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Medical Forum / Diseases and Disorders / Prostate BPH / April 2006

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Basic anatomy and physiology of the prostate - some questions

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Unknown@InvalidISP.gov - 16 Apr 2006 07:27 GMT
While the web has lots of information about bph lots of it is simply
copying from other sites or repeating platitudes and dumbing down
complex functions. Some of the following may be dumb too but perhaps
one of the long term posters has some useful web links or further
information.

I read the various posts (about 500 posts ago) about the prostatic
urethra not being a tube but a duct. I wasn't around at the time but
it seemed to me that this was a distinction without a difference. OTOH
the various methods of TURP (using the word in the generic sense) seem
to work so I must be wrong. How though?

Take your index and middle fingers. Scarify or abrade adjacent parts
of the fingers. You've now got a bloody mess. Ignore the pain. Don't
put anything on the wounds; instead tape the fingers together tightly.
Keep them taped together for a month or so. Hope you don't get an
infection and ignore the smell. At the unveiling you'll find that
you've grown webbed fingers. The skin will grow back with no
distinction between the two fingers. They'll be joined together. If I
understand correctly this is because there is no dividing object (the
skin) and the cells of the underlying tissue on both fingers are the
same.

You see where I'm going here...

So presuming that there's no "skin" (i.e. tube) lining the urethra
wouldn't it simply grow together naturally? Maybe the urine takes the
path of least resistance and simply works it way around the cells of
the prostate?

This is nonsense of course. Every web illustration and every anatomy
book I have shows the urethra as a tube and in fact there's
tantalizing comments about two types of cells: the stroma and another
(endothelial or epithelial?). The stroma is the bulk of the prostate
and the other is the lining of the tube or duct. But that causes
another problem: If the purpose of TURP is to remove tissue
(presumably stroma) won't it cut and destroy the lining of the
urethra? Refer to my finger analogy above for what will happen if this
occurs.

Another tantalizing piece of information is that TURP (generic)
vaporizes or coagulates the tissue. It doesn't say that it creates
scar tissue which would be one way of stopping the sides of the now
de-linered urethra joining together. Whoa! Vaporized? You know what
happens when water vaporizes in the shower. It condenses on a nearby
object. Where does the vaporized prostatic tissue go? Coagulate I just
can't envisage. Liquids coagulate forming solids but the walls of the
urethra are already solid...?

By whatever magical method TURP (generic) cuts out the tissue we still
have a problem. There are lots of ducts feeding into the urethra. Most
of them are tiny providing prostatic fluid as part of the ejaculate (I
presume these are something like the ducts in the female nipple) but
there are two relative biggies: the ejaculatory ducts which join the
prostatic urethra at a point called the "Veru". While big they're not
that big. A tiny piece of scar tissue could easily block both ducts.
In any event any TURP procedure just lops off some section of the
ducts. Doesn't anyone see a problem with this? Something like a stent
would simply obstruct the ejaculatory process altogether. Is this
discussed anywhere or is there something about this that everyone
except me knows?

Remember that comment above about two types of cells? Well, it appears
that there are also two types of hyperplasia (as in bph): one that
concerns the uncontrolled (is it really uncontrolled?) growth of the
stroma which can be shrunk with the DHT blockers and another which is
a growth of the endothelial or epithelial cells (the liner cells). It
sounds like these are like polyps in the colon which I presume are
like skin tags. They can only be removed surgically. Whoa again! If
we've got skin tags growing in the urethra couldn't they be blocking
the ejaculatory ducts anyway?

And why wouldn't the ejaculatory ducts be subject to the same problems
as the urethra: the strangulation by the growth of the stroma and the
polyps from the lining cells? I think I have a partial answer here.
The ejaculatory ducts can be blocked by growths within them (which are
called cysts) but the strangulation by the growing stroma doesn't
occur because the ejaculatory ducts are covered by a muscle sheath at
least up to "shortly" before the veru (no definition of "shortly"
supplied). Depending on how much shortly is doesn't a TURP run the
risk of cutting into the muscle sheath?

Apparently the prostate can't grow outwards because it's enclosed in a
capsule (is this the same as the "surgical capsule"?). This seems very
strange. What other organs are enclosed in capsules? Has anyone ever
thought of removing (or slashing) the capsule to allow outward growth
and avoid the whole problem? Also why is "trans urethral" resection
the way to go (other than open prostactectomy). What's wrong with
laprascopic surgery to suck out some of that excess stroma? Sort of
like liposuction for the prostate.

