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Medical Forum / Diseases and Disorders / Sinusitis / April 2005

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Couple of Questions - Bactroban and Singulair

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Tony - 25 Apr 2005 20:15 GMT
My allergist prescribed a bactroban/saline mix today.

I'm taking zyrtec, using flonase and have been getting
allergy shots for 6 months without much relief.

Most days I need to take 90-120 mg of Sudafed
and 800-1200 mg of Ibuprofen to reduce the sinus
pain although the fatigue is always present.

Maxillary sinuses have been swollen and aching
for 3 years or longer.

I went through every type of antibiotic last year.
I had success with some antibiotics but the inflammation
came back even after 4 weeks on Levaquin.

2 CT scans in 2004 showed no disease or obstructions.

The allergist also wants me to try Singulair to see if
that will stop the sinus inflammation.

Any ideas ?

Thanks,

Tony
Susan - 25 Apr 2005 20:28 GMT
> My allergist prescribed a bactroban/saline mix today.

How will you irrigate with this?  How often, what dose, and which method?

> I'm taking zyrtec, using flonase and have been getting
> allergy shots for 6 months without much relief.

Me, too, for years.  I recently learned why most folks get no relief
from allergy shots; the doses of antigen in common practice are way too
low.  I didn't know there was a difference til I left my old allergist,
whose shots gave me miraculous relief in the first several months for a
more local one after I moved.  A year of conventional shots and all my
allergies are back!  I went crawling back to the old allergist, who
desensitizes far more aggressively, and the first two shots gave me
relief already.  His testing had revealed that I'd gotten worse in the
past year.  He says I'll be back to where I was after 12 weeks of weekly
shots.

If he ever retires, I'm going to shoot myself.  ;-)

> Most days I need to take 90-120 mg of Sudafed
> and 800-1200 mg of Ibuprofen to reduce the sinus
> pain although the fatigue is always present.
>
> Maxillary sinuses have been swollen and aching
> for 3 years or longer.

I've been through similar, though, until this year, less severe stuff.

> I went through every type of antibiotic last year.
> I had success with some antibiotics but the inflammation
> came back even after 4 weeks on Levaquin.

My experience has been like yours.

> 2 CT scans in 2004 showed no disease or obstructions.

Same for me, except for mildly deviated septum.

> The allergist also wants me to try Singulair to see if
> that will stop the sinus inflammation.

Didn't help my sinus infection, though it made my allergies milder.  I
had an unusual effect; it dangerously elevated my bp, so I quit it.  It
may help you.

> Any ideas ?

I've recently learned the value of sinus irrigation, both with a squeeze
bottle or the pulsatile irrigator.

Also, drinking a LOT of water makes a big diff in thinning mucus so it's
more likely to drain.

Allergy barriers on bedding and a good bedroom air cleaner help me a
great deal; I don't know what you're allergic to, but if dust is in the
equation, go after it aggressively.

Susan
Tony - 26 Apr 2005 00:03 GMT
>> My allergist prescribed a bactroban/saline mix today.
>
> How will you irrigate with this?  How often, what dose, and which method?

I don't understand the script but the doc described it like
a small saline bottle that I would sniff twice a day.  It sounds
like a waste of money to me.  If the infection is inside the sinus,
the bactroban will only affect the tiny opening of the sinus in
the nasal passage.  The pharmacy would make the mix and
provide a small saline bottle.

>> I'm taking zyrtec, using flonase and have been getting
>> allergy shots for 6 months without much relief.
[quoted text clipped - 8 lines]
> already.  His testing had revealed that I'd gotten worse in the past year.
> He says I'll be back to where I was after 12 weeks of weekly shots.

> If he ever retires, I'm going to shoot myself.  ;-)

Allergy shots helped me back in 97/98 but I stopped
getting them after 18 months.  My sinuses eventually
healed along with the help of Zyrtec and Flonase.

After a few years of feeling OK and just using an OTC
antihistamine duirng allergy season, my sinuses gradually
got worse and the sinusitis infections kept occuring until
it became a constant state - chronic sinusitis.

