Medical Forum / Diseases and Disorders / Prostate Cancer / December 2004
And so it goes...
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Lech K. Lesiak - 17 Nov 2004 19:33 GMT Just got back from my first visit to my new uro.
PSA almost doubled since May - it clocked in at 10.
I'm up for another biospsy after that elevated result.
I've had five biopsies so far, last one in 2000.
Slightly diff procedure this time. They will use an anaesthetic and take 12 samples.
Regards, Lech Edmonton Alberta
Leonard Evens - 17 Nov 2004 20:43 GMT > Just got back from my first visit to my new uro. > [quoted text clipped - 3 lines] > > I've had five biopsies so far, last one in 2000. Have they done a free PSA test? Sometimes they can use the results of that test to decide whether additional biopsies are necessary. I am hardly an expert, but it is a bit hard to see how a cancer large enough to produce that much PSA would be missed 5 times. Perhaps they are looking in the wrong part of the prostate.
> Slightly diff procedure this time. They will use an anaesthetic and take > 12 samples. > > Regards, > Lech > Edmonton Alberta ron - 18 Nov 2004 15:31 GMT Hi Lech...Your high PSA is too high to be accounted for by normal PSA "leak" from a large gland. However, it could be the result of an infection. Has your doctor put you on a course of antibiotics and then remeasured the PSA to see what effect, if any, the antibiotic had? Did your doc do a DRE during the visit when the blood was drawn? If so was it done before or after the blood draw? Massaging the prostate prior to the blood draw (DRE, sex, etc) can elevate the PSA. Is your PSA erratic, does it go up and down? If so, this would be consistent with an infection or BPH.
Routine biopsy cannot sample the entire prostate. The area it does sample is where PCa most commonly occurs, but some PCas do occur in non-sampled regions. If your PSA has been increasing for several years and infection and BPH have been ruled out as the cause, then even though biopsy has not found it, there is a good chance that PCa is present. There are other things you can do to search for the PCa. Peritoneal biopsy can probe other areas of the prostate as can color doppler imaging. 12-sample biopsy is now fairly routine, often higher sampling rates are used on repeat biopsies. You might also consider the uPM3 urine test (Bostwick Labs) and, as Leonard has suggested, a free PSA test in order to confirm the presence of PCa...Best wishes and good health, Ron
> Just got back from my first visit to my new uro. > [quoted text clipped - 10 lines] > Lech > Edmonton Alberta Lech K. Lesiak - 18 Nov 2004 16:38 GMT > Hi Lech...Your high PSA is too high to be accounted for by normal PSA > "leak" from a large gland. However, it could be the result of an > infection. Has your doctor put you on a course of antibiotics and > then remeasured the PSA to see what effect, if any, the antibiotic > had? Did your doc do a DRE during the visit when the blood was drawn? No DRE. I have a cyst on my prostate that feels like the stereotypical cancerous prostate.
> Routine biopsy cannot sample the entire prostate. The area it does > sample is where PCa most commonly occurs, but some PCas do occur in > non-sampled regions. If your PSA has been increasing for several > years and infection and BPH have been ruled out as the cause, then > even though biopsy has not found it, there is a good chance that PCa > is present. There are other things you can do to search for the PCa. I'm scheduled for a 12 sample on Dec 15.
My PSA was steady for ten years varying between 4 and 6. The 10 I scored a couple of weeks ago is sudden.
The previous five biopsies I had done over the years were taken all over the place. They were generally about six samples, if I recall.
The new uro I have in Edmonton was recommended by the guy I had in Calgary for ten years, so I have confidence in him.
Cheers, Lech
Everett R. Wadsworth - 26 Nov 2004 03:23 GMT Lech, I was reading in this book "Surviving Prostate Cancer Without Surgery" that you should rule out prostatitis first as this could be why your PSA is elevated. It seems to make more sense to me to treat for an infection first to see if that don't get the PSA down before going to something invasive as a biopsy. Don't you agree? Has your uro said anything to you about prostatitis? If so, what has he done to rule out prostatitis? Regards, Everett
> Just got back from my first visit to my new uro. > [quoted text clipped - 10 lines] > Lech > Edmonton Alberta Leonard Evens - 26 Nov 2004 14:17 GMT > Lech, > I was reading in this book "Surviving Prostate Cancer Without Surgery" > that you should rule out prostatitis first as this could be why your > PSA is elevated. What you say makes sense, and I believe it is standard practice.
> It seems to make more sense to me to treat for an > infection first to see if that don't get the PSA down before going to > something invasive as a biopsy. Usually that is what your physician will do. The problem is that a large number of cases of prostatitis don't respond to antibiotics, and the patient may not even experience any special symptoms. It can also last for a long time.
> Don't you agree? Has your uro said > anything to you about prostatitis? If so, what has he done to rule out > prostatitis? If an antibiotic doesn't bring down the PSA, or it doesn't come down in a couple of months on its own, sometimes a free PSA test can help the doctor to decide whether or not to go to a biopsy.
