Dutasteride

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Amalia Rodrigues - 22 Mar 2005 12:35 GMT

My uros advice is to undergo surgical procedure for my BPH. Lately, the condition is affecting my life too much, having to get up almost every hour and a half during the night and being unable to sit during a long theater performance.

As I don't feel like surgery, I started today taking (on the very reserved advice of one uro) dutasteride, 0.5 mg. once daily.

I'd like to read the opinion of other people who are on the drug are their insights.

Thanks,

Hassan

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Spread deMocracy - 22 Mar 2005 19:51 GMT

HASSAN: I vote with your urologist: to get the surgery. [Maybe there is
a reason for his advice to have been "reserved", as you mention.] Unless
you have a medical condition that would preclude surgery? If you do elect
surgery, you might want to have a close look at laser such as PVP. (Lots
of info written here in this newsgroup about PVP.) We all hate getting
sliced but PVP is simple...no big deal at all. Why are you taking a DHT
Inhibitor? Did your blookwork confirm that your DHT is too high or is your
uro just guessing, as many do? If you don't have definitive bloodwork
across all the factors including SBGH, your condition may be driven by other
blood factors ranging from hypertension to estradiol. Finally, you likely
already know this: Finasteride, Dutasteride, and others are used to inhibit
DHT. By the time they kick in can take several months to 18 months before
you will notice any improvement. Then, after improvement, you have to stay
on them for maintenance. Likely you will need to supplement the DHT
blockers with Alpha Blockers, (Flomax, Cardura, Uroxatrol, or Hytrin), to
allow you to have a whiz while waiting the many months for the DHT blockers
to kick in. Many men report lots undesirables from the Alpha
Blockers--everything from retro-ejaculation, running nose, to dizziness and
shortness of breath. Lastly, this brief abstract speaks only to one DHT
inhibitor but may be worth the 30 seconds to read:

http://jncicancerspectrum.oupjournals.org/cgi/content/full/jnci;96/4/338?fulltex
t=male+breast+cancer+during+finasteride&searchid=QID_NOT_SET
Best of "outcomes" to you!

My uros advice is to undergo surgical procedure for my BPH. [SNIP]... I
started today taking (on the very reserved advice of one uro) dutasteride,
0.5 mg. once daily. [SNIP]

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Amalia Rodrigues - 27 Mar 2005 15:54 GMT

Thank you for caring, Mr. Democracy.

Actually, my doubts were arised by the following "state of the art" article I read in Medscape:

http://www.medscape.com/viewarticle/480671?src=search

As you can see, dutasteride can produce a big improvemente, even after a 48 month follow-up period. In the meantime, other less invasive techniques than cut and slice are being developed. If I could postpone my need for a surgical intervention, for, say, one or two years, probably these new techniques would become widely available.

After reading the article, I think that maybe my Uro (who is a urology professor and head of the urology dept. of a big medical center) is after all being too hasty in his reccommendation of surgery. Perhaps he has specialized in the use of the drastic cutting of prostate tissue away, and as often happens he prefers the use of a technique that he knows well to experimenting with techniques which are new to him. This happens to everybody.

I am also taking doxazosin, and next time I'll ask my family doctor to write me a bigger dosage, so I can wait until the dutasteride starts showing its effects (hopefully).

Thanks again, and I'd like to hears more comments,
hassan

: HASSAN: I vote with your urologist: to get the surgery. [Maybe there is
: a reason for his advice to have been "reserved", as you mention.] Unless
[quoted text clipped - 23 lines]
: started today taking (on the very reserved advice of one uro) dutasteride,
: 0.5 mg. once daily. [SNIP]

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