philget wrote...snip...

Absolutely, tumor volume is not the only factor that determines PSA
levels.  There are several steps involved in the production of PSA.
Consumption of materials that affect any of these steps (for example
causing a protein or enzyme involved in PSA production to be over /
under expressed) or that affect the permeability of organs could lead
to an increase or decrease in PSA levels measured in the blood stream.
This has been demonstrated in the literature.

BTW, it is also well documented that higher grade tumors produce less
PSA, so low PSA levels do not always insure a healthy prostate...Best
wishes and good health, ron

The Gleason Score recognizes that PC cell progression is not
synchronized.  There is some degree of variation in the loss of
cellular differentiation.  It is possible that pomegranate juice [PJ]
is very effective below a certain Gleason Number (not Score!), say 4,
but less effective for higher numbers.  If someone has a Gleason Score
of 3+4, PJ might wipe out the predominant 3 cells, but only some of the
4's.  The PSA would go down, as a result of the reduction in tumor
mass, but the overall effect would be to select for the higher grade
cancer.

A similar effect was found in the 5alpha-reductase inhibitor study.
The level of diagnosed PC was much lower than in controls, but there
was a greater degree of advanced cancer in the treated group.

One can argue that a PJ regimen is beneficial to the majority, but
since it can lower PSA, a new baseline reading should be taken after PJ
has had a chance to work.  Any subsequent PSA increase should be viewed
with suspicion (even if the PSA is very low).

The Pantuck study would suggest that PJ is of benefit even at high
Gleason Numbers.  Anything that increases PSA doubling times must be
good.  With possibly invasive cancer, a multi-pronged defense is called
for & I do not rely on PJ alone.  Incidentally, I prefer a combination
of CardioGranate, EstroGranate & the seed oil, since who needs all that
sugar?