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Medical Forum / Diseases and Disorders / Prostate Cancer / December 2004

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Lech K. Lesiak - 17 Nov 2004 19:33 GMT
Just got back from my first visit to my new uro.

PSA almost doubled since May  - it clocked in at 10.

I'm up for another biospsy after that elevated result.

I've had five biopsies so far, last one in 2000.

Slightly diff procedure this time.  They will use an anaesthetic and take
12 samples.

Regards,
Lech
Edmonton Alberta
Leonard Evens - 17 Nov 2004 20:43 GMT
> Just got back from my first visit to my new uro.
>
[quoted text clipped - 3 lines]
>
> I've had five biopsies so far, last one in 2000.

Have they done a free PSA test?   Sometimes they can use the results of
that test to decide whether additional biopsies are necessary.  I am
hardly an expert, but it is a bit hard to see how a cancer large enough
to produce that much PSA would be missed 5 times.  Perhaps they are
looking in the wrong part of the prostate.

> Slightly diff procedure this time.  They will use an anaesthetic and take
> 12 samples.
>
> Regards,
> Lech
> Edmonton Alberta
ron - 18 Nov 2004 15:31 GMT
Hi Lech...Your high PSA is too high to be accounted for by normal PSA
"leak" from a large gland.  However, it could be the result of an
infection.  Has your doctor put you on a course of antibiotics and
then remeasured the PSA to see what effect, if any, the antibiotic
had?  Did your doc do a DRE during the visit when the blood was drawn?
If so was it done before or after the blood draw?  Massaging the
prostate prior to the blood draw (DRE, sex, etc) can elevate the PSA.
Is your PSA erratic, does it go up and down?  If so, this would be
consistent with an infection or BPH.

Routine biopsy cannot sample the entire prostate.  The area it does
sample is where PCa most commonly occurs, but some PCas do occur in
non-sampled regions.  If your PSA has been increasing for several
years and infection and BPH have been ruled out as the cause, then
even though biopsy has not found it, there is a good chance that PCa
is present.  There are other things you can do to search for the PCa.
Peritoneal biopsy can probe other areas of the prostate as can color
doppler imaging.  12-sample biopsy is now fairly routine, often higher
sampling rates are used on repeat biopsies.  You might also consider
the uPM3 urine test (Bostwick Labs) and, as Leonard has suggested, a
free PSA test in order to confirm the presence of PCa...Best wishes
and good health, Ron

> Just got back from my first visit to my new uro.
>
[quoted text clipped - 10 lines]
> Lech
> Edmonton Alberta
Lech K. Lesiak - 18 Nov 2004 16:38 GMT
> Hi Lech...Your high PSA is too high to be accounted for by normal PSA
> "leak" from a large gland.  However, it could be the result of an
> infection.  Has your doctor put you on a course of antibiotics and
> then remeasured the PSA to see what effect, if any, the antibiotic
> had?  Did your doc do a DRE during the visit when the blood was drawn?

No DRE.  I have a cyst on my prostate that feels like the stereotypical
cancerous prostate.

> Routine biopsy cannot sample the entire prostate.  The area it does
> sample is where PCa most commonly occurs, but some PCas do occur in
> non-sampled regions.  If your PSA has been increasing for several
> years and infection and BPH have been ruled out as the cause, then
> even though biopsy has not found it, there is a good chance that PCa
> is present.  There are other things you can do to search for the PCa.

I'm scheduled for a 12 sample on Dec 15.

My PSA was steady for ten years varying between 4 and 6.  The 10 I scored
a couple of weeks ago is sudden.

The previous five biopsies I had done over the years were taken all over
the place.  They were generally about six samples, if I recall.

The new uro I have in Edmonton was recommended by the guy I had in Calgary
for ten years, so I have confidence in him.

Cheers,
Lech
Everett R. Wadsworth - 26 Nov 2004 03:23 GMT
Lech,
I was reading in this book "Surviving Prostate Cancer Without Surgery"
that you should rule out prostatitis first as this could be why your
PSA is elevated. It seems to make more sense to me to treat for an
infection first to see if that don't get the PSA down before going to
something invasive as a biopsy. Don't you agree?  Has your uro said
anything to you about prostatitis? If so, what has he done to rule out
prostatitis?
Regards,
Everett

> Just got back from my first visit to my new uro.
>
[quoted text clipped - 10 lines]
> Lech
> Edmonton Alberta
Leonard Evens - 26 Nov 2004 14:17 GMT
> Lech,
> I was reading in this book "Surviving Prostate Cancer Without Surgery"
> that you should rule out prostatitis first as this could be why your
> PSA is elevated.

What you say makes sense, and I believe it is standard practice.

> It seems to make more sense to me to treat for an
> infection first to see if that don't get the PSA down before going to
> something invasive as a biopsy.

Usually that is what your physician will do.  The problem is that a
large number of cases of prostatitis don't respond to antibiotics, and
the patient may not even experience any special symptoms.  It can also
last for a long time.

> Don't you agree?  Has your uro said
> anything to you about prostatitis? If so, what has he done to rule out
> prostatitis?

If an antibiotic doesn't bring down the PSA, or it doesn't come down in
a couple of months on its own, sometimes a free PSA test can help the
doctor to decide whether or not to go to a biopsy.

> Regards,
> Everett
[quoted text clipped - 13 lines]
>>Lech
>>Edmonton Alberta
Everett R. Wadsworth - 26 Nov 2004 22:21 GMT
> > Lech,
> > I was reading in this book "Surviving Prostate Cancer Without Surgery"
> > that you should rule out prostatitis first as this could be why your
> > PSA is elevated.
>
> What you say makes sense, and I believe it is standard practice.

