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Medical Forum / Diseases and Disorders / Sinusitis / December 2005test for chronic sinusitis
http://www.genengnews.com/news/bnitem.aspx?name=1115256XSL_NEWSML_TO_NEWSML_WEB.xml or http://tinyurl.com/7pnhd > http://www.genengnews.com/news/bnitem.aspx?name=1115256XSL_NEWSML_TO_NEWSML_WEB.xml > > or > > http://tinyurl.com/7pnhd "Chronic sinusitis is extremely debilitating to the millions of sufferers worldwide. The improvements in diagnostic testing will make it easier for the practitioner to appropriately treat these patients," said Dr. David Sherris, Professor and Chairman, Department of Otolaryngology, University of Buffalo. "In clinical studies, patients with chronic sinusitis were positive for the eMBP protein in their mucus, but it was not detected in patients with allergic rhinitis or in normal patients." "We are excited to partner with IMMCO on this groundbreaking tool for diagnosing CS. Existing interventions have been largely limited to the use of inhaled or oral corticosteroids, decongestants, anti-histamines, and sinus surgery but we believe that these interventions do not address the underlying cause of the inflammation. This is the only test on the market that physicians can use to assist in the diagnosis of CS based on the underlying etiology," said Gary Cantrell, Executive Vice President Sales and Marketing of specialty pharmaceuticals at Accentia. " So, where's the part where they detail how easy this will make it to successfully treat it? Susan > > http://tinyurl.com/7pnhd > So, where's the part where they detail how easy this will make it to > successfully treat it? I suspect that the key section of the press release is this: "While fungi are present in the majority of the population, it is an inflammatory response in susceptible patients that causes CS. This research has led to a better understanding of the condition and it has led to the development of new treatment strategies targeting the fungal etiology." The article suggests that an inflammatory response is usually the problem, not an infection. I get two ideas from this report: 1) it supports the "irrigate and you will get better without antibiotics" point of view for most patients; 2) it suggests that testing for the level of eMBP may be a good way to monitor progress instead of relying entirely on patient reports.  SignatureAlison Chaiken "From:" address above is valid. (650) 236-2231 [daytime] http://www.wsrcc.com/alison/ Predators fail often; prey fail only once. -- Tom Evslin > I suspect that the key section of the press release is this: > [quoted text clipped - 3 lines] > led to the development of new treatment strategies targeting the > fungal etiology." Id've liked some discussion of those treatment strategies, any studies supporting their effectiveness, with follow-ups. > The article suggests that an inflammatory response is usually the > problem, not an infection. I get two ideas from this report: 1) it > supports the "irrigate and you will get better without antibiotics" > point of view for most patients; The article supports that view, but the experiences discussed here by many do not, too often. I improve with irrigation, nasal sprays, decongestants and anti-inflammatories, but sometimes I still need abx. 2) it suggests that testing for the > level of eMBP may be a good way to monitor progress instead of relying > entirely on patient reports. It seems to me that the Mayo AFS theory is just that, and this is an attempt to bring a profitable test to market that may or may not improve quality of care for those of us suffering from chronic sinusitis. I guess time will tell. Susan I had just found this article and was going to post it. I'm beginning to believe that there is something to this. If the problem is inflammation, and you've had it a long time, then you are going to have to get rid of the inflammation first. I hate to keep bringing up my current ENT, but the man is brilliant. He is "up on" all the current theories including this one. He even talks to me like I'm an intelligent human being who can understand some of this information. He also mentioned the theory that some people are allergic to superantigens produced by Staph and admits that there are several theories and nobody really knows for sure. All I can relate is what I have experienced over the past several months. When I went to him in August, he just had me using the amphotericn B nasal wash and nebulized tobramycin along with nebulized Flovent. I used it for 2 months without much relief.at all. But after I have been on prednisone for a month starting with 40 mg. for a week and now down to 10 mg. and still using the ampo wash, I'm at least 75 % better than I was this time last month . I don't think it's just the prednisone, because I was on 10 mg. a couple of years ago for several months because of possible hypersensitivity pneumonitis from exposure to mold in my workplace.. When I tapered off of it, I gradually felt worse and worse until I developed the severe sinus pain and pressure behind my nose. After I showed him all of my exposure results to molds in that environment (IgG antibody testing to many molds showing chronic exposure), he