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Medical Forum / Diseases and Disorders / Prostate Cancer / May 2005

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Dietary Calcium... Damned if We Do... or Don't

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Ken - 23 May 2005 15:51 GMT
Below is an abridged version of the news item. To read the whole thing,
go to http://tinyurl.com/96z43

A study carried out at Fox Chase Cancer Center in Philadelphia and
published in this month's [May, 2005] American Journal of Clinical
Nutrition set out to examine the link between prostate cancer and
consumption of dairy products, calcium and vitamin D.

Dietary calcium was seen to be strongly associated with an increased
risk of prostate cancer, with the highest consuming tertile having a RR
of 2.2 compared with the least consuming tertile, and a 95% CI of 3.5
compared with 1.4.

Previous evidence indicating a reduced risk of colorectal cancer with
higher calcium consumption includes a study published in Cancer
Epidemiology, Biomarkers and Prevention (vol 14, pp126-132) in January,
which showed that women who consumed in excess of 800mg of calcium each
day could cut their risk of developing colorectal cancer by up to 46
percent. Deriving calcium from both diet and supplements was seen to
double the risk reduction observed when it came from either source
alone.

The Fox Chase scientists are not the first to draw attention to the
seemingly duplicitous relationship between calcium and cancer. A body
of evidence on the subject, which their results bolster, led them to
conclude that "the mechanisms by which dairy and calcium might
increase prostate cancer risk should be clarified and confirmed."
Ed Friedman - 23 May 2005 17:35 GMT
> Below is an abridged version of the news item. To read the whole thing,
> go to http://tinyurl.com/96z43
[quoted text clipped - 3 lines]
> Nutrition set out to examine the link between prostate cancer and
> consumption of dairy products, calcium and vitamin D.

It would be interesting to see which form of vitamin D they are talking
about.  Dairy products are supplemented with vitamin D2, a form never
found in nature.  The question is whether people who take the natural
form (vitamin D3) plus calcium are subject to any higher risk.
Considering it is known that there are vitamin D3 receptors on the
prostate which increase apoptosis, my best guess would be the the D2 is
interfering with this process and is the sole culprit to explain this
study's results.

Also, are they talking about calcium carbonate or calcium citrate
consumption?  Only about 2% of the calcium from calcium carbonate (vs.
almost all from calcium citrate) gets absorbed into the bloodstream, and
calcium carbonate increases stomach pH, resulting in less absorption of
all minerals and of water soluble vitamins.  This could also be
contributing to the increased rate of prostate cancer observed.

Ed Friedman
Ken - 25 May 2005 17:29 GMT
Ed, you raised good points, but which are related to the objective of
the report, i.e., "consumption of dairy products?"
 
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