I'm confused!
Jason - 16 Apr 2006 19:26 GMT
> While the web has lots of information about bph lots of it is simply
> copying from other sites or repeating platitudes and dumbing down
[quoted text clipped - 88 lines]
>
> I'm confused!

I'm sure the other posters can provide a better answer than I could provide
since they have done more research on this subject than I have done. See
if this helps:
When the prostate gland starts to enlarge--it does grow outward. Even if a
surgeon created lots of extra space in your body so that the prostate
could double in size--that would not solve the problem. The reason is
because when a prostate gland starts to expand or enlarge--it does so in
all directions--outward and inward. The inward enlargement of the prostate
is the problem because that is what causes the prostate problems that you
mentioned.
Does this answer at least some of your questions.
Jason

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Pete - 16 Apr 2006 19:56 GMT
Unknown...Dr. Sancha can address most of this if he is still with us.  I
will only address a couple of things.

I won't touch the tube versus a channel formed by the prostate since we
killed that long ago.  Let it suffice to say the urethra is not an organ
like an intestine is.  The prostatic urethra has a protective mucosa lining
it, like most other duct type organs in the body (but the urethra is not an
organ).

I believe that in any of the various prostate reduction techniques, if the
surgeon is adept, he is not supposed to interfere with the veru montanum or
the external sphincter (pertaining to your comment about scar tissue
blocking ducts).

And I believe the prostate can grow outwards as well as inwards.  I don't
know how restrictive the capsule you mention is.  I assume it is expandable,
using my common sense.

Dr. Sancha, if you are still with us, I would be very interested in your
comments on some of the detailed points this person brings up about surgery
"clogging things up", so to speak [excuse the paraphrase :-)].

Pete

> While the web has lots of information about bph lots of it is simply
> copying from other sites or repeating platitudes and dumbing down
[quoted text clipped - 88 lines]
>
> I'm confused!
Unknown@InvalidISP.gov - 17 Apr 2006 05:50 GMT
>Unknown...Dr. Sancha can address most of this if he is still with us.  I
>will only address a couple of things.

>I won't touch the tube versus a channel formed by the prostate since we
>killed that long ago.  Let it suffice to say the urethra is not an organ
>like an intestine is.  The prostatic urethra has a protective mucosa lining
>it, like most other duct type organs in the body (but the urethra is not an
>organ).

>I believe that in any of the various prostate reduction techniques, if the
>surgeon is adept, he is not supposed to interfere with the veru montanum or
>the external sphincter (pertaining to your comment about scar tissue
>blocking ducts).

>And I believe the prostate can grow outwards as well as inwards.  I don't
>know how restrictive the capsule you mention is.  I assume it is expandable,
>using my common sense.

One would think so, but... From:

http://kidney.niddk.nih.gov/kudiseases/pubs/prostateenlargement/

"As the prostate enlarges, the layer of tissue surrounding it stops it
from expanding, causing the gland to press against the urethra like a
clamp on a garden hose."

and from:

http://www.nfcr.org/Default.aspx?tabid=370&ccType=content&ccLinkId=26830

"The prostate is divided into three zones enclosed by a capsule. The
prostate capsule separates the prostate from the rest of the body."

and from:

http://www.cornellurology.com/cornell/bph/

"The prostate is tightly confined within the body by a capsule and
cannot expand outward. Therefore, as the prostate enlarges it is
forced inward, into the urethra. The result is the obstruction of the
urethra and the flow of urine."

These organizations are not exactly lightweights in the medical
business so they should know, eh?

However some sites do admit that the prostate which starts off
"walnut-sized" can expand to lemon-sized. If it expands how can
Cornell say that it "cannot expand outwards". Is it possible that they
consider that expansion downwards or upwards is not outwards? A
remarkable level of hair-splitting if that's the case. OTOH if it
expands outwards then wouldn't this relieve pressure on the urethra?

I'm still confused <g>.
Gordon Burditt - 17 Apr 2006 11:20 GMT
>"The prostate is tightly confined within the body by a capsule and
>cannot expand outward. Therefore, as the prostate enlarges it is
>forced inward, into the urethra. The result is the obstruction of the
>urethra and the flow of urine."

So how does my doctor conclude "you have a large prostate" by poking
around with his finger, if it can't expand outwards?  And he didn't
poke it down my urethra (you'd probably have heard me screaming
in Australia and France if he did that)..

