Medical Forum / Diseases and Disorders / Prostate Cancer / July 2005
80 Years old, Gleason 9, No metastasis to the bone
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G - 16 Jul 2005 21:17 GMT 80 Years old, Gleason 9, no metastasis to the bone
My father was just diagnosed.
Suggested treatment is castration (doctor's recommendation) or other hormone therapy.
Can anyone just give me some random thoughts. Other possibilities? What to expect? Life expectancy?
Thanks
george conklin - 16 Jul 2005 22:07 GMT > 80 Years old, Gleason 9, no metastasis to the bone > [quoted text clipped - 7 lines] > > Thanks At age 80, 100% of the male population can be diagnosed with PCa. Why was he tested? Some doctors say they will test an 80-year-old only if he brings with him BOTH parents!!!
Ben T - 16 Jul 2005 22:27 GMT George I am 79 years old, I will be 80 in 5 months. May I ask what your age is. Thanks Ben T
>> 80 Years old, Gleason 9, no metastasis to the bone >> [quoted text clipped - 11 lines] > was he tested? Some doctors say they will test an 80-year-old only if he > brings with him BOTH parents!!! Leonard Evens - 17 Jul 2005 01:24 GMT > George > I am 79 years old, I will be 80 in 5 months. Does your doctor recommend routine screening for prostate cancer?
> May I ask what your age is. > Thanks [quoted text clipped - 15 lines] >>was he tested? Some doctors say they will test an 80-year-old only if he >>brings with him BOTH parents!!! Ben T - 17 Jul 2005 01:41 GMT Leonard I have been seeing a urologist because of an enlarged prostate. For the last year or so my PSA was in the 4 to 5 range. Because of my age (79) he said that range was not alarming. I had a PSA of 8.2 a few months ago and that's when my uro decided I should have a biopsy.
I have BPH and Cancer. Biopsy 4/15/05
T1c Gleason 6, 3+3, 1/12 positive, localized, Age 79, Good health, Taking Proscar. TURP on 6/20/05
My Urologists says it is better for me to have a TURP before having EBRT. Which is not yet scheduled. Turp + 3 ½ weeks, I believe I am progressing as expected. I will try to answer any question. Ben
>> George >> I am 79 years old, I will be 80 in 5 months. [quoted text clipped - 20 lines] >>>was he tested? Some doctors say they will test an 80-year-old only if he >>>brings with him BOTH parents!!! Leonard Evens - 17 Jul 2005 01:59 GMT > Leonard > I have been seeing a urologist because of an enlarged prostate. For the [quoted text clipped - 17 lines] > Turp + 3 ½ weeks, I believe I am progressing as expected. I will try to > answer any question. I am hardly in a position to evaluate your case. Your doctor should know what he is doing. Some doctors won't do routine PSA testing in men your age, but a lot can depend on the individual. Perhaps it makes a difference if there is obstructive BPH, as seems true in your case. A sudden rise in PSA is also sometimes reason for concern. Also, it is really general health and life expectancy that counts rather than age. No one in my family has lived much past 80, but my wife's family typically lives into the 90s and her grandmother reached 104. You could say that when I was diagnosed at age 67, that I just got in under the wire for treatment on the life expectancy test. On the other hand, I had a Gleason 7=3+4 cancer, and many urologists consider that worth treating even if they don't expect their patients to live 15 years or more.
In any case, with a Gleason 6 cancer and a PSA less than 10, your prospects of living out your life without facing metastatic prostate cancer are pretty good at this point. Good luck.
> Ben > [quoted text clipped - 43 lines] > >> > >> Steve Kramer - 17 Jul 2005 15:47 GMT Will radiation do anything to help your BHP? Sounds like you're in great shape for ignorning the PCa and moving on.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05 PSA .07 .05 .06 .05 non Illegitimi carborundum
Leonard I have been seeing a urologist because of an enlarged prostate. For the last year or so my PSA was in the 4 to 5 range. Because of my age (79) he said that range was not alarming. I had a PSA of 8.2 a few months ago and that's when my uro decided I should have a biopsy.