It should be standard practice but my experience has shown me it
isn't.  The majority of uros will not go beyond the urinalysis.  This
rarely shows anything. This is the big mistake that is being made.
Actually the prostatic fluid should be cultured.  How many of you here
have had your prostatic fluid cultured?

> > It seems to make more sense to me to treat for an
> > infection first to see if that don't get the PSA down before going to
[quoted text clipped - 4 lines]
> the patient may not even experience any special symptoms.  It can also
> last for a long time.

Perhaps the reason it's not responding to antibiotics is due to the
fact the antibiotics can't penetrate the prostate since it's so
congested from infection. I saw a diagram of this in this book
"Surviving Prostate Cancer Without Surgery".

> > Don't you agree?  Has your uro said
> > anything to you about prostatitis? If so, what has he done to rule out
[quoted text clipped - 3 lines]
> a couple of months on its own, sometimes a free PSA test can help the
> doctor to decide whether or not to go to a biopsy.

The antibiotic won't bring down the PSA due to my reasons stated above
and now the uro will rule out an infection when most likely there is
one present and go on to a biopsy with all the risks involved with
that.  DOES THAT MAKE SENSE!!!
Regards,
Everett
Leonard Evens - 26 Nov 2004 23:06 GMT
>>>Lech,
>>>I was reading in this book "Surviving Prostate Cancer Without Surgery"
[quoted text clipped - 22 lines]
> congested from infection. I saw a diagram of this in this book
> "Surviving Prostate Cancer Without Surgery".

I got my information from www.nlm.nih.gov/medlineplus/prostatediseases.html
There are links there to a variety of sources of information.  I found
the Mayo Clinic link particularly informative,  but they all say
essentially the same thing.   Acute bacterial prostatitis can usually be
treated by antibiotics.  Chronic prostatitis may or may not be
bacterial, but it is often difficult to treat.  The Mayo Clinic site
does mention the possibility of culturing the prostate fluid or the
semem as well as the urine.   I must admit I am a bit skeptical about
the above book because (1) someone is clearly trying to promote it on
the internet and (2) the website advertising it says some things about
prostate cancer which I know are at best misleading and at worst just
plain wrong.   However,  I did check the author, and he does appear to
specialize in the treatment of prostatitis.  At least he seems to have
written a few papers about that.  So maybe he has something valuable to
say on that subject.   But I still think it is safer to stick with the
sources at the above website as a start and ultimately with my
urologist, whom I respect quite a lot.   Of course,  I don't have a
prostate any longer, so I can't get prostatitis, but I did refer a
friend who had chronic prostatitis to my urologist, and my friend was
happy with his treatment.

>>>Don't you agree?  Has your uro said
>>>anything to you about prostatitis? If so, what has he done to rule out
[quoted text clipped - 10 lines]
> Regards,
> Everett
Everett R. Wadsworth - 28 Nov 2004 01:52 GMT
Leonard,
This is great to hear your friend was happy with his treatment. What
treatment did he receive?
I was curious to know how you came to the decision to have a RP?  Are
you having any problems as a result from the operation?
Regards,
Everett  

> >>>Lech,
> >>>I was reading in this book "Surviving Prostate Cancer Without Surgery"
[quoted text clipped - 58 lines]
> > Regards,
> > Everett
Leonard Evens - 28 Nov 2004 03:59 GMT
> Leonard,
> This is great to hear your friend was happy with his treatment. What
> treatment did he receive?

I'm afraid I don't remember the details, but his prostatitis had been
dealt with the last time I spoke to  him and he was on the way to recovery.

In your other post, you describe how several urologists told you that
with such a high PSA, a biopsy was warranted.   You seem happy that by
not taking their advice, you avoided a biopsy and your problem was dealt
 with.  But if you had followed the urologist's advice and had a
biopsy,  it is reasonable to assume that the result would have been
negative.  If done correctly a biopsy is a safe and not specially
painful procedure.  One certainly shouldn't have one if one doesn't need
it,  but even if you had one unnecessarily,  it is highly unlikely you
would have suffered any long term side effects.  Presumably, having
eliminated prosate cancer as a cause,  your urologists would have looked
again at the possibility of prostatitis.  Needless to say, no surgeon
would have performed a radical prostatectomy with a negative biopsy.

Your urologists were going by the odds.  If you do that,  usually you
will be right,  but on occasion you will be wrong.  They were wrong in
your case,  but it would be a mistake for others to conclude from your
experience that they shouldn't believe what their urologists tell them.

> I was curious to know how you came to the decision to have a RP?

My PSA started rising and over a two year period it jumped from about
2.6 to about 4.5.   That rate of increase suggested a biopsy might be
warranted.  Again, that is going by the odds.  My primary care physician
actually wanted me to wait and have the test done again in a couple of
months,  but I had previously researched the subject and was concerned,
so he referred me to a urologist.  A subsequent test showed a PSA of
3.8.  The urologist, a local doctor who is highly regarded, thought it
was a borderline case and left it up to me whether to follow the PSA
with further tests or to have a biopsy.  He emphasized that the biopsy
was a safe and not very painful procedure.  I chose to have a biopsy
rather than wait.  He was right about the biopsy.  It was no big deal.