> Regards, > Everett [quoted text clipped - 13 lines] >>Lech >>Edmonton Alberta Everett R. Wadsworth - 26 Nov 2004 22:21 GMT > > Lech, > > I was reading in this book "Surviving Prostate Cancer Without Surgery" > > that you should rule out prostatitis first as this could be why your > > PSA is elevated. > > What you say makes sense, and I believe it is standard practice. It should be standard practice but my experience has shown me it isn't. The majority of uros will not go beyond the urinalysis. This rarely shows anything. This is the big mistake that is being made. Actually the prostatic fluid should be cultured. How many of you here have had your prostatic fluid cultured?
> > It seems to make more sense to me to treat for an > > infection first to see if that don't get the PSA down before going to [quoted text clipped - 4 lines] > the patient may not even experience any special symptoms. It can also > last for a long time. Perhaps the reason it's not responding to antibiotics is due to the fact the antibiotics can't penetrate the prostate since it's so congested from infection. I saw a diagram of this in this book "Surviving Prostate Cancer Without Surgery".
> > Don't you agree? Has your uro said > > anything to you about prostatitis? If so, what has he done to rule out [quoted text clipped - 3 lines] > a couple of months on its own, sometimes a free PSA test can help the > doctor to decide whether or not to go to a biopsy. The antibiotic won't bring down the PSA due to my reasons stated above and now the uro will rule out an infection when most likely there is one present and go on to a biopsy with all the risks involved with that. DOES THAT MAKE SENSE!!! Regards, Everett
Leonard Evens - 26 Nov 2004 23:06 GMT >>>Lech, >>>I was reading in this book "Surviving Prostate Cancer Without Surgery" [quoted text clipped - 22 lines] > congested from infection. I saw a diagram of this in this book > "Surviving Prostate Cancer Without Surgery". I got my information from www.nlm.nih.gov/medlineplus/prostatediseases.html There are links there to a variety of sources of information. I found the Mayo Clinic link particularly informative, but they all say essentially the same thing. Acute bacterial prostatitis can usually be treated by antibiotics. Chronic prostatitis may or may not be bacterial, but it is often difficult to treat. The Mayo Clinic site does mention the possibility of culturing the prostate fluid or the semem as well as the urine. I must admit I am a bit skeptical about the above book because (1) someone is clearly trying to promote it on the internet and (2) the website advertising it says some things about prostate cancer which I know are at best misleading and at worst just plain wrong. However, I did check the author, and he does appear to specialize in the treatment of prostatitis. At least he seems to have written a few papers about that. So maybe he has something valuable to say on that subject. But I still think it is safer to stick with the sources at the above website as a start and ultimately with my urologist, whom I respect quite a lot. Of course, I don't have a prostate any longer, so I can't get prostatitis, but I did refer a friend who had chronic prostatitis to my urologist, and my friend was happy with his treatment.
>>>Don't you agree? Has your uro said >>>anything to you about prostatitis? If so, what has he done to rule out [quoted text clipped - 10 lines] > Regards, > Everett Everett R. Wadsworth - 28 Nov 2004 01:52 GMT Leonard, This is great to hear your friend was happy with his treatment. What treatment did he receive? I was curious to know how you came to the decision to have a RP? Are you having any problems as a result from the operation? Regards, Everett
> >>>Lech, > >>>I was reading in this book "Surviving Prostate Cancer Without Surgery" [quoted text clipped - 58 lines] > > Regards, > > Everett Leonard Evens - 28 Nov 2004 03:59 GMT > Leonard, > This is great to hear your friend was happy with his treatment. What > treatment did he receive? I'm afraid I don't remember the details, but his prostatitis had been dealt with the last time I spoke to him and he was on the way to recovery.
In your other post, you describe how several urologists told you that with such a high PSA, a biopsy was warranted. You seem happy that by not taking their advice, you avoided a biopsy and your problem was dealt with. But if you had followed the urologist's advice and had a biopsy, it is reasonable to assume that the result would have been negative. If done correctly a biopsy is a safe and not specially painful procedure. One certainly shouldn't have one if one doesn't need it, but even if you had one unnecessarily, it is highly unlikely you would have suffered any long term side effects. Presumably, having eliminated prosate cancer as a cause, your urologists would have looked again at the possibility of prostatitis. Needless to say, no surgeon would have performed a radical prostatectomy with a negative biopsy.
Your urologists were going by the odds. If you do that, usually you will be right, but on occasion you will be wrong. They were wrong in your case, but it would be a mistake for others to conclude from your experience that they shouldn't believe what their urologists tell them.
> I was curious to know how you came to the decision to have a RP? My PSA started rising and over a two year period it jumped from about 2.6 to about 4.5. That rate of increase suggested a biopsy might be warranted. Again, that is going by the odds. My primary care physician actually wanted me to wait and have the test done again in a couple of months, but I had previously researched the subject and was concerned, so he referred me to a urologist. A subsequent test showed a PSA of 3.8. The urologist, a local doctor who is highly regarded, thought it was a borderline case and left it up to me whether to follow the PSA with further tests or to have a biopsy. He emphasized that the biopsy was a safe and not very painful procedure. I chose to have a biopsy rather than wait. He was right about the biopsy. It was no big deal.