I'm not familiar with "aggressive" allergy shot treatment.
I've been getting shots every week for 6 months and
will reach a maintenance dose in 5 weeks.  Then, I'll
be getting shots every 3 weeks.  I think I get skin testing
done at the 2 year point.

>> Most days I need to take 90-120 mg of Sudafed
>> and 800-1200 mg of Ibuprofen to reduce the sinus
[quoted text clipped - 26 lines]
> I've recently learned the value of sinus irrigation, both with a squeeze
> bottle or the pulsatile irrigator.

I've been using a squeeze bottle - warm tap water and regular salt.  It
cleans out the nasal passages and allows some fresh mucus to come
out of the sinuses.  I wonder if I need to boil the tap water.

> Also, drinking a LOT of water makes a big diff in thinning mucus so it's
> more likely to drain.

I drink water all day long.

> Allergy barriers on bedding and a good bedroom air cleaner help me a great
> deal; I don't know what you're allergic to, but if dust is in the
> equation, go after it aggressively.

> Susan

I did all of those things back in 1997.  I'm allergic to grass/weed/tree
pollen,
dust mites, animal dander, mold spores.

Thanks,

Tony
Susan - 26 Apr 2005 00:21 GMT
> I don't understand the script but the doc described it like
> a small saline bottle that I would sniff twice a day.  It sounds
> like a waste of money to me.  If the infection is inside the sinus,
> the bactroban will only affect the tiny opening of the sinus in
> the nasal passage.  The pharmacy would make the mix and
> provide a small saline bottle.

Yabbut, oral antibiotics don't get in there very well, either.  At least
this may penetrate as well without much systemic effect.

> Allergy shots helped me back in 97/98 but I stopped
> getting them after 18 months.  My sinuses eventually
[quoted text clipped - 4 lines]
> got worse and the sinusitis infections kept occuring until
> it became a constant state - chronic sinusitis.

I've read that the benefits of desensitization wear off within a few
years.  In my case, sooner, even with the new shots.

> I'm not familiar with "aggressive" allergy shot treatment.
> I've been getting shots every week for 6 months and
> will reach a maintenance dose in 5 weeks.  Then, I'll
> be getting shots every 3 weeks.  I think I get skin testing
> done at the 2 year point.

My allergist uses stronger doses than conventional allergists, who seem
to use doses so unlikely to provoke an adverse reaction that they also
don't work.  After a year of weekly shots, I wasn't even up to
desensitization dose levels!  It sounds as if your allergist is more
aggressive than average, too.  I will be up to my maintenance level
probably after 12 weeks, and be retested then.  After that, every 6 months.

> I've been using a squeeze bottle - warm tap water and regular salt.  It
> cleans out the nasal passages and allows some fresh mucus to come
> out of the sinuses.  I wonder if I need to boil the tap water.

I filter it in a Brita, and I nuke it.  Seems only prudent not to
introduce any more potential pathogens.

>>Also, drinking a LOT of water makes a big diff in thinning mucus so it's
>>more likely to drain.
>
> I drink water all day long.

Then you're ahead of me. I have to make a big effort in this direction.

> I did all of those things back in 1997.  I'm allergic to grass/weed/tree
> pollen,
> dust mites, animal dander, mold spores.

Very similar to me.  Dust mites and dust are my worst, then ragweed.
Followed by tree, grass pollen and cats (I have two).

Susan
Steven L. - 26 Apr 2005 16:28 GMT
> x-no-archive: yes
>
[quoted text clipped - 4 lines]
> I filter it in a Brita, and I nuke it.  Seems only prudent not to
> introduce any more potential pathogens.

I raised that issue with my ENT, but he assured me that city tap water
is safe to use in most parts of the country.  When I told him it wasn't
sterile, he replied, "Neither is your nose."  Surveys have shown that
about one-third of healthy people have Staphylococcus aureus in their
nasal passages.  Our nasal passages are lined with mucus whose job is to
trap germs and dust particles before they can enter the lungs.  So
boiling or distilling the irrigation solution isn't worth much because
it's just going to mix with this contaminated nasal mucus anyway.

The benefit of flushing out stagnant secretions outweighs the fact that
you're stirring up bacteria in your nasal passages and perhaps flushing
them deeper into your nasopharynx.