Much to my surprise, and to my doctor's, I think,  it showed not only
that I had prostate cancer, but that it was a Gleason 7=3+4, which is at
the top end of what is considered the moderate, treatable range.   My
urologist strongly recommended treating it since I had at least a ten to
fifteen year life expectancy at that time.  Had I not been in such good
health, paradoxically, he might have recommended watchful waiting
instead.  He suggested external radiation or surgery, and I chose
surgery after considering both the likely cure rates and side effects.
  I also liked the idea that I would get some feedback immediately
after surgery from the postsurgical pathology report.  My doctor told me
that if he did the surgery, there might be a 20 percent chance of stress
incontinence and a 2 percent or smaller chance of serious incontinence.
  He also told me that at my age at the time, 67, the chances of my
being permenantly impotent were about 50 percent.  But he also
explained,  and I already knew from my reading,  that impotence can be
treated.

My post surgical pathology report showed the cancer was still Gleason
7=3+4 and contained withing the prostate gland.   That was the best
possible result under the circumstances.  It is now four years after
surgery and my PSAs have all be in the undetectable range.   There is
still a small chance that the cancer will recur, but for all practical
purposes, I consider myself cured.   Even if it does recur, the chances
are that it can be treated by radiation and if not it will take a while
for symptoms to develop, at which point hormone therapy would be
available.   No matter what, I am very likely to die of something other
than prostate cancer in the next ten to twenty years.   Given that
Gleason 7 cancers are generally aggressive,  I think that had I not had
the cancer diagnosed and treated,  there would have been a sizable
chance I would have developed advanced metastatic prostate cancer within
ten years.  I don't know just what that likelihood was, but I do think
it would have been too high for me to want to chance it.  Advanced
prostate cancer is not fun, and the current methods of treating it have
limited effectiveness and unpleasant side effects of their own.

> Are
> you having any problems as a result from the operation?

I was continent within a month of the time the catheter came out (which
was two weeks after surgery).   I do occasionally have minor problems
with stress or urgency incontinence, but overall I am better off in that
respect than many men my age who have not had prostate cancer, and I am
actually better off than I was before surgery.  I was impotent for about
18 months following surgery, but I used a pump during that time and my
wife and I resumed our sex life with about the same frequency as before
surgery.  Since then,  I have regained serviceable erections. I can
often perform without aid, but 50 mg of Viagra gives me some extra
confidence.  Overall, considering our age and various other infirmities
such as arthritis, I think my wife and I are doing pretty well in that
department.

> Regards,
> Everett
Lech K. Lesiak - 28 Nov 2004 16:24 GMT
> actually better off than I was before surgery.  I was impotent for about
> 18 months following surgery, but I used a pump during that time and my
> wife and I resumed our sex life with about the same frequency as before
> surgery.  Since then,  I have regained serviceable erections. I can
> often perform without aid, but 50 mg of Viagra gives me some extra
> confidence.  Overall, considering our age and various other infirmities

Glad to hear that impotence after treatment is addressable.  I still have
enough of a sex drive that I would miss it.

Cheers,
Lech
George Conklin - 28 Nov 2004 23:01 GMT
> Your urologists were going by the odds.  If you do that,  usually you will
> be right,

 As you know, once you do a biopsy, depending on age, everyone will be
found to have prostate cancer, once the excuse is found to do one, whatever
that excuse happens to be.  The data run from 8% under 30 to 100% at age 80.
dale.j. - 29 Nov 2004 00:26 GMT
> > Your urologists were going by the odds.  If you do that,  usually you will
> > be right,
>
>   As you know, once you do a biopsy, depending on age, everyone will be
> found to have prostate cancer, once the excuse is found to do one, whatever
> that excuse happens to be.  The data run from 8% under 30 to 100% at age 80.

According to what I've read only 1 in 6 will be diagnosed with it.  It's
still a major cancer.  Thankfully this is going down due to early
detection.  Is that good or not?

Dale J.

Signature

Email:  dalej2@mac.com

Leonard Evens - 29 Nov 2004 04:20 GMT
>>>Your urologists were going by the odds.  If you do that,  usually you will
>>>be right,
[quoted text clipped - 6 lines]
> still a major cancer.  Thankfully this is going down due to early
> detection.  Is that good or not?

About one in six American men will be diagnosed with prostate cancer
some time in life.   What is going down is the number of American men
who die each year of prostate cancer.  This is startling because the
number of men at risk because of age has gone up.   There are a variety
of theories as to why this has happened, but one strong possibility is
that more men are having their cancers detected earlier and treated.
This is consistent with the clinical experience of urologists who report
that they are finding that a significantly smaller percentage of their
patients first present with cancer which has already metastasized.

> Dale J.
Leonard Evens - 29 Nov 2004 04:16 GMT
>>Your urologists were going by the odds.  If you do that,  usually you will
>>be right,
[quoted text clipped - 3 lines]
> that excuse happens to be.  
> The data run from 8% under 30 to 100% at age 80.

This is total nonsense.  I have never seen data which suggests that at
any age all, or even nearly all, biopsies in living men show evidence of
prostate cancer.  I can only presume you are confusing biopsy of a
living man's prostate with examination of prostates on autopsy.  They
are very different things.  The autopsy data suggest that many men have
insignificant cancers, but several studies have shown that the kinds of
cancers uncovered in living men through biopsy are generally clinically
significant.  If you have a reference for a study which confirms the
"data" you quote for biopsies on living men, you should give it.
Otherwise, keep quiet.

I personally know several men of ages 60 on up to close to 80 who have
had negative biopsies.   In fact,  I know more men who have had negative
biopsies than men who have had positive biopsies.  That is quite
consistent with the actual data about the frequency of biopsies with
findings of prostate cancer.