If some people have trouble with a 50 gram prostate, why can others
have a 120 gram prostate without the capsule exploding and/or the
urethra being blocked completely?

>However some sites do admit that the prostate which starts off
>"walnut-sized" can expand to lemon-sized. If it expands how can
>Cornell say that it "cannot expand outwards". Is it possible that they
>consider that expansion downwards or upwards is not outwards? A
>remarkable level of hair-splitting if that's the case. OTOH if it
>expands outwards then wouldn't this relieve pressure on the urethra?

It might be like blowing up a balloon.  It expands (some), but the
pressure exerted by the balloon skin (capsule) increases the more
air (prostate contents) you put in it, and this puts increasing
pressure on the urethra.

>I'm still confused <g>.

                    Gordon L. Burditt
Jason - 17 Apr 2006 17:47 GMT
> >Unknown...Dr. Sancha can address most of this if he is still with us.  I
> >will only address a couple of things.
[quoted text clipped - 49 lines]
>
> I'm still confused <g>.

You raised some issues that I had not considered prior to your post. I
read a report indicating that doctors can determine how much inward growth
(and eventually into the urethra) by determining the outward size of the
prostate gland. This leads me to believe that as the prostate expands--it
expands in all directions--including inward and outward. One poster
mentioned that the prostate can already expand to the size of lemon. That
proves that there is already room for some expansion. Do you know whether
or not men have developed the symptoms of BPH when the prostate gland is
still smaller than a lemon?
Jason

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Pete - 18 Apr 2006 00:20 GMT
>>> Unknown...Dr. Sancha can address most of this if he is still with
>>> us.  I will only address a couple of things.
[quoted text clipped - 59 lines]
> expansion. Do you know whether or not men have developed the symptoms
> of BPH when the prostate gland is still smaller than a lemon?

Absolutely Jason...did you already forget what chockman wrote in your other
post and I reconfirmed it.  No malice intended :-) ...Pete

> Jason
Jason - 18 Apr 2006 15:56 GMT
> >>> Unknown...Dr. Sancha can address most of this if he is still with
> >>> us.  I will only address a couple of things.
[quoted text clipped - 62 lines]
> Absolutely Jason...did you already forget what chockman wrote in your other
> post and I reconfirmed it.  No malice intended :-) ...Pete

Pete,
I read it but my memory is not perfect. I learn more every day. The
doctor's post was great. I respect you.
Jason

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Pete - 19 Apr 2006 02:34 GMT
>>>>> Unknown...Dr. Sancha can address most of this if he is still with
>>>>> us.  I will only address a couple of things.
[quoted text clipped - 70 lines]
> doctor's post was great. I respect you.
> Jason

Thanks Jason...Stick around.  Dr. Sancha is a definite plus for the group.
I told you this was a good group :-) ...Pete
Jason - 19 Apr 2006 03:43 GMT
> >>>>> Unknown...Dr. Sancha can address most of this if he is still with
> >>>>> us.  I will only address a couple of things.
[quoted text clipped - 73 lines]
> Thanks Jason...Stick around.  Dr. Sancha is a definite plus for the group.
> I told you this was a good group :-) ...Pete

You were correct. I have a question for you.
A patient has a prostate gland that is the size of a lemon. At this point,
there are no symptoms of BPH. If a surgean was able to cut away the
OUTSIDE of the prostate gland once (or more) a year so that it was reduced
to the normal size--would that patient ever develop BPH?
Jason

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Pete - 21 Apr 2006 00:59 GMT
>>>>>>> Unknown...Dr. Sancha can address most of this if he is still
>>>>>>> with us.  I will only address a couple of things.
[quoted text clipped - 83 lines]
> to the normal size--would that patient ever develop BPH?
> Jason

I have no idea Jason.  That is a very hypothetical and profound question.
Maybe Dr. Sancha will respond...Pete
Rich256 - 21 Apr 2006 02:54 GMT
>>>>>>>> Unknown...Dr. Sancha can address most of this if he is still
>>>>>>>> with us.  I will only address a couple of things.
[quoted text clipped - 77 lines]
> I have no idea Jason.  That is a very hypothetical and profound question.
> Maybe Dr. Sancha will respond...Pete

I can't imagine how cutting away the outside would affect tissue on the
inside causing BPH.

I was looking at a model of various size prostates yesterday.  I would
agree with a description of a normal one being the size of a plum and an
enlarged might be the size of a lemon.