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Susan - 26 Apr 2005 17:25 GMT
> I raised that issue with my ENT, but he assured me that city tap water
> is safe to use in most parts of the country.  When I told him it wasn't
[quoted text clipped - 4 lines]
> boiling or distilling the irrigation solution isn't worth much because
> it's just going to mix with this contaminated nasal mucus anyway.

> The benefit of flushing out stagnant secretions outweighs the fact that
> you're stirring up bacteria in your nasal passages and perhaps flushing
> them deeper into your nasopharynx.

Yabbut, I'm not following your doctor's logic.

It probably is safe to use tap water, but may not be as safe as
filtering and heating it.  Since I live where there's easy access to the
means to do both, it seems prudent.

I don't have to choose between not irrigating at all and irrigating with
cleaner water.

Susan
Murray Grossan - 29 Apr 2005 19:09 GMT
On 4/26/05 8:28 AM, in article
z6tbe.13668$lP1.8561@newsread1.news.pas.earthlink.net, "Steven L."
<sdlitvin@earthlinkNOSPAM.net> wrote:

> The benefit of flushing out stagnant secretions outweighs the fact that
> you're stirring up bacteria in your nasal passages and perhaps flushing
> them deeper into your nasopharynx.

Benefits include lowering the bacterial count, and thinning the mucus which
will allow the cilia to function - do their job of moving bacteria out of
your nose.
If you aren't using a Hydro Pulse to help restore cilia function, try
Humming: "oooommmmm"
Steven L. - 26 Apr 2005 16:23 GMT
> x-no-archive: yes
>
[quoted text clipped - 8 lines]
> the nasal passage.  The pharmacy would make the mix and
> provide a small saline bottle.

My ENT has told me that there are no scientific studies that show any
significant effect from irrigation with antibiotics.  At least there are
a few scientific studies that show some value with oral antibiotics.

And in my case, I turned out to be allergic to something in the
Bactroban ointment.  Not the antibiotic itself, but perhaps whatever the
ointment is made of.  Gave me far worse symptoms than before.

> I did all of those things back in 1997.  I'm allergic to grass/weed/tree
> pollen,
> dust mites, animal dander, mold spores.

Over and over again on this NG, we hear from patients who say that they
have every symptom of a sinus infection even though the CT scans are
normal.

That was my experience too.  I learned the hard way that CT scans have a
small percentage (maybe 5-10%) of false negatives--they can fail to show
localized sinus infections.  I finally found an ENT who was willing to
do surgery on me based on my symptoms and history, rather than trust the
CT scan which was negative.  And when he operated on me, sure enough, he
found serious problems in my sinuses that had not shown up on the CT
scan.  He told me he had the CT scan films in the operating theater
during my surgery and what he saw as he operated didn't match the CT
scan films.

In the final analysis, exploratory surgery is the only real way to know
what's going on in your sinuses.  The physician needs to push his
endoscope all the way into every sinus cavity, something that requires
you to be under general anesthesia.  That is usually done only as part
of a surgical procedure.

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Remove the NOSPAM before replying to me.

Tony - 26 Apr 2005 21:19 GMT
> Over and over again on this NG, we hear from patients who say that they
> have every symptom of a sinus infection even though the CT scans are
[quoted text clipped - 14 lines]
> to be under general anesthesia.  That is usually done only as part of a
> surgical procedure.

I saw 2 ENTs in 2004 and they both told me that I don't need surgery.
I did have a small white spot in my right maxillary on the last CT scan
but the report said it wasn't significant.  I'll insist on a new CT scan if
I don't improve in the next 3 months.  I'll have to search my HMO
for an ENT who will do exploratory surgery.

Did you improve after the exploratory surgery?

Did the chronic sinusitis return?

Do you have a daily maintenance routine like irrigating
with a bulb syringe or the Grossan irrigator?

Thanks for any advice.

Tony
Steven L. - 27 Apr 2005 03:35 GMT
>>Over and over again on this NG, we hear from patients who say that they
>>have every symptom of a sinus infection even though the CT scans are
[quoted text clipped - 22 lines]
>
> Did you improve after the exploratory surgery?

Yes, but I was never completely cured.

