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Medical Forum / Diseases and Disorders / Prostate BPH / December 2005

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Ovberactive Bladder VS  BPH

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Paul - 29 Nov 2005 14:22 GMT
How does one differentiate between BPH and an overactive bladder?
Derek F - 29 Nov 2005 19:22 GMT
> How does one differentiate between BPH and an overactive bladder?

Ultrasound scan of your prostate and test for retention.
Derek.
Lee M. - 01 Dec 2005 03:17 GMT
I thought I had BPH until I got a complete urological exam.  The symptoms
are similar so I don't think one can diagnose one vs the other without an
exam by a urologist.

The overactive bladder meds work pretty well once I got on the right dose.
I still go more often than I'd like but at least my bladder is a lot fuller
before the urge gets really strong.  I am using a patch (Oxytrol) now which
is a little more convenient (lasts 4 days) and doesn't give me dry mouth
like Ditropan did.

> How does one differentiate between BPH and an overactive bladder?
Spread_deMocracy - 02 Dec 2005 21:25 GMT
You will know.

BPH...you'll have a very full bladder, maybe even pain from the fullness of
the bladder, but you either will have a very, very hard time urinating--no
burning, just time...it will take a long time to start, and the stream will
be very low/slow or you will not be able to pee at all).  Overactive
bladder, you wanna pee often but there is not much there when you do, or,
you are dribbling into your underwear while experiencing the urge.  Your uro
will be able to shove a probe up your dongle to have a look, called a
Cystoscopy, and will be able to tell if you are obstructed, (BPH), or not.
Ain't fun either way.   All the best to you.

> How does one differentiate between BPH and an overactive bladder?
Pete - 03 Dec 2005 01:21 GMT
Spread...I like your description of BPH vs overactive bladder (OB), and I
find this question the OP asked very interesting and somewhat difficult to
answer, even though a cystoscopy should rule out BPH or a stricture.  I
basically agree with you but would like to expand on it if I may.

I have some comments and questions on the subject for everyone.  First let
me refresh everyone's memory that I just had a TURP in April (and it wasn't
really for gross BPH, but to remove scar tissue from a previous TUIP -  i.e.
my prostate was not grossly enlarged).  Therefore I shouldn't have BPH.  And
I do not believe I am retaining based on ultrasounds after voiding.

I have kind of a strange deal with the uro's (there all in one room where I
live - 5 surgeon MD's and one PA).  I see the PA most of the time (for
office visits and massages), and he will prescribe stuff that may or may not
help me, including stuff I ask for - if you recall I just asked him for some
elmiron (which is for IC) as a last resort recently -  which is going to be
a long haul (takes 3 months to a year to work, if it works at all), esp.
since I am not diagnosed with IC (based on the surgeon's cysto).

The PA said he thought I might have an overactive bladder before I had the
cysto and TURP (and my ultrasound was showing very little post void urine).
I told him I felt urgency all the time but could not go and had difficulty
going.  I believe that the people who have OB feel like they have to go (ie
the urge) *but* they *can go without difficulty* even though it may be a
small volume.  In other words the detrussor muscle in the bladder seems to
be over reacting or malfunctioning (for god only knows what reasons) and it
is creating an urge feeling to go even though the bladder is far from full.
If you watch the Detrol LA commercial, you see the woman getting off the
rowboat and running to the head.  But I think she can go, when she gets
there.

Sorry for the long lead in, but its relevant and leads to questions I can
never get an answer to from my uro's.  Anyway the uro gave me some detrol LA
capsules and said they may take a while to work (which I knew was BS since
they are anti-cholinergics which work on the sympathetic nervous system and
should start working right away - which they do).  I took the first pill and
within four to six hours I could hardly pee at all and I was already having
trouble peeing (especially at night).  So they were doing there job -
slowing down the contractions of the bladder detrussor muscle, and
consequently making it harder to pee (and in fact the package insert says
they can cause retention and you should not take them if you already have
retention).  I was going to stop taking them immediately, but took one more
the next day and it just blocked me up worse, so that was the end of that.
There are many anti-cholinergic drugs on the market (anti spasmodics etc)
that do similar things, (as well as the opiates like oxycodone and
hydrocodone and the anti depressants like amitriptyline) that can cause
constipation and urine retention.  Apparently detrol LA has an affinity for
the detrussor muscle, as well as its other systemic effects.

I told the uro I couldn't take it and he said I didn't give it long enough.
Bullshit, if it makes me worse I am not going to take it.  I think if you
already have trouble urinating (even though you don't have a blockage), then
the stuff is contraindicated.  The package insert does say it is
contraindicated if you have a blockage such as BPH or a stricture.  So
therefore it is for people who do not have retention from blockage and that
can pee, except that it feels like they have to pee too soon.  Do you see
what I am getting at.

If I was having difficulty voiding (even though I did not have a significant
blockage except for the previous scar tissue), I do not think it was
textbook OB like you see on the TV commercials.  Apparently there are many
people with "true" OB that are relieved by detrol LA and its sister drugs,
but its not for me, and I still don't know why I can't pee good later on in
the day and at night, but feel like I have to.  Incidentally IC (which is
90% female related) definitely causes the urgency syndrome, and people take
detrol for that also, along with elmiron, neurontin, etc.

