One of the first studies I have ever seen showing which microorgansim
flourish while taking oral antibiotics with a probiotic supplement.

J Antimicrob Chemother. 2000 Oct;46(4):603-12.  Related Articles, Links

Effect of supplements with lactic acid bacteria and oligofructose on the
intestinal microflora during administration of cefpodoxime proxetil.

Orrhage K, Sjostedt S, Nord CE.

Departments of Microbiology, Pathology and Immunology. Surgery, Huddinge
University Hospital, Karolinska Institutet, SE-141 86 Stockholm, Sweden.

Thirty healthy volunteers in three groups participated in a study of the
effect on the intestinal microflora of oral supplementation with
Bifidobacterium longum, Lactobacillus acidophilus and oligofructose, an
indigestible oligosaccharide, during oral administration of cefpodoxime
proxetil bd for 7 days.

Those in group A also received an oral supplement with c.1011 cfu of B.
longum BB 536 and L. acidophilus NCFB 1748 and 15 g oligofructose daily.

Those in group B received a supplement with oligofructose only.

Those in group C received placebo, for 21 days.

In all three groups there was a marked decrease in aerobic microorganisms,
involving mainly a rapid and almost complete disappearance of Escherichia
coli (P: < 0.05) during antimicrobial administration and, thereafter, an
overgrowth of enterococci (P: < 0.05).

(( my comment - I find it interesting certain microorganisms diminish, yet
the bacteria enterococcus thrives. Enterococcus is obviously taking
advantage of the altered environment caused by the antibiotic. This might be
one reason enterococcus continually show's up in a sufferer's prostatic
secretions? A result of multiple course antibiotics. )).

The number of intestinal yeasts also increased significantly (P: < 0.05) in
groups A and B over the same period.

(( my comment - this is further proof troublesome yeast and fungus do
multiply and flourish after antibiotic therapy ))

There was a dramatic decrease in anaerobic microorganisms on day 4 of
administration, mainly caused by loss of bifidobacteria (P: < 0.05) in all
groups. The number of lactobacilli also decreased but was significantly
higher in group A than in group C at the end of cefpodoxime proxetil
administration.

Clostridium difficile was found in only one person from group A, but six
persons each in groups B and C. Of the bifidobacterial strains isolated from
the faecal samples in group A, one was similar to the strain of B. longum
administered, but most volunteers were colonized by several different
strains of B. longum during the investigation period. The administered
strain of L. acidophilus was recovered from six patients in group A.

(( my comment - by the results of this study, it seems quite apparent that
the subjects in group A had the most positive results. Group A was the ONLY
group to use an oral probiotic supplement )).

Publication Types:
Clinical Trial
Controlled Clinical Trial

PMID: 11020259 [PubMed - indexed for MEDLINE]