I have BPH and Cancer. Biopsy 4/15/05
T1c Gleason 6, 3+3, 1/12 positive, localized, Age 79, Good health, Taking Proscar. TURP on 6/20/05
My Urologists says it is better for me to have a TURP before having EBRT. Which is not yet scheduled. Turp + 3 ½ weeks, I believe I am progressing as expected. I will try to answer any question. Ben
"Leonard Evens" <len@math.northwestern.edu> wrote in message news:Pd2dnTFdUPu6OETfRVn-oQ@comcast.com... >> George >> I am 79 years old, I will be 80 in 5 months. > > Does your doctor recommend routine screening for prostate cancer? > >> May I ask what your age is. >> Thanks >> Ben T >> >> >> "george conklin" <george@nxu.edu> wrote in message >> news:lGeCe.24230$eM6.19881@newsread3.news.atl.earthlink.net... >> >>>"G" <Son@notreal.ooo> wrote in message >>>news:siqid1d09c7dj7at4jh4nsitup1g521ur1@4ax.com... >>> >>>>80 Years old, Gleason 9, no metastasis to the bone >>>> >>>>My father was just diagnosed. >>>> >>>>Suggested treatment is castration (doctor's recommendation) or other >>>>hormone therapy. >>>> >>>>Can anyone just give me some random thoughts. Other possibilities? >>>>What to expect? Life expectancy? >>>> >>>>Thanks >>>> >>> >>> At age 80, 100% of the male population can be diagnosed with PCa. Why >>>was he tested? Some doctors say they will test an 80-year-old only if he >>>brings with him BOTH parents!!! >>> >> >> >>
Alan Meyer - 17 Jul 2005 16:04 GMT > Will radiation do anything to help your BHP? Sounds like you're in > great shape for ignorning the PCa and moving on. I don't know about BPH.
I read, IIRC it was in Dr. Walsh's book, that prostatitis is not cured by radiation (though it is by prostatectomy). In my own case, he turned out to be right. I had some prostatitis before radiation and had it again afterwards.
Alan
Glassman - 19 Jul 2005 03:02 GMT My 91 year old dad just had a bout of problems for the 1st time in his life. Never sick a day, then heart probs compounded by not being able to void. They cathed him while he was recovering from the pacemaker, but after a month when the cath was removed, he still couldn't urinate. He saw a URO and had some procedure that led the doc to tell him that no surgery will be done, and his enlarged prostate would be treated with meds. He must have PCa but the doc never mentioned it to him. Flomax plus some other stuff, and after another month or so, he is now perfectly fine.
 Signature JK Sinrod Sinrod Stained Glass Studios www.sinrodstudios.com Coney Island Memories www.sinrodstudios.com/coneymemories
Leonard Evens - 19 Jul 2005 03:59 GMT > My 91 year old dad just had a bout of problems for the 1st time in his > life. Never sick a day, then heart probs compounded by not being able to [quoted text clipped - 3 lines] > done, and his enlarged prostate would be treated with meds. He must have PCa > but the doc never mentioned it to him. That sounds like his urologist diagnosed the problem as BPH, and he is treating it with drugs to control that. Difficulty with urination is a problem in a man of any age and needs to be treated. If it isn't, it can lead to kidney failure.
It is highly likely that any man your father's age with an intact prostate has at least some microscopic evidence of prostate cancer. But that is different from what urologists consider a clinical case of the disease. Few urologists would actively look for prostate cancer in a man that old since there would be little point in treating it. But if it had risen to the level where it was causing symptoms such as urinary obstruction, they would certainly treat it.
> Flomax plus some other stuff, and > after another month or so, he is now perfectly fine. Sounds good.
Leonard Evens - 17 Jul 2005 01:23 GMT >>80 Years old, Gleason 9, no metastasis to the bone >> [quoted text clipped - 11 lines] > was he tested? Some doctors say they will test an 80-year-old only if he > brings with him BOTH parents!!! Please don't pay attention to this guy. He knows little or nothing about prostate cancer. It is true that the overwhelming majority of 80 year old men, if they died and had an autopsy, would show microscopic evidence of prostate cancer. But that is very different from a clinical diagnosis, particularly with a Gleason 9 cancer.
I have no idea how events unfolded, but I would not be surprised if his doctor found some reason to be concerned. Most doctors don't recommend routine screening for porstate cancer in men over 80, but they do treat it if it makes itself known. Your father may have had some symptoms which could have been caused by prostate cancer. His doctor may have found something whey examining his prostate with his finger. Or it may have been something else. Whatever the reason, when they did a biopsy, they found a Gleason 9 cancer. They had to take that seriously because their experience shows that such cancers may progress rapidly. But they can be treated with hormone therapy or what is equivalent castration. That can often extend life considerably and more important delay some of the more debilitating aspects of advanced prostate cancer. My guess is that had they found a less aggressive cancer, they would have suggested watchful waiting, and it is possible no treatment at all would have been necessary.
