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Medical Forum / Diseases and Disorders / Prostate BPH / March 2006

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Kidney related questions/comments for Dr. Sancha

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Pete - 22 Feb 2006 03:33 GMT
Hi Dr. Sancha (and everyone else),

I think you know how much I respect you, and appreciate your efforts in the
ng.  I have been debating whether to write this, since it will probably be
long and I'll start rambling, but you told me to go ahead, twice.  I am not
a happy camper, and have stopped going to my uro's office (been in and out
of there 20 times in 2005 - mostly seeing the PA for massages and consults,
but also some visits to the MD who did my TURP last April - which
exacerbated my chronic prostatitis, which you may recall).  I will be seeing
a new general surgeon Friday for my rectal problems.

I don't want to get repetitive and repeat all my medical problems, which are
sprinkled throughout the newsgroup, so I will try to address my questions
and comments mostly to the subject of urine production by the kidneys during
the day, versus at night.  I like to use the English system for volume
measurements, but I will use metric, since that is what you go by.  Please
remember I have been to many doctors in my life, so try to go easy on
getting another opinion out of town (which I have done several times in my
life for my various ailments - all to no avail), plus I live by myself and
don't have anyone to help me, except for one person.  I only wish that some
of the many doctors I have been to were as kind and caring, and as
knowledgeable as you are.

I certainly know you can not diagnose me (legally or ethically) over the
Internet, and would never ask you to, like I mentioned to you once before.
If you could just provide your opinions, and comments, or suggestions (like
you are so good at doing in all your posts), I would appreciate it.  Perhaps
I can get some piece of mind.

I had a TUIP in 1995 and the TURP last April (which was mainly to get rid of
the scar tissue caused by the TUIP).  Both procedures were to increase my
urine flow, and decrease my retention, nocturia, urge, etc.  I have a normal
size prostate, and a history of chronic non bacterial prostatitis (which I
call prostatitis/urethritis/cystitis - ie a continuum).  I had bacterial
prostatitis in 1997, but my urine and expressed secretion tests under the
microscope throughout 2005, basically show WBC's, but no pus or bacteria.
Was on antibiotics much of 2005, little or no help.

It took me over 3 months to get over the TURP since it just exacerbated my
prostatitis, which I already had before the TURP.  Anyway, the main reason I
am writing this is to try to understand why I can void during the day, but
not later in the day and at night (it is quite bothersome at night).  I am
58 years old, a retired engineer, and live by myself, and lead a strange
life style compared to someone as active as you are.  I  go to bed late and
get up around noon time and have a light breakfast, and eat late at night
for my main meal.  I don't think that is relevant, but I want to explain
exactly what is going on.

It took me a long time to void properly after the TURP and I was worried
about scar tissue or a stricture from the procedure.  Anyway, If I drink a
lot after getting up, I can get a good flow, say from 2:00 PM to 8:00 PM.  I
understand that if you don't drink much you are less likely to urinate :-),
but I believe this is much more complicated than that.  I drink at least 2
liters of liquid per day and more likely 3 to 4 liters.  But later in the
day, especially after my nightly meal which is around 9 to 10:00 PM, it
seems that my urine production stops (or my urethra is closing off for some
reason), and I have some theories on that.

I have measured my urine flow many times recently when I'm drinking a good
amount, and my flow is good.  I have measured as high as 28 ml/sec average,
and usually around 23 ml/sec average.  I'm sure you will say "that is good
Pete".  So you would think that the TURP helped, and there is not a
permanent stricture or impedance.  But later on in the day everything seems
to slow down and stop.  I may be drinking less later on,  but I don't think
that is the reason in itself.  I can drink a 16 ounce glass of water with my
dinner at night, and I swear it never comes back out, plus my food has
liquid in it.  If I go to the bathroom five times during the night, I would
say my total output is no more than 200 ml or so (ie 40 ml per voiding).
Like I say I just dribble, and have difficulty getting started.  But yet I
remember filling the catheter night bag (the big bag for night time) when I
had my foley catheter after the TURP.

Also, it is interesting to note that one morning (afternoon for you all)
when I got up, I started making a bunch of phone calls, and never drank
anything and didn't get done till say three or four in the afternoon, and I
voided a fair amount.  This is very interesting because I didn't drink
anything at all, and during the night I could not void good, like always.
So where did the urine come from after I got up, if I didn't drink anything.