It was a set like this:

http://www.gpianatomicals.com/models/300.htm
Jason - 21 Apr 2006 06:35 GMT
> >>>>>>>> Unknown...Dr. Sancha can address most of this if he is still
> >>>>>>>> with us.  I will only address a couple of things.
[quoted text clipped - 19 lines]
> >>>>>>>
> >>>>>>> and from:

http://www.nfcr.org/Default.aspx?tabid=370&ccType=content&ccLinkId=26830

> >>>>>>> "The prostate is divided into three zones enclosed by a capsule.
> >>>>>>> The prostate capsule separates the prostate from the rest of the
[quoted text clipped - 62 lines]
>
> http://www.gpianatomicals.com/models/300.htm

My memory is not perfect but I seem to recall that the doctor stated in
his most recent post that he has seen some prostate glands that were the
size of an orange.

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Pete - 22 Apr 2006 01:32 GMT
> I can't imagine how cutting away the outside would affect tissue on
> the inside causing BPH.
[quoted text clipped - 6 lines]
>
> http://www.gpianatomicals.com/models/300.htm

Rich...I don't even want to think of what that little "gem" costs :-):-)
...Pete
Rich256 - 22 Apr 2006 03:44 GMT
>> I can't imagine how cutting away the outside would affect tissue on
>> the inside causing BPH.
[quoted text clipped - 9 lines]
> Rich...I don't even want to think of what that little "gem" costs :-):-)
> ...Pete

It was sitting on a shelf by the window in the room I was in while
waiting for the Dr. to show up.
Temujin - 21 Apr 2006 13:01 GMT
>A patient has a prostate gland that is the size of a lemon. At this point,
>there are no symptoms of BPH. If a surgean was able to cut away the
>OUTSIDE of the prostate gland once (or more) a year so that it was reduced
>to the normal size--would that patient ever develop BPH?
According to Dr. Sancha's post earlier in this thread, the outer part
of the enlarged prostate is the original prostatic tissue, while all of
the hyperplasic growth is on the inside.  If you took away the outside,
you would be left with the still-growing hyperplasic tissue (and maybe
no prostate function), so you would probably have to get the process
redone or get BPH anyway.  Who wants to get surgery once (or more) a
year anyway, just to avoid a procedure that we know works?
Jason - 21 Apr 2006 18:06 GMT
> >A patient has a prostate gland that is the size of a lemon. At this point,
> >there are no symptoms of BPH. If a surgean was able to cut away the
[quoted text clipped - 7 lines]
> redone or get BPH anyway.  Who wants to get surgery once (or more) a
> year anyway, just to avoid a procedure that we know works?

Thanks for your post. That makes sense.
Jason

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fgomsan@gmail.com - 17 Apr 2006 19:51 GMT
Dear Unk,

Too many complex and metaphysical questions for a relatively simple
subject. This urethral lining problem mesmerizes a lot of patients. I
will try to help.

1. prostatic urethral lining.
If you think of the prostatic urethra as the throat of a boy, and of
the prostatic hyperplasia as the tonsils in a boy's throat, you will
quickly understand that removing the hyperplastic tissue works exactly
as removing the tonsils. You have to cut through the epithelial lining
of the prostatic urethra to reach the hyperplastic tissue. When you
finish there is a wound in both cases, there is a surface that needs to
undergo repairs, and the borders of the wound start to grow new
epithelial cells that will eventually cover the wound surface. if you
look inside the boy's throat just after the operation you will see two
wound surfaces, if you look inside the prostatic urethra after TURP or
PVP, there is a 360º wound surface. After tonsillectomy, it is
impossible for those surfaces to stick together, because they are never
in contact. After TURP or PVP it is theoretically possible that two
surfaces in contact could develop adherences, but this is extremely
rare. TURP and PVP cavities usually have a diameter of 2-3 cm, so
surfaces do not stick together, and the urine gets between these
surfaces, making it difficult to develop adherences.

2. Prostatic ducts obstruction
Prostatic ducts can become obstructed, the glands keep secreting and
then you have a retention cyst. They are very common and easy to see
with ultrasound of the prostate. You can also see retention cysts after
TURP.  So some of these ducts get obstructed with the surgery as you
sugggest, but this does not derive into major clinical problems.
A TURP could cut the ejaculatory ducts if it is very aggressive and
penetrates the so called central zone of the prostate, but usually TURP
and PVP are restricted to the hyperplastic tissue, that derives from
the transitional zone of the prostate. So it is relatively rare to
obstruct the ejaculatory ducts with prostatic surgery. It is not a
cause of much concern for patients or urologists. Some young people
suffer obstruction of the ejaculatory ducts after infections, or for
unknown causes and they notice they ejaculate less volume of semen, and
they have fertility problems, but this obstruction rarely causes pain
or other symptoms.