Much to my surprise, and to my doctor's, I think, it showed not only that I had prostate cancer, but that it was a Gleason 7=3+4, which is at the top end of what is considered the moderate, treatable range. My urologist strongly recommended treating it since I had at least a ten to fifteen year life expectancy at that time. Had I not been in such good health, paradoxically, he might have recommended watchful waiting instead. He suggested external radiation or surgery, and I chose surgery after considering both the likely cure rates and side effects. I also liked the idea that I would get some feedback immediately after surgery from the postsurgical pathology report. My doctor told me that if he did the surgery, there might be a 20 percent chance of stress incontinence and a 2 percent or smaller chance of serious incontinence. He also told me that at my age at the time, 67, the chances of my being permenantly impotent were about 50 percent. But he also explained, and I already knew from my reading, that impotence can be treated.
My post surgical pathology report showed the cancer was still Gleason 7=3+4 and contained withing the prostate gland. That was the best possible result under the circumstances. It is now four years after surgery and my PSAs have all be in the undetectable range. There is still a small chance that the cancer will recur, but for all practical purposes, I consider myself cured. Even if it does recur, the chances are that it can be treated by radiation and if not it will take a while for symptoms to develop, at which point hormone therapy would be available. No matter what, I am very likely to die of something other than prostate cancer in the next ten to twenty years. Given that Gleason 7 cancers are generally aggressive, I think that had I not had the cancer diagnosed and treated, there would have been a sizable chance I would have developed advanced metastatic prostate cancer within ten years. I don't know just what that likelihood was, but I do think it would have been too high for me to want to chance it. Advanced prostate cancer is not fun, and the current methods of treating it have limited effectiveness and unpleasant side effects of their own.
> Are > you having any problems as a result from the operation? I was continent within a month of the time the catheter came out (which was two weeks after surgery). I do occasionally have minor problems with stress or urgency incontinence, but overall I am better off in that respect than many men my age who have not had prostate cancer, and I am actually better off than I was before surgery. I was impotent for about 18 months following surgery, but I used a pump during that time and my wife and I resumed our sex life with about the same frequency as before surgery. Since then, I have regained serviceable erections. I can often perform without aid, but 50 mg of Viagra gives me some extra confidence. Overall, considering our age and various other infirmities such as arthritis, I think my wife and I are doing pretty well in that department.
> Regards, > Everett Lech K. Lesiak - 28 Nov 2004 16:24 GMT > actually better off than I was before surgery. I was impotent for about > 18 months following surgery, but I used a pump during that time and my > wife and I resumed our sex life with about the same frequency as before > surgery. Since then, I have regained serviceable erections. I can > often perform without aid, but 50 mg of Viagra gives me some extra > confidence. Overall, considering our age and various other infirmities Glad to hear that impotence after treatment is addressable. I still have enough of a sex drive that I would miss it.
Cheers, Lech
George Conklin - 28 Nov 2004 23:01 GMT > Your urologists were going by the odds. If you do that, usually you will > be right, As you know, once you do a biopsy, depending on age, everyone will be found to have prostate cancer, once the excuse is found to do one, whatever that excuse happens to be. The data run from 8% under 30 to 100% at age 80.
dale.j. - 29 Nov 2004 00:26 GMT > > Your urologists were going by the odds. If you do that, usually you will > > be right, > > As you know, once you do a biopsy, depending on age, everyone will be > found to have prostate cancer, once the excuse is found to do one, whatever > that excuse happens to be. The data run from 8% under 30 to 100% at age 80. According to what I've read only 1 in 6 will be diagnosed with it. It's still a major cancer. Thankfully this is going down due to early detection. Is that good or not?
Dale J.
 Signature Email: dalej2@mac.com
Leonard Evens - 29 Nov 2004 04:20 GMT >>>Your urologists were going by the odds. If you do that, usually you will >>>be right, [quoted text clipped - 6 lines] > still a major cancer. Thankfully this is going down due to early > detection. Is that good or not? About one in six American men will be diagnosed with prostate cancer some time in life. What is going down is the number of American men who die each year of prostate cancer. This is startling because the number of men at risk because of age has gone up. There are a variety of theories as to why this has happened, but one strong possibility is that more men are having their cancers detected earlier and treated. This is consistent with the clinical experience of urologists who report that they are finding that a significantly smaller percentage of their patients first present with cancer which has already metastasized.
> Dale J. Leonard Evens - 29 Nov 2004 04:16 GMT >>Your urologists were going by the odds. If you do that, usually you will >>be right, [quoted text clipped - 3 lines] > that excuse happens to be. > The data run from 8% under 30 to 100% at age 80. This is total nonsense. I have never seen data which suggests that at any age all, or even nearly all, biopsies in living men show evidence of prostate cancer. I can only presume you are confusing biopsy of a living man's prostate with examination of prostates on autopsy. They are very different things. The autopsy data suggest that many men have insignificant cancers, but several studies have shown that the kinds of cancers uncovered in living men through biopsy are generally clinically significant. If you have a reference for a study which confirms the "data" you quote for biopsies on living men, you should give it. Otherwise, keep quiet.
I personally know several men of ages 60 on up to close to 80 who have had negative biopsies. In fact, I know more men who have had negative biopsies than men who have had positive biopsies. That is quite consistent with the actual data about the frequency of biopsies with findings of prostate cancer.
By the way, your figures are suspicious even for autopsy data. There have been several such studies and they report widely divergent numbers. Most authorities would put the percentage well below 100 percent at any age.