I echo the other recommendations. It wouldn't hurt to get one or more medical opinions. Castration or hormone therapy does have some undesirable side effects, so if it can put off for a while, that would be better. But you don't wan to fool around with a Gleason 9 cancer, even in a man of 80.
george conklin - 17 Jul 2005 12:38 GMT >>>80 Years old, Gleason 9, no metastasis to the bone >>> [quoted text clipped - 17 lines] > prostate cancer. But that is very different from a clinical diagnosis, > particularly with a Gleason 9 cancer. This is a position you take, but no one taken by scientists. Every time physicians point out the facts, you deny them. And the quote I gave is accurate. Your emotional response to science belongs somewhere else, but not in a .science group. Your personal choices are just that and they do not reflect or change the research literature.
Leonard Evens - 17 Jul 2005 14:22 GMT >>>>80 Years old, Gleason 9, no metastasis to the bone >>>> [quoted text clipped - 21 lines] > physicians point out the facts, you deny them. And the quote I gave is > accurate. You are again showing your ignorance. The use of castration or hormone therapy for advanced prostate cancer has been established scientifically for decades. The scientist who discovered the link won the Nobel Prize for it. Gleason 9 cancers are known to be very aggressive. While there is controversy about PSA testing, and aggressive early treatment in an attempt to treat early prostate cancer, there is no controversy about cases like this.
> Your emotional response to science belongs somewhere else, but not in a > .science group. Your personal choices are just that and they do not reflect > or change the research literature. Your errors about the science need correction. But in addition this was cross posted to the prostate cancer support group. The poster wanted help in relation to a older man who faces the prospect of advanced prostate cancer. Neither you nor I knows the details of the case nor why his doctor made the recommendations he did. It is decidely not helpful to suggest by implication that this man should be abandoned medically and his cancer should just take its course. That is what you do when you raise doubts based on comapring apples and oranges.
george conklin - 17 Jul 2005 19:39 GMT >>>>>80 Years old, Gleason 9, no metastasis to the bone >>>>> [quoted text clipped - 25 lines] > therapy for advanced prostate cancer has been established scientifically > for decades. Stop changing the subject. I wrote that by age 80, we will all have PCa. You wrote that took exception to that because what they found at age 80 was somehow different. It is not. You say, "very different from a clinical diagnosis." And the point was that if you look, everyone is going to get a clinical diagnosis by age 80.
> Your errors about the science need correction. But in addition this was > cross posted to the prostate cancer support group. The poster wanted help > in relation to a older man who faces the prospect of advanced prostate > cancer. I just respond to the science group; cross postings are provided by the original posters.
Here is the article you don't like:
"My one wish with prostate cancer," says Dr. Thomas Stamey, a veteran researcher at Stanford University, "is that before a doctor does anything aggressive, he would tell his patient that all men will develop the disease eventually." He pauses to let the bad news sink in. "The good news," he wants doctors to add, "is that the rate of dying from prostate cancer is infinitesimal."
Now, notice you said infinitesimal is too small. But he is considering that if you look, you will give 100% of those 80 or up a PCa diagnosis. So if you add in all those over 80 into the diagnosis pool, you are going to come up with "small."
Stamey has been in a reflective mood of late because of the growing realization, by him and others, that the screening test he helped discover is far less useful for detecting prostate cancer than many had once believed. In 1987, a team led by Stamey found that high levels of prostate-specific antigen (PSA) circulating in the blood were a strong indication of prostate tumors.
Before then, the only way to detect prostate cancer was with a painful biopsy, and this is still used to confirm the disease. But with a simple PSA test , doctors thought they could weed out men who don't need the more invasive procedure, as well as spot tumors at an earlier, more treatable stage.
The test has proven a powerful draw: about half of all men over the age of 50 get annual PSA tests. Now, Stamey hopes that men will be open to the older means of screening for prostate cancer.
"I don't think PSA adds very much," he says.
The End of the PSA Era? These second thoughts stem from a troubling variety of evidence that suggests widespread testing is possibly causing more harm than good. Although death rates from prostate cancer are lower than they were before PSA screening, these rates have also declined in countries where this type of testing is not commonly used.
If one were to randomly biopsy men, as Dr. Wael Sakr of Wayne State University did on a group who were accidentally killed on the streets of Detroit, about 8 percent of those in their 20s would have prostate cancer, with the rates steadily increasing as men age. Indeed, about 80 percent will develop the disease by the age of 70.
Some of these tumors are clearly dangerous. But most are slow moving, and many prostate cancer patients can go 20 years without any need for treatment, according to a recent study led by Dr. Peter Albertson. With widespread PSA screening picking up these relatively benign tumors, Stamey fears that the tests are leading to unnecessary treatment and worry.
"I've been as guilty as anyone else," he says.
Not everyone is willing to give up on PSA screening quite yet.
