Hi,
    While I don't have much evidence, It seems to me that niether
wine, grapes, grape juice, chocolate, grape seed extract, grape skin
extract, nor pycnogenol contain enough resveratrol to be very
effective. The efficacy of these interventions may be from synergism
between other substances. I think only the new resveratrol pills can
provide over 5 mg/day.
     Perhaps some have more detailed knowledge.

Thomas

Actually no. In grapes, it isn't concentrated enough to do any good.
So while grapes may have other good effects, you won't be getting
what Resveratrol gives you. Same for grape juice.

You have to get it in fermented red wine to get the concentrations you
need. And most of the red wines won't have it in major quantities.
You have to get Pinot Noir red wine that is grown near the 50th
parallel where the summers are nasty enough to produce lots of
fungal attacks on the Pinot Noir grape which has a thin skin and
lots of grapes per bunch, making it an ideal candidate for fungal
attack. This then causes the massive Resveratrol production in the
thin skin which is then fermented into the Pinot Noir red wine.

You must take care to prevent oxygen getting in contact with your
red wine once the bottle is opened, so use a nitrogen resealer like
www.privatepreserve.com which might get you another day or two to
stretch out the bottle. Less recommended is the VacuVin which claims
to make a vacumn (it doesn't). Resveratrol is an extremely fragile
molecule. A test of multiple Resveratrol dietary supplements at
a (very) reputable laboratory showed that none were biologically
active, and this included one very well known manufacturer (that
makes a mint of its Resveratrol supplement.)

There does exist one manufacturer at this time who makes a Resveratrol
pill which is protected against oxygen exposure during manufacture
and in the packaging and has passed the test at the same lab. I don't
want to get into a commercial food fight at this point but draw your
own conclusions.

There is enough solid research about longevity and red wine and
Resveratrol that it is pretty obvious to be good for you in small
quantities (1 glass per day for women, 1-2 glasses per day for men);
however the alcohol effects can be annoying. So a good pill could let
you take a break from the alcohol during the work week and then on
the weekend you could wine and let your body take a break from the
pill.

Studies are underway with rodent and rhesus longevity. Resveratrol
has already passed big-time on yeast, worms, and fruitflies for
longevity extension.

The effect is to slow metabolism, extend the time that a cell has
to reconstruct its DNA before self-destructing or worse multiplying
(cancerous), literally provide more generations of cellular division
by lengthening the lifetime of each cell, while at the same time
suppressing those aspects that create and cause cancer. This has been
shown over and over and over in paper after paper (hundreds, maybe
thousands by now.) It is quite remarkable. There is really nothing
else like it in the corpus of medicine. Attempts to patent variations
on the molecule should prove unsuccessful as tests have shown variations
to be inferior in effect to the original fragile molecule.

You already know that from Sinclair's experiments Resveratrol
mimics Caloric Restriction effects and there are decades of
research on that and its benefits.

Draw your conclusion and take your risks (or not) going forward.

Stuart