By the way, your figures are suspicious even for autopsy data.   There
have been several such studies and they report widely divergent numbers.
  Most authorities would put the percentage well below 100 percent at
any age.
Outlivecancer - 10 Dec 2004 08:52 GMT
>n

>But if you had followed the urologist's advice and had a
>biopsy,  it is reasonable to assume that the result would have been
>negative.  If done correctly a biopsy is a safe and not specially
>painful procedure.  One certainly shouldn't have one if one doesn't need      
    My PSA was 2.9, the DRE by my
uro and subsequent iopsy and RP saved
my life,what is the big deal about a biopsy?Now the quality of life issues
matter more.
EverettRWadsworth@yahoo.com - 11 Dec 2004 02:23 GMT
What quality of life issues are you talking about? What side-effects
are you experiencing as a result of your surgery?
Regards,
Everett

>Outlivecancer wrote:
>   My PSA was 2.9, the DRE by my
>uro and subsequent iopsy and RP saved
>my life,what is the big deal about a biopsy?Now the quality of >life
issues
>matter more.
EverettRWadsworth@yahoo.com - 11 Dec 2004 02:24 GMT
What quality of life issues are you talking about? What side-effects
are you experiencing as a result of your surgery?
Regards,
Everett

>Outlivecancer wrote:
>   My PSA was 2.9, the DRE by my
>uro and subsequent iopsy and RP saved
>my life,what is the big deal about a biopsy?Now the quality of >life
issues
>matter more.
Outlivecancer - 14 Dec 2004 13:02 GMT
As I was commenting the dre and biopsy were vital my PSA was only 2.9.The
quality of life issues are incontinence-not so bad except when tired at night
and stress incontinence and slowly unevenly improving ED after 1 1/2 years,
plus GIRD from lying down and arthritis from muscle loss-now better.Hassle but
am dedicted to learning better lifestyle from all this,thanks for asking.
EverettRWadsworth@yahoo.com - 14 Dec 2004 14:42 GMT
Did your uro offer you other treatments besides surgery?  If so did
your uro lead you to believe surgery was your best option?

>Outlivecancer wrote:
>The quality of life issues are incontinence-not so bad except >when
tired at night and stress incontinence and slowly >unevenly improving
ED after 1 1/2 years, plus GIRD from lying >down and arthritis from
muscle loss-now better.Hassle but
>am dedicted to learning better lifestyle from all this,thanks for
>asking.
Outlivecancer - 20 Dec 2004 19:36 GMT
>Did your uro offer you other treatments besides surgery?  If so did
>your uro lead you to believe surgery was your best option?

No and yes,but given 3 straight <0.1PSAs
It feels great to be cancer free.How do I argue,but the cancer marked a
lifestlye change for me in health consciousness.
I eat well and don't smoke,drink.
Lech K. Lesiak - 27 Nov 2004 13:57 GMT
> PSA is elevated. It seems to make more sense to me to treat for an
> infection first to see if that don't get the PSA down before going to
> something invasive as a biopsy. Don't you agree?  Has your uro said
> anything to you about prostatitis? If so, what has he done to rule out
> prostatitis?

No, he hasn't.  However, since he has a medical degree, is a specialist in
urology, I think I'll take his advice rather than second guessing him
based on a book I haven't even seen.

Cheers,
Lech
Everett R. Wadsworth - 28 Nov 2004 01:34 GMT
Let me tell you that I had a high PSA.  I went to 5 different highly
regarded uros here in a big city.  They are all top experts on the
prostate with highly regarded credentials.  They all came to the same
conclusion about my PSA that it was too high and they all suspected
prostate cancer.  Yes, they all gave me a urinalysis which was
negative for any infection.  Not one of them wanted to culture the
prostatic fluid.  They all wanted to biopsy me. If it wasn't for the
information I read in the book "Surviving Prostate Cancer Without
Surgery" I would have gotten a biopsy with all the risks involved and
who knows where I'd be now but instead I demanded culturing of
prostatic fluid and had to get it done by a non-urologist and an
infection was found and I finally got it treated properly and my PSA
returned to zero.  If you ask me urologists only act in their own
interests and don't seem to want to bother with anything they can't
bill for.  I will never trust another urologist again no matter how
good their credentials are.
Regards,
Everett

> > PSA is elevated. It seems to make more sense to me to treat for an
> > infection first to see if that don't get the PSA down before going to
[quoted text clipped - 8 lines]
> Cheers,
> Lech
Lech K. Lesiak - 28 Nov 2004 16:13 GMT
> Let me tell you that I had a high PSA.  I went to 5 different highly
> regarded uros here in a big city.  They are all top experts on the
[quoted text clipped - 3 lines]
> negative for any infection.  Not one of them wanted to culture the
> prostatic fluid.  They all wanted to biopsy me.

Maybe they had good reason.  I'll ask my uro about this next time I see
him.

If it wasn't for the
> information I read in the book "Surviving Prostate Cancer Without
> Surgery" I would have gotten a biopsy with all the risks involved and

There are risks involved, and it's not a pleasant procedure.  I've had
five of them, and never had any difficuly except for the expected rectal
bleeding.

> returned to zero.  If you ask me urologists only act in their own
> interests and don't seem to want to bother with anything they can't
> bill for.  I will never trust another urologist again no matter how
> good their credentials are.

In Canada they would be paid the same either way so I don't think that's
the motivating factor.

Cheers,
Lech
dale.j. - 28 Nov 2004 22:44 GMT
In article
<Pine.A41.4.05.10411280909260.14240-100000@srv1.calcna.ab.ca>,

> > Let me tell you that I had a high PSA.  I went to 5 different highly
> > regarded uros here in a big city.  They are all top experts on the
[quoted text clipped - 25 lines]
> Cheers,
> Lech

The doc found it on the first biopsy.  I had the RP and at two years
A-OK.  I'm thankful at this date.  My second annual birthday marathon 8
KM run will be Dec 2, you're all invited.