"We know it's not a perfect test," says Jamie Bearse, a spokesperson for National Prostate Cancer Coalition, which advocates annual PSA screening for men 40 years and older. Bearse is hopeful that newer screening tests will prove more discerning. In the meantime, he says, the PSA test is the best early detection option men have. "They would rather know, than not know."
Normal vs. Abnormal PSA Yet it is increasingly hard to determine even a broad risk prediction from PSA testing. Traditionally, doctors used a PSA measurement of 4 as a key cut off point: lower than 4 millimeters of PSA in the blood meant that men were considered cancer free, whereas higher or equal to 4 suggested the need for a biopsy to confirm the disease.
But looking at nearly 5,500 men who had a PSA test and then at least one biopsy, researchers found this cutoff point often missed tumors or implied that men had cancers that weren't in fact really there, according to recent results published in the Journal of the American Medical Association.
Indeed, a PSA level of 4.1 millimeters accurately predicts only 20 percent of prostate cancers and leads to false alarms about 6 percent of the time. Lowering the threshold will detect more cancers, but at the price of causing men to undergo biopsies for no reason or finding many benign tumors that only need to be monitored. A PSA cutoff of 2.1, for example, would yield false readings more than 85 percent of the time to catch only slightly more than half of all tumors.
The authors of the study, led by Dr. Ian Thompson of the University of Texas Health Science Center in San Antonio, call for a substantial "reeducation" effort on the increasingly murky role of PSA. "It will be a challenge to the medical community to change the long held notion that there is a 'normal' PSA level," the authors write.
Researchers still hold out hope for measuring PSA velocity, the rise of PSA over time that gives an indication if the tumor is growing. As an initial detection tool, Stamey says that doctors should return to looking at increasing age, along with a family history of the disease, as a way of determining who may be at greater risk for prostate cancer and in need of a biopsy to catch tumors early.
Other than that, he adds, "We have as much a way of predicting who will need a biopsy based on looking at someone's eyes." Ongoing studies are continuing to look at whether PSA testing saves lives, and the American Cancer Society and other test supporters urge men to discuss the pros and cons of screening with their doctors. But the creator of the PSA test is calling for the end.
"All men will develop a prostate cancer," says Stamey. "That's a given."
You seem to disagree with the last statement and I can find no evidence that Stamey is wrong. That worries you. Why?
Leonard Evens - 17 Jul 2005 21:09 GMT > Stop changing the subject. I wrote that by age 80, we will all have PCa. > You wrote that took exception to that because what they found at age 80 was > somehow different. It is not. You say, "very different from a clinical > diagnosis." And the point was that if you look, everyone is going to get a > clinical diagnosis by age 80. Hint: Look up the concept of conditional probability.
>>Your errors about the science need correction. But in addition this was >>cross posted to the prostate cancer support group. The poster wanted help [quoted text clipped - 111 lines] > > george conklin - 18 Jul 2005 02:27 GMT >> Stop changing the subject. I wrote that by age 80, we will all have >> PCa. You wrote that took exception to that because what they found at age [quoted text clipped - 3 lines] > > Hint: Look up the concept of conditional probability. Irrelevant. The push for a 'diagnosis' is not scientific but cultural.
>> "All men will develop a prostate cancer," says Stamey. "That's a given." >> >> You seem to disagree with the last statement and I can find no >> evidence that Stamey is wrong. That worries you. Why? Why does Stamey's comment worry you?
Steve Kramer - 17 Jul 2005 15:44 GMT Ha! Great one George. I'd never heard that one before.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05 PSA .07 .05 .06 .05 non Illegitimi carborundum
> > 80 Years old, Gleason 9, no metastasis to the bone > > [quoted text clipped - 11 lines] > was he tested? Some doctors say they will test an 80-year-old only if he > brings with him BOTH parents!!! george conklin - 17 Jul 2005 19:42 GMT >> > 80 Years old, Gleason 9, no metastasis to the bone >> > [quoted text clipped - 11 lines] >> was he tested? Some doctors say they will test an 80-year-old only if he >> brings with him BOTH parents!!!
> Ha! Great one George. I'd never heard that one before. It really is a quick way of saying that looking for PCa after age 80 will do more harm than good. As you can see from Len, there are powerful cultural reactions against new ideas if new ideas do not involve cutting.
Steve Kramer - 17 Jul 2005 22:20 GMT > > Ha! Great one George. I'd never heard that one before. > > It really is a quick way of saying that looking for PCa after age 80 > will do more harm than good. As you can see from Len, there are powerful > cultural reactions against new ideas if new ideas do not involve cutting. Actually, with Leonard, I think you're barking up the wrong tree. You're right that PSA screening is probably silly after 80. He's right that G's father, with his Gleason 9 (espeicially in that G's father might have had the disease for years) should take it seriously and make sure he knows just how bad it is before treating it or dismissing it.