3. prostatic urethra as a tube or duct:
I have not seen two prostatic urethras looking exactly the same. They
tend to be different, as prostatic shapes vary from person to person.
You never see two mouths that are exactly the same, do you? Some
prostatic urethras look from the inside like an open tube, other
prostatic urethras are not an open tube, but an obstructed tube,
because there are two masses of tissue that grow from the sides and
coapt in the midline. Some urethras look like a tube with a full
bladder (there is pressure inside the prostatic urethral lumen and it
opens up) and as a colapsed tube when the bladder is empty. In the
embryo, the urethra is a tube that is only lined with epithelial cells.
Then some buds start to develop from the urethra and these buds invade
the surrounding mesenchyma (this is the name of embryonal tissue that
has not yet differenciated into a mature tissue). These buds are hollow
bags of epithelial cells that will later differenciate into the
prostatic glands (the parenchyma - the glandular tissue) - these cells
will secrete the prostatic secretion, and will produce the famous PSA.
The surrounding tissue will differenciate into the prostatic stroma
(collagen, smooth muscle fibers, elastin, and other components) - a
scaffold that will support the prostatic glands.

4. TURP and PVP and vaporization
TURP and PVP are performed with surgical instruments that allow for
continuous irrigation of the prostatic urethra and bladder. When tissue
is vaporized with a greenlight laser, or cut with a TURP resectoscope,
there are many tissue particles that float in this irrigation fluid and
are taken out of the patient through the scope. They just do not
condensate. TURP and PVP destroy the urethral lining (the correct word
should be endothelial - rather than epithelial, endo means inside, and
epi outside, so the epithelium applies to the skin, and the endothelium
to all "internal skins", it is used for any lining of internal organs),
but this epithelium grows again and when you look inside after some
time, you see it has regenerated completely. In some areas there is
some scar tissue, specially after TURP, but as it happens with wounds
in the skin, the regenerative process manages to cover the wound
surface completely.

5. Prostatic capsule.
The prostate does not have a proper capsule. It is surrounded by
fascial sheaths that are almost only visible under the microscope.

In a 20 year old prostate, there is an area near the bladder neck,
surrounding the urethral endothelium, the transitional zone, that will
be the origin of the benign hyperplastic tissue. It will start to grow
and it will progressively push the original prostatic tissue outwards.
In an old man with a big prostate, this growth of tissue from the area
surrounding the urethra will have pushed the original prostatic tissue
outwards, and between these two parts of the prostate, the central
hyperplastic tissue and the external original prostatic tissue there is
a very clear cleavage plane. When an open prostatectomy is performed,
the surgeon incises the prostate until he reaches this cleavage plane,
and then uses his finger to enucleate the hyperplastic tissue, he
breaks the urethra and extracts the BPH tissue with a hole in the
middle (like a donut) - the urethra. Then the incission is closed with
a suture. This gives the impression of a "surgical capsule", that is
tipically 5-10 mm thick, and this is really the original prostate.
We surgeons talk about the capsule knowing that we refer to the
original prostatic tissue. When we perform TURP (well, I do not perform
TURP any longer) or PVP, we want to reach the "capsule" (the surgical
capsule), to make sure we remove all the hyperplastic tissue.
Apparently, some prostates are more distensible than others, and that
explains in part that some men with relatively small prostates are very
obstructed (the growth is not able to push the prostate outwards, so it
obstructs the urethral lumen) and some men with much bigger prostates
can urinate very well (a more distensible original prostate allows this
tissue to enlarge the prostate, and the urethra is not so compressed).
This also happens with e.g. kidney tumors. A tumor inside the kidney
can push the renal tissue and compress it and when you look at the
kidney it appears to be encapsulated, but what you see is renal tissue
that has been compressed and seems to form a capsule around the tumor.
Open prostatectomies on very big prostates are like opening the skin of
an orange (the surgical capsule or the original prostatic tissue) and
extracting the flesh (the hyperplastic tissue)...

6.- liposuction of the prostate...