I also echo Leonards posting.

Dale J.

Signature

Email:  dalej2@mac.com

Everett R. Wadsworth - 29 Nov 2004 03:28 GMT
Yes, a biopsy certainly is an unpleasant procedure.  Acquaintances of
mine have been thru it and let me know just how unpleasant of a
procedure it can be. Rectal Bleeding might be one of the only risks
you are aware of and is immediately apparent but there other major
risks that you are probably not aware of which Dr. Hennenfent, a
leading authority on prostate cancer has uncovered and writes about in
his book. Cancer can actually escape out of the prostate by the path
left by the needle. One study of 350 men actually showed this in 7 of
the men. Another study found in 10% of men prostate cells were being
released into the bloodstream during the biopsy. In theory it is also
possible partially obstructed prostatic acini which resulted from a
silent untreated infection develop into pre-cancerous cells.  It is
possible that by doing a biopsy it can disperse these cells into the
tissue between the acini where they set off prostate cancer. So it's
possible repeated biopsies will actually find prostate cancer as the
biopsy could be causing it.

So, by having myself "properly" checked for prostatitis from the
"proper" culturing of prostatic fluid rather than being rushed to have
a biopsy which the uros suggested and is standard practice in the
urology profession I avoided all these risks. Perhaps in my case I got
lucky but than again I wonder how many needless biopsies are being
performed which could quite possibly cause the cancer or its spread
when a simple culturing of prostatic fluid for infection is all that's
needed.
Regards,
Everett

>  If it wasn't for the
> > information I read in the book "Surviving Prostate Cancer Without
[quoted text clipped - 3 lines]
> five of them, and never had any difficuly except for the expected rectal
> bleeding.
Leonard Evens - 29 Nov 2004 05:26 GMT
> Yes, a biopsy certainly is an unpleasant procedure.  Acquaintances of
> mine have been thru it and let me know just how unpleasant of a
> procedure it can be.

Men vary greatly in  how they respond to biopsy.  Do a google groups
search of alt.support.cancer.prostate on the subject.  You will find
that the great majority of men there had experiences similar to mine.
It is not something that one would seek out for the experience, but it
is about as unpleasant as a typical dental procedure.

> Rectal Bleeding might be one of the only risks
> you are aware of and is immediately apparent but there other major
> risks that you are probably not aware of which Dr. Hennenfent, a
> leading authority on prostate cancer

Dr. Hennenfent may be many things, but he is certainly not a leading
authority on prostate cancer.    Check his publications with a
Medline/Pubmed search, and you will see that he has done little or
nothing in that area.  I did such a search and found 11 papers listed
since 1988.  Two of those related to prostate cancer.   If you pick any
of the known experts on prostate cancer and do a similar search you will
find many, many more such papers.  Patrick Walsh, for example, has
published hundreds of such papers.

> has uncovered and writes about in
> his book. Cancer can actually escape out of the prostate by the path
[quoted text clipped - 7 lines]
> possible repeated biopsies will actually find prostate cancer as the
> biopsy could be causing it.

All these things are possible, but the upshot is that real authorities
don't believe that there is a significant risk that prostate cancer is
spread by doing a biopsy.  The point is that prostate cancer cells can
be released into the bloodstream anyway, by many things, biopsy or not.
 It is believed that it is only when those cells develop the ability to
survive far from their point of origin that metastasis takes place.

I'm aware that studies of the kind you describe do exist because I've
seen references to them before.  But I did several Medline/Pubmed
literature searches with different keywords, and I was unable to find
any such references.  I did find one reference that was vaguely related,
but if anything it showed there was no significant risk of metastasis
following biopsy.  I conclude that this has not proved to be a viable
research topic.   You have to understand that there are lots of people
doing research in various aspects of prostate cancer.   Anything and
everything that might be relevant is examined.  Any researcher who could
provide convincing proof that there was a significant risk of spread of
prostate cancer following biopsy would make his reputation then and
there.  Nothing could prevent others from following up on it.  Moreover,
the mechanisms behind metastasis are being explored by many active
researchers, and they certainly wouldn't ignore this possibility.

> So, by having myself "properly" checked for prostatitis from the
> "proper" culturing of prostatic fluid rather than being rushed to have
[quoted text clipped - 6 lines]
> Regards,
> Everett
Lech K. Lesiak - 29 Nov 2004 16:19 GMT
> Men vary greatly in  how they respond to biopsy.  Do a google groups
> search of alt.support.cancer.prostate on the subject.  You will find
> that the great majority of men there had experiences similar to mine.
> It is not something that one would seek out for the experience, but it
> is about as unpleasant as a typical dental procedure.

I agree.  For me it's about the same as a root canal.

Cheers,
Lech
Leonard Evens - 29 Nov 2004 19:27 GMT
>>Men vary greatly in  how they respond to biopsy.  Do a google groups
>>search of alt.support.cancer.prostate on the subject.  You will find
[quoted text clipped - 3 lines]
>
> I agree.  For me it's about the same as a root canal.

I found my root canals worse than my biopsy.

> Cheers,
> Lech
dale.j. - 29 Nov 2004 22:17 GMT
> >>Men vary greatly in  how they respond to biopsy.  Do a google groups
> >>search of alt.support.cancer.prostate on the subject.  You will find
[quoted text clipped - 8 lines]
> > Cheers,
> > Lech

I wish you guys wouldnt talk about root canals (LOL) there is a
possibility I may have to have one.  I'll know more on Wed.  I hate
dentists, well, not the person but the work, it's always been a pain, in
the mouth and in the pocketbook.