Outlivecancer - 10 Dec 2004 08:52 GMT >n
>But if you had followed the urologist's advice and had a >biopsy, it is reasonable to assume that the result would have been >negative. If done correctly a biopsy is a safe and not specially >painful procedure. One certainly shouldn't have one if one doesn't need My PSA was 2.9, the DRE by my uro and subsequent iopsy and RP saved my life,what is the big deal about a biopsy?Now the quality of life issues matter more.
EverettRWadsworth@yahoo.com - 11 Dec 2004 02:23 GMT What quality of life issues are you talking about? What side-effects are you experiencing as a result of your surgery? Regards, Everett
>Outlivecancer wrote: > My PSA was 2.9, the DRE by my >uro and subsequent iopsy and RP saved >my life,what is the big deal about a biopsy?Now the quality of >life issues
>matter more. EverettRWadsworth@yahoo.com - 11 Dec 2004 02:24 GMT What quality of life issues are you talking about? What side-effects are you experiencing as a result of your surgery? Regards, Everett
>Outlivecancer wrote: > My PSA was 2.9, the DRE by my >uro and subsequent iopsy and RP saved >my life,what is the big deal about a biopsy?Now the quality of >life issues
>matter more. Outlivecancer - 14 Dec 2004 13:02 GMT As I was commenting the dre and biopsy were vital my PSA was only 2.9.The quality of life issues are incontinence-not so bad except when tired at night and stress incontinence and slowly unevenly improving ED after 1 1/2 years, plus GIRD from lying down and arthritis from muscle loss-now better.Hassle but am dedicted to learning better lifestyle from all this,thanks for asking.
EverettRWadsworth@yahoo.com - 14 Dec 2004 14:42 GMT Did your uro offer you other treatments besides surgery? If so did your uro lead you to believe surgery was your best option?
>Outlivecancer wrote: >The quality of life issues are incontinence-not so bad except >when tired at night and stress incontinence and slowly >unevenly improving ED after 1 1/2 years, plus GIRD from lying >down and arthritis from muscle loss-now better.Hassle but
>am dedicted to learning better lifestyle from all this,thanks for >asking. Outlivecancer - 20 Dec 2004 19:36 GMT >Did your uro offer you other treatments besides surgery? If so did >your uro lead you to believe surgery was your best option? No and yes,but given 3 straight <0.1PSAs It feels great to be cancer free.How do I argue,but the cancer marked a lifestlye change for me in health consciousness. I eat well and don't smoke,drink.
Lech K. Lesiak - 27 Nov 2004 13:57 GMT > PSA is elevated. It seems to make more sense to me to treat for an > infection first to see if that don't get the PSA down before going to > something invasive as a biopsy. Don't you agree? Has your uro said > anything to you about prostatitis? If so, what has he done to rule out > prostatitis? No, he hasn't. However, since he has a medical degree, is a specialist in urology, I think I'll take his advice rather than second guessing him based on a book I haven't even seen.
Cheers, Lech
Everett R. Wadsworth - 28 Nov 2004 01:34 GMT Let me tell you that I had a high PSA. I went to 5 different highly regarded uros here in a big city. They are all top experts on the prostate with highly regarded credentials. They all came to the same conclusion about my PSA that it was too high and they all suspected prostate cancer. Yes, they all gave me a urinalysis which was negative for any infection. Not one of them wanted to culture the prostatic fluid. They all wanted to biopsy me. If it wasn't for the information I read in the book "Surviving Prostate Cancer Without Surgery" I would have gotten a biopsy with all the risks involved and who knows where I'd be now but instead I demanded culturing of prostatic fluid and had to get it done by a non-urologist and an infection was found and I finally got it treated properly and my PSA returned to zero. If you ask me urologists only act in their own interests and don't seem to want to bother with anything they can't bill for. I will never trust another urologist again no matter how good their credentials are. Regards, Everett
> > PSA is elevated. It seems to make more sense to me to treat for an > > infection first to see if that don't get the PSA down before going to [quoted text clipped - 8 lines] > Cheers, > Lech Lech K. Lesiak - 28 Nov 2004 16:13 GMT > Let me tell you that I had a high PSA. I went to 5 different highly > regarded uros here in a big city. They are all top experts on the [quoted text clipped - 3 lines] > negative for any infection. Not one of them wanted to culture the > prostatic fluid. They all wanted to biopsy me. Maybe they had good reason. I'll ask my uro about this next time I see him.
If it wasn't for the
> information I read in the book "Surviving Prostate Cancer Without > Surgery" I would have gotten a biopsy with all the risks involved and There are risks involved, and it's not a pleasant procedure. I've had five of them, and never had any difficuly except for the expected rectal bleeding.
> returned to zero. If you ask me urologists only act in their own > interests and don't seem to want to bother with anything they can't > bill for. I will never trust another urologist again no matter how > good their credentials are. In Canada they would be paid the same either way so I don't think that's the motivating factor.
Cheers, Lech
dale.j. - 28 Nov 2004 22:44 GMT In article <Pine.A41.4.05.10411280909260.14240-100000@srv1.calcna.ab.ca>,
> > Let me tell you that I had a high PSA. I went to 5 different highly > > regarded uros here in a big city. They are all top experts on the [quoted text clipped - 25 lines] > Cheers, > Lech The doc found it on the first biopsy. I had the RP and at two years A-OK. I'm thankful at this date. My second annual birthday marathon 8 KM run will be Dec 2, you're all invited.