> Do you have a daily maintenance routine like irrigating
> with a bulb syringe or the Grossan irrigator?

Yes.

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Tony - 26 Apr 2005 21:25 GMT
> In the final analysis, exploratory surgery is the only real way to know
> what's going on in your sinuses.  The physician needs to push his
[quoted text clipped - 3 lines]
>
> Steven D. Litvintchouk

What about an MRI of the sinuses?  My allergist said the
CT scan is the best way of seeing disease and drainage
problems due to physical structure.  I thought the MRI
was the best way to see soft tissue like the sinus lining.

Are the HMOs unwilling to pay for a sinus MRI or
is it just a fact that the CT scan is the best way of
viewing sinus disease?

Tony
Steven L. - 27 Apr 2005 03:48 GMT
>>In the final analysis, exploratory surgery is the only real way to know
>>what's going on in your sinuses.  The physician needs to push his
[quoted text clipped - 8 lines]
> problems due to physical structure.  I thought the MRI
> was the best way to see soft tissue like the sinus lining.

But because the MRI is not as good at imaging bone as the CT, it's not
going to offer any guidance to the surgeon.  (That's even more important
if you've already had sinus surgery once before, because the surgery
changed the anatomy of your sinuses.)  And it's so sensitive that it can
pick up artifacts as if they're actual disease.  It's generally used
only when invasive fungal sinusitis is suspected.

> Are the HMOs unwilling to pay for a sinus MRI or
> is it just a fact that the CT scan is the best way of
> viewing sinus disease?

In my hard-won experience, the best way of viewing sinus disease is to
go for surgery and let the surgeon push his endoscope into every sinus
cavity while you're under general anesthesia.

Failing that, the CT scan, while not 100% reliable (as I and others can
attest), is the best they've got at this time.

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kathywb2001@yahoo.com - 27 Apr 2005 11:11 GMT
Bactroban is very good for gram + infections;  it has no gram =
coverage at all.  So if your infection is caused by staph or strep or
another gram + organism then it should be effective.  It should be used
until you don't have symptoms.  I'm not so sure about long time use or
its ability to reach all of the sinuses.  I have used it a lot over the
years and seems to have totally lost its effectiveness.  Plus, if you
are only killing the gram + organisms, there will be more selection for
gram - organisms which can really be bad news.  But if is your first
time using it there should be no problem.  In people with long standing
problems, that's why I keep stressing direct sinus culures, not just
nose swabs.

   I think that possibly the false negative CT scans are more than
5-10% especially in ethmoid disease which many of the people on this
group that have been misdiagnosed have.   But then again, we may be the
5-10%.  I also kept getting mostly negative scans, but during surgery I
had extensive ethmoid disease.  Also most recently, I've had several
negative scans and have found out that they are "limited" so they
don't show everything.  I had a detailed scan done at National Jewish
about a year ago that did show "mild" chronic ethmoid sinusitis (even
after surgery) with reactive bone formation, which I have now found out
is from bone infection.  So you might want to see if you can get a more
detailed scan.  Make sure you get the results yourself though, because
noone informed me of this.   I personally think that it isn't the
amount that shows up on the scan, but what is actually up there.

   I don't think I would recommend sinus surgery unless the opening
are too small or you have polyps or something blocking the openings
that keep you from draining.  Even then I would suggest a culture to
see what is causing the problem.   You need to be on the right
antibiotic.   If you have surgery and the infection isn't cleared up
you could end up with infection in the bone.

  I would also recommend boiling the water you use for irrigation and
keeping it covered unless you are using premixed solutions.  I was
negligent about doing this and think that is the way I ended up with a
multiply resistant  "bug"    Some bacteria such as Pseudomonas and
Stenotrophomonas can  even be found in bottled water.  I think
distilled water is OK.  You're not likely to get something like this
unless you've been on  lots of antibiotics or are immunocompromised.

    It is also possible that you  have allergic fungal sinusitis, and
all the antibiotics in the world are not going to help unless you get
rid of the fungus that is causing the problem.   Both my latetest ENT
and ID doctor say that fungi are difficult to culture in many typical
hospital laboratories.