Prostatic tissue is quite elastic, but it is also quite rubery or
tough... there is no way of performing what you suggest...The
hiperplastic tissue is a benign tumor of the prostate, it has stroma
(collagen, muscle fibres, etc..) and parenchyma (glandular tissue).
Ellen Shapiro from new york has been studying the proportion of stroma
and parenchyma in BPH, a difficult question to investigate.... but
there are two components also in BPH. The smooth muscle in the stroma
responds with relaxation to alpha blockers. The glandular tissue
responds to finasteride with atrophy. Both mechanisms derive in
symptoms improvement in patients through different mechanisms.

It is a pity these google groups do not allow for drawing. It would be
very nice to use some drawings to explain these things.

My best wishes to all, I hope this was helpful.

Fernando Gómez Sancha
http://drgomezsancha2.blogspot.com
Jason - 17 Apr 2006 23:50 GMT
> Dear Unk,
>
[quoted text clipped - 132 lines]
> Fernando G=F3mez Sancha
> http://drgomezsancha2.blogspot.com

Fernando,
Thanks for your excellent post. I learned some things that I did not
know as a result of your post.
jason

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Pete - 18 Apr 2006 02:04 GMT
Dr. Sancha...Your response was awesome as usual.  Thanks so much, and I
loved your comment about the metaphysics :-) .  It is great to hear from you
again, and this is a great thread, and "unknown" raised some good points
which you have certainly helped to clarify.  I really liked your para 5 on
the capsule (and surgical capsule, versus sheath, etc), and I reread it
several times.  I am going to make a "physics" type comment on the growth of
the prostate in response to "unknowns" comments he made earlier in regards
to the apparent misuse of the term capsule, and the outward/inward stuff
that he quoted from the three credible web sites.  I get the idea that all
three of those web sites are misusing the word capsule, but I am really not
sure.  I believe you refer to the capsule as "the original prostatic
tissue", as you put it.

I look at it this way.  First let me say things in nature can grow in
different manners (both in plants and animals).  Trees grow from the top up,
whereas grass blades grow from the bottom up.  You indicate how the prostate
grows in para 5, and I think I understand it after reading it several times
(ie the dividing cleavage plane, etc).

However, no matter how something grows, I see it as continuously growing
until it sees a resistance.  This is simple physics.  I think the prostate
does grow in all directions (even if it is the inner "hyperplastic tissue"
pushing the outer "original prostatic tissue" outward - I hope I said that
right).  But if you will bear with me, I think "inward" and "outward" tend
to become meaningless in a sense.  In other words the growing part (which is
inside the original tissue) will keep expanding in whatever direction it can
until it sees a resistance that will not "expand" or "yield" any more.

Now, how far the original tissue (which I believe is the capsule that the
web sites were referring to) will expand, will determine how much the inner
hyperplastic tissue will start closing off the urethra.  So I believe the
hyperplastic tissue does grow in all directions and it keeps pushing outward
as long as it can, until it sees a resistance that wont let it go in that
direction any longer and then it can only push (or grow) inward.  I would
also like to note that it seems to me even after it hits a hard resistance,
that it would still try to keep growing outward, and compress tissue in that
area similar to the kidney tumor you mentioned - am I correct?

Sorry about all that, but I was trying to be very clear :-) .  I have also
made an in-line comment after your para 1, about surfaces sticking together
after surgery.

Pete

> Dear Unk,
>
[quoted text clipped - 20 lines]
> cm, so surfaces do not stick together, and the urine gets between
> these surfaces, making it difficult to develop adherences.

Dr. Sancha...I have always wondered about surfaces sticking together (or
"healing shut" as I used to say) after surgery (all kinds of surgery - not
just prostate - eg nasal passages etc).  A 2-3 cm diameter hole is pretty
big hole (2.54 cm equal one inch) but when the urethra is in the relaxed
mode (ie you are not peeing), couldn't the tissue forming the channel
collapse on itself so to speak, or is what's left of the prostate too stiff
for that.  And like you said if it did try to start sticking, would it get
loosened up when you urinate.  In my TURP, the uro said he remove very
little (and my prostate was already small), so I would think there would be
a much greater chance for the surfaces to heal shut later on - does this
make sense.