I also echo Leonards posting.
Dale J.
 Signature Email: dalej2@mac.com
Everett R. Wadsworth - 29 Nov 2004 03:28 GMT Yes, a biopsy certainly is an unpleasant procedure. Acquaintances of mine have been thru it and let me know just how unpleasant of a procedure it can be. Rectal Bleeding might be one of the only risks you are aware of and is immediately apparent but there other major risks that you are probably not aware of which Dr. Hennenfent, a leading authority on prostate cancer has uncovered and writes about in his book. Cancer can actually escape out of the prostate by the path left by the needle. One study of 350 men actually showed this in 7 of the men. Another study found in 10% of men prostate cells were being released into the bloodstream during the biopsy. In theory it is also possible partially obstructed prostatic acini which resulted from a silent untreated infection develop into pre-cancerous cells. It is possible that by doing a biopsy it can disperse these cells into the tissue between the acini where they set off prostate cancer. So it's possible repeated biopsies will actually find prostate cancer as the biopsy could be causing it.
So, by having myself "properly" checked for prostatitis from the "proper" culturing of prostatic fluid rather than being rushed to have a biopsy which the uros suggested and is standard practice in the urology profession I avoided all these risks. Perhaps in my case I got lucky but than again I wonder how many needless biopsies are being performed which could quite possibly cause the cancer or its spread when a simple culturing of prostatic fluid for infection is all that's needed. Regards, Everett
> If it wasn't for the > > information I read in the book "Surviving Prostate Cancer Without [quoted text clipped - 3 lines] > five of them, and never had any difficuly except for the expected rectal > bleeding. Leonard Evens - 29 Nov 2004 05:26 GMT > Yes, a biopsy certainly is an unpleasant procedure. Acquaintances of > mine have been thru it and let me know just how unpleasant of a > procedure it can be. Men vary greatly in how they respond to biopsy. Do a google groups search of alt.support.cancer.prostate on the subject. You will find that the great majority of men there had experiences similar to mine. It is not something that one would seek out for the experience, but it is about as unpleasant as a typical dental procedure.
> Rectal Bleeding might be one of the only risks > you are aware of and is immediately apparent but there other major > risks that you are probably not aware of which Dr. Hennenfent, a > leading authority on prostate cancer Dr. Hennenfent may be many things, but he is certainly not a leading authority on prostate cancer. Check his publications with a Medline/Pubmed search, and you will see that he has done little or nothing in that area. I did such a search and found 11 papers listed since 1988. Two of those related to prostate cancer. If you pick any of the known experts on prostate cancer and do a similar search you will find many, many more such papers. Patrick Walsh, for example, has published hundreds of such papers.
> has uncovered and writes about in > his book. Cancer can actually escape out of the prostate by the path [quoted text clipped - 7 lines] > possible repeated biopsies will actually find prostate cancer as the > biopsy could be causing it. All these things are possible, but the upshot is that real authorities don't believe that there is a significant risk that prostate cancer is spread by doing a biopsy. The point is that prostate cancer cells can be released into the bloodstream anyway, by many things, biopsy or not. It is believed that it is only when those cells develop the ability to survive far from their point of origin that metastasis takes place.
I'm aware that studies of the kind you describe do exist because I've seen references to them before. But I did several Medline/Pubmed literature searches with different keywords, and I was unable to find any such references. I did find one reference that was vaguely related, but if anything it showed there was no significant risk of metastasis following biopsy. I conclude that this has not proved to be a viable research topic. You have to understand that there are lots of people doing research in various aspects of prostate cancer. Anything and everything that might be relevant is examined. Any researcher who could provide convincing proof that there was a significant risk of spread of prostate cancer following biopsy would make his reputation then and there. Nothing could prevent others from following up on it. Moreover, the mechanisms behind metastasis are being explored by many active researchers, and they certainly wouldn't ignore this possibility.
> So, by having myself "properly" checked for prostatitis from the > "proper" culturing of prostatic fluid rather than being rushed to have [quoted text clipped - 6 lines] > Regards, > Everett Lech K. Lesiak - 29 Nov 2004 16:19 GMT > Men vary greatly in how they respond to biopsy. Do a google groups > search of alt.support.cancer.prostate on the subject. You will find > that the great majority of men there had experiences similar to mine. > It is not something that one would seek out for the experience, but it > is about as unpleasant as a typical dental procedure. I agree. For me it's about the same as a root canal.
Cheers, Lech
Leonard Evens - 29 Nov 2004 19:27 GMT >>Men vary greatly in how they respond to biopsy. Do a google groups >>search of alt.support.cancer.prostate on the subject. You will find [quoted text clipped - 3 lines] > > I agree. For me it's about the same as a root canal. I found my root canals worse than my biopsy.
> Cheers, > Lech dale.j. - 29 Nov 2004 22:17 GMT > >>Men vary greatly in how they respond to biopsy. Do a google groups > >>search of alt.support.cancer.prostate on the subject. You will find [quoted text clipped - 8 lines] > > Cheers, > > Lech I wish you guys wouldnt talk about root canals (LOL) there is a possibility I may have to have one. I'll know more on Wed. I hate dentists, well, not the person but the work, it's always been a pain, in the mouth and in the pocketbook.
