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Medical Forum / Diseases and Disorders / Sinusitis / February 2006

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Ketek

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afisher39 - 31 Jan 2006 19:01 GMT
I've read the alerts about Ketek causing liver failure in 3 patients,
but this is the only drug that is working on my infection (I have tried
all the big guns--cipro, biaxin (horrible side effects which get worse
everytime I take it), and avelox. Zithromax and augmentim dont' even
touch it.

Here's my question: I have surgery scheduled for Feb 9, I'm on day 8
of a 10-day course but I will run out before my surgery. My surgeon
says I should be in the best shape possible during surgery. I have a
call into him to see if he suggests taking another course of Ketek. Has
anyone here taken 15 days of it?

My allergist says that it has been used in Germany and Spain for 10-15
years, but isn't comfortable prescribing more than 10 days. My surgeon
in Stanford says he routinely prescribes 10 days if needed.

I appreciate your all answeres to my questions.  This is a great group.
Don Brady - 01 Feb 2006 05:17 GMT
>I've read the alerts about Ketek causing liver failure in 3 patients,
>but this is the only drug that is working on my infection (I have tried
[quoted text clipped - 13 lines]
>
>I appreciate your all answeres to my questions.  This is a great group.

I am not knowledgeable in this area but would monitoring with liver function
tests be helpful?

The following tests could be useful (I see them mentioned at
http://www.medpagetoday.com/ProductAlert/Prescriptions/tb/2525 in the context
of a patient who did have liver toxicity):

  " *   The patient's initial alanine aminotransferase level was 948 U/L
(reference range, 0 to 40 U/L);
   * His aspartate aminotransferase level was 200 U/L (reference range, 0 to
40 U/L).
   * His alkaline phosphatase was 291 U/L (reference range, 0 to 40 U/L);
   * And his total bilirubin level, 65.0 µmol/L, or 3.8 mg/dL. "
afisher39 - 04 Feb 2006 04:10 GMT
Thank you Don for the excellent link. I'll be watchful. I'm on my third
course of Ketek and can't wait to have my surgery next week at
Stanford. This is good lesson for me and perhaps to other readers, why
it's not a good idea to be on antibiotics for years to the point where
only the strongest and potentially the most dangerous ones are
effective.

I also want to take this opportunity to thank many of your posters,
Steven in particular, who talked about their experiences which
encouraged me to continue to seek help. I also had clear CT scans for
10 years and was dismissed by 3 ENT's, including one belonging to Mayo
Clinic's famous sinus group.  I would get an infection and take
antibiotics, so by the time of the appt. my sinuses would be clear or
just barely cloudy. It wasn't until almost every antibiotic available
stopped working that my infection got so bad that it finally showed up
as a massive infection.  Then the ENT's began thinking that I had
anatomical problems (e.g., Haller Cells and cysts) that might be
contributing to my problem.

I think that it is outrageous that doctors do not listen to patients.
If I have learned anything from this ordeal it is that you have to be
your own advocate.

Thanks again Don and your very professional group.
 
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