But, I was entertained by the "both parents" idiom. And, I remain entertained by the clash of the two .edu's.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05 PSA .07 .05 .06 .05 non Illegitimi carborundum
Stephen Jordan - 17 Jul 2005 22:53 GMT On July17, Steve Kramer responded to George Conklin:
> Actually, with Leonard, I think you're barking up the wrong tree. > You're right that PSA screening is probably silly after 80. He's [quoted text clipped - 5 lines] > But, I was entertained by the "both parents" idiom. And, I remain > entertained by the clash of the two .edu's. I'll agree that it's interesting to watch the two ".edu's" firing at each other.
I do have a couple of questions:
(1) We know Leonard's academic credentials from earlier posts. What are George's credentials? Please forgive me if the info has been posted previously; I haven't seen it.
(2) Would George please enlighten us by specifying what he recommends to alleviate the problems he perceives.
Regards,
Steve J
"The true aim of medicine is not to make men virtuous; it is to safeguard and rescue them from the consequences of their vices. The physician does not preach repentance; he offers absolution." -- H.L. Mencken
george conklin - 18 Jul 2005 02:37 GMT > On July17, Steve Kramer responded to George Conklin: > [quoted text clipped - 23 lines] > > Steve J Only hard-core research can settle the issues, research which has not been done. I find that a cultural problem made worse by economics. There are billions of $ in treatments, but nothing much allowed for research. As I have said before, women have been far more aggressive than men in demanding research. We have interest groups pushing 'screening' and physicians such as Stamey saying the results of screening have been very disappointing. I do have an easily-found home page and numerous other google references for my current interests. www.nccu.edu/artsci/social/conklin.htm
Very often with research on cancer you find only very small improvements in results, as in maybe 2-3 months. I am afraid that the research on PCa is heading in that direction too.
Stephen Jordan - 18 Jul 2005 02:46 GMT On July 17, I inquired:
>>(1) We know Leonard's academic credentials from earlier posts. What are >>George's credentials? Please forgive me if the info has been posted >>previously; I haven't seen it. >> >>(2) Would George please enlighten us by specifying what he recommends >>to alleviate the problems he perceives. And George responded
> Only hard-core research can settle the issues, research which has not > been done. I find that a cultural problem made worse by economics. There [quoted text clipped - 9 lines] > in results, as in maybe 2-3 months. I am afraid that the research on PCa > is heading in that direction too. As I read it, George has declined to answer my questions.
We may therefore draw our own conclusions as to the value of his opinions.
Regards,
Steve J
george conklin - 18 Jul 2005 12:56 GMT > On July 17, I inquired: > [quoted text clipped - 16 lines] > > Steve J Oh dear. I point out that the science needed to answer questions is not available, and you get mad. Tough. The issue is WHY it is not available even after 100 years of prostate surgery. I posted a reference to a well-known research doctor and you claim it is my opinion? ha Ha ha.
Steve Kramer - 19 Jul 2005 11:30 GMT I guess that answers your question, Stephen. None.
I apologize to all others for the minimal credence I initially gave.
 Signature PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05 PSA .07 .05 .06 .05 non Illegitimi carborundum
> > On July17, Steve Kramer responded to George Conklin: > > [quoted text clipped - 37 lines] > in results, as in maybe 2-3 months. I am afraid that the research on PCa > is heading in that direction too. Ed Friedman - 18 Jul 2005 17:16 GMT > 80 Years old, Gleason 9, no metastasis to the bone > [quoted text clipped - 7 lines] > > Thanks G,
You should educate yourself about prostate cancer (PC) as much as possible before making any decisions. Personally, I find the choice a no brainer. With a Gleason of 9, you must assume that the PC is not locally confined. By far the best treatment for non-localized PC can be seen at: http://prostateweb.com/pdfs/ASCO_PCF_02_2005.pdf Personally, I would go for the high dose testosterone option following the intermittent hormonal blockade.
The theory behind why this works can be found in my paper at: http://www.tbiomed.com/content/2/1/10
I'm sure that you will find doctors that disagree with my model, and with the treatment outlined above. However, I would challenge all such doctors to find any experimental result that deviates in the slightest from what my model predicts. Basically, if a PC doctor is so ignorant that he has no idea of something so basic as to why obese men have such a higher rate of PC, then why would you trust your life to such a doctor?
Ed Friedman
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