Dale J.
 Signature Email: dalej2@mac.com
Everett R. Wadsworth - 30 Nov 2004 23:01 GMT Yes, Patrick Walsh sure has published hundreds of papers but you are missing the whole point. Dr. Hennenfent is not a urologist like Patrick Walsh is. Dr. Patrick Walsh is a surgeon and his interest is in doing surgery. Dr. Hennenfent has spent 20 years doing research on the diseases of the prostate and on the various treatments being offered. He wrote about his findings in his new book "Surviving Prostate Cancer Without Surgery". Dr Hennenfent's main interest is to understand why prostate cancer occurs in nearly 100% of men if they live long enough and the best possible ways to prevent this from occuring and if it should occur the best treatment possible to prolong the quality of life. Dr. Hennenfent is concerned with the best interests of the patient like you and I and all those patients out there reading this, not the best interests of the urologist which is to do surgery which has never been proven to extend life anyway. Regards, Everett
> Dr. Hennenfent may be many things, but he is certainly not a leading > authority on prostate cancer. Check his publications with a [quoted text clipped - 4 lines] > find many, many more such papers. Patrick Walsh, for example, has > published hundreds of such papers. Leonard Evens - 01 Dec 2004 02:07 GMT > Yes, Patrick Walsh sure has published hundreds of papers but you are > missing the whole point. Dr. Hennenfent is not a urologist like > Patrick Walsh is. Dr. Patrick Walsh is a surgeon and his interest is > in doing surgery. Walsh is a surgeon, but he has interests in all aspects of prostate cancer. Also, working with him at Hopkins are leading figures who are doing research in nonsurgical aspects of prostate cancer. It is just plain wrong to assume that because he is a surgeon, Walsh is only interested in surgical aspects of prostate cancer. He is a major figure in research in prostate cancer.
> Dr. Hennenfent has spent 20 years doing research on > the diseases of the prostate and on the various treatments being > offered. Those 20 years have resulted in very little publishable work.
> He wrote about his findings in his new book "Surviving > Prostate Cancer Without Surgery". Anyone can write a book. Papers in scientific journals have to be reviewed by experts in the field. Peer review is not perfect, but it is the best we have.
> Dr Hennenfent's main interest is to > understand why prostate cancer occurs in nearly 100% of men if they > live long enough That is canard which people keep repeating, but it is not really true. It is based on autopsy findings. There have been several such studies which report varying figures for the percentage of autopsies which show some evidence of prostate cancer. The percentage of men over 80 who show evidence of such cancers is very high, but I don't think there is consensus that it is as high as 100 percent. Be that as it may, there is a vast difference between prostate cancer discovered in an autopsy and prostate cancer clinically detected in living men. Also, all experts, including Walsh, agree that it is seldom true that men over 80 need to be treated aggressively for prostate cancer. So that is really a non-issue.
> and the best possible ways to prevent this from > occuring and if it should occur the best treatment possible to prolong > the quality of life. Dr. Hennenfent is concerned with the best > interests of the patient like you and I and all those patients out > there reading this, not the best interests of the urologist which is > to do surgery which has never been proven to extend life anyway. Actually, in the sense you mean it, NO method of treating prostate cancer has been shown to be effective. There are two questions here which need to be looked at. First, is any there any method which we can be certain is effective at curing early prostate cancer? The way to test this is to take a population of men, randomly divide them into two groups, apply a certain treatment to one of the groups and do nothing for the other group. Then follow them for long enough to determine what might happen. There are several such studies in progress now, but the results are not yet in. A Swedish study did show that radical prostatectomy was more effective in an average 6 year follow up period of avoiding death from prostate cancer than watchful waiting. The study didn't find any difference, however, in overall death rates, and some have tried to draw conclusions from that. Unfortunately, the study period was too short and the differences too small to draw any conclusion of that nature from the data. So the Swedish men would have to be followed further to see what happens in the long run. There is a similar study in the US, but the results are not in yet. In any event, it is not clear that given its 12 year followup period that those men will be followed long enough to really settle the question.
Such randomized studies are considered the gold standard of proof in medical biostatistics. But they are not the only form of evidence. For example, no such study has ever shown that smoking causes lung cancer, yet all authorities agree that it does. Similarly, other kinds of studies do suggest that treatment of early prostate cancer is effective.
There is no convincing evidence that any other method to treat early prostate cancer is more effective than surgery. If Dr. Hennefelt claims otherwise, he is misleading his readers.
The second question is what to do with prostate cancer which has metastasized. There are some hopeful experimental approaches which may provide help in the next several years, but at present the only established method is cutting off male hormones which prostate cells, including most prostate cancer cells, need to grow. That can delay the development of prostate cancer for some period of time, which can vary between a year and over ten years. But ultimately it fails.
There is no convincing evidence that hormone therapy can cure prostate cancer.