   Finally, I've done extensive research on chronic sinusitis and have
come to the conclusion that there are about as many opinions as to what
causes it as there are doctors.  Seems to me like we're still in the
"dark ages" when dealing with sinusitis.

(These are just my opinions dealing with years of sinus problems that
have gone under diagnosed and led to many complications.)

Good luck!!

Kathyw
afdr9lk - 27 Apr 2005 01:38 GMT
> My ENT has told me that there are no scientific studies that show any
> significant effect from irrigation with antibiotics.  At least there are
> a few scientific studies that show some value with oral antibiotics.

So are you/he/she saying it hasn't been studied or that it has and the
results were negative?
Steven L. - 27 Apr 2005 04:02 GMT
>> My ENT has told me that there are no scientific studies that show any
>> significant effect from irrigation with antibiotics.  At least there
>> are a few scientific studies that show some value with oral antibiotics.
>
> So are you/he/she saying it hasn't been studied or that it has and the
> results were negative?

He was saying the former.

There has been one study that suggests that Bactroban irrigation may be
helpful in sinusitis patients suffering from MRSA.  That seems to be
about it.

Signature

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Murray Grossan - 29 Apr 2005 19:42 GMT
On 4/26/05 8:02 PM, in article
QgDbe.14738$An2.6202@newsread2.news.pas.earthlink.net, "Steven L."
<sdlitvin@earthlinkNOSPAM.net> wrote:

>>> My ENT has told me that there are no scientific studies that show any
>>> significant effect from irrigation with antibiotics.  At least there
[quoted text clipped - 8 lines]
> helpful in sinusitis patients suffering from MRSA.  That seems to be
> about it.

Depends  on how the irrigation is administered. There is a huge difference
in simple vs pulsatile irrigaiton. There are more references at
www.ent-cosnlult.com:

Management Of Sinusitis In Cystic Fibrosis, Moss RB, King W. . Arch
Otolaryngol Head Neck Surg. 1995;1 21:566-572.

Stresses the use of pulsatile irrigator with nasal adaptor for home use.
Recommends antibiotic irrigation of sinuses. 
***************

Method For Rapid Evaluation Of Topical Of Topically Applied Agents To Cystic
Fibrosis, Wine JJ, King W, Lewiston NJ Am J Physiol. 1991261 (Lung Cell Mol
Physiol. 5):L21 8-L221

Pulsatile sinus irrigation makes an ideal vehicle for local administration
of antibiotics and other products. 
*****************
Management of Chronic Sinusitis in Cystic Fibrosis, Davidson, T.,
Laryngoscope 105:354 April 1995.

Cystic fibrosis is commonly associated with sinusitis due to mucociliary
system failure. Patients may benefit by lung transplant. Pre-op pulsatile
saline irrigation with tobramycin is found to be a successful means of
clearing the sinus of disease.
augustwestern - 25 Apr 2005 23:01 GMT
> My allergist prescribed a bactroban/saline mix today.

I've been doing this for 6 months. My Dr says to use this mix just as I
would an oral antibiotic, in other words, for 2-3-4 weeks when a chronic or
acute sinus infection is going on, then discontinue. The ointment mixes up
best and I use my regular Hydropulse saline salt/soda mix for the medium. So
far, so good, as I haven't needed any oral antibiotics and I've had 3 sinus
infections this year that did respond to this treatment after 3-5 days.

> The allergist also wants me to try Singulair to see if
> that will stop the sinus inflammation.

Helps me a little. Not a miracle drug as the ads would have you believe.
Susan - 25 Apr 2005 23:06 GMT
>>My allergist prescribed a bactroban/saline mix today.
>
[quoted text clipped - 9 lines]
>
> Helps me a little. Not a miracle drug as the ads would have you believe.

Please describe this treatment further... you're irrigating with
ointment in saline solution?  How much ointment and how frequently?

Susan
augustwestern - 26 Apr 2005 06:26 GMT
> x-no-archive: yes
>
[quoted text clipped - 6 lines]
> > far, so good, as I haven't needed any oral antibiotics and I've had 3 sinus
> > infections this year that did respond to this treatment after 3-5 days.