Dale J.

Signature

Email:  dalej2@mac.com

Everett R. Wadsworth - 30 Nov 2004 23:01 GMT
Yes, Patrick Walsh sure has published hundreds of papers but you are
missing the whole point.  Dr. Hennenfent is not a urologist like
Patrick Walsh is.  Dr. Patrick Walsh is a surgeon and his interest is
in doing surgery.  Dr. Hennenfent has spent 20 years doing research on
the diseases of the prostate and on the various treatments being
offered.  He wrote about his findings in his new book "Surviving
Prostate Cancer Without Surgery".  Dr Hennenfent's main interest is to
understand why prostate cancer occurs in nearly 100% of men if they
live long enough and the best possible ways to prevent this from
occuring and if it should occur the best treatment possible to prolong
the quality of life. Dr. Hennenfent is concerned with the best
interests of the patient like you and I and all those patients out
there reading this, not the best interests of the urologist which is
to do surgery which has never been proven to extend life anyway.
Regards,
Everett

> Dr. Hennenfent may be many things, but he is certainly not a leading
> authority on prostate cancer.    Check his publications with a
[quoted text clipped - 4 lines]
> find many, many more such papers.  Patrick Walsh, for example, has
> published hundreds of such papers.
Leonard Evens - 01 Dec 2004 02:07 GMT
> Yes, Patrick Walsh sure has published hundreds of papers but you are
> missing the whole point.  Dr. Hennenfent is not a urologist like
> Patrick Walsh is.  Dr. Patrick Walsh is a surgeon and his interest is
> in doing surgery.  

Walsh is a surgeon, but he has interests in all aspects of prostate
cancer.  Also, working with him at Hopkins are leading figures who are
doing research in nonsurgical aspects of prostate cancer.  It is just
plain wrong to assume that because he is a surgeon, Walsh is only
interested in surgical aspects of prostate cancer.  He is a major figure
in research in prostate cancer.

> Dr. Hennenfent has spent 20 years doing research on
> the diseases of the prostate and on the various treatments being
> offered.  

Those 20 years have resulted in very little publishable work.

> He wrote about his findings in his new book "Surviving
> Prostate Cancer Without Surgery".  

Anyone can write a book.  Papers in scientific journals have to be
reviewed by experts in the field.   Peer review is not perfect, but it
is the best we have.

> Dr Hennenfent's main interest is to
> understand why prostate cancer occurs in nearly 100% of men if they
> live long enough

That is canard which people keep repeating, but it is not really true.
It is based on autopsy findings.   There have been several such studies
which report varying figures for the percentage of autopsies which show
some evidence of prostate cancer.   The percentage of men over 80 who
show evidence of such cancers is very high,  but I don't think there is
consensus that it is as high as 100 percent.   Be that as it may,  there
is a vast difference between prostate cancer discovered in an autopsy
and prostate cancer clinically detected in living men.   Also, all
experts,  including Walsh, agree that it is seldom true that men over 80
need to be treated aggressively for prostate cancer.  So that is really
a non-issue.

> and the best possible ways to prevent this from
> occuring and if it should occur the best treatment possible to prolong
> the quality of life. Dr. Hennenfent is concerned with the best
> interests of the patient like you and I and all those patients out
> there reading this, not the best interests of the urologist which is
> to do surgery which has never been proven to extend life anyway.

Actually, in the sense you mean it,  NO method of treating prostate
cancer has been shown to be effective.   There are two questions here
which need to be looked at.   First, is any there any method which we
can be certain is effective at curing early prostate cancer?   The way
to test this is to take a population of men, randomly divide them into
two groups,  apply a certain treatment to one of the groups and do
nothing for the other group.  Then follow them for long enough to
determine what might happen.  There are several such studies in progress
now,  but the results are not yet in.   A Swedish study did show that
radical prostatectomy was more effective in an average 6 year follow up
period of avoiding death from prostate cancer than watchful waiting.
The study didn't find any difference, however, in overall death rates,
and some have tried to draw conclusions from that.  Unfortunately,  the
study period was too short and the differences too small to draw any
conclusion of that nature from the data.   So the Swedish men would have
to be followed further to see what happens in the long run.   There is a
similar study in the US,  but the results are not in yet.   In any
event,  it is not clear that given its 12 year followup period that
those men will be followed long enough to really settle the question.

Such randomized studies are considered the gold standard of proof in
medical biostatistics.  But they are not the only form of evidence.  For
example,  no such study has ever shown that smoking causes lung cancer,
yet all authorities agree that it does.  Similarly, other kinds of
studies do suggest that treatment of early prostate cancer is effective.

There is no convincing evidence that any other method to treat early
prostate cancer is more effective than surgery.   If Dr. Hennefelt
claims otherwise, he is misleading his readers.

The second question is what to do with prostate cancer which has
metastasized.   There are some hopeful experimental approaches which may
provide help in the next several years,  but at present the only
established method is cutting off male hormones which prostate cells,
including most prostate cancer cells, need to grow.  That can delay the
development of prostate cancer for some period of time, which can vary
between a year and over ten years.  But ultimately it fails.

There is no convincing evidence that hormone therapy can cure prostate
cancer.