The suggestion that Walsh just wants to do surgery and doesn't care about his patients is nonsense. He has treated many men who had prostate cancer, and a very large number of them have done very well. To all intents and purposes, they were cured. The question is how many of those "cured" men would have done well without being treated at all. Certainly some of them would have gone on to advanced prostate cancer and some of those would have died, had Walsh not treated them. Those men clearly benefited. Others might never have had a problem if their cancers had been left alone. I find it implausible, but I have to admit it is possible that the percentage in the first categoy is very small and that in the second category is very large. Today, noone knows just what those percentages are. But it is nonsense to suggest that anyone has anything better to suggest to men who have been diagnosed with an early prostate cancer which is still confined to the prostate.
> Regards, > Everett [quoted text clipped - 7 lines] >>find many, many more such papers. Patrick Walsh, for example, has >>published hundreds of such papers. George Conklin - 01 Dec 2004 10:56 GMT > > Yes, Patrick Walsh sure has published hundreds of papers but you are > > missing the whole point. Dr. Hennenfent is not a urologist like [quoted text clipped - 7 lines] > interested in surgical aspects of prostate cancer. He is a major figure > in research in prostate cancer. Walsh is a major advocate for surgery and to say othewise is simply inaccurate. He is in fact virtually blind to alternatives and if you want to avoid surgery, go to Harvard not Johns Hopkins.
Leonard Evens - 01 Dec 2004 15:12 GMT >>>Yes, Patrick Walsh sure has published hundreds of papers but you are >>>missing the whole point. Dr. Hennenfent is not a urologist like [quoted text clipped - 11 lines] > inaccurate. He is in fact virtually blind to alternatives and if you want > to avoid surgery, go to Harvard not Johns Hopkins. You don't know what you are talking about. You constantly tend to see things in stark black/white categories and you seem unable to make distinctions. Walsh is a surgeon and probably reflects a surgeons bias, but he is not blind, virtually or otherwise, to alternatives.
In Guide to Surviving Prostate Cancer, he is quite positive about radiation as a primary treatment for prostate cancer. In the 80s, radiation was not very successful at treating early prostate cancer, and most urologists reflected that in their recommendations even into the early 90s. The problem was that they couldn't supply an adequate dose to kill the cancer without significant damage to surrounding tissues. But, as Walsh makes clear in his book, modern methods of radiation can focus the radiation on the prostate and avoid damage to surrounding tissues. As a result, much higher radiation doses are applied to the tumor, and the therapy is much more effective. In his book, the only doubt he raises about external radiation is that long term results are not yet in. He makes the point that we just don't know how external radiation compares to surgery for over 10 years, and that is correct. But his book is now four years old, and more data is in. I wouldn't be surprised if he was even more positive about radiation in his next book.
It is true that he is negative about the advantages of brachytherapy over external radiation. I tend to agree with him about that. I don't see a whole lot of point in brachytherapy. If I had chosen radiation, I would have chosen external radiation. Brachytherapy certainly has its advocates, and Walsh may be proved wrong about this.
Walsh is also quite negative about using hormone suppressing therapy as a primary treatment for early prostate cancer. From what I've read, I think he is absolutely correct about this. In this, I believe he reflects wide spread opinion among experts in the treatment of prostate cancer. There is a very small group of oncologists who think hormone therapy is appropriate in such cases, mostly when there is a strong possibility that the cancer has already spread. They may of course be proven correct, but right now I don't see any evidence that they are. Of course, all experts agree that hormone therapy is appropriate for metastatic prostate cancer. Here Walsh thinks that such therapy can be delayed until overt symptoms occur, and he quotes some research supporting that in his book. But there is some current evidence that earlier use may extend life in some cases of metastatic prostate cancer. I think the situation is unclear on that subject, and we shall just have to wait to see what research in the subject reveals.
Walsh is also pretty negative about using surgery or any aggressive treatment to try to cure prostate cancer in older men. He readily admits that such cancers are not likely to cause a problem during the lifetime of the patient and they are better off being treated with watchful waiting followed by hormone therapy if necessary. He even questions whether such men should be given routine PSA tests.
I think you are out of date about Harvard. They are now doing lots of radical prostatectomies at Harvard related hospitals in Boston. Several men who post at alt.support.cancer.prostate have had prostatectomies there. Here is a quote from Harvard's Dana-Farber Cancer Center's website.
"Patients in good health who are younger than 70 years old are usually offered surgery as treatment for prostate cancer."
This is pretty consistent with general practice and certainly with what Walsh does. But some other urologists will suggest surgery in some men over 70. It is really not age that is relevant, but life expectancy. Surgery is usually considered a reasonable choice for men with moderate cancers (Gleason 5-7 and PSA under 10) and a life expectancy of at least 10 years. It is also sometimes suggested for younger men (under 60) with Gleason 8 and/or higher PSAs, although it is not clear it will be helpful in such cases. The argument is that it is the best chance the patient has for a cure, albeit uncertain.
In any event, there is no evidence that any other method of treating early prostate cancer is more effective than surgery at curing the disease. Don't you wonder why no one has suggested a double blind randomized study comparing external radiation or hormone therapy to dummy procedures? It is because they recognize that there is no point in it.
I had given you credit for being consistent about this in believing that there is no proof that any method of treating prostate cancer is superior to watchful waiting (followed by hormone therapy if the cancer metastasizes). If you are one of those who just rail against surgery, I am disappointed in you.
