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Medical Forum / Diseases and Disorders / Prostate BPH / May 2005

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DHEA and BPH

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JC - 12 May 2005 17:49 GMT
Some Internet sites (commercial) refering to Dr...and Professors...studies
say that DHEA can shrink prostate due to the production of estrogens, others
recommand to keep away from it as the resulting increase of testosterone
will enlarge prostate and increase risk of cancer.
Has somebody with BPH experienced DHEA or has "scientific" information about
this matter ?

Thanks.

RM
Oliverio - 13 May 2005 14:28 GMT
According to "The Natural Prostate Cure" by Roger Mason, a book that comes
with Beta Sitosterol shipments, testosterone is your friend.  The enemy is
estrogen/estradiol.  He does say that one should do hormone testing and not
blindly take hormone supplements, which I do to some degree.  I take 25 mcg
DHEA, 50 mcg levothyroxine (doctor prescribed),  25 mcg melatonin (primarily
for sleep), and of course beta sitosterol.  Also, I rub on natural
progesterone creme daily (I think it combats bad dihydrotestosterone and
helps balance my hormonal levels).

Anyway, I think it reduces my BPH symptoms.

> Some Internet sites (commercial) refering to Dr...and Professors...studies
> say that DHEA can shrink prostate due to the production of estrogens, others
[quoted text clipped - 6 lines]
>
>  RM
esp-electro.com - 28 May 2005 06:50 GMT
Hello! I've got good news for you!
Men have solved their BPH problem with a new treatment called (E.S.P.)
Electrically Stimulated Peripheral Therapy.
This treatment has been reported to reduce swelling and pain within the
first few treatments, sometimes earlier, and sent their BPH into remission!
Do NOT confuse ESP therapy with Tens or Rife. ESP WORKS and it is claimed to
completely handle BPH, Thrombosis and Rheumatics.
Have a look for yourself, plenty of information located at
http://www.esp-electro.com
I am the E.S.P. serious illness agent for the United States and Canada. When
you decide to purchase this simple, convenient and easily affordable compact
system, small enough to fit comfortably in your pocket, contact me, David at
esp_electro@yahoo.com and we can take it from there.
I'm located in the greater Washington DC area.
Here's to your recovery from pain and suffering for good!
David
ESP ELECTRO REP USA

> According to "The Natural Prostate Cure" by Roger Mason, a book that comes
> with Beta Sitosterol shipments, testosterone is your friend.  The enemy is
[quoted text clipped - 23 lines]
>>
>>  RM
Ed Friedman - 13 May 2005 20:30 GMT
> Some Internet sites (commercial) refering to Dr...and Professors...studies
> say that DHEA can shrink prostate due to the production of estrogens, others
[quoted text clipped - 6 lines]
>
>  RM

RM,

You raise an interesting point.  The real question to be answered is
what causes BPH before you can start to talk about a cure.  Since it
only seems to occur later in life, with frequency increasing with age,
then it may well be due to a decrease in the rate of apoptosis (the same
problem with prostate cancer).  Normal prostate cells are supposed to
die after ~500 days, and testosterone(T) binding to the membrane
androgen receptor(mAR) being what induces the proteins that cause
apoptosis (programmed cell death).  This apoptosis is prevented by DHT
binding to intracellular androgen receptor(iAR).  As the cells age and
iAR loses its functionality, then apoptosis is supposed to occur.  (A
separate mechanism kicks in when mAR loses its functionality.)  As you
age, your levels of T and therefore your ability to produce apoptotic
proteins from mAR keeps decreasing.

DHT inhibitors coupled with high levels of T should eliminate BPH.
However, it is very dangerous to administer high levels of T unless you
have a doctor who knows what he is doing.  E.g., it can result in high
levels of estradiol, which can lead to prostate cancer.  Also, you have
to optimize levels of DHEA, cortisol, etc. for overall health reasons -
in short you need a doctor who specializes in this.

If you want to know more about the theoretical basis of all of this, you
can check it out at:

http://www.tbiomed.com/content/2/1/10

Ed Friedman
 
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