I have had several nose surgeries in my life and when they remove turbinates
(for example), I guess it's the cotton they jam up your nose that prevents
the sticking together syndrome, but the cotton comes out in a couple or
three days, and I always wondered if the healing process (which has just
started) could still cause the closing off to take place.  This applies to
so many other types of surgery also, and is interesting at best.  I guess
that's why you surgeons make all the big bucks, until someone screams "it
didn't work" :-) :-) .  Thanks again Dr. Sancha, and I apologize to everyone
for my rambling again.  You know me :-) ...Pete

> 2. Prostatic ducts obstruction
> Prostatic ducts can become obstructed, the glands keep secreting and
[quoted text clipped - 111 lines]
> Fernando Gómez Sancha
> http://drgomezsancha2.blogspot.com 
Temujin - 18 Apr 2006 02:23 GMT
>Dr. Sancha wrote:
>TURP and PVP cavities usually have a diameter of 2-3 cm, so
>surfaces do not stick together, and the urine gets between these
>surfaces, making it difficult to develop adherences.

Dr. Sancha,

Many thanks for an extremely informative post.  Did you mean to say a
2-3 mm cavity diameter?  2-3 cm is about an inch (2.54 cm) which seems
awfully large.  How long does the healing of the epithelial layer take?
I had a PVP almost a month ago and still have a lot of discomfort (not
really a burning, but a very intense sensation) at the end of
urination.  It hasn't really improved since a few days after surgery.
Otherwise, the results are amazing.  I never peed like this, even as a
teenager!  And no retro, which has surprised me.
Unknown@InvalidISP.gov - 18 Apr 2006 07:13 GMT
>Dear Unk,

Is that the Russian version of "Uncle"? Just joking.

Thank you for taking the time to respond to my rather confused post. I
was just about to suggest to Pete that you probably wouldn't as I was
really asking for a condensed course in urology but then you came
through. I'll need a little time to absorb what you've written but
some questions that already come to mind are included in-line below.

At the end you suggest drawings. You might want to look at

http://www.prostate.com.ph/anatomy_prostate_diseases.htm

I'm not sure I buy this guy's theories but he has some interesting
drawings of the anatomy of the prostate including identification of
such items as the transitional zone (scroll down).

>Too many complex and metaphysical questions for a relatively simple
>subject. This urethral lining problem mesmerizes a lot of patients. I
>will try to help.

>1. prostatic urethral lining.
>If you think of the prostatic urethra as the throat of a boy, and of
[quoted text clipped - 14 lines]
>surfaces do not stick together, and the urine gets between these
>surfaces, making it difficult to develop adherences.

OK, I think I'm clear there although I wonder where the epithelial
cells come from to re-grow the urethra. (A problem similar to severe
skin burns.)

>2. Prostatic ducts obstruction

>Prostatic ducts can become obstructed, the glands keep secreting and
>then you have a retention cyst. They are very common and easy to see
>with ultrasound of the prostate. You can also see retention cysts after
>TURP.  So some of these ducts get obstructed with the surgery as you
>sugggest, but this does not derive into major clinical problems.

Huh! See below.

>A TURP could cut the ejaculatory ducts if it is very aggressive and
>penetrates the so called central zone of the prostate, but usually TURP
[quoted text clipped - 6 lines]
>they have fertility problems, but this obstruction rarely causes pain
>or other symptoms.

I'm not quite sure what a cyst is although I had one removed from my
elbow recently and my wife has them in her breasts. I suppose all that
one needs to know is that they're some type of non-cancerous growth
somewhere between a pimple and a skin tag. If I understand correctly
the ejaculatory ducts drain into the central zone and the destruction
of tissue is on the other side of the urethra in the transitional zone
(working on the drawings on the website I quoted above). I presume
this also means that hyperplastic tissue in the urethra cannot
obstruct the ejaculatory ducts?

Is the ultrasound of the prostate you mention in the paragraph about
prostatic ducts the TRUS procedure; i.e. relatively painless, quick
and simple?

Now we get to the nasty part. Personally if I suffer from bph at all
it's very minor but I do suffer from reduced (very much so) ejaculate
to the point where I now put out maybe a wet spot (aka prostate dust)
after much long effort. This is down from a tablespoon or more eight
to ten years ago (I'm in my mid-sixties). This is extremely
disconcerting to me and even repeated visits to my pcp with trials of
every possible medication that might help and to a urologist
specializing in sexual problems who informed me that "Medical science
can do nothing for you" I have not even the glimmer of a solution in
sight. Naturally your, "It is not a cause of much concern for patients
or urologists" and your flippant disregard of the obstruction of the
prostatic ducts is like a red flag to a bull (being Spanish you should
understand the figure of speech <g>). I regard sex as so important
that only a life-threatening situation would cause me to do anything
that would result in any interference with the process. And, despite
some PC comments by people who should know better, orgasm (the only
reason to have sex) is dependent upon duration of ejaculation and
duration is dependent upon quantity. Less quantity, shorter duration,
less pleasure.