The suggestion that Walsh just wants to do surgery and doesn't care
about his patients is nonsense.   He has treated many men who had
prostate cancer, and a very large number of them have done very well.
To all intents and purposes, they were cured.   The question is how many
of those "cured" men would have done well without being treated at all.
 Certainly some of them would have gone on to advanced prostate cancer
and some of those would have died, had Walsh not treated them.  Those
men clearly benefited.  Others might never have had a problem if their
cancers had been left alone.  I find it implausible,  but I have to
admit it is possible that the percentage in the first categoy is very
small and that in the second category is very large.   Today, noone
knows just what those percentages are.  But it is nonsense to suggest
that anyone has anything better to suggest to men who have been
diagnosed with an early prostate cancer which is still confined to the
prostate.

> Regards,
> Everett
[quoted text clipped - 7 lines]
>>find many, many more such papers.  Patrick Walsh, for example, has
>>published hundreds of such papers.
George Conklin - 01 Dec 2004 10:56 GMT
> > Yes, Patrick Walsh sure has published hundreds of papers but you are
> > missing the whole point.  Dr. Hennenfent is not a urologist like
[quoted text clipped - 7 lines]
> interested in surgical aspects of prostate cancer.  He is a major figure
> in research in prostate cancer.

  Walsh is a major advocate for surgery and to say othewise is simply
inaccurate.  He is in fact virtually blind to alternatives and if you want
to avoid surgery, go to Harvard not Johns Hopkins.
Leonard Evens - 01 Dec 2004 15:12 GMT
>>>Yes, Patrick Walsh sure has published hundreds of papers but you are
>>>missing the whole point.  Dr. Hennenfent is not a urologist like
[quoted text clipped - 11 lines]
> inaccurate.  He is in fact virtually blind to alternatives and if you want
> to avoid surgery, go to Harvard not Johns Hopkins.

You don't know what you are talking about.   You constantly tend to see
things in stark black/white categories and you seem unable to make
distinctions.  Walsh is a surgeon and probably reflects a surgeons bias,
but he is not blind, virtually or otherwise, to alternatives.

In Guide to Surviving Prostate Cancer, he is quite positive about
radiation as a primary treatment for prostate cancer.   In the 80s,
radiation was not very successful at treating early prostate cancer, and
most urologists reflected that in their recommendations even into the
early 90s.  The problem was that they couldn't supply an adequate dose
to kill the cancer without significant damage to surrounding tissues.
But, as Walsh makes clear in his book, modern methods of radiation can
focus the radiation on the prostate and avoid damage to surrounding
tissues.  As a result, much higher radiation doses are applied to the
tumor, and the therapy is much more effective.   In his book, the only
doubt he raises about external radiation is that long term results are
not yet in.  He makes the point that we just don't know how external
radiation compares to surgery for over 10 years, and that is correct.
But his book is now four years old, and more data is in.   I wouldn't be
surprised if he was even more positive about radiation in his next book.

It is true that he is negative about the advantages of brachytherapy
over external radiation.  I tend to agree with him about that.   I don't
see a whole lot of point in brachytherapy.  If I had chosen radiation, I
would have chosen external radiation.  Brachytherapy certainly has its
advocates, and Walsh may be proved wrong about this.

Walsh is also quite negative about using hormone suppressing therapy as
a primary treatment for early prostate cancer.   From what I've read,  I
think he is absolutely correct about this.  In this, I believe he
reflects wide spread opinion among experts in the treatment of prostate
cancer.   There is a very small group of oncologists who think hormone
therapy is appropriate in such cases,  mostly when there is a strong
possibility that the cancer has already spread.   They may of course be
proven correct, but right now I don't see any evidence that they are.
Of course,  all experts agree that hormone therapy is appropriate for
metastatic prostate cancer.   Here Walsh thinks that such therapy can be
delayed until overt symptoms occur, and he quotes some research
supporting that in his book.  But there is some current evidence that
earlier use may extend life in some cases of metastatic prostate cancer.
  I think the situation is unclear on that subject, and we shall just
have to wait to see what research in the subject reveals.

Walsh is also pretty negative about using surgery or any aggressive
treatment to try to cure prostate cancer in older men.   He readily
admits that such cancers are not likely to cause a problem during the
lifetime of the patient and they are better off being treated with
watchful waiting followed by hormone therapy if necessary.  He even
questions whether such men should be given routine PSA tests.

I think you are out of date about Harvard.  They are now doing lots of
radical prostatectomies at Harvard related hospitals in Boston.  Several
 men who post at alt.support.cancer.prostate have had prostatectomies
there.   Here is a quote from Harvard's Dana-Farber Cancer Center's website.

"Patients in good health who are younger than 70 years old are usually
offered  surgery as treatment for prostate cancer."

This is pretty consistent with general practice and certainly with what
Walsh does.  But some other urologists will suggest surgery in some men
over 70.  It is really not age that is relevant, but life expectancy.
Surgery is usually considered a reasonable choice for men with moderate
cancers (Gleason 5-7 and PSA under 10) and a life expectancy of at least
10 years.   It is also sometimes suggested for younger men (under 60)
with Gleason 8 and/or higher PSAs, although it is not clear it will be
helpful in such cases.  The argument is that it is the best chance the
patient has for a cure, albeit uncertain.

In any event, there is no evidence that any other method of treating
early prostate cancer is more effective than surgery at curing the
disease.   Don't you wonder why no one has suggested a double blind
randomized study comparing external radiation or hormone therapy to
dummy procedures?  It is because they recognize that there is no point
in it.

I had given you credit for being consistent about this in believing that
 there is no proof that any method of treating prostate cancer is
superior to watchful waiting (followed by hormone therapy if the cancer
metastasizes).  If you are one of those who just rail against surgery,
I am disappointed in you.