said that the same type of thing can happen in the sinuses!!! It makes perfect sense, at least in my situation, because I've been getting out the same kind of clear glue-jelly like junk from my sinuses that I had been coughing up before I quit work. My lungs cleared up, but my sinuses didn't. Maybe it is just because I was on such a high dose that first week and have gradually tapered down. I really don't know. I don't like being on prednisone and hope that I can get off of it as soon as possible and just use the ampho washes. But considering this time last year, I wanted to die I was in such pain, anything is better than that. The benefits outweigh the risks in my case because I had no life at all the way it was. It's also a far cry from the ENT that I was seeing this time last year that told me sinusitis didn't cause pain and he might as well be treating me for pain in my knee. I was in such severe pain that day that I had to lay down flat in the back seat of the car for the 20 miles to get to the office that seemed like an eternity and he just looked at me like he didn't believe me and had no compassion at all. BTW, the new ENT (that I will refer to fromnow on as my ENT, said that he thinks all of the bacteria that I have had cultured out are just colonizing because, even though the sinuses are normaly sterile, after surgery to open them up the bacteria can find their way there and just colonize without causing an infection. However, I am still keeping my appointment with the ID doctor in January just to get his opinon also. But I can honestly say that I feel better than I did even on the IV antibiotics. Take it for what it's worth as always, it is just my opinion. Kathyw > It's also a far cry from the ENT that I was seeing this time last year > that told me sinusitis didn't cause pain and he might as well be > treating me for pain in my knee. I was in such severe pain that day > that I had to lay down flat in the back seat of the car for the 20 > miles to get to the office that seemed like an eternity and he just > looked at me like he didn't believe me and had no compassion at all. When I have an active infection, I get very painful, deep aches in the large muscles of my legs, and very painful, achey large joints, my shoulders, hips, knees. Susan On 11/30/05 7:18 AM, in article 3v5u6aF14c78uU1@individual.net, "Susan" <nevermind@nomail.com> wrote: > x-no-archive: yes > [quoted text clipped - 10 lines] > > Susan Vacuum sinusitis is extremely painful, and the X ray may be negative. > On 11/30/05 7:18 AM, in article 3v5u6aF14c78uU1@individual.net, "Susan" > <nevermind@nomail.com> wrote: [quoted text clipped - 15 lines] > > Vacuum sinusitis is extremely painful, and the X ray may be negative. What is vacuum sinusitis? I've never heard the term. Susan Vacuum sinusitis is when the pressure in the sinus cavities cannot be the same as the surroundings where you are, so there is a different pressure in your sinuses then in the air/room around you. I can tell you from my experience, that this is indeed very very painfull. I had this when landing on LAX a few years ago. The pressure in the plain cabin went up as we started descending. Because the little ways to the sinuses were blocked, there started to be a pressure difference between the cabin and my sinuses, and i can tell you that that is not nice. At a certain point i really thought i was going to be unconsious. I really started to have fear for landing, not flying. Now i always take a decongestant with me, Otrivin in Europe, it is xylometazoline. But i had it last year again (althow not so bad as in LAX) when i was flying back home from Munich to Amsterdam. Plain started desending and i started getting pain. Feels like hard stabbing with a knife or so in your head. I also had it when i was driving the I10 from east to Palm Spings. There is before Palm Springs a large descent in the road (it goes off hill) and even that change in pressure was enough to get these horrible pains. I even had to stop the car! Then suddenly i heard a "ssssssss" and the pressure was the same again and pain was gone. I don't know what to do about this but spray with Otrivin. Andries > x-no-archive: yes > [quoted text clipped - 21 lines] > > Susan > Vacuum sinusitis is when the pressure in the sinus cavities cannot be the > same as the surroundings where you are, so there is a different pressure in [quoted text clipped - 20 lines] > > Andries Thanks for the explanation. I have no idea how it came up in this thread, since I've never had nor described that experience. What I said was that when an infection is acting up in my right ethmoid sinus untreated, I get large muscle aches in my legs, and painful joints all over my body. Susan On 12/2/05 3:12 AM, in article 35d71$43902bea$54758103$31958@news.chello.nl, > Vacuum sinusitis is when the pressure in the sinus cavities cannot be the > same as the surroundings where you are, so there is a different pressure in [quoted text clipped - 46 lines] >> >> Susan For those with tendency to vacuuum sinusitis, a Benzedrex inhaller used before landing often helps. I wrote: > 2) it suggests that testing for the > > level of eMBP may be a good way to monitor progress instead of