One of my theories is that when I eat my dinner I am consuming salt (I do
not overdue it though and usually don't put salt on prepared foods with a
lot of sodium in them), and salt causes the body to retain fluid.  But by
the same token food has liquid in it and you would think that may add to
urine production.  Anyway do you think I am out in left field here, or is it
possible that the salt in my food is slowing down my urine production in
late evening and all night.  I think I remember Ed saying once that pizza
can cause fluid retention.

My nights are miserable.  I never sleep good - no talk of pills please - I
have taken every pill known to man :-) .  I only catch catnaps and am up
every hour and a half to two hours going to the bathroom, but I just dribble
and can not get started, but remember I can pee like a race horse earlier in
the day.  I don't think I am retaining, because when I do my "press on the
belly test" that I have done since I was a kid, it does not feel like I have
to go badly.  But I do have a very aggravating urge feeling during the
night, but I am not sure if I really have any volume in my bladder to speak
of.  If you are thinking of overactive bladder, I don't think so.  I have
tried detrol LA which is an anti-cholinergic, and it just plugs me up so I
can't pee at all, immediately within 4 hours.  I can not take any of the
alpha blockers (including flomax) because they plug my nose up immediately,
and completely.

I have read that as you get older you tend to pee more at night due to the
kidneys not concentrating the urine as much (I believe a normal young
adult's urine production is 2/3 during the day and 1/3 during the night).  I
appear to be just the opposite, ie I am not voiding more volume at night as
I get older, and I do not seem to be having one third of my urine production
taking place during the night.  I hear others in the group say they void
real good at night after their PVP's etc.  Well I can't pee hardly at all
during the late day or at night, but yet I can during the day.  So it makes
me wonder if my kidneys just aren't producing a lot of urine at night for
whatever reason(s).

Remember Dr. Sancha, no talk of nephrologists here :-):-) .  Another theory
I have is - could it just be my metabolism and it is biological in nature.
But if my kidneys aren't producing as much urine as they should be at night,
then why do I have the urge feeling.  I have some free sample catheters from
Lofric and was thinking about self cathing myself in the morning after
urinating to see if, and how much I am retaining, but I really don't want to
do that yet.  I have never self cathed and I don't want to stir things up
down there with my prostatitis type problems and my immune deficiency.  But
it would give me piece of mind knowing that I am not retaining.  I know  I
can go to the uro and get a pvr, but like I said, I have been there 20 times
last year, and the self cath would be more accurate anyway.

Dr. Sancha, could you give me a rough order of magnitude on how long it
takes for most liquids to be processed by the kidney after you drink them
(some can be absorbed directly through the stomach versus the small
intestine so that will be relevant I believe).  And why does asparagus make
your urine smell really bad.  If I eat asparagus I can smell it in my urine
within two hours, so that makes me think the kidney is processing liquids
within two hours.  And if you drink a lot of liquids you will start voiding
within two hours, or sooner.  Is that approximately correct.  And if it is,
what happened to the sixteen ounce glass of water I had with my dinner at
night.  I do not pee much of it back out at night.  Approximately what
percentage of liquid intake is voided back out when you urinate (ie if you
drink 4 liters of liquid a day, approximately how much passes out as urine
for a normal healthy person).

I apologize for the length of this and for my rambling, and was trying to
figure out how to wrap it up.  I hope you get the bulk of what I have been
trying to say.  I would like to think my kidneys are working okay (since I
have too many damn other problems), since I can void large amounts, at a
good flow rate during the day.  But I don't understand what is going on
later in the day and at night, when it seems that my urethra is closing up,
or my kidneys just aren't producing urine anymore, or both.  Please do the
best you can in responding to this.  If I can get any piece of mind at all,
it would be greatly appreciated.