All current methods of treating early prostate cancer aim to effectively destroy the prostate along with any cancer contained therein. Surgery removes it entirely, radiation zaps it, etc. They have very similar side effects because they all basically do the same thing. Any man who wants to have his prostate cancer treated should thoroughly explore the advantages and disadvantages of each available method and choose accordingly. Often the skill and experience of the doctors he has available may be more important than the treatment method. He should not be scared off by words or irrational fears about being "cut".
ron - 01 Dec 2004 02:53 GMT > Dr Hennenfent's main interest is to > understand why prostate cancer occurs in nearly 100% of men if they > live long enough and the best possible ways to prevent this from > occuring and if it should occur the best treatment possible to prolong > the quality of life. Dr. Hennenfent is concerned with the best > interests of the patient like you and I Hi Everett...So what does Dr. Hennenfent recommend as the best treatment for PCa...Best wishes and good health, Ron
Everett R. Wadsworth - 01 Dec 2004 16:04 GMT Dr. Hennenfent does not recommend one best treatment. He would use gleason score, DNA ploidy, PSA among others over time to help determine the rate of growth of the cancer. Surgery would never be an option. Regards, Everett
> > Dr Hennenfent's main interest is to > > understand why prostate cancer occurs in nearly 100% of men if they [quoted text clipped - 5 lines] > Hi Everett...So what does Dr. Hennenfent recommend as the best > treatment for PCa...Best wishes and good health, Ron Leonard Evens - 02 Dec 2004 12:59 GMT > Dr. Hennenfent does not recommend one best treatment. He would use > gleason score, DNA ploidy, PSA among others over time to help > determine the rate of growth of the cancer. Surgery would never be an > option. What other options would he consider? And why would he always exclude surgery?
I am not sure what you mean by DNA ploidy. There is some very recent work on trying to judge the aggressiveness of a prostate cancer using modern DNA technique. Hennenfent is not involved in this research, and I have not seen any indication that it is now being used in clinical settings. It is recognized by everyone that when such technologies become available, they will help enormously by reducing the number of cases which need to be treated aggressively.
The rate of growth of PSA is a criterion used by all people who treat prostate cancer. It is used first of all in order to determine if a biopsy is necessary. There is also some current research (by Catalona and others) which suggests that if PSA grows faster than 2.0 ng/ml in the year preceding diagnosis of prostate cancer, then the cancer is more likely to spread. It would be important, I think, to treat such a cancer immediately rather than following it further. PSA rate of growth is also used o monitor the treatment of advanced metastatic prostate cancer, but that is just to determine if the treatment (by hormone suppressing drugs) is still working. When that treatment fails, as it almost always does, unless the patient dies first of something else, there is not much left to do except try various experimental approaches.
The Gleason score has been used for years to estimate the aggressiveness of prostate cancer.
Unfortunately, none of this information, or even all of it together, can at present, with high reliability in many patients, allow the doctor to determine when more aggressive action is needed. If an early cancer is not treated aggressively, it may metastasize at any point, and then it can't be cured. Whether metastasis will happen ever and when it will happen if it does are impossible to determine given current knowledge.
For older men, it is often worth taking a chance that the cancer will never develop into a problem during the patient's lifetime. For some men in their late 60s with a Gleason 6 tumor and other indications that the cancer is small and non-aggressive, it seems worth following the patient to see what happens. But for most men under 70 and some over 70 in good health, it seems prudent on the basis of current knoweldge to try to eliminate the tumor by aggressive therapy, either surgery or radiation. Such therapy is extremely effective at doing this in a very large number of cases. For example, a man with a Gleason 6 tumor and PSA less than 10, thhe chances of the cancer showing signs of recurring through a PSA rise within 10 years of such treatment is over 90 percent. So there is no question that many men who receive such treatment do well. The open question is how many would do just as well if they were not treated at all. Most urologists and radiation oncologists think, on the basis of the evidence so far, that treatment improves the odds signficantly. Some skeptics dispute that, and perhaps Hennenfelt is one of them. But it is important to remember that at present, no one really knows for sure.
> Regards, > Everett [quoted text clipped - 8 lines] >>Hi Everett...So what does Dr. Hennenfent recommend as the best >>treatment for PCa...Best wishes and good health, Ron ron - 02 Dec 2004 19:25 GMT
> I am not sure what you mean by DNA ploidy. Hi Leonard...Ploidy analysis has been around for a while, it might even be mentioned in Walsh's book. Bostwick Labs is one of the labs that performs this analysis. Basically they look at the biopsy sample and see if the DNA is diploid or aneuploid. If the sample tests as non-diploid, then that is a signal that the PCa may be aggresive. The following link will tell you more...Best wishes and good health, Ron
http://www.bostwicklaboratories.com/patientservices/dna.html
Leonard Evens - 02 Dec 2004 21:02 GMT > > [quoted text clipped - 8 lines] > > http://www.bostwicklaboratories.com/patientservices/dna.html Thanks. I did find the reference in Walsh's book to what he calls microarray analysis, which is presumably related. I also did a Medline/Pubmed search. My impression is that this method does show significant promise, but it is not entirely clear at present how much it adds to standard approaches. It does still seem to me to be somewhat "experimental", but perhaps in a few years it will be standard practice.
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