I'm getting to the end of possible medical solutions although I have
yet to try L-Dopa (pcp doesn't think it would be appropriate),
Apomorphine (difficult to obtain in the US and extremely expensive),
and TRT (my T levels are mid-range as are all the other hormone
levels) so I had a thought that maybe I'm actually ejaculating more
but it's being forced back into the bladder due to weakness in the
bladder neck. The only (miniscule I agree) evidence for this is that
my urine is very frothy especially the first pee of the morning. OTOH
it's not more so immediately after sex. Still no one says that frothy
urine (cloudy, yes) is an indication of retrograde ejaculation. And
then it hit me (a "eureka" moment): If the prostatic urethra in bph
can become obstructed why not the ejaculatory ducts? Maybe I have huge
bloated seminal vesicles that have been trying to deliver their load
for years but their outlet has been closed off? Well it's worth some
investigation, hence my presence here and my question above about a
TRUS test.

There's an interesting site about ejaculatory duct blockage at

http://www.ejaculatoryductobstruction.org/

and a very informative paper by Paul Turek in pdf form at:

http://urology.ucsf.edu/patientGuides/pdf/maleInf/Treatment_Ejac_Duct.pdf

Unfortunately they too seem to think that the reason for sex is other
than pleasure.

>3. prostatic urethra as a tube or duct:

>I have not seen two prostatic urethras looking exactly the same. They
>tend to be different, as prostatic shapes vary from person to person.
>You never see two mouths that are exactly the same, do you?

Like snowflakes, nothing in nature is *exactly* the same but, although
I haven't made a study of it, I'd say all the mouths I've see have
been the same, commonly speaking. The landmarks--teeth, tongue, throat
opening, etc-- are the same.

> Some
>prostatic urethras look from the inside like an open tube, other
[quoted text clipped - 3 lines]
>bladder (there is pressure inside the prostatic urethral lumen and it
>opens up) and as a colapsed tube when the bladder is empty.

Given that the external sphincter is the thing that stops urine
leaking out, isn't the prostatic urethra simply an extension of the
bladder and thus would be full of urine normally? Except immediately
after ejaculation (presuming good bladder neck control).

> In the
>embryo, the urethra is a tube that is only lined with epithelial cells.
[quoted text clipped - 7 lines]
>(collagen, smooth muscle fibers, elastin, and other components) - a
>scaffold that will support the prostatic glands.

>4. TURP and PVP and vaporization

>TURP and PVP are performed with surgical instruments that allow for
>continuous irrigation of the prostatic urethra and bladder. When tissue
[quoted text clipped - 10 lines]
>in the skin, the regenerative process manages to cover the wound
>surface completely.

>5. Prostatic capsule.

>The prostate does not have a proper capsule. It is surrounded by
>fascial sheaths that are almost only visible under the microscope.

>In a 20 year old prostate, there is an area near the bladder neck,
>surrounding the urethral endothelium, the transitional zone, that will
[quoted text clipped - 11 lines]
>a suture. This gives the impression of a "surgical capsule", that is
>tipically 5-10 mm thick, and this is really the original prostate.

This is an explanation of why Cornell think that the prostate can't
expand outwards. If I understand your paragraph correctly the original
prostate doesn't expand at all but it's pushed outwards by the new
tissue in the transitional zone. They're splitting hairs.

>We surgeons talk about the capsule knowing that we refer to the
>original prostatic tissue. When we perform TURP (well, I do not perform
[quoted text clipped - 13 lines]
>an orange (the surgical capsule or the original prostatic tissue) and
>extracting the flesh (the hyperplastic tissue)...

>6.- liposuction of the prostate...

>Prostatic tissue is quite elastic, but it is also quite rubery or
>tough... there is no way of performing what you suggest...The
[quoted text clipped - 6 lines]
>responds to finasteride with atrophy. Both mechanisms derive in
>symptoms improvement in patients through different mechanisms.

>It is a pity these google groups do not allow for drawing. It would be
>very nice to use some drawings to explain these things.

>My best wishes to all, I hope this was helpful.

Very. Thanks once again.

>Fernando Gómez Sancha
>http://drgomezsancha2.blogspot.com
 
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