Thank you so much once again for all of your support to all of the members
in this newsgroup...Pete
fgomsan@gmail.com - 01 Mar 2006 13:24 GMT
Pete,

Thanks for your long and detailed description of symptoms. Urine
production by the kidneys is regulated by many feedback mechanisms that
allow us to keep our homeostasis (our internal fluid, acid-base and
electrolite balances). The kidneys regulate the amount of fluid in our
body opening the tap when there is too much water and closing it when
there is not so much. There are many factors involved in the control of
urine production, and the regulation is very complex. It is true that
older people tend to urinate more at night, and this happens because
they accumulate liquid outside their blood vessels in the form of
oedema - their legs and sacrum area swell progressively during the day.
So the water they drink is accumulated there during the day due to the
hydrostatic pressure when they stand as well as the difficulties in
returning the blood through the venous system towards the heart. When
they lay down at night, this water is reabsorbed into their bloodstream
and then the kidney detects the entrance of water into the system and
starts to produce urine. These men feel very well during the day and
have to wake up to void several times at night, and every time they
void they pass a lot of urine. It is known as nocturnal poliuria, and
is diagnosed with a simple frequency-volume chart (e.g. writing down
how much you drink and how much you pass and at what times). They
usually pass more volume of urine during the night than during the day.

But your case is quite different. I am certain that your flow is
impressive after TURP, and you should not have any problem passing
water at night if you produced enough urine during the night. For some
reason, you seem not to produce much urine when you sleep.

My impression is that you probably wake up due to an abnormal sensation
of urge to urinate that might be explained by your prostatitis. If your
bladder was hyperactive, the sensation of urge would be caused by an
involunctary bladder contraction, and you would respond to
anticholinergics. But it is also posible that you have a sensation of
urge without contraction. These things can also happen as a result of
bladder ageing.

I would suggest you to prepare an excel table with the hours of the day
and night in one column, another column for the amounts you drink and
another column for the amounts you pass. We will then know what is the
real situation and will be able to interpret your fluid balance. If
your production of urine during the day is good the chances are your
renal function is perfectly OK.

I wonder what would happen if you drank a fair amount of liquid after
your dinner. And also what would happen if you kept on drinking and did
not go to bed. You would probably wake up and void as you do during the
day.

The asparragus contains an essential oil called asparragine (I guess
this is the name in English) that is eliminated with urine, and this
oil is volatile and produces that characteristic odour.

Interpreting the fluid balance is tricky, these are the insensible
losses
   * Faeces approximately 100 ml/ day
   * Lungs approximately 400 ml/ day
   * Skin approximately 600 ml/ day - and this depends on the
temperature (if you sweat, you loose water).

So you will find you drink more than you urinate. Also, you must take
into account that food contains water as well....

In summary, I guess you probably do not produce much urine during the
night (this also happens to me sometimes, I wake up and pass a dribble
in the morning, specially if I did not drink much in the evening). You
probably wake up due to an abnormal sensation of urge to urinate, and
as there is not much urine in the bladder, you do not pass urine as you
do during the day. If you do this frequency volume chart we might be
able to understand what happens. It would also be interesting to see
what happens if you keep on drinking e.g. two glasses of water every
half an hour during the entire night, my guess is that you will keep on
passing water. Let's keep in touch and see what conclusions we can
reach.

Bests,

Fernando Gómez Sancha
http://drgomezsancha2.blogspot.com
Pete - 01 Mar 2006 20:07 GMT
> Pete,
>
[quoted text clipped - 71 lines]
> keep on passing water. Let's keep in touch and see what conclusions
> we can reach.

Dr. Sancha...I am not a religious person, but God bless you for your awesome
response, and I thank you so much.  Damn it, you don't know how much I wish
you were my urologist :-) .  You have already given me some peace of mind,
as to my kidneys working properly.

I will try drinking lots of water tonight (in the wee hours of the morning).
I was going to try this many times but didn't because I don't sleep good,
but hell, what's the difference (if I don't sleep because I feel I have to
go and can't, or I don't sleep because I feel I have to go and can go).

I still think it may possibly have something to do with salt causing the
body to retain fluid (You didn't comment on that - or did you just by pass
it as not applicable).  My flow is good during the day, but I can feel it
stopping later, especially after eating at night.  Also if you remember, I
did fill the urine bag at night after my TURP - but maybe I was drinking
more before bed to help clean debris out, but I don't think I was drinking
during the night.

Thank you so much again, and I will do the test tonight (and maybe again
tomorrow night) and get back to you...Pete
 
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