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Medical Forum / Diseases and Disorders / Prostate BPH / October 2005

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How can one tell of too much testosterone?

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Spread_deMocracy - 27 Oct 2005 02:54 GMT
From time to time I check in with this newsgroup and also one of the BPH
bloggers, (see below)..I know blogs have lots of personal opinion, but once
in a while my curiosity is piqued.   The new posting about hormones piques
my curiosity.  Anyone on this newsgroup able to confirm this, and if so,
provide more scientific explanations or an authoritative reference?  Thanks
in advance...
I'm referring to latest posting, see "...size..." at
http://bph-prostate-enlarged.blogspot.com/
Ed Friedman - 27 Oct 2005 18:18 GMT
> From time to time I check in with this newsgroup and also one of the BPH
> bloggers, (see below)..I know blogs have lots of personal opinion, but once
[quoted text clipped - 4 lines]
> I'm referring to latest posting, see "...size..." at
> http://bph-prostate-enlarged.blogspot.com/ 

Well, that web site is partly true and partly nonsense.  Basically,
estradiol will cause inappropriate cell division within the prostate, so
you want to keep that level low.  Also, DHT will prevent the normal
apoptosis that occurs for prostate cells, so you want to keep that level
very low.  Finally, testosterone is what produces the apoptotic proteins
that kills the prostate cells when they get old (or are cancerous).  So,
to eliminate BPH (and early stage prostate cancer), you want high
testosterone, very low DHT (you need a 5AR2 inhibitor to achieve this)
and low estradiol (you need arimidex to achieve this).  All of these are
only available by prescription and must be taken under a knowledgable
doctor's care.

If you want to read more about the science involved here, check out my
paper at:

http://www.tbiomed.com/content/2/1/10

My next paper should clarify this all greatly, and hopefully will be
published in that same journal before the end of this year.

Ed Friedman
Spread_deMocracy - 28 Oct 2005 00:42 GMT
Ed:  very special thank you.   All these years I have never read anything
that so clearly linked DHT to testosterone and BPH...In my own case, I asked
several specialists along the way to my PVP.  None drew the relationship
that you just did.   Your response goes in my own personal clipping file of
useful info.   Thanks much.

Curiosity question:  why are you publishing papers on this topic?  What's
your association to the field of BPH?  Good luck with the publications.

"Ed Friedman" <ed@math.uchicago.edu> wrote [SNIP]
Ed Friedman - 28 Oct 2005 19:21 GMT
> Ed:  very special thank you.   All these years I have never read anything
> that so clearly linked DHT to testosterone and BPH...In my own case, I asked
[quoted text clipped - 6 lines]
>
> "Ed Friedman" <ed@math.uchicago.edu> wrote [SNIP]

Actually, I am publishing in the area of prostate cancer.  I started
doing the research when my own PSA went up to 6.5.  When doing my
research, I couldn't help but notice that both BPH and breast cancer
seemed to be behaving the same way, with regards to hormone receptors,
as does prostate cancer.  In my own case, my PSA is 2.1 at the last
reading and I'm pretty much following what I suggested.  One important
caveat however - if you take any 5AR2 inhibitors (e.g. proscar or
avodart) or iAR inhibitors (e.g. casodex or flutamide) you must avoid
all phytoestrogens, especially soy products and flaxseed products.  My
next paper should clarify all of this.

Ed Friedman
Spread_deMocracy - 29 Oct 2005 01:59 GMT
Ed:  thanks for clarifying... We need what your are working on.    Sounds to
me like leading edge.   Here's wishing you the very best of success in your
research: statistically significant "P" values and happy "t-test" results.
Regards.

> Spread_deMocracy wrote:  Ed:...[SNIP]...Curiosity question:  why are you
> publishing papers on this topic?  [SNIP]....

>> "Ed Friedman" <ed@math.uchicago.edu> wrote > Actually, I am publishing in
>> the area of prostate cancer.  [SNIP]....
 
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