I would like to ask the following questions if you all haven't fallen asleep
reading this.  Never could get a good answer from a uro.  Oh, BTW there is
another very popular uro term (which I'm sure you are all familiar with)
called "nocturia" which means getting up at night to urinate.  I certainly
have that big time, but like the OB, I think most people that have nocturia,
get up, but they can go, and some even go more at night than during the day
(which gets complicated).

Here is my main question/quandary.  I have a lot of pain/discomfort/urge
which I have told you about in the past, and I mainly contribute it to
prostatitis/urethritis/cystitis (non bacterial).  The TURP really messed me
up for three months afterward (then I really had the urge).  I can void
pretty good if I drink a lot during the day (it would seem the roto router
opened me up some and I certainly would hope got rid of my previous scar
tissue).  But my urge is still there even shortly after voiding, and I have
difficulty voiding later in the day and all night.  It's like some kind of
inflammation is closing my urethra up later in the day.  I go to bed late
and get up late but I believe that is not relevant.  It makes sense that if
I drink more (say from 12 noon to 6 pm), I would pee more (I'm not stupid).
But there is something taking place later on, and it seems to definitely get
worse at night.  I don't eat dinner till 9 pm or after, but again I consider
that irrelevant.

Does anyone have any idea what may be causing the difficulty at late day and
night.  One theory I have is salt in my food helps retain urine, and I told
the uro that once and he said eating should make you void more (I believe he
meant from the liquid in the food as well as what you drank).  And even if I
don't have as much volume in my bladder at night because I have stopped
drinking so to speak, why the hell does it feel like I have to go all the
time.  I believe it is definitely some king of inflammatory response, but
not retention caused by a blockage from BPH.

Sorry this was so long.  Probably should have started a new thread, but the
subject here was certainly relevant, as well as Spreads response.  Thanks
for taking the time to read it...Pete

> You will know.
>
[quoted text clipped - 10 lines]
>
>> How does one differentiate between BPH and an overactive bladder?
Lee M. - 03 Dec 2005 15:16 GMT
I think Pete's description is about right.  I thought I had BPH based
primarily on the frequency/urgency symptoms and the fact that sometimes I
will void a pretty large volume within an hour of the previous void (this
still happens occasionally).  I should have realized when several BPH drugs
(Flomax, Uroxatrol, Saw P) didn't help that maybe that wasn't the problem.

Based on his exam, my uro (who I chose because he was PVP capable) said he
didn't think the PVP would help me.  He started me on Detrol (which didn't
help), then 10mg Ditropan, which  helped a little, then finally 15mg
Ditropan which helped to the point that it's manageable.  I still am rarely
able to go more than 2-2.5 hrs between voiding (except at night when I get
up only once) unless I am sweating a lot or I am very busy and don't think
about it.  When I do get the urge now, it's doesn't put me in a panic if I'm
not near a restroom like it used to.

Prior to starting the overactive bladder meds, I never voided more than
about 7 oz.  Now it's almost always 8 or more and sometimes up to 14 oz.  I
have become somewhat "calibrated" to the level of urgency so I know if I
really have to go based on volume in the bladder vs just think I have to go
based on the urges.  I am now using Oxtrol which is a patch.  It doesn't
give me dry mouth like the Ditropan did.

Good luck to Paul.

>  I believe that the people who have OB feel like they have to go (ie the
> urge) *but* they *can go without difficulty* even though it may be a small
> volume.  In other words the detrussor muscle in the bladder seems to be
> over reacting or malfunctioning (for god only knows what reasons) and it
> is creating an urge feeling to go even though the bladder is far from
> full.

>>> How does one differentiate between BPH and an overactive bladder?
Pete - 04 Dec 2005 02:03 GMT
Lee...I understand from your response that the Ditropan has helped increase
your time between voiding somewhat (and thus increased your volume).  Did
you notice if either the Ditropan or the Detrol made it more difficult to
void, when you did void (since they are causing a reduction in the detrusor
muscle contractions so to speak)...Pete

> I think Pete's description is about right.  I thought I had BPH based
> primarily on the frequency/urgency symptoms and the fact that
[quoted text clipped - 28 lines]
>
>>>> How does one differentiate between BPH and an overactive bladder?
Lee M. - 04 Dec 2005 15:16 GMT
No I didn't.  I have a pretty decent stream unless I wait too long.  The uro
said if the bladder gets stretched too much from overfilling, it loses it's
ability to contract and squeeze out the urine.  He says that's why the flow
is slow when I wait too long.

> Lee...I understand from your response that the Ditropan has helped
> increase your time between voiding somewhat (and thus increased your
[quoted text clipped - 34 lines]
>>
>>>>> How does one differentiate between BPH and an overactive bladder?
Pete - 04 Dec 2005 20:14 GMT
> No I didn't.  I have a pretty decent stream unless I wait too long. The
> uro said if the bladder gets stretched too much from overfilling,
> it loses it's ability to contract and squeeze out the urine.  He says
> that's why the flow is slow when I wait too long.