> Please describe this treatment further... you're irrigating with
> ointment in saline solution?  How much ointment and how frequently?
>
> Susan

I should note that I have colonized staph of the skin and nose that oral
antibiotics have been unable to eradicate. From what I'm told, having
colonized staph isn't all that uncommon. Staph is a ubiquitous germ in our
environment and once you become colonized, it is often difficult to
completely get rid of it.

The Dr suggested using a new Ocean bottle of saline for the saline medium
but since I had a spare brand new clean empty nasal atomizer spray bottle,
I used this new atomizer sprayer instead (holds about an oz. and a half of
water). For the saline portion I use my normal Hydropulse saline/soda rinse
mix which I mix up a gallon at a time using distilled water. I was told to
put about inch and a quarter strip of Bactroban ointment directly into the
spray bottle filled with saline solution and shake vigorously until the
Bactroban is in solution. This takes some hard shaking. I was told to use
only the Bactroban ointment as it was water soluble. I was then told to use
the mixed spray exactly as I would an oral antibiotic when I have a sinus
infection and feel like I need oral antibiotics. I then use the spray 2-3
times daily for 3 weeks or at least a week past when all signs of infection
have resolved. I shake it up and do a couple squirts on each side each time.
There is little or no taste that I can tell. So far, after about 2-3 days I
begin noticing an improvement. I do these Bactroban squirts an hour or so
after my normal saline Hydropulse irrigations, AM & PM.

Before making each new batch of Bactroban/saline mix, I do wash the spray
bottle out with dilute vinegar and then dilute bleach and water. I certainly
don't see any reason to pay a pharmacist to mix this up for you if you have
good hygiene.

I haven't needed any oral antibiotics since sometime last fall. I've used 4
rounds of this intranasal Bactroban saline mix in the past 5-6 months when
sinus infections were getting started. I feel this Bactroban/saline mix has
been a factor in these infections not progressing as they would have in the
past. I have also so far avoided the sinus surgery that 2 Drs had told me I
needed. Besides daily Hydropulse irrigations and this Bactroban mix, I do
Flonase daily and sometime antihistamines.

I can't say that the Bactroban/saline mix is a good idea for people with
sinus infections in general, but for me and my personal situation, it's
proven to be a very useful tool. I asked the Dr about becoming immune to the
positive effects of the Bactroban and he didn't see a problem as long as I
used the mixed spray just like you would an oral antibiotic.

btw- The same Dr who prescribed the Bactroban/saline mix also said that
daily irrigation with the Hydropulse was a must for me and a very good idea
for anyone with chronic sinus infections.      AW
Susan - 26 Apr 2005 13:32 GMT
>>x-no-archive: yes
>>
[quoted text clipped - 69 lines]
> daily irrigation with the Hydropulse was a must for me and a very good idea
> for anyone with chronic sinus infections.      AW

Thanks for all the info.  You say your doc told you to use the mixture
like orals; you mean the length of time and frequency, right?

Also, why not put it in your pulsatile irrigator instead?  I just read
an abstract finding that atomizers were the least effective at sinus
penetration, though clearly it's helping you.

Thanks again.

Susan
augustwestern - 26 Apr 2005 20:43 GMT
> >>Please describe this treatment further... you're irrigating with
> >>ointment in saline solution?  How much ointment and how frequently?
[quoted text clipped - 46 lines]
> > daily irrigation with the Hydropulse was a must for me and a very good idea
> > for anyone with chronic sinus infections.      AW

> Thanks for all the info.  You say your doc told you to use the mixture
> like orals; you mean the length of time and frequency, right?

Correct

> Also, why not put it in your pulsatile irrigator instead?

Because the Dr told me to do it the way I described.

I just read
> an abstract finding that atomizers were the least effective at sinus
> penetration, though clearly it's helping you.
>
> Thanks again.
>
> Susan

I find for myself that a fine mist from an atomizer works better than an
Ocean type squirt bottle. The squirt bottle shoots too big a stream of fluid
which then runs down my throat or out my nose. My infections are usually in
my front and maxillary sinuses so the fine mist works well.

Bactroban can get very expensive if you have an 80.00 copay for a 3 month Rx
and you also use it on your skin.
btw-Teva has just started making a generic form of Bactroban. I have a tube
but haven't used any yet.     AW

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