to be doing me some > good!! :-) give it a try! My mistake, the solution was 4 tsp/200 cc for a 5% solution. What has worked for you? Judy > At what dose do you use it? There was a previous suggestion of 4 > tsp/500cc to create a 5% solution. I've seen big containers of it at [quoted text clipped - 9 lines] > > once a day!( some times everyother day), But it seems to be doing me some > > good!! :-) give it a try! On 6/26/06 5:29 AM, in article 1151324986.654983.93480@b68g2000cwa.googlegroups.com, "judy.n" > At what dose do you use it? There was a previous suggestion of 4 > tsp/500cc to create a 5% solution. I've seen big containers of it at [quoted text clipped - 9 lines] >> once a day!( some times everyother day), But it seems to be doing me some >> good!! :-) give it a try! Xylitol works out to two tsp _ 5 gms, so two tsp to 100 cc equals a 5% soltuion. How does the Whole Foods price compare to the price at http://www.xylitolnow.com/ Thanks for correcting my math about the solutions. I didn't check to see how many pounds were in the container: I did check the Xlear.com site, and they sell a pound for 6.99 and up to 5 lb for 24.99, seems a little less expensive than xylitolnow.com. I believe that Trader Joe's carries it as well. (The nearest Trader Joe's is in the next state, but I make special trips to shop there...) Judy > On 6/26/06 5:29 AM, in article > 1151324986.654983.93480@b68g2000cwa.googlegroups.com, "judy.n" [quoted text clipped - 16 lines] > soltuion. How does the Whole Foods price compare to the price at > http://www.xylitolnow.com/ On 6/26/06 4:50 AM, in article 0b7b24206e967082a2ee99749e1a5440@localhost.talkaboutsupport.com, "Perry1229" <perrykoster@cox.net> wrote: > Just want to add! I have used Xylitol for the last 6 months and the funny > thing is , I'm the one with the bad nose,but all my kids and wife get the [quoted text clipped - 4 lines] > once a day!( some times everyother day), But it seems to be doing me some > good!! :-) give it a try! Do you get your xylitol from http://www.xylitolnow.com/?
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