Lee...Overfilling would be more than 16 ounces for a normal bladder.  You
said you void around 8 ounces but have OB (or at least take ditropan for OB
symptoms).  I do not understand why your bladder would be overstretched
(from holding say 8-12 ounces), and thus cause the loss in ability to
contract that you mention.  Are you saying your bladder is overstretched at
that smaller amount.  If it is than perhaps you have another problem besides
OB, e.g. some kind of fibrosis that prevents it from stretching (that's just
an example for talking purposes).

My understanding of OB is that is a premature sensation that you have to go
because of an overactive detrusor muscle (for simple explanation), and is
not necessarily related to how much the bladder can
can actually hold.  If any normal person with a normal bladder lets their
bladder overfill (and the longer you wait the worse it gets), there may be a
feeling of "its hard to start peeing" - which we all have experienced from
the time we were children.  You know your in the car and you can't get off
the road and you have been drinking beer or whatever, etc, etc, :-)

Pete

>> Lee...I understand from your response that the Ditropan has helped
>> increase your time between voiding somewhat (and thus increased your
[quoted text clipped - 34 lines]
>>>
>>>>>> How does one differentiate between BPH and an overactive bladder?
Lee M. - 05 Dec 2005 00:00 GMT
I've never measured the volume when my bladder was so full I had a hard time
starting.  I have measured as much as 14 oz when I had a pretty strong urge
but had no trouble starting and had a decent stream.  The OB medication has
allowed me to fill my bladder more before the urge was strong enough I felt
I really had to go.  It has not got me to where I was 20-30 years ago when I
suspect (wasn't conscious of it at the time) I went 4-5 hours between voids.

>> No I didn't.  I have a pretty decent stream unless I wait too long. The
>> uro said if the bladder gets stretched too much from overfilling,
[quoted text clipped - 60 lines]
>>>>
>>>>>>> How does one differentiate between BPH and an overactive bladder?
Spread_deMocracy - 02 Dec 2005 21:38 GMT
"D'oh!!"   One more thought after I pressed "Send"...

Likely your doctor will first do a DRE.  A "DRE" is a digital, rectal exam.
An experienced doctor can tell from the DRE if your prostate is somewhat
enlarged.   If it is, he/she ought to then prescribe one of the Alpha
Blockers, such as FLOMAX, UROXATROL, HYTRIN, etc.   This relaxes the urinary
channel to permit your to have a rather fulfilling whiz.   I found that mine
kicked in about 2 or 3 hours after taking it and I felt rather happy about
that.    Or, if your doctor really wants to impress you, he/she will
recommend the above PLUS either PROSCAR or AVODART.  These latter two are
used to shrink the prostate down, but only after many months.   [Watch out
for the side effects for any of the above meds!!!!!]

> How does one differentiate between BPH and an overactive bladder?
fgomsan@gmail.com - 11 Dec 2005 10:01 GMT
Paul,

Bladder overactivity is the presence of unconscious contractions of the
bladder. A normal bladder gets filled with urine with very low
pressure, when it gets full, it sends messages to the brain saying "I
am full" and then the owner decides to urinate when it is socially
acceptable. Only when the owner says "now" the bladder starts
contracting. This is how the bladder should behave.

Bladder overactivity can be idiopathic (no known cause) - affects about
10% of the population with various degrees of severity - or secondary
to certain problems, mainly obstruction caused by BPH, or cofee & tea &
orange juice consumption.

So BPH and old age causes bladder overactivity. When BPH is operated by
any means (TURP, PVP), bladder overactivity tends to improve WITH TIME.
It can take months or even years to improve, and it will only do so in
90% of patients.

The diagnosis of bladder overactivity is not based in symptoms
(unreliable witnesses), but in a urodynamic study that demonstrates the
presence of involunctary bladder contractions during bladder filling.

All the best,
http://drgomezsancha2.blogspot.com
Pete - 12 Dec 2005 01:24 GMT
> Paul,
>
[quoted text clipped - 19 lines]
> the presence of involunctary bladder contractions during bladder
> filling.

Dr. Sancha...Thank you for your detailed and informative post.  What is the
name of the urodynamic study (and how is it done) you refer to that
demonstrates the presence of involuntary bladder contractions during bladder
filling...Pete

> All the best,
> http://drgomezsancha2.blogspot.com 
fgomsan@gmail.com - 12 Dec 2005 08:28 GMT
Pete,

A urodynamic study is performed introducing a pressure transducer
inside the blader per urethram, as well as a filling catheter. Another
pressure measuring devide is introduced in the rectum. Then the bladder
is filled with water and the pressure readings are recorded. The rectal
pressure rises when the abdominal pressure is risen by coughs or
straining, and this also rises pressures inside the bladder. When
bladder pressures rise without a rise in rectal pressure that reveals a
bladder contraction. If the filling is made with radiographic contrast
under an xray machine, then you also have the possibility of correlate
pressure readings with radiographic images (video-urodynamic study).
The whole thing takes 20-30 minutes. The risk is minimal, mainly to
develop a urinary infection, and thus, antibiotics are usually
prescribed before the procedure.
 
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