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Medical Forum / Diseases and Disorders / Prostate Cancer / March 2005Testosterone
Could you tell me how testosterone increases the growth of tumor in prostate cancer patients ? Also, would you please include some information on how it is supposed to be one of good memory enhancers in humans ? Thanks a lot > Could you tell me how testosterone increases the growth of tumor in > prostate cancer patients ? > Also, would you please include some information on how it is supposed > to be one of good memory enhancers in humans ? > > Thanks a lot Testosterone(T) increases the growth of prostate cancer(PCa) by binding to the intracellular androgen receptor, which stimulates growth. T also is converted to estradiol, which is essential for PCa to start up in the first place. Basically, virtually all cells in the body use T. Low levels of T have been associated with high blood pressure, high cholesterol, high blood sugar, high triglicerides, osteoporosis, memory loss, and Alzheimer's disease. High levels of T when bound to the membrane androgen receptor have been shown to kill PCa. Ed Friedman > High levels of T when bound to the membrane androgen receptor > have been shown to kill PCa. Was that a misprint? Is that really true? If so, why are the urologists trying to reduce our T levels?? Mike >> High levels of T when bound to the membrane androgen receptor >> have been shown to kill PCa. [quoted text clipped - 3 lines] > > Mike He is getting his information from a specific source which may not represent the general opinion in the profession. It is complicated. As usual beware of anything you read on the internet, including what I am telling you. >> High levels of T when bound to the membrane androgen receptor >> have been shown to kill PCa. [quoted text clipped - 3 lines] > > Mike Mike, It is really true. You can get the full details when my paper is published. I've made it through peer review and I'll post an announcement here when it is published and available for access online. To answer your question, urologists are unaware of the science since the key articles are just starting to hit print. Also, not all urologists are ignorant of this, since Dr. Leibowitz and Dr. Tucker use this fact to save the lives of their prostate cancer patients. The most important paper (besides mine) is "Membrane androgen receptor activation induces apoptotic regression of human prostate cancer cells in vitro and in vivo", J Clin Endoc Metab, 2005, 90:893-903. Ed Friedman |
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