All current methods of treating early prostate cancer aim to effectively
destroy the prostate along with any cancer contained therein.  Surgery
removes it entirely, radiation zaps it, etc.  They have very similar
side effects because they all basically do the same thing.  Any man who
wants to have his prostate cancer treated should thoroughly explore the
advantages and disadvantages of each available method and choose
accordingly.  Often the skill and experience of the doctors he has
available may be more important than the treatment method.   He should
not be scared off by words or irrational fears about being "cut".
ron - 01 Dec 2004 02:53 GMT
> Dr Hennenfent's main interest is to
> understand why prostate cancer occurs in nearly 100% of men if they
> live long enough and the best possible ways to prevent this from
> occuring and if it should occur the best treatment possible to prolong
> the quality of life. Dr. Hennenfent is concerned with the best
> interests of the patient like you and I

Hi Everett...So what does Dr. Hennenfent recommend as the best
treatment for PCa...Best wishes and good health, Ron
Everett R. Wadsworth - 01 Dec 2004 16:04 GMT
Dr. Hennenfent does not recommend one best treatment.  He would use
gleason score, DNA ploidy, PSA among others over time to help
determine the rate of growth of the cancer. Surgery would never be an
option.
Regards,
Everett

> > Dr Hennenfent's main interest is to
> > understand why prostate cancer occurs in nearly 100% of men if they
[quoted text clipped - 5 lines]
> Hi Everett...So what does Dr. Hennenfent recommend as the best
> treatment for PCa...Best wishes and good health, Ron
Leonard Evens - 02 Dec 2004 12:59 GMT
> Dr. Hennenfent does not recommend one best treatment.  He would use
> gleason score, DNA ploidy, PSA among others over time to help
> determine the rate of growth of the cancer. Surgery would never be an
> option.

What other options would he consider?  And why would he always exclude
surgery?

I am not sure what you mean by DNA ploidy.  There is some very recent
work on trying to judge the aggressiveness of a prostate cancer using
modern DNA technique.  Hennenfent is not involved in this research, and
I have not seen any indication that it is now being used in clinical
settings.  It is recognized by everyone that when such technologies
become available, they will help enormously by reducing the number of
cases which need to be treated aggressively.

The rate of growth of PSA is a criterion used by all people who treat
prostate cancer.   It is used first of all in order to determine if a
biopsy is necessary.  There is also some current research (by Catalona
and others) which suggests that if PSA grows faster than 2.0 ng/ml in
the year preceding diagnosis of prostate cancer, then the cancer is more
likely to spread.   It would be important, I think, to treat such a
cancer immediately rather than following it further.   PSA rate of
growth is also used o monitor the treatment of advanced metastatic
prostate cancer, but that is just to determine if the treatment (by
hormone suppressing drugs) is still working.   When that treatment
fails, as it almost always does, unless the patient dies first of
something else,  there is not much left to do except try various
experimental approaches.

The Gleason score has been used for years to estimate the aggressiveness
of prostate cancer.

Unfortunately, none of this information, or even all of it together, can
at present, with high reliability in many patients, allow the doctor to
determine when more aggressive action is needed.   If an early cancer is
not treated aggressively,  it may metastasize at any point, and then it
can't be cured.   Whether metastasis will happen ever and when it will
happen if it does are impossible to determine given current knowledge.

For older men, it is often worth taking a chance that the cancer will
never develop into a problem during the patient's lifetime.   For some
men in their late 60s with a Gleason 6 tumor and other indications that
the cancer is small and non-aggressive, it seems worth following the
patient to see what happens.  But for most men under 70 and some over 70
in good health, it seems prudent on the basis of current knoweldge to
try to eliminate the tumor by aggressive therapy,  either surgery or
radiation.   Such therapy is extremely effective at doing this in a very
large number of cases.   For example, a man with a Gleason 6 tumor and
PSA less than 10,  thhe chances of the cancer showing signs of recurring
through a PSA rise within 10 years of such treatment is over 90 percent.
 So there is no question that many men who receive such treatment do
well.  The open question is how many would do just as well if they were
not treated at all.   Most urologists and radiation oncologists think,
on the basis of the evidence so far,  that treatment improves the odds
signficantly.  Some skeptics dispute that, and perhaps Hennenfelt is one
of them.  But it is important to remember that at present, no one really
knows for sure.   

> Regards,
> Everett
[quoted text clipped - 8 lines]
>>Hi Everett...So what does Dr. Hennenfent recommend as the best
>>treatment for PCa...Best wishes and good health, Ron
ron - 02 Dec 2004 19:25 GMT

> I am not sure what you mean by DNA ploidy.

Hi Leonard...Ploidy analysis has been around for a while, it might
even be mentioned in Walsh's book.  Bostwick Labs is one of the labs
that performs this analysis.  Basically they look at the biopsy sample
and see if the DNA is diploid or aneuploid.  If the sample tests as
non-diploid, then that is a signal that the PCa may be aggresive.  The
following link will tell you more...Best wishes and good health, Ron

http://www.bostwicklaboratories.com/patientservices/dna.html
Leonard Evens - 02 Dec 2004 21:02 GMT
>  
>
[quoted text clipped - 8 lines]
>
> http://www.bostwicklaboratories.com/patientservices/dna.html

Thanks.  I did find the reference in Walsh's book to what he calls
microarray analysis, which is presumably related.   I also did a
Medline/Pubmed search.   My impression is that this method does show
significant promise, but it is not entirely clear at present how much it
adds to standard approaches.   It does still seem to me to be somewhat
"experimental", but perhaps in a few years it will be standard practice.
 
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