relying > > entirely on patient reports. > It seems to me that the Mayo AFS theory is just that, and this is an > attempt to bring a profitable test to market that may or may not > improve quality of care for those of us suffering from chronic > sinusitis. I guess time will tell. I agree on all points. Clearly some patients have infections that require antibiotic treatment, but perhaps there are others who do not. It sounds like the CRSFungal Profile is already approved so real testing by real doctors and real patients will determine its value. If an immunoassay could replace the CT scan, at least sinus sufferers would get a reduced radiation dose. SignatureAlison Chaiken "From:" address above is valid. (650) 236-2231 [daytime] http://www.wsrcc.com/alison/ Predators fail often; prey fail only once. -- Tom Evslin On 11/29/05 5:52 PM, in article 3v4eubF13oturU1@individual.net, "Susan" <nevermind@nomail.com> wrote: > x-no-archive: yes > [quoted text clipped - 26 lines] > > Susan Since he MBP is in the mucus, why not remove the mucus containing the MBP? Seems to work. >Since he MBP is in the mucus, why not remove the mucus containing the MBP? >Seems to work. I am not sure that I follow the Mayo and the other theories about the mucus being a persistent problem. Isn't the mucus continually cleared anyway? Hope I'm not annoying everyone with this, but there are new details posted about tomorrow night's talk at Stanford: http://www.stanfordhospital.com/newsEvents/eventsLectures/2005/1205/1201conqueri ngSinusitis The speaker is Peter Hwang, professor of otolaryngology and there will be "an emphasis on recent innovations such as computerized surgical navigation and new drug delivery technologies." SignatureAlison Chaiken "From:" address above is valid. (650) 236-2231 [daytime] http://www.wsrcc.com/alison/ Predators fail often; prey fail only once. -- Tom Evslin >Hope I'm not annoying everyone with this Not at all. >, but there are new details >posted about tomorrow night's talk at Stanford: [quoted text clipped - 4 lines] >be "an emphasis on recent innovations such as computerized surgical >navigation and new drug delivery technologies." Yes I personally am not too sold on the signficance of computerized surgical navigation but it certainly has great marketing appeal (pardon my cynicism). >> Hope I'm not annoying everyone with this > > Not at all. Speak for yourself... she was starting to annoy me. (Just kidding!) >> , but there are new details >> posted about tomorrow night's talk at Stanford: [quoted text clipped - 7 lines] > Yes I personally am not too sold on the signficance of computerized surgical > navigation but it certainly has great marketing appeal (pardon my cynicism). This is nothing new. I agree, this sounds like a sales pitch to me. >>> http://www.stanfordhospital.com/newsEvents/eventsLectures/2005/1205/1201conqueri ngSinusitis >>> [quoted text clipped - 6 lines] > >This is nothing new. I agree, this sounds like a sales pitch to me. Lest we sound too negative, I would go to the talk myself if I were close by, and will be very interested if the original poster can post a summary if she goes......... On 11/30/05 11:12 AM, in article j9uro11u4gai4n60qaspvhg7fis41n9h0v@4ax.com, > Isn't the mucus continually cleared anyway? \ That's the whole point. If the cilia movement is impaired the mucus is not cleared. That's why you need to restore cilia movement.! How do you get your cilia to work again? I had a sinus infection 4 weeks ago and I still have clear mucus draining. I have been useing saline rinse 2x a day and gargling with warm salt water, drinking tea but it is still there. shirley On 12/1/05 3:36 AM, in article 14739-438EE057-417@storefull-3132.bay.webtv.net, "Shirley Thebaglady" <thebagladyshirleyann@webtv.net> wrote: > How do you get your cilia to work again? Pulsatile irrigation works because of the rate of pulsation - more effective at removing mucus containng MBP, Biofilm, and bacteria.Pulsation rate also "harmonizes" the cilia rate. Plus tea, chicken soup, proteolytic enzymes such as Clear.ease taken via buccal pouch, plus sound such as "oooommmmmm" >>Since he MBP is in the mucus, why not remove the mucus containing the MBP? >>Seems to work. [quoted text clipped - 3 lines] > > Isn't the mucus continually cleared anyway? Once sinusitis sets in, the sinus ostia can be blocked and then the mucus cannot clear. The same thing can happen with a deviated septum. I suspect that the toxins released by bacteria and fungi help to paralyze the ciliary action too. SignatureSteven D. Litvintchouk Email: sdlitvin@earthlinkNOSPAM.net Remove the NOSPAM before replying to me. An interesting and intriging idea. But I don't think that just using saline rinses are going to get rid of it or most of us should have been better a long time ago since we all all doing that. There has to be more to it than it just being in the mucus. <snip> >> Susan > Since he MBP is in the mucus, why not remove the mucus containing the MBP? > Seems to work. Where is the MBP being generated? That's where the problem is. Not the fact that it ends up in the mucus. If you have high blood sugar you don't remove the blood. |
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